... matrix metalloproteinases, serine and threonine proteases, cathepsins) at the "cell-matrix" interface that leads to the ... In this case, a decrease in the expression of Snail and the matrix metalloproteinase 3, 10, 12 and 13 genes and an increase in ... A relationship between the application of drugs on the basis of matrix metalloproteinase inhibitors in cancer therapy and ... and activate the expression of vimentin and matrix metalloproteinases, thereby increasing cell migration. A team of researchers ...
... inhibits cell invasion and metastasis by targeting MMP11 and MMP13 matrix-metalloproteinases and small GTPases such as ... By targeting transcripts of genes such as transcription factors, matrix-metalloproteinases, Bcl-2 family gene members, small ... In humans, miR-125 family is composed of three homologs: hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125b-2. MiR-125a has been ... By targeting Bcl-2 family members transcripts, miR-125 is involved in regulation of apoptosis as well. Depending on the context ...
It is theorised that drugs interfering with matrix metalloproteinases, such as tetracyclines, anthracyclines, quinolones and ... February 2, 2010. Archived from the original on November 26, 2012. Retrieved March 16, 2010. Pollack A (March 15, 2010). " ...
"Crocetin Inhibits Invasiveness of MDA-MB-231 Breast Cancer Cells via Downregulation of Matrix Metalloproteinases", Planta ... 2, pp. 109-14, doi:10.1016/0304-3835(91)90203-T, PMID 2025883 Rubio-Moraga, A.; Castillo-López, R.; Gómez-Gómez, L.; Ahrazem, O ... 2, pp. 146-51, doi:10.1055/s-0030-1250178, PMID 20803418 Deo, B. (2003), "Growing Saffron-The World's Most Expensive Spice" ( ... Negbi 1999, p. 2. "Saffron: leading producers worldwide 2019". Statista. Retrieved 2021-01-14. R. Rasti. TED Case Study ...
These proteases include; cathepsins B, L, and S, the matrix metalloproteinases MMP-1, MMP-2, MMP-3, and MMP-9, and the ... There are a number of proteases that possess the potential to degrade both the extracellular matrix and neuronal cells that are ... could have large negative effects on the extracellular matrix. Microglia synthesize amyloid precursor protein (APP) in response ... 1066 (1-2): 78-85. doi:10.1016/j.brainres.2005.10.050. PMID 16325157. S2CID 34963522. Wang J, Rogove AD, Tsirka AE, Tsirka SE ( ...
... matrix metalloproteinases (MMPs) to produce proinflammatory and proapoptotic chemicals. There are also activation of cytokines ... 78 (2): 114-121. doi:10.1212/WNL.0b013e31823efc93. ISSN 0028-3878. PMC 3466672. PMID 22205760. (CS1 maint: multiple names: ... 143 (2): 135-140. doi:10.1007/s007010170118. ISSN 0942-0940. PMID 11459084. S2CID 1235411. Zalewski, Nicholas L.; Rabinstein, ... The rising intracellular calcium level activates a series of enzymes like phospholipase A2 (PLA2), COX-2, calcineurin, calpain ...
... tissue inhibitors of metalloproteinase) may be responsible for the abnormal degradation of the valve matrix and therefore lead ... The extracellular matrix of the aorta in patients with BAV shows marked deviations from that of the normal tricuspid aortic ... "Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation". The ... Its heritability ( h 2 {\displaystyle h^{2}} ) is as high as 89%. Both familial clustering and isolated valve defects have been ...
For example, Matrix metalloproteinases (MMPs) are known to be up-regulated in cancer sites. By inserting an infection blocking ... 2011). "Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting". FEBS J. 278 (1): 16-27. ... AAV-2-HSV-TK: Herpes simplex virus type 1 thymidine kinase (HSV-TK) is a common anti-cancer therapy that converts the ... AAV-2-sc39TK: sc39TK is a five-codon substitution from HSV-TK where silent mutations have been introduced into the GCV- ...
Finally, many of these signaling processes can be regulated by matrix metalloproteinases (MMPs) as the targets of many MMPs are ... Ethell IM, Ethell DW (October 2007). "Matrix metalloproteinases in brain development and remodeling: synaptic functions and ... The hypothesized non-selective pathways indicate that the axons are guided to their destinations by the matrix through which ... or they may arise from changes activated in the extracellular matrix of the synaptic cleft. AChR experiences multimerization ...
It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Mutations in this ... Yana I, Weiss SJ (2000). "Regulation of Membrane Type-1 Matrix Metalloproteinase Activation by Proprotein Convertases". Mol. ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Campan M, Yoshizumi M, Seidah NG, Lee ME, Bianchi C, Haber E ... J. 314 (Pt 2): 521-32. doi:10.1042/bj3140521. PMC 1217081. PMID 8670066. Miranda L, Wolf J, Pichuantes S, Duke R, Franzusoff A ...
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This process in turn activates osteoclasts which begin to destroy bone, and it activates matrix metalloproteinases that destroy ... Its mechanism of action involves inhibition of matrix metalloproteinases (such as collagenase), which degrade the teeth's ... which leads to the accumulation of a mycotic and bacterial matrix at the gum line, called dental plaque. Other contributors are ... stimulating fibroblast proliferation and metalloproteinases activation favouring cardiac remodelling. During SARS Covid 19 ...
360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin ... A recent development is Tinosorb S Aqua, which is bemotrizinol in a PMMA matrix dispersed in water. This makes it possible to ... 2.0.CO;2. PMID 11594052. S2CID 29879472. "basf-chemtrade.de" (PDF). www.basf-chemtrade.de. Archived from the original (PDF) on ... Retrieved 2 July 2022. Osterwalder, U.; Luther, H.; Herzog, B. (2001). "Über den Lichtschutzfaktor hinaus - neue effiziente und ...
... promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the ... Quiescent PaSCs produce metalloproteinases such as MMP-2, MMP-9, and MMP-13 and their inhibitors, which assist in the turnover ... Activated PaSCs and other myo-fibroblast cells contribute to the formation of a provisional matrix at the injury site, which ... The activated PaSCs then grow in number, migrate and secrete extracellular matrix components such as type I collagen, ...
... bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem. 282 :7723-32. Pulichino AM, Wang IM, Caron A, ... 2:33-9. Berninger A, Webber MP, Weakley J, Gustave J, Zeig-Owens R, Lee R, Al-Othman F, Cohen HW, Kelly K, Prezant DJ. (2010) ... 2:455-70. Uchida T, Makita K. (2008) Acute lung injury and alveolar epithelial function. Masui. 57:51-9. Tang PS, Mura M, Seth ... Type 2 pneumocytes are more resistant to damage, which is important as these cells produce surfactant, transport ions and ...
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... places it in the mammalian matrix metalloproteinase family". Biochemistry. 30 (25): 6115-23. doi:10.1021/bi00239a005. PMID ... doi:10.1016/s0076-6879(76)45032-2. PMID 1012003. Lepage T, Gache C (March 1989). "Purification and characterization of the sea ...
MiR-712 targets tissue inhibitor of metalloproteinases 3 (TIMP3). TIMPs normally regulate activity of matrix metalloproteinases ... A number of pro-atherogenic genes including matrix metalloproteinases (MMPs) are upregulated by d-flow, mediating pro- ... MMPs) which degrade the extracellular matrix (ECM). Arterial ECM is mainly composed of collagen and elastin fibers, providing ... 129 (2): 303-17. doi:10.1016/j.cell.2007.03.030. PMID 17397913. Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, ...
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... tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase ... tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase ... Metalloproteinase 9, and fibronectin. PAK1 has been shown to interact with: ARHGEF2, ARPC1B, BMX, C-Raf, CDC42, Cyclin- ... 2 (6): 1657-69. doi:10.1016/j.celrep.2012.11.018. PMC 3554793. PMID 23260667. Wang G, Song Y, Liu T, Wang C, Zhang Q, Liu F, ...
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This protein may also be important in inhibition of matrix metalloproteinases. These ideas are extremely important in the ... Additionally, pVHL is important for extracellular matrix formation. ... Type 2 has also been further subdivided based on risks of renal cell carcinoma. In types 1, 2A and 2B the mutant pVHL is ... Since iron, 2-oxoglutarate and oxygen are necessary for the inactivation of HIF, it has been theorized that a lack of these ...
... is also used as standard for comparison of hyaluronidase, elastase and matrix-metalloproteinase-1 inhibition of ... Nema NK, Maity N, Sarkar BK, Mukherjee PK (September 2013). "Matrix metalloproteinase, hyaluronidase and elastase inhibitory ... elastase and matrix-metalloproteinase-1 inhibitor". Indian Journal of Pharmacology. 44 (5): 584-587. doi:10.4103/0253- ... 68 (2): 111-114. doi:10.1055/s-2002-20256. PMID 11859458. Yu F, Wang Q, Zhang Z, Peng Y, Qiu Y, Shi Y, et al. (June 2013). " ...
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The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in ... of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix". ... Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. This gene belongs to the tissue ... Apte SS, Mattei MG, Olsen BR (Jun 1994). "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) ...
for DX-2400, a Matrix metalloproteinase-14 (MPP-14) targeted monoclonal antibody intended to inhibit tumor blood vessel ... 2009). "Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis". Cancer Research. ... 83 (1): 60-2. PMID 21585174. Mashiach-Farkash, E; Rak, R; Elad-Sfadia, G; Haklai, R; Carmeli, S; Kloog, Y; Wolfson, HJ (2012 ... 1 (1): 2-14. doi:10.1002/acn3.19. PMC 3900310. PMID 24466563. Kim, Enoch; Stewart Campbell; Olivier Schueller; et al. (June ...
... epithelial cell function have been found to disrupt milk protein production due to secretion of matrix metalloproteinases. ... Osteocytes work through various mechanosensory mechanisms to assist in the routine turnover over bony matrix. Outside of a few ... Osteocytes arise from osteoblasts that are trapped within a self-secreted matrix. While osteocytes also have reduced synthetic ... 1 (2): 167-191. doi:10.1111/j.1365-2184.1968.tb00957.x. ISSN 0960-7722. S2CID 86353634. Patt HM, Quastler H (July 1963). " ...
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