*Tryptase

... due to genetic mutations resulting in the formation of FIP1L1-PDGFRA fusion genes or the presence of systemic mastocytosis. ... "Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future". Cancer Research. ...

*CD117

Gupta R, Bain BJ, Knight CL (2002). "Cytogenetic and molecular genetic abnormalities in systemic mastocytosis". Acta Haematol. ... Patnaik MM, Tefferi A, Pardanani A (2007). "Kit: molecule of interest for the diagnosis and treatment of mastocytosis and other ...

*Cromoglicic acid

"Cromolyn sodium in the management of systemic mastocytosis". J. Allergy Clin. Immunol. 85 (5): 852-5. doi:10.1016/0091-6749(90) ... to treat mastocytosis, dermatographic urticaria and ulcerative colitis. Another oral product, Intercron (sodium cromoglicate in ...

*Mastocytosis

... indolent systemic mastocytosis, aggressive systemic mastocytosis, and leukemic systemic mastocytosis (which comprises 3% of ... UP and TMEP can evolve into indolent systemic mastocytosis. This should be considered if patients develop any systemic symptoms ... Systemic mastocytosis was first reported by French scientists in 1936. Mast cell tumors are found in many species of animals. ... If the level is elevated, this most probably implies that the mastocytosis is systemic and can only be confirmed by undergoing ...

*Midostaurin

Over 95% of patients with adult onset systemic mastocytosis and approximately 40% of children with cutaneous mastocytosis are ... Midostaurin is an investigational treatment in patients with advanced forms of systemic mastocytosis and D816V c-Kit mutation ... and advanced systemic mastocytosis. It is a semi-synthetic derivative of staurosporine, an alkaloid from the bacterium ... "Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis". New England Journal of Medicine. 374 (26): 2530-41. doi: ...

*Clonal hypereosinophilia

... of patients with systemic mastocytosis. Also referred to as SM-eo (systemic mastocytosis with eosinophilia) or SM-SEL (systemic ... systemic mastocytosis, etc.) (see causes of eosinophilia). Absent these causes, patients were diagnosed in the World Health ... "Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis". Current ... mastocytosis with chronic eosinophilic leukemia), this disease's clonal eosinophils bear the same driving mutation, D816V in ...

*Dermatographic urticaria

Dermographism may occur in Mastocytosis (systemic mast cell proliferation). Dermographism can be treated by substances (i.e. an ...

*Omalizumab

... in a patient with systemic mastocytosis and undetectable specific IgE". Ann Allergy Asthma Immunol. 104 (6): 537-9. doi:10.1016 ... "Omalizumab is effective in treating systemic mastocytosis in a nonatopic patient". Allergy. 65 (7): 926-7. doi:10.1111/j.1398- ... cutaneous or systemic mastocytosis, bee venom sensitivity (anaphylaxis), idiopathic anaphylaxis, eosinophil-associated ... The main adverse effect is anaphylaxis (a life-threatening systemic allergic reaction), with a rate of occurrence of 1 to 2 ...

*Imatinib

One study demonstrated that imatinib mesylate was effective in patients with systemic mastocytosis, including those who had the ... systemic mastocytosis, and myelodysplastic syndrome. It is taken by mouth. Common side effects include vomiting, diarrhea, ... aggressive systemic mastocytosis without or an unknown D816V c-KIT mutation, hypereosinophilic syndrome and/or chronic ... "Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial". Cancer. 107 (2): 345-51. doi:10.1002/cncr.21996 ...

*ETV6

"Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis". Current ...

*Lymphocyte-variant hypereosinophilia

"Tyrosine Kinase Inhibitors and Therapeutic Antibodies in Advanced Eosinophilic Disorders and Systemic Mastocytosis". Current ...

*Cancer biomarkers

September 2008). "FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic ...

*Organic brain syndrome

"Mixed organic brain syndrome as a manifestation of systemic mastocytosis". "Organic brain syndrome". MedlinePlus. Khan A, Joyce ... including alcoholism Sedative hypnotic dependence and drug abuse Intracranial hemorrhage/trauma Korsakoff Syndrome Mastocytosis ...

*Mast cell leukemia

In a small proportion of cases, acute mast cell leukemia may evolve from a more progressive form of systemic mastocytosis. The ... November 2004), "Histidine carboxylase (HDC) as novel marker of immature neoplastic mast cells in systemic mastocytosis", Blood ... June 2002). "Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for ... July 2001). "Myelomastocytic overlap syndromes: biology, criteria, and relationship to mastocytosis". Leuk. Res. 25 (7): 595- ...

*Darier's sign

... is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria ...

*Urticaria pigmentosa

Alto WA, Clarcq L (June 1999). "Cutaneous and systemic manifestations of mastocytosis". Am Fam Physician. 59 (11): 3047-54, ... DermAtlas 27 The Mastocytosis Society Mastokids The Masto Forum UK Mastocytosis Support BC Health Guide About.com with Pictures ... Most treatments for mastocytosis can be used to treat urticaria pigmentosa. Many common anti-allergy medications are useful ... Yanagihori H, Oyama N, Nakamura K, Kaneko F (2005). "c-kit Mutations in Patients with Childhood-Onset Mastocytosis and Genotype ...

*FIP1L1

Elevations of serum VitaminB12 and tryptase are seen regularly in systemic mastocytosis, a disease which may also present with ... 2004). "CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and ...

*Hydroxycarbamide

2009). "Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series ... Psoriasis Systemic mastocytosis Chronic myelogenous leukemia (largely replaced by imatinib, but still in use for its cost- ...

*Eosinophilia

Hodgkin lymphoma Some forms of non-Hodgkin lymphoma Lymphocyte-variant hypereosinophilia Systemic mastocytosis Systemic ... to severe life-threatening drug reactions with eosinophilia and systemic symptoms (DRESS). Drugs that have been shown to cause ... to severe life-threatening drug reactions with eosinophilia and systemic symptoms (DRESS). Drugs that have been shown to cause ...

*International Classification of Diseases for Oncology

M9741/3 Malignant mastocytosis Systemic tissue mast cell disease Aggressive systemic mastocytosis or Systemic mastocytosis with ... lymphadenopathy M9768/1 T-gamma lymphoproliferative disease M9769/1 Immunoglobulin deposition disease Systemic light chain ...

*TPSAB1

... is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis". J ...

*List of MeSH codes (C04)

... mastocytosis, systemic MeSH C04.557.450.565.465.750.500 --- leukemia, mast-cell MeSH C04.557.450.565.465.875 --- mast-cell ... mastocytosis MeSH C04.557.450.565.465.249 --- mastocytoma MeSH C04.557.450.565.465.500 --- mastocytosis, cutaneous MeSH C04.557 ...

*Ciclosporin

... acute systemic mastocytosis, and, infrequently, in rheumatoid arthritis and related diseases, although it is only used in ...

*Theodore Harold Maiman

Maiman died from systemic mastocytosis on May 5, 2007 in Vancouver, British Columbia, Canada, where he lived with his wife, ...

*Hypereosinophilia

... many cases of systemic mastocytosis, chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, myelofibrosis, ... The toxic oil syndrome is associated with hypereosinophilia/eosinophilia and systemic symptoms due to one or more contaminants ... Rarely, these reactions are severe causing, for example, the drug reaction with eosinophilia and systemic symptoms (DRESS) ... Hypereosiophilia or eosinophilia may be associated with the following autoimmune diseases: systemic lupus erythematosus ...

*Eosinophilic pneumonia

... eosinophilia Tuberculosis Fungal infection Sarcoidosis Drug reaction with eosinophilia and systemic symptoms Mastocytosis ...

*Rabeprazole

... and systemic mastocytosis. Rabeprazole is also useful alongside antibiotic therapy for the treatment of the pathogen ... of orally administered dose is expected to enter systemic circulation (the bloodstream). Once in the blood, rabeprazole is ...