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*  CD11a
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ... antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)". Lu C, Takagi J, Springer TA (May 2001). " ... CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Efalizumab acts as an ... to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a ...
*  CD2
It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in ... CD2 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Sayre PH, Reinherz EL (1989). "Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review". Scand ... "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3". Proc Natl Acad Sci U S ...
*  Mixed lymphocyte reaction
Tissue Antigens. 39:225. 9. Lindemann M. 2014. Ex vivo assessment of cellular immune function - applications in patient care ... Mixed lymphocyte reaction (MLR) is a test used by pharmaceutical and biotech organizations to show the safety of a drug or ... "Why are Mixed Lymphocyte Reactions Performed?". Retrieved 7 January 2017. 1. Meo, T.: The MLR test in the mouse. 1979. In ... Lymphocyte interaction: A potential histocompatibility test in vitro. Science 143:813. 4. Benacerraf, B. and H.O. McDevitt. ...
*  Lymphocyte function-associated antigen 1
... (LFA-1) is found on all T-cells and also on B-cells, macrophages, neutrophils and NK ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... LFA-1 is part of the family of leukocyte integrins that are recognised by their common β-chains (β2, CD18). LFA-1 also has a ... LFA-1 is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor ...
*  ICD-10 Chapter III: Diseases of the blood and blood-forming organs, and certain disorders involving the immune mechanism -...
Lymphocyte function antigen-1 (LFA-1) defect (D84.1) Defects in the complement system C1 esterase inhibitor deficiency (C1-INH ... Major histocompatibility complex class I deficiency Bare lymphocyte syndrome (D81.7) Major histocompatibility complex class II ... Nonfamilial hypogammaglobulinaemia Agammaglobulinaemia with immunoglobulin-bearing B-lymphocytes Common variable ...
*  Timothy A. Springer
"Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... "A novel lymphocyte function-associated antigen (LFA-1): cellular distribution, quantitative expression, and structure". J. ... "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3". Proc Natl Acad Sci U S ... His lab elucidated different steps in the homing process of lymphocytes with a special focus on the integrin LFA-1. His ...
*  ICAM5
... localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol ... New members and novel functions". Immunol. Res. 17 (3): 313-27. doi:10.1007/BF02786454. PMID 9638475. Benson DL, Yoshihara Y, ... 2000). "Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction ... 46 (1): 18-23. doi:10.1002/(SICI)1097-0029(19990701)46:1. 3.0.CO;2-G. PMID 10402269. Mizuno T, Yoshihara Y, Kagamiyama H, et al ...
*  ICAM3
... of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1". ... 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1". The ... a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes". The Journal of ... It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM3 has been shown to interact with ...
*  Lifitegrast
... inhibits an integrin, lymphocyte function-associated antigen 1 (LFA-1), from binding to intercellular adhesion ... "The Pharmacologic Assessment of A Novel Lymphocyte Function-Associated Antigen-1 Antagonist (SAR 1118) for the Treatment of ... This mechanism down-regulates inflammation mediated by T lymphocytes. Lifitegrast was initially designed and developed by ...
*  CD226
... is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation ... a novel adhesion molecule involved in the cytolytic function of T lymphocytes". Immunity. 4 (6): 573-81. doi:10.1016/S1074-7613 ... CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') or DNAM-1 (DNAX ... Ralston KJ, Hird SL, Zhang X, Scott JL, Jin B, Thorne RF, Berndt MC, Boyd AW, Burns GF (August 2004). "The LFA-1-associated ...
*  RASGRP2
Katagiri K, Shimonaka M, Kinashi T (2004). "Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell ... mutation affects platelet function and causes severe bleeding". Journal of Experimental Medicine. 211: 1349-62. doi:10.1084/jem ... antigen receptor is dependent on phospholipase C-gamma1". J. Biol. Chem. 279 (12): 11875-81. doi:10.1074/jbc.M310717200. PMID ... 16 (1): 55-65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560. RASGRP2 human gene location in the UCSC Genome Browser. ...
*  Immunological synapse
p-SMAC (peripheral-SMAC) within which the lymphocyte function-associated antigen-1 (LFA-1) and the cytoskeletal protein talin ... This complex as a whole is postulated to have several functions including but not limited to: Regulation of lymphocyte ... is the interface between an antigen-presenting cell or target cell and a lymphocyte such as an effector T cell or Natural ... The process of formation begins when the T-cell receptor (TCR) binds to the peptide:MHC complex on the antigen-presenting cell ...
*  Odulimomab
It is a mouse monoclonal antibody directed against the alpha chain of the protein lymphocyte function-associated antigen 1 ... "Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and ... Whitcup, SM; Chan, CC; Kozhich, AT; Magone, MT (1999). "Blocking ICAM-1 (CD54) and LFA-1 (CD11a) inhibits experimental allergic ... "Role of calcineurin-dependent drugs on the immunosuppressive effect induced by the anti-LFA-1 antibody in a fetal intestinal ...
*  Efalizumab
... binds to the CD11a subunit of lymphocyte function-associated antigen 1 and acts as an immunosuppressant by ... Li S, Wang H, Peng B, Zhang M, Zhang D, Hou S, Guo Y, Ding J (March 2009). "Efalizumab binding to the LFA-1 alphaL I domain ... inhibiting lymphocyte activation and cell migration out of blood vessels into tissues. Efalizumab was associated with fatal ... 1 (6): 583-9. doi:10.4161/mabs.1.6.9884. PMC 2791316 . PMID 20073129. "EMEA press release regarding suspension" (PDF). Archived ...
*  Eugene C. Butcher
"Short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of ... He and his research team have shown that lymphocytes use a variety of different adhesion molecules or "homing receptors" to ... A major focus of the group is on understanding the physiologic significance and control of targeted lymphocyte trafficking. To ... They are interested in the structure and function of these molecules, and their importance in disease models. Finally, they ...
*  Leukocyte adhesion deficiency-1
... including lymphocyte function-associated antigen 1 (LFA-1), complement receptor 3 (CR-3), and complement receptor 4 (CR-4). The ... It also impairs immune cell interaction, immune recognition, and cell-killing lymphocyte functions. The lack of CR3 interferes ... Leukocyte adhesion deficiency-1 (LAD1) is a rare and often fatal genetic disorder in humans. The main sign of the disease is ... deficiency of LFA-1 causes neutrophils to be unable to adhere to and migrate out of blood vessels, so their counts can be high ...
*  CD11
For example, LFA1 (CD11a/CD18) short representation of Lymphocyte Function-associated Antigen 1, also called αLβ2 integrin Mac1 ... CD11b/CD18) present on macrophages that is also called Macrophage-1 antigen (CR3) and αmβ2 integrin. CD11c/CD18 also called ...
*  Index of immunology articles
A Lipopolysaccharide binding protein Low-affinity nerve growth factor receptor LPHN1 Lymphocyte function-associated antigen 1 ... opsonization Antibody-dependent cell-mediated cytotoxicity Antibody-dependent enhancement Antigen Antigen presentation Antigen ... Fc receptor Fc receptor-like molecule FcεRI Fibroblast-like synoviocyte FITkit FluoroSpot Forssman antigen Fragment antigen- ... Herd immunity Heterophile Heterophile antigen Heterosubtypic immunity Histamine Histocompatibility Human leukocyte antigen ...
*  List of MeSH codes (D12.776.395)
... lymphocyte function-associated antigen-1 MeSH D12.776.395.550.200.625.903 -- l-selectin MeSH D12.776.395.550.200.700 -- ... antigens, cd22 MeSH D12.776.395.550.200.098 -- antigens, cd24 MeSH D12.776.395.550.200.131 -- antigens, cd31 MeSH D12.776. ... lymphocyte homing MeSH D12.776.395.550.200.625.144 -- antigens, cd44 MeSH D12.776.395.550.200.625.347 -- integrin alpha4beta1 ... 395.550.200.170 -- antigens, cd146 MeSH D12.776.395.550.200.175 -- antigens, cd164 MeSH D12.776.395.550.200.200 -- cadherins ...
*  List of MeSH codes (D23)
... antigens, cd11b MeSH D23.050.301.264.035.111.074 --- antigens, cd11c MeSH D23.050.301.264.035.111.400 --- lymphocyte function- ... antigens, cd11c MeSH D23.101.100.110.111.400 --- lymphocyte function-associated antigen-1 MeSH D23.101.100.110.113 --- antigens ... antigens, cd29 MeSH D23.101.100.150 --- antigens, differentiation, b-lymphocyte MeSH D23.101.100.150.101 --- antigens, cd5 MeSH ... antigens, cd40 MeSH D23.101.100.894 --- antigens, differentiation, t-lymphocyte MeSH D23.101.100.894.080 --- antigens, cd1 MeSH ...
*  List of MeSH codes (D12.776.543)
... lymphocyte function-associated antigen-1 MeSH D12.776.543.750.705.877.903 -- l-selectin MeSH D12.776.543.750.705.880.600 -- ... lymphocyte function-associated antigen-1 MeSH D12.776.543.550.200.625.903 -- l-selectin MeSH D12.776.543.550.200.700 -- ... lymphocyte function-associated antigen-1 MeSH D12.776.543.750.705.408.600.500 -- macrophage-1 antigen MeSH D12.776.543.750. ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 -- antigens, cd79 MeSH D12.776.543.750.705.816.824 -- receptors, antigen, ...
*  Rituximab
... lymphocyte function-associated antigen). It elicits shedding of CD23. It downregulates the B cell receptor. It induces ... Although the function of CD20 is unknown, it may play a role in Ca2+ influx across plasma membranes, maintaining intracellular ... including non-Hodgkin's lymphoma and lymphocyte predominant subtype, of Hodgkin's Lymphoma. Rituximab has been shown to be an ... "Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell-mediated antibody-dependent ...
*  Alan M. Krensky
He identified the human lymphocyte function-associated antigens 1-3, immunomodulatory HLA derived peptides (AllotrapTM), ... Krensky AM, Weiss A, Crabtree G, Davis M, Parham P: Mechanisms of disease: T lymphocyte - antigen interactions in transplant ... Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2 (CD2), and LFA-3 (CD58). Proc. Natl ... Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. ...
*  CD18
Huang C, Springer TA (August 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) ... CD18 antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGB2 Info with links in the Cell Migration ... 16 (1): R42. doi:10.1186/ar4471. Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M ( ... For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the ...
*  Immune tolerance
... costimultory molecules on antigen presenting cells upon interaction with CTLA-4 or lymphocyte function-associated antigen 1 ( ... tumor antigens, alloantigens, and self-antigens in inflamed tissue. Immune recognition of non-self-antigens typically ... Those lymphocytes that have receptors that bind strongly to self-antigens are removed by induction of apoptosis of the ... In these tissues, maturing lymphocytes are exposed to self-antigens presented by medullary thymic epithelial cells and thymic ...
*  GNLY
Granulysin is a member of the saposin-like protein (SAPLIP) family and is released from cytotoxic T cells upon antigen ... Granulysin is present in cytolytic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granulysin is made ... 1997). "Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with ... Donlon TA, Krensky AM, Clayberger C (1990). "Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome ...
*  LFA
... a classification of autism Lunar Flag Assembly Lymphocyte function-associated antigen (disambiguation), (LFA-1, 2, and 3) ... the principle behind immunochromatographic rapid tests Low-functioning autism, ...