MAP kinase kinase kinase
MAP kinase MAP kinase kinase MAP kinase kinase kinase kinase List of unusual biological names "Global Identification, ... is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently, MAP kinase kinase activates MAP ... These MAP kinases include the extracellular regulated kinases (ERKs), the c-Jun N-terminal Kinases (JNKs), and the p38 MAP ... MAP+Kinase+Kinase+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 2.7.11.25 Portal: Biology ...
RAF kinase
MAP kinase signaling specificity". Science. 296 (5577): 2345-2347. doi:10.1126/science.1073344. PMID 12089430. S2CID 93194160. ... Chadee DN, Yuasa T, Kyriakis JM (February 2002). "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by ... Activation of RAF kinases requires interaction with RAS-GTPases. The three RAF kinase family members are: A-RAF B-RAF c-Raf ... RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse ...
Mitogen-activated protein kinase
Signal transduction MAP kinase kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 ... Similarly, both dual-specificity MAP kinase phosphatases and MAP-specific tyrosine phosphatases bind to MAP kinases through the ... Nemo-like kinase: atypical MAPK) ERK1/2 kinases ERK1/2 pathway JNK kinases p38 MAP kinases MEKK2 (MAP3K2) ASK1 (MAP3K5) Pearson ... A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine ...
Mitogen-activated protein kinase 9
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ... MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine. This article incorporates text from the United States National ... Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases". Cell. 103 (2): 239-52. doi:10.1016/S0092-8674(00)00116- ... This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, ...
P38 mitogen-activated protein kinases
MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to ... p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast ... Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar ... Dusik V, Senthilan PR, Mentzel B, Hartlieb H, Wülbeck C, Yoshii T, Raabe T, Helfrich-Förster C (2014). "The MAP Kinase p38 Is ...
Phosphorylase kinase
Kilimann MW (1990). "Molecular genetics of phosphorylase kinase: cDNA cloning, chromosomal mapping and isoform structure". J ... The phosphorylase kinase is completely activated when the β and α subunits are phosphorylated by protein kinase A and the delta ... In the active site, there is significant homology between PhK and other so-called P-loop protein kinases such as protein kinase ... Phosphorylase kinase (PhK) is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release ...
Mitogen-activated protein kinase kinase
Signal transduction MAP kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase Dérijard B, et al. (1995). "Independent ... Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which ... define independent MAP kinase signal transduction pathways. The acronym MEK derives from MAPK/ERK Kinase. MEK is a member of ... Mitogen-Activated+Protein+Kinase+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ...
Janus kinase 1
1992). "Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24". Mamm. Genome. 3 (1): 36- ... Janus kinase 1 has been shown to interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1, IL10RA, PTPN11, STAM2, STAT3, STAT5A, ... Janus+Kinase+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (Genes on human ... JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the ...
MADD (gene)
MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene. Tumor necrosis factor alpha ... "Entrez Gene: MADD MAP-kinase activating death domain". Chow VT, Lee SS (1997). "DENN, a novel human gene differentially ... variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in ... 4 (2): 141-50. doi:10.1093/dnares/4.2.141. PMID 9205841. Zhang Y, Zhou L, Miller CA (1998). "A splicing ...
RAPGEF3
September 2003). "cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase ... While protein kinase A (PKA) or cAMP-dependent protein kinase and cyclic nucleotide regulated ion channel (CNG and HCN) were ... opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B ... "The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways". Nature. 437 (7058): 574-8. doi ...
MAPK1
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal- ... binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase ... The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to ... "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. 94 ( ...
MAPK4
MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine Portal: Biology v t e (Articles with short description, Short ... December 2000). "Arabidopsis map kinase 4 negatively regulates systemic acquired resistance". Cell. 103 (7): 1111-20. doi: ... Gonzalez FA, Raden DL, Rigby MR, Davis RJ (June 1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues ... Davis RJ (December 1995). "Transcriptional regulation by MAP kinases". Molecular Reproduction and Development. 42 (4): 459-67. ...
MARK4
MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene. MARK4 belongs to the ... "Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4". Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E ( ... MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in ... Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (April 2008). "Control of AMPK-related kinases by USP9X and ...
Tropomyosin receptor kinase C
Valent A, Danglot G, Bernheim A (1997). "Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to ... Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, ... The TrkC receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable ... The TrkC locus encodes at least eight isoforms including forms without the kinase domain or with kinase insertions adjacent to ...
STK4
Glantschnig H, Rodan GA, Reszka AA (2002). "Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation ... kinase, which acts upstream of the stress-induced mitogen-activated protein kinase (MAPK) cascade. The encoded protein can ... Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene. The protein encoded by this gene is ... Creasy CL, Chernoff J (1995). "Cloning and characterization of a human protein kinase with homology to Ste20". J. Biol. Chem. ...
CLK3 (gene)
"Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523-4. doi:10.1007/s004390050861 ... Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. The CLK3 gene encodes a serine/ ... Clk dual-specificity kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CLK3 genome ... "Entrez Gene: CLK3 CDC-like kinase 3". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure ...
MAPK8IP1
... and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions ... 1999). "Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun -amino-terminal kinase ... 1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383): 1671-4. doi:10.1126 ... "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383): 1671-4. doi:10.1126/science ...
CLK1
"Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523-4. doi:10.1007/s004390050861 ... Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene. This gene encodes a member of the ... "Entrez Gene: CLK1 CDC-like kinase 1". Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (Oct 1996). "SRPK1 ... Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (1996). "SRPK1 and Clk/Sty protein kinases show distinct ...
Yersinia pestis
YopJ acetylates MAPK kinases at serines and threonines that are normally phosphorylated during activation of the MAP kinase ... YopO is a protein kinase also known as Yersinia protein kinase A (YpkA). YopO is a potent inducer of human macrophage apoptosis ... "Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways". PLOS ONE. 3 (1): e1375. Bibcode:2008PLoSO... ... Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ, Orth K (May 2006). "Yersinia YopJ acetylates and inhibits kinase ...
CLK2
"Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Human Genetics. 103 (4): 523-4. doi:10.1007/ ... Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene. This gene encodes a member of the ... This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle ... "Entrez Gene: CLK2 CDC-like kinase 2". Human CLK2 genome location and CLK2 gene details page in the UCSC Genome Browser. ...
MAP3K3
Slattery ML, Lundgreen A, Wolff RK (2012). "MAP kinase genes and colon and rectal cancer". Carcinogenesis. 33 (12): 2398-408. ... Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on ... "Entrez Gene: MAP3K3 mitogen-activated protein kinase kinase kinase 3". Gilmore PM, McCabe N, Quinn JE, Kennedy RD, Gorski JJ, ... pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". The Journal of Biological ...
RAPGEF4
... "cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically ... 38 (4): 578-88. doi:10.1016/j.mcn.2008.05.006. PMID 18583150. S2CID 871060. Gelinas JN, Banko JL, Peters MM, Klann E, Weeber EJ ... 64 (4): 1262-72. doi:10.2337/db14-0576. PMID 25315008. McPhee I, Gibson LC, Kewney J, Darroch C, Stevens PA, Spinks D, Cooreman ... 85 (4): 1303-42. doi:10.1152/physrev.00001.2005. PMID 16183914. S2CID 14539206. Schmidt M, Dekker FJ, Maarsingh H (Apr 2013). " ...
FER (gene)
1990). "The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q)". ... 1990). "Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277-82. PMID 2156206. ... Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase". FEBS Lett. 215 (2): ... Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of ...
MAPK6
MAP kinases). MAP kinases, also known as extracellular signal-regulated kinases (ERKs), are activated through protein ... According to the model, the structure of ERK3/MAPK6 kinase domain resembles other MAP kinases. The modelled ERK3/MAPK6 kinase ... MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine. Portal: Biology (Articles with short description, Short ... "The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain ...
FHOD1
"The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway". Biochemical and Biophysical Research Communications. 335 ... is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells". The Journal of ... 13 (4): 615-20. doi:10.3892/ijmm.13.4.615. PMID 15010865. Wang Y, El-Zaru MR, Surks HK, Mendelsohn ME (June 2004). "Formin ... doi:10.1016/S0378-1119(99)00127-4. PMID 10352228. Boehm MB, Milius TJ, Zhou Y, Westendorf JJ, Koka S (October 2005). " ...
MAP2K1IP1
... this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase ... A complex with a critical role in endosomal map kinase signaling". J. Biol. Chem. 279 (22): 23422-30. doi:10.1074/jbc. ... "Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1". Wunderlich W, Fialka I, Teis D, Alpi A ... and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade. MAP2K1IP1 has been shown to ...
MAPK10
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ... and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, ... Mohit AA, Martin JH, Miller CA (1995). "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human ... MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine. Overview of all the structural information available in the PDB ...
Activity-regulated cytoskeleton-associated protein
The Arc transcript is dependent upon activation of the mitogen-activated protein kinase or MAP kinase (MAPK) cascade, a pathway ... Impey S, Obrietan K, Storm DR (1999). "Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity". Neuron ... Treisman R (1996). "Regulation of transcription by MAP kinase cascades". Current Opinion in Cell Biology. 8 (2): 205-15. doi: ... mRNA induction by Ca2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase ...
TMEM242
This protein is known to be involved in the MAP Kinase pathway. The MAP Kinase pathway is associated with the Alzheimer's ... There are four casein kinase II phosphorylation sites, and this motif is a serine/threonine kinase. There are six N- ... The four types are cAMP and cGMP dependent protein kinase phosphorylation site, casein kinase II phosphorylation site, N- ... These sites include cAMP and cGMP dependent protein kinase phosphorylation sites, casein kinase II phosphorylation sites, and a ...
Protein phosphatase
Camps M, Nichols A, Arkinstall S (January 2000). "Dual specificity phosphatases: a gene family for control of MAP kinase ... Protein kinases (PKs) are the effectors of phosphorylation and catalyse the transfer of a γ-phosphate from ATP to specific ... The addition of a phosphate group may activate or de-activate an enzyme (e.g., kinase signalling pathways) or enable a protein- ... Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". ...