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*  Tumor necrosis factor superfamily
Lymphotoxin-alpha (LT-alpha) and lymphotoxin-beta (LT-beta), two related cytokines produced by lymphocytes that are cytotoxic ... Lymphotoxin-alpha, formerly known as Tumor necrosis factor-beta (TNF-β), is a cytokine that is inhibited by interleukin 10. ... "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Cell ... One such example is the Asn34-Arg82 hydrogen bond in the M. musculus TNF alpha. The PROSITE pattern for this family is located ...
*  Lymphotoxin beta
Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is ... Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through ... The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules ... The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal ...
*  Lymphotoxin alpha
LT-α can also form heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. The interaction ... Lymphotoxin alpha has been shown to interact with LTB. Lymphotoxin ENSG00000223919, ENSG00000173503, ENSG00000226275, ... "Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice". Immunity ... Lymphotoxin-alpha (LT-α) or tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene. ...
*  Pateclizumab
It binds to lymphotoxin alpha. This drug was developed by Genentech/Roche. World Health Organization (2011). "International ...
*  MSC (gene)
Knight JC, Keating BJ, Kwiatkowski DP (2004). "Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1". ...
*  HBXIP
Lee SH, Park SG, Lim SO, Jung G (2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in ...
*  Tumor necrosis factor alpha
The last exon shares similarity with lymphotoxin alpha (LTA, known also as TNF-β). The 3' UTR of TNFα contains an AU-rich ... Tumor Necrosis Factor-alpha at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal Medicine ... Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, Pennica D, Goeddel DV, Gray PW (1985). "Human lymphotoxin and ... Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) ...
*  Galectin-2
The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of ... 2004). "Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro ...
*  LIGHT (protein)
... and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity. 8 (1): 21-30. doi:10.1016/S1074-7613(00)80455-0. ... This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two ... "The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells". The Journal of ... and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". The Journal of Biological Chemistry. 278 (16 ...
*  Herpesvirus entry mediator
... and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity. 8 (1): 21-30. doi:10.1016/S1074-7613(00)80455-0. ...
*  Lymphotoxin beta receptor
The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded ... The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees. Lymphotoxin beta receptor has been shown to ... 1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell ... VanArsdale, T L; VanArsdale S L; Force W R; Walter B N; Mosialos G; Kieff E; Reed J C; Ware C F (Mar 1997). "Lymphotoxin-beta ...
*  Diet-induced obesity model
Mice without lymphotoxin alpha, lymphotoxin beta, or a lymphotoxin beta receptor gained less weight on a high-fat diet than ... Mice without lymphotoxin alpha, lymphotoxin beta, or a lymphotoxin beta receptor had poorly composed microbiota, which made ... Scientists used mice to study the effect of lymphotoxins on metabolism. ... "Lymphotoxin regulates commensal responses to enable diet-induced obesity". Nature Immunology. 13 (10): 947-953. doi:10.1038/ni. ...
*  LTA
... in Singapore Lawn Tennis Association in the United Kingdom Lieutenant Lipoteichoic acid Lymphotoxin alpha Lambda Theta Alpha, ...
*  Index of immunology articles
... antigen 1 Lymphokine Lymphoproliferative response Lymphotoxin Lymphotoxin alpha Lymphotoxin beta Lymphotoxin beta receptor ... alpha subunit Interleukin 23 subunit alpha Interleukin 28 receptor, alpha subunit Interleukin 34 Interleukin 35 Interleukin 6 ... alpha subunit Interleukin 10 receptor, beta subunit Interleukin 12 Interleukin 12 subunit beta Interleukin 13 Interleukin 16 ... beta 1a Interferon beta 1b Interferon gamma Interferon type I Interferon type II Interferon type III Interferon-alpha/beta ...
*  Lymphotoxin
The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. Lymphotoxin beta ... Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 ... Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts ... Lymphotoxin at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  List of MeSH codes (D12.776)
... tumor necrosis factor-alpha MeSH D12.776.467.374.750.500 - lymphotoxin MeSH D12.776.467.374.750.750 - tumor necrosis factor- ... alpha 1-antichymotrypsin MeSH D12.776.377.715.085.085 - alpha 1-antitrypsin MeSH D12.776.377.715.085.100 - alpha-macroglobulins ... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 ...
*  List of MeSH codes (D12.644)
... lymphotoxin MeSH D12.644.276.992.750 --- tumor necrosis factor-alpha MeSH D12.644.276.996 --- wnt proteins MeSH D12.644.276.996 ... tumor necrosis factor-alpha MeSH D12.644.276.174.750 --- tumor necrosis factors MeSH D12.644.276.174.750.500 --- lymphotoxin ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.644.360.375.100.200 --- gtp-binding protein alpha subunits, gi-go MeSH ... gtp-binding protein alpha subunits, gq-g11 MeSH D12.644.360.375.100.400 --- gtp-binding protein alpha subunits, gs MeSH D12.644 ...
*  TRAF3
Wu MY, Wang PY, Han SH, Hsieh SL (April 1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in ... "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97- ... This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF ... VanArsdale TL, VanArsdale SL, Force WR, Walter BN, Mosialos G, Kieff E, Reed JC, Ware CF (March 1997). "Lymphotoxin-beta ...
*  PLA2G2D
2001). "SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency". Genes Immun. 1 ... types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res. 22 (9 ...
*  TANK (gene)
"A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97- ... "Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated ... "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97- ...
*  MAP3K14
... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Régnier CH, ... NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science. 278 (5339): 866-9. doi:10.1126/science. ... NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science. 278 (5339): 866-9. doi:10.1126/science. ...
*  MAP3K8
This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar ... lymphotoxin beta receptor, and CD40". The Journal of Biological Chemistry. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID ... Ballester A, Velasco A, Tobeña R, Alemany S (Jun 1998). "Cot kinase activates tumor necrosis factor-alpha gene expression in a ... "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97- ...
*  CHUK
Zhu F, Park E, Liu B, Xia X, Fischer SM, Hu Y (February 2009). "Critical role of IkappaB kinase alpha in embryonic skin ... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Ninomiya- ... Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous ... Kwak YT, Li R, Becerra CR, Tripathy D, Frenkel EP, Verma UN (August 2005). "IkappaB kinase alpha regulates subcellular ...
*  NF-κB
"Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) ... A select set of cell-differentiating or developmental stimuli, such as lymphotoxin β-receptor (LTβR), BAFF or RANKL, activate ... a) Chandel NS, Trzyna WC, McClintock DS, Schumacker PT (July 2000). "Role of oxidants in NF-kappa B activation and TNF-alpha ... Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha ( ...
*  TRAF2
Devin A, Lin Y, Yamaoka S, Li Z, Karin M (June 2001). "The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2- ... and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. 278 (16): 14363-9. doi:10.1074/ ... TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 ... lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602-6. doi:10.1074/jbc.C100103200. PMID 11278268. Baud V, Liu ...
*  RELA
Wang D, Westerheide SD, Hanson JL, Baldwin AS (Oct 2000). "Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on ... such as the ligand activation of the lymphotoxin-β receptor (LTβR). In vivo studies revealed that RELA is also under ... Ruby CE, Leid M, Kerkvliet NI (Sep 2002). "2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-alpha and anti- ... Wang D, Westerheide SD, Hanson JL, Baldwin AS (Oct 2000). "Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on ...