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*  Thymus
In the medulla, the network of reticular cells is coarser than in the cortex, the lymphoid cells are relatively fewer in number ... A rare population of hematopoietic progenitor cells enter the thymus from the blood, and expands by cell division to generate a ... The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, T cells mature. T cells are ... These syndromes are caused by defective hematopoietic progenitor cells which are the precursors of both B- and T cells. This ...
*  CFU-GEMM
The common myeloid progenitor (CMP) and the common lymphoid progenitor (CLP) are the first branch of cell differentiation in ... CFU-GEMM cells are the multipotential progenitor cells for myeloid cells; they are thus also called common myeloid progenitor ... The CFU-GEMM cell is capable of differentiating into white blood cells, red blood cells, and platelets, all of which are ... The cells are characterized by expressing the cell surface markers CD33, CD34 and HLA-DR. These surface markers are proteins on ...
*  Lymphopoiesis
NK cells Dendritic cells (lymphoid lineage; DC2 ) Progenitor B cells Pro-B cells => Early Pro (or pre-pre)-B cells => Late Pro ... B cells Large Pre-B cells => Small Pre-B cells Immature B cells B Cells => (B1 cells; B2 cells) Plasma cells Pro-T cells T- ... natural killer cells (NK) and (4) dendritic cells. T Cells, B Cells and NK Cells (and all other Innate lymphoid cells) are ... early lymphoid progenitors, and finally to the CLP Common lymphoid progenitor, a cell type fully committed to the lymphoid ...
*  Lymphatic system
The primary or central lymphoid organs generate lymphocytes from immature progenitor cells. The thymus and the bone marrow ... as the primary site for cells relating to adaptive immune system including T-cells and B-cells. Cells in the lymphatic system ... The other 95% of T cells begin a process of apoptosis, a form of programmed cell death. Secondary or peripheral lymphoid organs ... T cells, on the other hand, travel from the bone marrow to the thymus, where they develop further. Mature T cells join B cells ...
*  Interleukin 3
... into lymphoid progenitor cells. In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, ... Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the ... He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and ... "CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2". J. Immunol. ...
*  FIP1L1
... malignancies can begin in myeloid or lymphoid progenitor cells or in precursors to these myeloid and lymphoid progenitor cells ... occurs in lymphoid precursor cells to promote the proliferation and differentiation of precursor cells along the lymphoid ... The ~30% of patients in whom the fusion gene effects non-eosinophilic granulocyte or lymphoid cell linages present with signs ... may reveal increases in eosinophils and mast cells but usually does not contain elevated numbers of precursor cells or cells ...
*  GLD-2
... a kind of cell types including myeloid progenitor cells and lymphoid progenitor cells. The polyadenylation activity of GLD-2, ... This is the process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, ... We can also find them in some other source tissues are the fibroblast, HeLa cell, MCF-7 cell, melanoma cell line and thymus. ... Check date values in: ,access-date= (help) 8. ↑ "GO:0002244 » Hematopoietic progenitor cell differentiation". NextProt BETA. ...
*  Myeloid tissue
... which come from common lymphoid progenitor cells that give rise to B cells and T cells. Those cells' differentiation (that is, ... In hematopoiesis, myeloid or myelogenous cells are blood cells that arise from a progenitor cell for granulocytes, monocytes, ... myeloid cells in the narrowest sense of the term can be distinguished from lymphoid cells, that is, lymphocytes, ... Orkin SH, Zon LI (2008). "Hematopoiesis: an evolving paradigm for stem cell biology". Cell. 132 (4): 631-644. doi:10.1016/j. ...
*  Breakthrough infection
HSCs tend to favor the production of myeloid progenitor cells over lymphoid progenitor cells. Mature lymphocytes are also ... limit the proliferation of HSCs and production of lymphoid progenitor cells. This is compounded by the fact that, with time, ... Even when B cells do bind to the pathogen, immune response is still frequently repressed. If B cell receptors bind to the ... Typically, the cells live for multiple decades, but there is variation in the longevity of these cells depending on the type of ...
*  B cell
HSCs first differentiate into multipotent progenitor (MPP) cells, then common lymphoid progenitor (CLP) cells. From here, their ... B-2 cell - FO B cells and MZ B cells. Regulatory B (Breg) cell - An immunosuppressive B cell type that stops the expansion of ... Of the three B cell subsets, FO B cells preferentially undergo T cell-dependent activation while MZ B cells and B1 B cells ... T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. BCRs allow the B cell to bind to a ...
*  ASH1L
... of ASH1L in lineage marker-negative hematopoietic progenitor cells skews differentiation from myelomonocytic towards lymphoid ... Cell. 149 (4): 819-31. doi:10.1016/j.cell.2012.03.035. PMC 3350859 . PMID 22541069. Human ASH1L genome location and ASH1L gene ... localizes to both nuclei and cell-cell tight junctions". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7284-9. doi:10.1073/pnas.97.13. ... Cell. Biol. 19 (9): 6441-7. PMC 84613 . PMID 10454589. Nakamura T, Blechman J, Tada S, Rozovskaia T, Itoyama T, Bullrich F, ...
*  Acute biphenotypic leukaemia
... of leukemia which arises in multipotent progenitor cells which have the ability differentiating into both myeloid and lymphoid ... The cells could display both myeloid lineage and lymphoid or undifferentiated morphology. Therefore, the diagnosis cannot based ... Anemia: reduction metrocytes that could produce red blood cells, resulting in a lack of red blood cells. Patients are prone to ... Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to ...
*  L-selectin
High expression of L-selectin on human bone marrow progenitor cells is an early sign of cells becoming committed to lymphoid ... CD34, found on endothelial cells. MadCAM-1, found on endothelial cells of gut-associated lymphoid tissue. PSGL-1, binds with ... The receptor is commonly found on the cell surfaces of T cells. Naive T-lymphocytes, which have not yet encountered their ... "Cell-cell contact mechanisms". Curr. Opin. Immunol. 4 (1): 33-7. doi:10.1016/0952-7915(92)90120-4. PMID 1375831. Nicholson IC ( ...
*  DTX1
"Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1". Immunity. 16 (2): 231-43. doi:10.1016/ ... Cell. 90 (2): 281-91. doi:10.1016/S0092-8674(00)80336-0. PMID 9244302. Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, ... "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells". Molecular Immunology. 39 (13 ... "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development". Immunity. 18 ( ...
*  Haematopoiesis
They are derived from common lymphoid progenitors. The lymphoid lineage is primarily composed of T-cells and B-cells (types of ... which generates T and B cell progenitors through a bipotential myeloid-T progenitor and a myeloid-B progenitor stage. The main ... differentiated cells may regain attributes of progenitor cells. An example is PAX5 factor, which is important in B cell ... The other daughters of HSCs (myeloid and lymphoid progenitor cells) can follow any of the other differentiation pathways that ...
*  MiR-155
... or common lymphoid progenitor (CLP) cells. CMPs represent the cellular population that has become myeloid lineage and it is the ... Mayani H (Mar 2010). "Biological differences between neonatal and adult human hematopoietic stem/progenitor cells". Stem Cells ... leukemic cells to healthy B cells and promote their transformation to tumorigenic-like cells Selection of competent B cells ... all of which are derived from hematopoietic stem-progenitor cells (HSPCs). HSPCs are primitive cells capable of self-renewal ...
*  FLT3LG
"Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells ... 2003). "Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human ... 1994). "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells". ... 2002). "Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells ...
*  CD117
... multipotent progenitors (MPP), and common myeloid progenitors (CMP) express high levels of CD117. Common lymphoid progenitors ( ... Signaling through CD117 plays a role in cell survival, proliferation, and differentiation. Hematopoietic progenitor cells are ... It is also a marker for mouse prostate stem cells. In addition, mast cells, melanocytes in the skin, and interstitial cells of ... the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells ...
*  Dendritic cells- based cancer vaccines
Plasmacytoid dendritic cells (pDCs) differentiate from lymphoid progenitor cells in the lymphoid tissues. They express CD123 ... Dendritic cells (DCs) are most powerful antigen presenting cells for the induction of antigen specific T cell response and ... Mature DCs have ability to present antigens in the lymphoid tissues and prime, activate and expand effector immune cells with ... Myeloid or conventional DCs (cDCs) are derived from myeloid progenitor cells in the bone marrow and are characterized by ...
*  Nuocyte
These include Natural Helper Cells (NHCs), Innate Helper 2 (Ih2) cells and Multi-Potent Progenitor (MPP) type 2 cells. The ... MPP type 2 cells appear to differ from the other populations in that they have a myeloid, rather than lymphoid, origin. ... Pro-T cell progenitors retain nuocyte developmental potential but, unlike T cells, the thymus is dispensable for their ... Mirchandani, A; Salmond, R; Liew, F (2012). "Interleukin-33 and the function of innate lymphoid cells". Trends in Immunology. ...
*  Xenotransplantation
Lymphoid progenitor cells are created by this process and move to the thymus where negative selection eliminates T cells found ... stimulated by CD4+ T cells) and NK cells (stimulated by the release of Il-2). Thus, the role of MHC molecules and T cell ... where they coexist with the recipient's stem cells. The bone marrow stem cells give rise to cells of all hematopoietic lineages ... Antigens of phagocytosed graft cells can also be presented by the host's class I MHC molecules to CD8+ T cells. The strength of ...
*  Severe combined immunodeficient mice
... and lymphoid cells from blood transplants, leading to the formation of human immune cells, such as B and T cells, within the ... Mice with SCIDs have lymphocyte progenitors, but these cells are unable to survive to maturity. This results in a lack of B and ... Human immune cells are used to develop human lymphoid organs within these immunodeficient mice, and many different types of ... Some SCID mice are able to produce monocytes, granulocytes, and red blood cells from the hematopoietic stem cells (HSC) present ...
*  Cell potency
Examples of oligopotent stem cells are the lymphoid or myeloid stem cells. A lymphoid cell specifically, can give rise to ... not to a different blood cell type like a red blood cell. Examples of progenitor cells are vascular stem cells that have the ... Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the ... In cell biology, a unipotent cell is the concept that one stem cell has the capacity to differentiate into only one cell type. ...
*  CD8+ cell
... where hematopoietic stem cells are made into lymphoid progenitor cells. These lymphoid progenitor cells will then move to the ... and thus will allow the CD8+ T cell to bind to infected cells. Once bound, the naïve CD8+ T cell will become mature CD8+ T cell ... Infected nucleated cells will present MHC Class I molecules on their cell surface. The CD8 chain on the naïve CD8+ T cell will ... These immune cells are characterized by a CD8 protein on their cell surface that allow them to recognize, bind and kill cells ...
*  FMS-like tyrosine kinase 3 ligand
... and common lymphoid progenitor (CLP) cells. It also induces the mobilization of the hematopoietic progenitors and stem cells in ... B cells and T cells)) by activating the hematopoietic progenitors. It acts by binding to and activating FLT3 (CD135) which is ... In strains of plasmodium, FLT3L was shown to be released from mast cells and cause the expansion of dendritic cells, leading to ... FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development. A lack of ...
*  Immunosenescence
Hematopoietic stem cells (HSC), which provide the regulated lifelong supply of leukocyte progenitors that are in turn able to ... It should be further noted that changes in the lymphoid compartment is not solely responsible for the malfunctioning of the ... The cytotoxicity of Natural Killer (NK) cells and the antigen-presenting function of dendritic cells is known to diminish with ... Mocchegiani, E; M. Malavolta (2004). "NK and NKT cell functions in immunosenescence". Aging Cell. 3 (4): 177-184. doi:10.1111/j ...
*  Carcinogenesis
December 2015). "Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma". ... Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist ... and stem cells are the only cells that can transmit DNA from the zygote to cells late in life. Other cells cannot keep DNA from ... The cancer stem cell hypothesis proposes that the different kinds of cells in a heterogeneous tumor arise from a single cell, ...