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*  TPSB2
1990). "Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family". Proc. Natl. Acad. Sci. U ... 2000). "The human mast cell tryptase tetramer: a fascinating riddle solved by structure". Biochim. Biophys. Acta. 1477 (1-2): ... Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. ... Caughey GH (2002). "New developments in the genetics and activation of mast cell proteases". Mol. Immunol. 38 (16-18): 1353-7. ...
*  Mastocytoma
Mast Cell Tumors from The Pet Health Library Mast Cell Tumors in Dogs from Pet Cancer Center Mast Cell Tumors in Cats from Pet ... A mastocytoma or mast cell tumor is a type of round-cell tumor consisting of mast cells. It is found in humans and many animal ... Up to 25 percent of skin tumors in dogs are mast cell tumors, with a similar number in cats. Mast cell tumors are known among ... Mast cells also respond to tissue trauma. Mast cell granules contain histamine, heparin, platelet-activating factor, and other ...
*  TPSG1
2010). "Mast cell tryptase promotes breast cancer migration and invasion". Oncol. Rep. 23 (3): 615-9. doi:10.3892/or_00000676. ... 1999). "Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel ... Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. ... TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 ...
*  Talizumab
... mast cells, and dendritic cells, rendering these cells insensitive to allergen activation. The chimeric form of TNX-901, was ... without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils. Talizumab was tested in ... without triggering the activation of mast cells and basophils, which bear on their surface high affinity IgE receptors, which ... it would probably invariably induce an extensive scale of mast cell and basophil activation and hence the development of ...
*  Histamine H2 receptor
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various ... oxyntic cells) Vascular smooth muscle Neutrophils Mast cells Heart Uterus Central nervous system tissues Caudate-putamen ... Cell Physiology. 278 (6): C1246-55. doi:10.1152/ajpcell.2000.278.6.c1246. PMID 10837353. Suh BC, Lee H, Jun DJ, Chun JS, Lee JH ... It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth ...
*  Degranulation
... and mast cells. It is also used by certain lymphocytes such as natural killer (NK) cells and cytotoxic T cells, whose main ... via the activation of tyrosine kinases within the cell. The mast cell releases a mixture of compounds, including histamine, ... Antigens interact with IgE molecules already bound to high affinity Fc receptors on the surface of mast cells to induce ... Cytotoxic T cells and NK cells release molecules like perforin and granzymes by a process of directed exocytosis to kill ...
*  MS4A2
Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for ... Wilson BS, Pfeiffer JR, Oliver JM (2003). "FcepsilonRI signaling observed from the inside of the mast cell membrane". Mol. ... is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which ... Tedder TF, Streuli M, Schlossman SF, Saito H (1988). "Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface ...
*  Basophil activation
The inner cell surface of the granules becomes the outer cell surface of the basophile /mast cell during degranulation process ... There are receptors (FcεR) for the constant region of IgE, the Fc region, on several types of cells, including Mast cells and ... This is why basophiles are considered with mast cells to be the key cells in allergic diseases. Immunoglobulin E (IgE) is a ... Allergic symptoms are caused by an initial systemic histamine release by activated basophiles and mast cells, that may lead to ...
*  Tryptase
... mast cell serine proteinase II, mast cell proteinase II, mast cell serine proteinase tryptase, rat mast cell protease II, and ... Tryptase is also known by mast cell tryptase, mast cell protease II, skin tryptase, lung tryptase, pituitary tryptase, mast ... most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell ... Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH (May 1990). "Human mast cell tryptase: multiple cDNAs ...
*  Cromoglicic acid
MCT mast cells found in the mucosa are stabilised." Nedocromil is another mast cell stabilizer that also works in controlling ... This drug prevents the release of inflammatory chemicals such as histamine from mast cells. Because of their convenience (and ... Pharmaceutical companies have produced 20 related compounds that are equally or more potent at stabilising mast cells and none ... Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (2015). "Topical antihistamines and mast cell stabilisers for ...
*  Mast cell
Other neoplastic disorders associated with mast cells include mast cell sarcoma and mast cell leukemia. Mast cell activation ... connective tissue-type mast cells and mucosal mast cells. The activities of the latter are dependent on T-cells. Mast cells are ... Mastocytosis is a rare clonal mast cell disorder involving the presence of too many mast cells (mastocytes) and CD34+ mast cell ... Surface markers: cell surface markers of mast cells were discussed in detail by Heneberg, claiming that mast cells may be ...
*  Mast cell stabilizer
... s are cromone medications used to prevent or control certain allergic disorders. They block mast cell ... Mast cell stabilizer medications include: β2-adrenergic agonists Cromoglicic acid Ketotifen Methylxanthines[citation needed] ... "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis". Cochrane ... Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. As inhalers they are ...
*  Mast cell sarcoma
... a rare benign mast cell tumor without destructive growth. In the cases observed, mast cell sarcoma terminated quickly as mast ... Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma is a tumor made of ... Mast cell sarcoma is an extremely rare tumor. Only 3 cases are reported so far. Prognosis is extremely poor. People with a mast ... "Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma". Am J Surg Pathol. 27 (7): 1013 ...
*  Mast cell leukemia
If the mast cells represent less than 10% of blood cells, the tumor is called "aleukemic" mast cell leukemia. Acute mast cell ... Mast cell tryptase is an enzyme contained in mast cell granules. Mast cell numbers are best estimated by tryptase ... Measurement of histidine carboxylase in the marrow cells of patients with mast cell leukemia is a very sensitive marker of mast ... March 1999). "Expression of Bcl-2 by human bone marrow mast cells and its overexpression in mast cell leukemia". Am. J. Hematol ...
*  Mast cell activation syndrome
The role of mast cells in functional GI disorders Mast Cell Activation Syndrome - May 2015 Spectrum of mast cell activation ... Mast cell activation syndrome (MCAS) is one type of mast cell activation disorder (MCAD), and is an immunological condition in ... "Presentation, Diagnosis, and Management of Mast Cell Activation Syndrome." Mast Cells: Phenotypic Features, Biological ... where patients have an abnormally increased number of mast cells, patients with MCAS have a normal number of mast cells that do ...
*  Fc receptor
Activation of mast cells following engagement of FcεRI results in a process called degranulation, whereby the mast cell ... natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells - that contribute to ... FcεRI is found on epidermal Langerhans cells, eosinophils, mast cells and basophils. As a result of its cellular distribution, ... B cells). They allow these cells to bind to antibodies that are attached to the surface of microbes or microbe infected cells, ...
*  Collagen receptor
... mast cell activation; keratinocyte adhesion and it is the main regulator of cell migration. Integrin α10β1 preferentially binds ... It is expressed mainly in epithelial cells and leukocytes and expression rate changes due to cell cycle phase.Functions include ... Functions include: Chondrocyte proliferation and bone growth; regulation of cell proliferation, cell adhesion and induction of ... mammary gland development; arterial wound repair; regulation of cell proliferation, cell adhesion and MMP expression; kidney ...
*  Boxer (dog)
"Mast Cell Tumour". Genetic Welfare Problems of Companion Animals. ufaw.org.uk: Universities Federation for Animal Welfare. ... The breed is particularly predisposed to mast cell tumours, a cancer of the immune system. Median lifespan was 10.25 years. ...
*  MCD peptide
Buku, A; Priceb, JA; Mendlowitzc, M; Masurd, S (2001). "Mast cell degranulating peptide binds to RBL-2H3 mast cell receptors ... The MCD peptide has an immunotoxic effect on mast cells by releasing histamine from these cells. MCD peptide has also been ... Mast cell degranulating (MCD) peptide is a cationic 22-amino acid residue peptide, which is a component of the venom of the ... As a mast cell activator, the MCD peptide evokes large increases in antigen-specific serum immunoglobulin G (IgG) responses. ...
*  Schmidt sting pain index
MCD peptide destroys mast cells. Feeling only slight pain, Schmidt has described the sting of the Anthophorid bee, categorized ... Melittin is the main toxin of bee venom, and it damages red blood cells and white blood cells. Apamin is a neurotoxin that ...
*  Giemsa stain
"Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin". Arch ... Giemsa stains the fungus Histoplasma, Chlamydia bacteria, and can be used to identify mast cells. Giemsa's solution is a ... It can be used to study the adherence of pathogenic bacteria to human cells. It differentially stains human and bacterial cells ... It is also used in Wolbachia cell stain in Drosophila melanogaster. Giemsa stain is a classic blood film stain for peripheral ...
*  Allergy
... on the surface of other kinds of immune cells called mast cells and basophils, which are both involved in the acute ... and activates the sensitized cell. Activated mast cells and basophils undergo a process called degranulation, during which they ... Cytokines from mast cells may play a role in the persistence of long-term effects. Late-phase responses seen in asthma are ... If later exposure to the same allergen occurs, the allergen can bind to the IgE molecules held on the surface of the mast cells ...
*  Irritable bowel syndrome
Treatment with mast cell stabilisers offers a reasonably safe and promising option for the management of those patients with ... Mast cells play a central pathophysiological role in IBS and possibly in functional dyspepsia, although not well defined. ▸ ... Frieri M (2015). "Mast Cell Activation Syndrome". Clin Rev Allergy Immunol. doi:10.1007/s12016-015-8487-6. PMID 25944644. Joo ... Increased mast cell activation is a common finding in the mucosa of patients with functional GI disorders. ... ▸ ...
*  Dog health
"Cutaneous Mast Cell Tumors". The Merck Veterinary Manual. 2006. Retrieved 2007-08-21. Modiano J, Breen M, Burnett R, Parker H, ... Frequently seen cancers include lymphoma, melanoma, mast cell tumors (which are considered to be potentially malignant, even ... Boxers and Pugs are prone to multiple mast cell tumors. Scottish Terriers have eighteen times the risk of mixed breed dogs to ... Inusah S, Thomas R, Avery P, Lindblad-Toh K, Ostrander E, Cutter G, Avery A (2005). "Distinct B-cell and T-cell ...
*  Antileukotriene
Frieri M (2015). "Mast Cell Activation Syndrome". Clin Rev Allergy Immunol. doi:10.1007/s12016-015-8487-6. PMID 25944644. ... They are less effective than corticosteroids for treating asthma, but more effective for treating certain mast cell disorders. ... Agents such as montelukast and zafirlukast block the actions of cysteinyl leukotrienes at the CysLT1 receptor on target cells ... and suppressed oxidative bursts in polymorphonuclear cells at 1.8 µmol/L in vitro [56]. Inhibition of IFN-γ production, strong ...
*  O2 (UK)
... the company was also able to reduce energy use by removing air conditioning units from some of its cell sites and reducing ... announced on 15 December 2009 that it had successfully demonstrated a 4G connection using LTE technology installed in six masts ... who initiated the chain of cells between London Heathrow and BT Tower in January 1985. Cellnet was established in 1985 as a ... 1.4 million distribution of smart metering technology across the company's cell sites, offices and retail stores, and upgrades ...
*  CFU-Mast
... is a colony forming unit. It gives rise to mast cells. Kasugai T, Tei H, Okada M, et al. (March 1995). "Infection with ... enlarges splenic mast-cell-progenitor pool: prominent impairment of responses in age-related stromal cell-impairment mouse SCI/ ... Nippostrongylus brasiliensis induces invasion of mast cell precursors from peripheral blood to small intestine". Blood. 85 (5 ...