*Lymphoid enhancer-binding factor 1

Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a ... Lymphoid enhancer-binding factor 1 has been shown to interact with: ALX4, AML-1, CTNNB1, EP300, MITF PIAS4, SMAD2, and SMAD3. ... "Entrez Gene: LEF1 lymphoid enhancer-binding factor 1". Erdfelder F, Hertweck M, Filipovich A, Uhrmacher S, Kreuzer KA (2010). " ... Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene. ...

*ALX4

... has been shown to interact with Lymphoid enhancer-binding factor 1. GRCh38: Ensembl release 89: ENSG00000052850 - Ensembl ... "Entrez Gene: ALX4 aristaless-like homeobox 4". Boras, Kata; Hamel Paul A (Jan 2002). "Alx4 binding to LEF-1 regulates N-CAM ... Boras K, Hamel PA (2002). "Alx4 binding to LEF-1 regulates N-CAM promoter activity". J. Biol. Chem. 277 (2): 1120-7. doi: ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Wakui K, Gregato G, Ballif BC, et al. (2005). "Construction of a natural panel ...

*PIAS4

Mothers against decapentaplegic homolog 7 and Lymphoid enhancer-binding factor 1. GRCh38: Ensembl release 89: ENSG00000105229 ... "A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy ... Lee PS, Chang C, Liu D, Derynck R (2003). "Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta ... 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J ...

*Mothers against decapentaplegic homolog 2

Labbé E, Letamendia A, Attisano L (July 2000). "Association of Smads with lymphoid enhancer binding factor 1/T cell-specific ... superfamily of growth factors into the cell nucleus. Binding of a subgroup of TGFβ superfamily ligands to extracellular ... The association with SMAD4 is important for the translocation of this protein into the cell nucleus, where it binds to target ... Hocevar BA, Smine A, Xu XX, Howe PH (June 2001). "The adaptor molecule Disabled-2 links the transforming growth factor β ...

*Beta-catenin

Labbé E, Letamendia A, Attisano L (July 2000). "Association of Smads with lymphoid enhancer binding factor 1/T cell-specific ... "The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac ... Beta-catenin has a central role in directing several developmental processes, as it can directly bind transcription factors and ... Once bound to the receptor complex, axin will be rendered incompetent for β-catenin binding and GSK3 activity. Importantly, the ...

*Mesenchyme

... activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 ... Specific markers of mesenchymal tissue include the additional expression of ECM factors such as fibronectin and vitronectin. ... The interaction with ectoderm and somite-forming morphogenic factors cause some primary mesenchyme to form neural mesenchyme, ... 174 (1): 1-14. PMID 3518538. Hay, E. D. (2005). "The mesenchymal cell, its role in the embryo, and the remarkable signaling ...

*Cadherin-catenin complex in learning and memory

Expression of lymphoid enhancer-binding factor 1 (LEF-1) triggers the translocation of β-catenin to the nucleus, where it ... For example, the cadherin-α-catenin complex binds the actin cytoskeleton, though whether it binds via binding proteins or ... In homodimeric form, α-catenins do not bind β- catenins, but preferentially bind F-actin and other proteins promoting F-actin ... Dimerized cadherins readily bind to their presynaptic cadherin partners. Inhibition of N-cadherin binding via blocking ...

*C9orf84

Ccaat-enhancer-binding proteins, and Lymphoid enhancer-binding factor 1 are all related to immunity. C9orf84 is the only gene ... Ccaat/Enhancer Binding Proteins, and Lymphoid enhancer-binding factor 1. ETS1, ... Several of the most common and most conserved transcription factor binding sites families that are predicted to be found in ... The promoter for C9orf84 Isoform 1 in humans is 639 bp long and overlaps with the 5' untranslated region of the gene. There are ...

*List of MeSH codes (D12.776.660)

... tcf transcription factors MeSH D12.776.660.235.400.800.500 -- lymphoid enhancer-binding factor 1 MeSH D12.776.660.235.400.800. ... telomeric repeat binding protein 2 MeSH D12.776.660.352.500.500 -- hepatocyte nuclear factor 1-alpha MeSH D12.776.660.352. ... hepatocyte nuclear factor 1-beta MeSH D12.776.660.650.875.500 -- lamin type a MeSH D12.776.660.650.875.750 -- lamin type b. ... t cell transcription factor 1 MeSH D12.776.660.235.700.500 -- heterogeneous-nuclear ribonucleoprotein group a-b MeSH D12.776. ...

*High-mobility group

... domain HMGN1 HMGN2 HMGN3 HMGN4 Sex-Determining Region Y Protein TCF Transcription Factors Lymphoid enhancer-binding factor 1 T ... Furthermore, these HMG-box DNA-binding proteins increase the flexibility of the DNA upon binding. Gene regulatory network HMG- ... The high-mobility group protein such as HMO1 alters DNA architecture by binding, bending and looping. ... box Transcription factors Rajeswari MR, Jain A (2002). "High-mobility-group chromosomal proteins, HMGA1 as potential tumour ...

*TCF7

"Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 ... Transcription factor 7 is a protein that in humans is encoded by the TCF7 gene. GRCh38: Ensembl release 89: ENSG00000081059 - ... Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related ... Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel ...

*List of MeSH codes (D12.776)

... tcf transcription factors MeSH D12.776.664.235.400.800.500 - lymphoid enhancer-binding factor 1 MeSH D12.776.664.235.400.800. ... cleavage stimulation factor MeSH D12.776.664.962.452.249 - poly(a)-binding protein i MeSH D12.776.664.962.452.500 - poly(a)- ... eukaryotic initiation factor-4f MeSH D12.776.664.962.750.750 - nuclear cap-binding protein complex MeSH D12.776.765.678.968.900 ... rheumatoid factor MeSH D12.776.377.715.548.114.345 - binding sites, antibody MeSH D12.776.377.715.548.114.345.180 - ...

*TCF7L1

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription ... The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle ... Transcription factor 7-like 1 (T-cell specific, HMG-box), also known as TCF7L1, is a human gene. ... Castrop J, van Norren K, Clevers H (Feb 1992). "A gene family of HMG-box transcription factors with homology to TCF-1". Nucleic ...

*Haematopoiesis

... is transcription factor CCAAT-enhancer binding protein α (C/EBPα). Mutations in C/EBPα are associated with acute myeloid ... They are derived from common lymphoid progenitors. The lymphoid lineage is primarily composed of T-cells and B-cells (types of ... Growth factors initiate signal transduction pathways, which lead to activation of transcription factors. Growth factors elicit ... One of the key players in self-renewal and development of haematopoietic cells is stem cell factor (SCF), which binds to the c- ...

*RUNX1

... and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ... but its DNA binding affinity is enhanced by 10 fold if it heterodimerises with the core binding factor β (CBFβ), also via the ... 23 RUNX1 enhancer). This +23 RUNX1 enhancer contains conserved motifs that encourage binding of various haematopoiesis related ...

*CEBPE

"A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is ... The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions ... CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. ... "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is ...

*DVL1

... "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled ... Warner DR, Pisano MM, Roberts EA, Greene RM (Mar 2003). "Identification of three novel Smad binding proteins involved in cell ... a novel Dvl-binding protein". Mol. Cell. Biol. 21 (1): 330-42. doi:10.1128/MCB.21.1.330-342.2001. PMC 88806 . PMID 11113207. ... 8 (1): 118-30. doi:10.1101/gad.8.1.118. PMID 8288125. Pizzuti A, Novelli G, Mari A, Ratti A, Colosimo A, Amati F, Penso D, ...

*Arrestin beta 1

... "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled ... Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, Ma L, Pei G (March 2001). "Direct binding of beta-arrestins to two distinct ... Bennett TA, Maestas DC, Prossnitz ER (2000). "Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated ... Localization of the arrestin binding locus to the clathrin terminal domain". J. Biol. Chem. 272 (23): 15017-22. doi:10.1074/jbc ...

*TRA (gene)

... a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected ... 1998). "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino ... 1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): ... Chilson OP, Kelly-Chilson AE (1989). "Mitogenic lectins bind to the antigen receptor on human lymphocytes". Eur. J. Immunol. 19 ...

*ELF1

The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate ... "cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1". Molecular ... E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene. This gene encodes ... Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two- ...

*TCF3

Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans ... Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also ... Kamps MP, Murre C, Sun XH, Baltimore D (Feb 1990). "A new homeobox gene contributes the DNA binding domain of the t(1;19) ... Huggins GS, Chin MT, Sibinga NE, Lee SL, Haber E, Lee ME (Oct 1999). "Characterization of the mUBC9-binding sites required for ...

*Chromosome 10 (human)

... nuclear receptor-binding factor 2 NSMCE4A: non-SMC element 4 homolog A OTUD1: encoding protein OTU deubiquitinase 1 PCBD1: 6- ... Nucleolar GTP-binding protein 4 HELLS: Lymphoid-specific helicase HKDC1: hexokinase domain containing 1 KIN: DNA/RNA-binding ... Enhancer of polycomb homolog 1 ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6 ... fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1 ...

*IRF8

Interferon Consensus Sequence-binding protein (ICSBP) is a transcription factor of the interferon regulatory factor (IRF) ... "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible ... IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP knockout (KO) mice, as revealed by lack of ... Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in ...

*HOXC4

"The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids ... 2 enhancer in human B cells. Relevance to class switch DNA recombination". J. Biol. Chem. 279 (40): 42258-69. doi:10.1074/jbc. ... and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas". Am. J ... Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ (2001). "The binding of Ku antigen to ...

*MEF2B

Myocyte enhancer binding factor 2B (MEF2B) is a transcription factor part of the MEF2 gene family including MEF2A, MEF2C, and ... "Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas". Virchows Archiv: An International Journal of ... "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors". Genes & ... Li M, Linseman DA, Allen MP, Meintzer MK, Wang X, Laessig T, Wierman ME, Heidenreich KA (Sep 2001). "Myocyte enhancer factor 2A ...

*DNA vaccination

Macrophage scavenger receptors bind to a variety of macromolecules, including polyribonucleotides and are thus candidates for ... Immune responses to this method can be affected by factors including needle type, needle alignment, speed of injection, volume ... References, S.; Boyle, C.; Morin, M.; Webster, R.; Robinson, H. (1996). "Role of different lymphoid tissues in the initiation ... Additional modifications to improve expression rates include the insertion of enhancer sequences, synthetic introns, adenovirus ...