Loading...
*  Tumor necrosis factor superfamily
Lymphotoxin-alpha (LT-alpha) and lymphotoxin-beta (LT-beta), two related cytokines produced by lymphocytes that are cytotoxic ... "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Cell ... Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10. ... The PROSITE pattern for this family is located in a beta-strand in the central section of the protein that is conserved across ...
*  Lymphotoxin beta
Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is ... and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB ... Lymphotoxin-beta (LT-beta) also known as tumor necrosis factor C (TNF-C) is a protein that in humans is encoded by the LTB gene ... Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through ...
*  Lymphotoxin beta receptor
The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees. Lymphotoxin beta receptor has been shown to ... 1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell ... The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded ... hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta ...
*  Lymphotoxin
The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. Lymphotoxin beta ... Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 ... Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts ... Lymphotoxin at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Sergio A. Lira
2007). "Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid". Proc Natl Acad Sci ...
*  TRAF3
Wu MY, Wang PY, Han SH, Hsieh SL (April 1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in ... This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF ... VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF (March 1997). "Lymphotoxin-beta ... VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF (March 1997). "Lymphotoxin-beta ...
*  LIGHT (protein)
"The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells". The Journal of ... and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". The Journal of Biological Chemistry. 278 (16 ... a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene ... "homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry ...
*  TRAF5
... an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor". The Journal of Biological ...
*  Lymphotoxin alpha
"Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice". Immunity ... LT-α can also form heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. The interaction ... "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Cell ... Lymphotoxin-alpha (LT-α) or tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. ...
*  TRAF2
... and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. 278 (16): 14363-9. doi:10.1074/ ... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Baud V, Liu ... Devin A, Lin Y, Yamaoka S, Li Z, Karin M (June 2001). "The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2- ... Li S, Wang L, Dorf ME (January 2009). "PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked ...
*  Diablo homolog
... and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". The Journal of Biological Chemistry. 278 (16 ...
*  Baculoviral IAP repeat-containing protein 2
... and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. 278 (16): 14363-9. doi:10.1074/ ... "Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for ...
*  TANK (gene)
"Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated ...
*  Diet-induced obesity model
Mice without lymphotoxin alpha, lymphotoxin beta, or a lymphotoxin beta receptor gained less weight on a high-fat diet than ... Mice without lymphotoxin alpha, lymphotoxin beta, or a lymphotoxin beta receptor had poorly composed microbiota, which made ... Scientists used mice to study the effect of lymphotoxins on metabolism. ... "Lymphotoxin regulates commensal responses to enable diet-induced obesity". Nature Immunology. 13 (10): 947-953. doi:10.1038/ni. ...
*  MAP3K14
... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Régnier CH, ... Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation with ... Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation ...
*  CHUK
... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Ninomiya- ... Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB (November 2001). "Regulation of beta-catenin function by ... Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation ... Sakurai H, Miyoshi H, Toriumi W, Sugita T (April 1999). "Functional interactions of transforming growth factor beta-activated ...
*  IKK2
... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. ISSN 0021-9258. PMID ... IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB ... Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB (November 2001). "Regulation of beta-catenin function by ... Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation ...
*  MAP3K8
... lymphotoxin beta receptor, and CD40". The Journal of Biological Chemistry. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID ...
*  Pathology of multiple sclerosis
The collaboration between LTB on Th17 cells and LTBR (Lymphotoxin beta receptor) on meningeal radio-resistant cells is very ... With responses to therapy: It is known that 30% of MS patients are non-responsive to Beta interferon. The heterogeneous ... Wiesemann E, Deb M, Hemmer B, Radeke HH, Windhagen A (2008). "Early identification of interferon-beta responders by ex vivo ... December 2005). "HLA class II and response to interferon-beta in multiple sclerosis". Acta Neurol Scand. 112 (6): 391-4. doi: ...
*  Index of immunology articles
... antigen 1 Lymphokine Lymphoproliferative response Lymphotoxin Lymphotoxin alpha Lymphotoxin beta Lymphotoxin beta receptor ... beta 1a Interferon beta 1b Interferon gamma Interferon type I Interferon type II Interferon type III Interferon-alpha/beta ... beta subunit Interleukin 12 Interleukin 12 subunit beta Interleukin 13 Interleukin 16 Interleukin 2 Interleukin 20 receptor, ... Beta-2 microglobulin Binding antibody Biological response modifiers Blocking antibody Blotto (biology) BNAber Body odor Bone ...
*  High endothelial venules
The normal phenotype of HEV is possibly maintained by DC-secreted lymphotoxin (TNF-beta). HEV cuboidal endothelial cells ...
*  Infliximab
... has high specificity for TNF-α, and does not neutralize TNF beta (TNFβ, also called lymphotoxin α), an unrelated ...
*  Galectin-2
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and ... 2004). "Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro ... Gitt MA, Barondes SH (1986). "Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes". ... can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level ...
*  List of MeSH codes (D12.644)
... transforming growth factor beta MeSH D12.644.276.992 --- tumor necrosis factors MeSH D12.644.276.992.500 --- lymphotoxin MeSH ... gtp-binding protein beta subunits MeSH D12.644.360.375.730 --- gtp-binding protein gamma subunits MeSH D12.644.360.375.940 --- ... beta-msh MeSH D12.644.400.460.115 --- gamma-msh MeSH D12.644.400.465 --- msh release-inhibiting hormone MeSH D12.644.400.470 ... beta-msh MeSH D12.644.548.691.525.690.583.115 --- gamma-msh MeSH D12.644.548.691.525.883 --- thyrotropin MeSH D12.644.548.691. ...
*  List of MeSH codes (D12.776)
... beta-crystallin a chain MeSH D12.776.306.366.300.200 - beta-crystallin b chain MeSH D12.776.331.199.750.500 - succinate ... lymphotoxin MeSH D12.776.467.374.750.750 - tumor necrosis factor-alpha MeSH D12.776.467.750.500.125 - interferon type i, ... beta-2 microglobulin MeSH D12.776.377.715.182.160 - beta-thromboglobulin MeSH D12.776.377.715.182.200 - complement factor h ... thyroid hormone receptors beta MeSH D12.776.624.664.700.915 - RNA-binding protein FUS MeSH D12.776.624.664.700.957 - stathmin ...
*  RELA
Spencer E, Jiang J, Chen ZJ (Feb 1999). "Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP". ... such as the ligand activation of the lymphotoxin-β receptor (LTβR). In vivo studies revealed that RELA is also under ... Suyang H, Phillips R, Douglas I, Ghosh S (Oct 1996). "Role of unphosphorylated, newly synthesized I kappa B beta in persistent ... evidence for involvement of C/EBP beta". The Journal of Biological Chemistry. 278 (26): 23586-93. doi:10.1074/jbc.M211646200. ...