T-cell depletion
Soiffer, RJ (1992). "Prevention of graft-versus-host disease by selective depletion of CD6-positive T lymphocytes from donor ... However, depletion of regulatory T cells results in more intense flares of systemic lupus erythematosus. The in vivo depletion ... This problem is partially answered by more selective depletion, such as depletion of CD3+ or αβT-cell and CD19 B cell, which ... Depletion can occur naturally (i.e. in HIV) or be induced for treatment purposes. TCD can reduce the risk of graft-versus-host ...
AIDS-related complex
... leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as ...
CD20
May 2019). "B-Lymphocyte Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double- ... B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and ... Stamenkovic I, Seed B (June 1988). "Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III ... This gene encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into ...
Alastair Compston
... following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)". Journal of Clinical Investigation. 119 (7): 2052-61 ...
Chronic fatigue syndrome treatment
May 2019). "B-Lymphocyte Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double- ... "B-cell depletion using several infusions of rituximab over 12 months was not associated with clinical improvement in patients ...
Canine transmissible venereal tumor
Liao K, Hung S, Hsiao Y, Bennett M, Chu R (2003). "Canine transmissible venereal tumor cell depletion of B lymphocytes: ...
Canine parvovirus
There is depletion of lymphocytes in lymph nodes and necrosis and destruction of the intestinal crypts. Anaerobic bacteria that ...
Porcine circovirus
PCV-2 (first isolated in 1997) causes PMWS, which over time results in significant depletion of lymphocytes; postmortem ...
GSK2831781
"Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3(+) )-activated T lymphocytes prevents delayed-type ... Haudebourg T, Dugast A, Coulon F, Usal C, Triebel F, Vanhove B (December 15, 2007). "Depletion of LAG-3 positive cells in ...
Immutep
"Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3+)-activated T lymphocytes prevents delayed-type ... Li B (2008). "Lymphocyte activation gene-3 fusion protein increases the potency of a granulocyte macrophage colony-stimulating ... Triebel F (May 1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393-405. doi: ... Casati C (March 2008). "Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation ...
Theralizumab
"CD4 depletion in HIV-infected haemophilia patients is associated with rapid clearance of immune complex-coated CD4+ lymphocytes ... The severe reactions in humans could have only occurred, they believe, in those with memory T lymphocytes. Animals raised in a ... Paradoxically, some kinds of the men's white blood cells (lymphocytes and monocytes, involved in immune responses) had vanished ...
4-Ipomeanol
Prior to death the dogs also showed rapid and shallow respiration, while in rats labored respiration and lymphocyte depletion ...
Indoleamine 2,3-dioxygenase
The first mechanism is based on tryptophan depletion from the tumor microenvironment. The second mechanism is based on the ... production of catabolic products called kynurenins, that are cytotoxic for T lymphocytes and NK cells. Overexpression of human ...
Calcium release activated channel
STIM1 is a crucial component of the CRAC influx mechanism in lymphocytes, acting as a sensor of low Ca2+ concentration in the ... STIM proteins sense the depletion of luminal Ca2+ from the ER and trigger activation of CRAC channels in the surface membrane ... Yarkoni and Cambier (2011) reported that STIM1 expression differs in murine T and B lymphocytes; mature T cells express about 4 ... The primary mechanism of extracellular Ca2+ entry in lymphocytes involves CRAC channels. ...
Lupus
The cytokines B-lymphocyte stimulator (BLyS), also known as B-cell activating factor (BAFF), interleukin 6, interleukin 17, ... January 2002). "Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus". Arthritis and ... B and T cell tolerance for apoptotic cells is abrogated, and the lymphocytes get activated by these autoantigens; inflammation ... Necrosis is increased in T lymphocytes. Tingible body macrophages (TBMs) - large phagocytic cells in the germinal centers of ...
Shimon Slavin
Later, Slavin introduced the concept of post-transplant depletion of host-vs-graft and graft-vs-host reactive lymphocytes with ... Sep 1984). "Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat ... Prigozhina TB, Elkin G, Khitrin S, Slavin S (Nov 2004). "Depletion of donor-reactive cells as a new concept for improvement of ... Slavin S (Jul 1993). "Depletion of donor-reactive cells as a new concept for improvement of mismatched bone marrow engraftment ...
Innate lymphoid cell
Mice lacking ILC3s due to the deletion of RORγt or depletion suffered severe infections by Candida albicans. It has been shown ... Approximately 10-15% of lymphocytes were identified as ILCs, most of them producing IFN-γ ILC1s. ILC3s in the oropharyngeal ... of the resident lymphocyte population, in human lean adipose depots. A high fat diet increases ILC1 number, and activation of ... of these specific transcription factors activate or repress target genes critical in the differentiation of the lymphocyte ...
Françoise Barré-Sinoussi
However, the depletion of the CD4 lymphocytes made it very difficult to isolate the virus in patients with the disease later ... Barré-Sinoussi and her colleagues decided to add lymphocytes from a blood donor in order to save the culture and it proved ... "Naive T-Cell Depletion Related to Infection by X4 Human Immunodeficiency Virus Type 1 in Poor Immunological Responders to ... began and clinical observations suggested that the disease attacked immune cells because of the significant CD4 cell depletion ...
Thymoglobulin
Experiments on ALS that confirmed its efficacy in lymphocyte depletion led to testing of different types of preparations ... Since the discovery of a link between antilymphocyte serum (ALS) and lymphocyte depletion by Metchnikoff in 1899, various ... of ATG can induce lysis of T lymphocytes through the classical complement pathway along with B cell and NK cell depletion as ... While these antibodies have a variety of specificities, their main mechanism of immunosuppression is through depletion of T ...
Anti-thymocyte globulin
Guinea pigs and injected it into normal mice he observed a marked depletion in the number of circulating mouse lymphocytes. ... Temporary depletion of the T-cell population at the time of the transplant also risks delayed acute rejection, which may be ... A similar trial of anti-lymphocyte globulin showed a trend in reduction of acute graft versus host that was not statistically ... A rabbit anti-T lymphocyte globulin made by Neovii Pharmaceuticals is marketed outside of the United States under the name ...
NEDD9
"Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance". J. ... NEDD9 depletion sensitizes breast tumor cell lines to the Aurora A inhibitor alisertib. Consideration of NEDD9 as a biomarker ... In lymphocytes, integrin or TCR signaling induces NEDD9 phosphorylation by tyrosine kinases Fyn and Lck (SRC family kinases), ... Ice RJ, McLaughlin SL, Livengood RH, Culp MV, Eddy ER, Ivanov AV, Pugacheva EN (2013). "NEDD9 depletion destabilizes Aurora A ...
List of MeSH codes (E02)
... lymphocyte depletion MeSH E02.095.520.450.800 - transplantation conditioning MeSH E02.095.520.750 - radioimmunotherapy MeSH ... lymphocyte transfusion MeSH E02.095.135.140.650 - platelet transfusion MeSH E02.095.135.164 - blood transfusion, autologous ...
Tumor-infiltrating lymphocytes
Lympho-depletion is thought to eliminate the negative effects of other lymphocytes that may compete for growth factors and ... Tumor infiltrating lymphocyte entry in the public domain NCI Dictionary of Cancer Terms Lion Biotechnologies, Inc. (Lymphocytes ... "Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes ... CD8+-Enriched Autologous Tumor-infiltrating Lymphocytes Following a Lymphocyte Depleting Regimen in Metastatic Digestive Tract ...
Cladribine
... leading to the selective depletion of dividing and non-dividing T and B lymphocytes. In contrast, the DCK:5'-NT ratio is ... As a result, a reduction in lymphocyte count (lymphopenia) may be reported following treatment. In clinical trials, lymphocyte ... it is proposed to have a transient effect on B and T lymphocyte depletion, interrupting the cascade of immune events central to ... This ratio differs between cell types, with high levels in T and B lymphocytes, resulting in selective targeting of these cells ...
FGL2
Rüegg C, Pytela R (1995). "Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein". ... it has been shown that depletion of the Treg cell population in murine models for disease lead to enhanced immune responses to ... 1998). "Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes". J. Immunol. 161 (1): 138- ... HCV's core protein has been found to increase the levels of expression of sFGL2 and cause virus-specific CD4+ T lymphocytes to ...
List of MeSH codes (E05)
... lymphocyte depletion MeSH E05.478.610.800 - transplantation conditioning MeSH E05.490.630.569 - microscopy, phase-contrast MeSH ... lymphocyte count MeSH E05.200.500.195.107.595.500.150 - cd4 lymphocyte count MeSH E05.200.500.195.107.595.500.150.160 - cd4-cd8 ... lymphocyte culture test, mixed MeSH E05.478.550.520 - immunization, passive MeSH E05.478.550.520.050 - adoptive transfer MeSH ...
Purine nucleoside phosphorylase deficiency
In addition to the symptoms associated with immunodeficiency, such as depletion of T-cells, decline of lymphocyte activity, and ... although removal of metabolites by maternal PNP may delay the deleterious effects on PNP-deficient lymphocytes. Few newborn ...
MHC class II
Mutations in the HLA gene complex can lead to bare lymphocyte syndrome (BLS), which is a type of MHC class II deficiency. Like ... It results in the depletion of CD4 T cells and some immunoglobulin isotypes even though there are normal levels of both CD8 ... One type of MHC class II deficiency, also called bare lymphocyte syndrome, is due to mutations in the genes that code for ... Cross-presentation Bare lymphocyte syndrome "Histocompatibility". Archived from the original on 2008-12-26. Retrieved 2009-01- ...
Glucocorticoid
... s are also shown to play a role in the development and homeostasis of T lymphocytes. This has been shown in ... potassium depletion, and metabolic alkalosis. Glucocorticoids cause immunosuppression, decreasing the function and/or numbers ... The diminished amounts of IL-2 also cause fewer T lymphocyte cells to be activated. The effect of glucocorticoids on Fc ... This includes inhibitory effects on lymphocyte proliferation, as in the treatment of lymphomas and leukemias, and the ...
Major histocompatibility complex, class I-related
Specific clones of MR1 T lymphocytes (MC.7.G5) were able to kill various cancer cells in vivo and in vitro and were inert to ... On one hand its depletion can prevent unpreferable polarization of immune cells and impaired NK and CD8+ T cells activity. On ... Same result was shown in reaction to healthy but stressed or damaged cells, which were unable to activate MR1 T lymphocytes. ... This again suggests that some MR1 T lymphocytes can specifically react to a cancer cell derived ligand presented on the MR1 ...