MLANA
The same name is also used to refer to the gene which codes for the antigen. The MART-1/melan-A antigen is specific for the ... of Belgium called the gene melan-A, presumably an abbreviation for "melanocyte antigen." MART-1/melan-A is a protein antigen ... The names MART-1 and melan-A were coined by two groups of researchers who independently sequenced the gene for this antigen in ... MART-1/melan-A is a putative 13 kDa transmembrane protein consisting of 118 amino acids. It has a single transmembrane domain. ...
Tumor antigens recognized by T lymphocytes
The main antigenic peptides recognized by such CTL are derived from tyrosinase, Melan-A (also known as MART-1), and gp100. The ... In some patients, the majority of the tumor-specific T cells recognize mutated antigens. The contribution of these antigens to ... The carcinoma cells still harbour the viral genes and antigens. As expected T cell responses against antigens encoded by genes ... Cancer therapy targeted at tumor antigens can involve the direct use of these antigens in vaccines, but also the adoptive ...
Mikael Pittet
"High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte ... antigen (HLA)-A2 individuals". J Exp Med. 190 (5): 705-15. doi:10.1084/jem.190.5.705. PMC 2195613. PMID 10477554. Zippelius A, ... 44 (2): 1-12. doi:10.1016/j.immuni.2015.11.024. PMC 4758865. PMID 26872698. Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, ... 25 (1): 129-41. doi:10.1016/j.immuni.2006.04.015. PMID 16860762. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T ...
Adoptive cell transfer
Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. Loss of B cells can be countered with ... Toxicity was encountered in patients who received high-avidity TCRs that recognized either the MART-1 or gp100 melanoma- ... melanocyte antigens, in mice when targeting melanocyte antigens, in patients with renal cancer using a CAR targeting carbonic ... Cancer-testes antigen MAGE-A3 is not known to be expressed in any normal tissues. However, targeting an HLA-A*0201-restricted ...
Eftilagimod alpha
The investigators for this work used influenza matrix protein antigen and the tumor antigens Melan-A/MART-1 and survivin to ... In the absence of antigen presentation via MHC class II molecules, efti reactivates dormant antigen-experienced memory T cells ... circulating tumor antigen), and efti increases activation of antigen-presenting cells (APCs) as they take up that debris. This ... Subjects administered efti had higher levels of HBsAg antibody in their blood as well as higher levels of antigen-specific T ...
Tumor-infiltrating lymphocytes
TILs can not only recognize over-expressed self/melanocyte differentiation antigens, such as Melan-A/MART-1 (melanoma-specific ... Autologous TIL therapy for metastatic melanoma has broad T cell recognition of both defined and undefined tumor antigens ... gp100, tyrosinase, and survivin, but TILs can also recognize other unknown antigens specific to the tumor and individual ... 64 (1): 71-90. doi:10.1146/annurev-med-112311-083918. PMID 23092383. Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, ...
ALECSAT
Tumor antigens are typically cancer/testis antigens. Chemically inducing this antigen in T-cells by DNA demethylation allows ... gp100 and MART-1) can successfully proliferate if melanoma cell lines are carefully preselected. At the same department, the ... when injected with overexpressed tumor antigens, have been shown to enhance migration of antigen-presenting cells (APCs) into ... After this, the lymphocytes are treated for three days in order to induce the expression of CGL antigen. Next, another set of ...
T cell receptor T cell therapy
Each T cell's TCR is specific to one antigen and sits on the T cell's surface. The affinity of human TCRs to tumor antigens is ... MART-1) Metastatic melanova/synovial cell carcinoma (NY-ESO-1) Multiple myeloma (NY-ESO-1) Zhao L, Cao YJ (2019). "Engineered T ... Appropriate target antigens are identified by subtraction. First the entire set of antigens presented by tumor cells is ... The recipient T cell then recognized a different antigen, enabling the use of these cells to target non-surface antigens. One ...
Infection-induced anorexia
van Niekerk, Gustav; Loos, Ben; Nell, Theo; Engelbrecht, Anna-Mart (2016-04-06). "Autophagy-A free meal in sickness-associated ... in the presentation of epitopes in nonprovisional antigen presenting cells and the removal of damaged proteins and organelles, ... van Niekerk, Gustav; Isaacs, Ashwin W.; Nell, Theo; Engelbrecht, Anna-Mart (2016). "Sickness-Associated Anorexia: Mother ... 2016: 1-12. doi:10.1155/2016/8071539. PMC 4942670. PMID 27445441. Material was copied from this source, which is available ...
QMCF Technology
QMCF cell lines express Large-T antigen and EBNA-1 proteins which bind the viral sequences on the QMCF plasmid and hence ... Silla, Toomas; Hääl, Ingrid; Geimanen, Jelizaveta; Janikson, Kadri; Abroi, Aare; Ustav, Ene; Ustav, Mart (December 2005). " ... Thereafter 1-6 µg of plasmidial DNA is transfected by electroporation into QMCF cells (CHO or HEK293 based cells) for ... EBNA-1 protein binding site as nuclear retention elements ensure stable propagation of plasmids in mammalian cells. In addition ...
Filamentous bacteriophage
Simon Roux, Mart Krupovic, Rebecca A. Daly, Adair L. Borges, Stephen Nayfach, Frederik Schulz, Emiley A. Eloe-Fadrosh et al.: ... Smith GP (June 1985). "Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface". ... Prisco A, De Berardinis P (24 April 2012). "Filamentous bacteriophage fd as an antigen delivery system in vaccination". ... Gene 1, coding for an ATPase, is a conserved marker gene that (along with three additional genetic features) was used to ...
Virus
Shuda M, Feng H, Kwun HJ, Rosen ST, Gjoerup O, Moore PS, Chang Y (October 2008). "T antigen mutations are a human tumor- ... Gorbalenya, Alexander E.; Krupovic, Mart; Mushegian, Arcady; Kropinski, Andrew M.; Siddell, Stuart G.; Varsani, Arvind; Adams, ... Cells such as the macrophage are specialists at this antigen presentation. The production of interferon is an important host ... Vaccines can consist of live-attenuated or killed viruses, viral proteins (antigens), or RNA. Live vaccines contain weakened ...
HHAT
"Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T ... Genes on human chromosome 1, Human gene pages with Wikidata item, All stub articles, Human chromosome 1 gene stubs). ...
2011 in the United States
"WAL-MART STORES, INC. v. DUKES ET AL" (PDF). supremecourt.gov. June 20, 2011. "Supreme Court Decision in Wal-Mart Class-Action ... Porter, David L.; Levine, Bruce L.; Kalos, Michael; Bagg, Adam; June, Carl H. (August 10, 2011). "Chimeric Antigen Receptor- ... The court ruled in favor of Wal-mart, only on the class action status of the dispute of the women's claims. The ruling rejects ... The ruling involves the class-action status of a sex discrimination case against Wal-mart containing 1.6 million litigants. ...
Satellite (biology)
HBV provides a surface antigen, HBsAg, which is utilized by HDV to create a super-infection resulting in liver failure. HDV is ... Krupovic, Mart; Kuhn, Jens H.; Fischer, Matthias G. (2016-01-01). "A classification system for virophages and satellite viruses ... Krupovic, Mart; Kuhn, Jens H.; Fischer, Matthias G. (7 October 2015). "A classification system for virophages and satellite ... 161 (1): 233-247. doi:10.1007/s00705-015-2622-9. hdl:11858/00-001M-0000-0028-DC34-F. ISSN 0304-8608. PMID 26446887. Bernard La ...
List of biologists
Discovered prostate-specific antigen (PSA) which led to the development of the PSA test Erik Acharius (1757-1819), Swedish ... Abbreviation in botany: Mart. Abbreviation in botany: J.Martyn Abbreviation in botany: Martyn Abbreviation in zoology: ... American immunologist known for the idea that antigen-presenting cells respond to "danger signals" Carl Maximowicz (1827-1891 ... Israeli immunologist who works on synthetic antigens, molecules that trigger the immune system Prideaux John Selby (1788-1867 ...
Caspian seal
Morbillivirus antigen was also detected in multiple tissues, including lung, lymph nodes, spleen, brain, pancreas, liver, and ... Harkonen, Tero; Jüssi, Mart; Baimukanov, Mirgaly; Bignert, Anders; Dmitrieva, Lilia; Kasimbekov, Yesbol; Verevkin, Mikhail; ... 127 (1): 83-97. doi:10.1016/s0269-7491(03)00251-3. PMID 14553998. Reeves, R; Stewart, B; Clapham, P; Powell, J (2002). Guide to ... Their dental formula is 3.1.4.22.1.4.1. The skull structure of the Caspian seal suggests it is closely related to the Baikal ...
Irish government response to the COVID-19 pandemic
... marts and other market places, casinos and bingo halls, playgrounds, holiday caravan parks, organised indoor and outdoor social ... household contacts of a person with COVID-19 to restrict movements for five days and take three antigen tests, people required ... On 1 May, Taoiseach Leo Varadkar announced the extension of the current restrictions to 18 May at the earliest. On 1 May 2020, ... Farrell, Peter (1 May 2020). "At a glance: What restrictions are going to be lifted and when?". RTÉ News and Current Affairs. ...
COVID-19 pandemic in British Columbia
On February 26, rapid COVID-19 antigen tests became available for people that are at least 70 years old. As of March 10, the ... Shoppers Drug Mart, and T&T Supermarket reported positive tests for COVID-19. Vancouver Coastal Health issued COVID-19 exposure ... Mangione, Kendra (March 1, 2021). "Everyone in B.C. will be able to get a 1st dose of coronavirus vaccine by end of July: ... On March 1, B.C. Health officials predicted that all British Columbians should be able to get the first doses of COVID-19 ...
Nucleocytoviricota
PMID 30837339.PDF Guglielmini, Julien; Woo, Anthony C.; Krupovic, Mart; Forterre, Patrick; Gaia, Morgan (2019-09-10). " ... the FLAP endonuclease and the processing factor proliferating cell nuclear antigen. Other proteins include DNA dependent RNA ... It has a length of 1 micrometer long and .5 micrometer wide. Its genome can be up to 2.5 million base pairs long. The ... 1-42. doi:10.1007/978-3-540-68618-7_1. ISBN 978-3-540-68617-0. ISSN 0070-217X. PMC 2908299. PMID 19216434. Ornes, Stephen (2017 ...
Peptide vaccine
The whole peptide vaccine is to mimic the epitope of an antigen, so epitope design is the most important stage of vaccine ... Marincola FM, Rivoltini L, Salgaller ML, Player M, Rosenberg SA (July 1996). "Differential anti-MART-1/MelanA CTL activity in ... The peptides mimic the epitopes of the antigen that triggers direct or potent immune responses. Peptide vaccines can not only ... The antibodies from people infected by hookworm can recognize the dominant epitope of the antigen called Necator americanus APR ...
Social impact of the COVID-19 pandemic in New Zealand
In early February 2021, Luxon advocated that rapid antigen testing be conducted in schools twice a week for both students and ... and a Munchy Mart convenience store were identified as areas of interest in the Delta community outbreak. On 29 September, the ... On 1 April, Ardern described 20-29 year olds as the most vulnerable demographic to COVID-19 and called on them to comply with ... From 1 September 2021, the Ministry of Health eased Level 4 restrictions to allow funeral viewings by family and whanau at a ...
List of RNA-Seq bioinformatics tools
S-MART handles mapped RNA-Seq data, and performs essentially data manipulation (selection/exclusion of reads, clustering and ... July 2016). "Linking the T cell receptor to the single cell transcriptome in antigen-specific human T cells". Immunology and ... "Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens". Nature Biotechnology. 40 ... 12 (1): 451. doi:10.1186/1471-2105-12-451. PMC 3295828. PMID 22099972. Liu B, Yuan J, Yiu SM, Li Z, Xie Y, Chen Y, et al. ( ...
History of coronavirus
Serological tests (antigen-antibody reactions) further indicated that the virus was not related (not reactive) to antibodies ( ... Mart; Kuhn, Jens H. (2016). "Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses ( ... "The structure of antigen-antibody complexes. A study by electron microscopy". The Journal of Experimental Medicine. 118 (3): ... antigen-antibody complexes). Employing these techniques, she had successfully identified IBV and MHV as structurally distinct ...
SARS-CoV-2 Alpha variant
Several rapid antigen tests for SARS-CoV-2 are in widespread use globally for COVID-19 diagnostics. They are believed to be ... marts [Expert report of 21 February 2021: Forecasts for infection rates and hospital admissions for reopening scenarios 1 March ... COG-UK (20 December 2020), p. 1. Chand et al., p. 6. Kemp, S.A.; Collier, D.A.; Datir, R.P.; Ferreira, I.A.T.M.; Gayed, S.; ... 1 June 2021. Retrieved 2 June 2021. "WHO announces simple, easy-to-say labels for SARS-CoV-2 Variants of Interest and Concern ...