... (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. ... Patients with LAD also have poorly functioning neutrophils. LAD1, a subtype of LAD, is caused by a lack of integrins that ...

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ... CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Efalizumab acts as an ... ". "Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)". ... to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed in all leukocytes. LFA-1 plays a ...

"Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1-deficient Mice". The Journal of Experimental Medicine. ... S100a9 null mice demonstrated that myeloid cells could function relatively normally without these proteins but they had a major ... "Myeloid Cell Function in MRP-14 (S100A9) Null Mice". Molecular and Cellular Biology. 23 (7): 2564-2576. doi:10.1128/MCB.23.7. ... "Divalent cation regulation of the function of the leukocyte integrin LFA-1". The Journal of Cell Biology. 116 (1): 219-226. doi ...

... localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol ... New members and novel functions". Immunol. Res. 17 (3): 313-27. doi:10.1007/BF02786454. PMID 9638475. S2CID 19901365. Benson DL ... 2000). "Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction ... 849 (1-2): 58-66. doi:10.1016/S0006-8993(99)01984-8. PMID 10592287. S2CID 353053. Tian L, Kilgannon P, Yoshihara Y, et al. ( ...

... of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1". ... 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1". The ... Svajger U, Anderluh M, Jeras M, Obermajer N (October 2010). "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake ... ICAM3 has an important function in the immune cell response, as it helps facilitate initial interactions between T cells and ...

May 2011). "The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the ... Lifitegrast inhibits an integrin, lymphocyte function-associated antigen 1 (LFA-1), from binding to intercellular adhesion ... This mechanism down-regulates inflammation mediated by T lymphocytes. Lifitegrast was initially designed by Sunesis and ...

Katagiri K, Shimonaka M, Kinashi T (2004). "Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell ... mutation affects platelet function and causes severe bleeding". Journal of Experimental Medicine. 211 (7): 1349-62. doi:10.1084 ... antigen receptor is dependent on phospholipase C-gamma1". J. Biol. Chem. 279 (12): 11875-81. doi:10.1074/jbc.M310717200. PMID ... 16 (1): 55-65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. RASGRP2 human gene location in the UCSC Genome Browser. ...

p-SMAC (peripheral-SMAC) within which the lymphocyte function-associated antigen-1 (LFA-1) and the cytoskeletal protein talin ... This complex as a whole is postulated to have several functions including but not limited to: Regulation of lymphocyte ... is the interface between an antigen-presenting cell or target cell and a lymphocyte such as a T/B cell or Natural Killer cell. ... If the KIR receptors of NK cell find their cognate antigen on the surface of target cell, formation of the lytic synapse is ...

July 2002). "Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune ... It is a mouse monoclonal antibody directed against the alpha chain of the protein lymphocyte function-associated antigen 1 ... 74 (1): 35-41. doi:10.1097/00007890-200207150-00007. PMID 12134096. S2CID 35637410. v t e v t e (Drugs not assigned an ATC code ... Whitcup SM, Chan CC, Kozhich AT, Magone MT (November 1999). "Blocking ICAM-1 (CD54) and LFA-1 (CD11a) inhibits experimental ...

... binds to the CD11a subunit of lymphocyte function-associated antigen 1 and acts as an immunosuppressant by ... Li S, Wang H, Peng B, Zhang M, Zhang D, Hou S, Guo Y, Ding J (March 2009). "Efalizumab binding to the LFA-1 alphaL I domain ... inhibiting lymphocyte activation and cell migration out of blood vessels into tissues. Efalizumab was associated with fatal ... 1 (6): 583-9. doi:10.4161/mabs.1.6.9884. PMC 2791316. PMID 20073129. "EMEA press release regarding suspension" (PDF). Archived ...

... (LFA) may refer to: LFA-1 CD2, LFA-2 CD58, LFA-3 This disambiguation page lists articles ... associated with the title Lymphocyte function-associated antigen. If an internal link led you here, you may wish to change the ...

"Short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of ... He and his research team have shown that lymphocytes use a variety of different adhesion molecules or "homing receptors" to ... A major focus of the group is on understanding the physiologic significance and control of targeted lymphocyte trafficking. To ... They are interested in the structure and function of these molecules, and their importance in disease models. Finally, they ...

... a classification of autism Lunar Flag Assembly Lymphocyte function-associated antigen (disambiguation), (LFA-1, 2, and 3) ... the principle behind immunochromatographic rapid tests Low-functioning autism, ...

... including lymphocyte function-associated antigen 1 (LFA-1), complement receptor 3 (CR-3), and complement receptor 4 (CR-4). The ... It also impairs immune cell interaction, immune recognition, and cell-killing lymphocyte functions. The lack of CR3 interferes ... Leukocyte adhesion deficiency-1 (LAD1) is a rare and often fatal genetic disorder in humans. The main sign of the disease is ... 38 (1): 54-60. doi:10.1007/s12016-009-8132-3. PMID 19437145. S2CID 3068072. (Articles with short description, Short description ...

... the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule". J Exp ... The main function of these proteins is to allow neutrophils to make their way out of the blood stream and into the infected ... In LAD-III, as platelet function is also affected, this could be used to differentiate it from the other types.[citation needed ... Sanchez-Madrid F, Nagy JA, Robbins E, Simon P, Springer TA (1983). "A human leukocyte differentiation antigen family with ...

For example, LFA1 (CD11a/CD18) short representation of Lymphocyte Function-associated Antigen 1, also called αLβ2 integrin Mac1 ... CD11b/CD18) present on macrophages that is also called Macrophage-1 antigen (CR3) and αMβ2 integrin. CD11c/CD18 also called ...

Binding of CD18 and CD11a results in the formation of lymphocyte function-associated antigen-1 (LFA-1), a protein found on B ... Huang C, Springer TA (August 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) ... CD18+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ITGB2 Info with links in the Cell ... These complement receptors participate in the innate immune response by recognizing foreign antigen peptides and phagocytizing ...

A Lipopolysaccharide binding protein Low-affinity nerve growth factor receptor LPHN1 Lymphocyte function-associated antigen 1 ... opsonization Antibody-dependent cell-mediated cytotoxicity Antibody-dependent enhancement Antigen Antigen presentation Antigen ... Fc receptor Fc receptor-like molecule FcεRI Fibroblast-like synoviocyte FITkit FluoroSpot Forssman antigen Fragment antigen- ... Herd immunity Heterophile Heterophile antigen Heterosubtypic immunity Histamine Histocompatibility Human leukocyte antigen ...

... lymphocyte function-associated antigen-1 MeSH D12.776.395.550.200.625.903 - l-selectin MeSH D12.776.395.550.200.700 - selectins ... antigens, cd22 MeSH D12.776.395.550.200.098 - antigens, cd24 MeSH D12.776.395.550.200.131 - antigens, cd31 MeSH D12.776.395.550 ... lymphocyte homing MeSH D12.776.395.550.200.625.144 - antigens, cd44 MeSH D12.776.395.550.200.625.347 - integrin alpha4beta1 ... antigens, cd43 MeSH D12.776.395.560.631.650.264 - antigens, cd164 The list continues at List of MeSH codes (D12.776) § MeSH ...

... antigens, cd11b MeSH D23.050.301.264.035.111.074 - antigens, cd11c MeSH D23.050.301.264.035.111.400 - lymphocyte function- ... antigens, cd11b MeSH D23.101.100.110.111.074 - antigens, cd11c MeSH D23.101.100.110.111.400 - lymphocyte function-associated ... antigens, differentiation, t-lymphocyte MeSH D23.101.100.894.080 - antigens, cd1 MeSH D23.101.100.894.090 - antigens, cd2 MeSH ... antigens, cd29 MeSH D23.050.301.264.894 - antigens, differentiation, t-lymphocyte MeSH D23.050.301.264.894.080 - antigens, cd1 ...

... lymphocyte function-associated antigen-1 MeSH D12.776.543.550.200.625.903 - l-selectin MeSH D12.776.543.550.200.700 - selectins ... lymphocyte function-associated antigen-1 MeSH D12.776.543.750.705.877.903 - l-selectin MeSH D12.776.543.750.705.880.600 - ... lymphocyte function-associated antigen-1 MeSH D12.776.543.750.705.408.600.500 - macrophage-1 antigen MeSH D12.776.543.750. ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 - antigens, cd79 MeSH D12.776.543.750.705.816.824 - receptors, antigen, t- ...

He identified the human lymphocyte function-associated antigens 1-3, immunomodulatory HLA derived peptides (AllotrapTM), ... Krensky AM, Weiss A, Crabtree G, Davis M, Parham P: Mechanisms of disease: T lymphocyte - antigen interactions in transplant ... Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2 (CD2), and LFA-3 (CD58). Proc. Natl ... Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. ...

Huang C, Springer TA (Aug 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) ... leukocyte function associated antigen-1 (LFA-1), and fibrinogen. These three proteins are generally expressed on endothelial ... Katz FE, Parkar M, Stanley K, Murray LJ, Clark EA, Greaves MF (Jan 1985). "Chromosome mapping of cell membrane antigens ... Beyond its classically described functions as an adhesion and viral entry molecule, ICAM-1 has now been characterized ...

... and lymphocyte function-associated antigen 1 (LFA-1 (integrin)). Mac-1 and LFA-1 are receptors found on leukocytes. This ... and lymphocyte function-associated antigen 1 (LFA-1 (integrin)). This induced production happens through the activation of NF- ... So, all needed functions provided by V in SeV can be provided by C in HPIV1. Thus, C and V have these "overlapping functions" ... The genomic RNA functions as the template for the viral RNA transcription until the NP protein concentration increases. As the ...

... costimultory molecules on antigen presenting cells upon interaction with CTLA-4 or lymphocyte function-associated antigen 1 ( ... tumor antigens, alloantigens, and self-antigens in inflamed tissue. Immune recognition of non-self-antigens typically ... In these tissues, maturing lymphocytes are exposed to self-antigens presented by medullary thymic epithelial cells and thymic ... Self-antigens are present due to endogenous expression, importation of antigen from peripheral sites via circulating blood, and ...

... , or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells ( ... "Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein". The ... lymphocyte-function antigen 3 (LFA-3), is a glycoprotein that plays a vital role in the body's immune response. The natural ... "Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses". The Journal of ...

Together, CR3 and CR4 are involved in various functions of the T and B lymphocytes and NK cells. For instance, while both CR3 ... on T lymphocytes: activation-dependent up-regulation and regulatory function". Eur. J. Immunol. 31 (4): 1173-80. doi:10.1002/ ... CR3 and CR4, both members of the β2-integrin family, are generally thought to exhibit overlapping functions in myeloid cells ... CR3 and CR4 are thought to exhibit overlapping functions; however, the distinct binding sites to iC3b suggests differences in ...

Abbas AB, Lichtman AH (2009). "Ch.3 Antigen capture and presentation to lymphocytes". Basic Immunology. Functions and disorders ... Antigen presentation: MHC molecules bind to both T cell receptor and CD4/CD8 co-receptors on T lymphocytes, and the antigen ... T lymphocytes are selected for their TCR incapacity to recognize self antigens, yet T lymphocytes can react against the donor ... T lymphocytes of the recipient take the incompatible peptide-binding groove as nonself antigen.[clarification needed] ...

Read S, Malmström V, Powrie F (July 2000). "Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function ... which define antigen-specific cells following 24-48h stimulation with antigen. In addition to the search for novel protein ... Antigen-activated T cells produce IL-2 which then acts on IL-2 receptors on regulatory T cells alerting them to the fact that ... June 2014). "Human antigen-specific CD4⁺ CD25⁺ CD134⁺ CD39⁺ T cells are enriched for regulatory T cells and comprise a ...

Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death. ... the process by which external stimuli regulate internal cellular functioning. The key to optimal cellular functioning is ... Structure-function studies of the HIV-1 coreceptors. Seminars in Immunology, Vol. 10 pp. 237-248. Bleul, C.C., Wu, L., Hoxie, J ... The members of the CD family of co-receptors have a wide range of function. As well as being involved in forming a complex with ...