*Alastair Compston

... following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)". Journal of Clinical Investigation. 119: 2052-61. doi ...

*4-Ipomeanol

Prior to death the dogs also showed rapid and shallow respiration, while in rats labored respiration and lymphocyte depletion ...

*Thymoglobulin

Experiments on ALS that confirmed its efficacy in lymphocyte depletion led to testing of different types of preparations ... Since the discovery of a link between antilymphocyte serum (ALS) and lymphocyte depletion by Metchnikoff in 1899, various ... of ATG can induce lysis of T lymphocytes through the classical complement pathway along with B cell and NK cell depletion as ... While these antibodies have a variety of specificities, their main mechanism of immunosuppression is through depletion of T ...

*List of MeSH codes (E02)

... lymphocyte depletion MeSH E02.095.520.450.800 --- transplantation conditioning MeSH E02.095.520.750 --- radioimmunotherapy MeSH ... lymphocyte transfusion MeSH E02.095.135.140.650 --- platelet transfusion MeSH E02.095.135.164 --- blood transfusion, autologous ...

*International Classification of Diseases for Oncology

... lymphocyte depletion, diffuse fibrosis M9655/3 Hodgkin lymphoma, lymphocyte depletion, reticular M9659/3 Nodular lymphocyte ... lymphocyte rich Lymphocyte-rich classical Hodgkin lymphoma Hodgkin disease, lymphocyte predominance, NOS Hodgkin disease, ... lymphocyte depletion Hodgkin disease, nodular sclerosis, syncytial variant M9670/3 Malignant lymphoma, small B lymphocytic, NOS ... lymphocyte-rich, NOS Thymoma, lymphocytic, NOS Thymoma, predominantly cortical, NOS Thymoma, organoid, NOS M8583/3 Thymoma, ...

*Canine parvovirus

There is depletion of lymphocytes in lymph nodes and necrosis and destruction of the intestinal crypts. Anaerobic bacteria that ...

*GSK2831781

"Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3(+) )-activated T lymphocytes prevents delayed-type ... "Depletion of LAG-3 positive cells in cardiac allograft reveals their role in rejection and tolerance". Transplantation. 84 (11 ...

*Prima BioMed

"Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3+)-activated T lymphocytes prevents delayed-type ... Triebel F (May 1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171: 1393-405. doi: ... CS1 maint: Uses authors parameter (link) Li B (2008). "Lymphocyte activation gene-3 fusion protein increases the potency of a ... Casati C (Mar 2008). "Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal ...

*AIDS-related complex

... leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as ...

*Canine transmissible venereal tumor

Liao K, Hung S, Hsiao Y, Bennett M, Chu R (2003). "Canine transmissible venereal tumor cell depletion of B lymphocytes: ...

*Porcine circovirus

... which over time results in significant depletion of lymphocytes; postmortem examination of diseased animals reveals enlarged ...

*Pathophysiology of HIV/AIDS

"Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the ... When the CD4 lymphocyte count falls below 200 cells/ml of blood, the HIV host has progressed to AIDS, a condition characterized ... CD4 T-cell depletion and chronic inflammation are the two signature events that drive HIV pathogenesis and progression to AIDS ... However, direct killing by HIV alone cannot account for the observed depletion of CD4+ T cells since only 0.01-0.10% of CD4+ T ...

*Françoise Barré-Sinoussi

However, the depletion of the CD4 lymphocytes made it very difficult to isolate the virus in patients with the disease later ... Barré-Sinuossi and her colleagues decided to add lymphocytes from a blood donor in order to save the culture and it proved ... "Naive T-Cell Depletion Related to Infection by X4 Human Immunodeficiency Virus Type 1 in Poor Immunological Responders to ... began and clinical observations suggested that the disease attacked immune cells because of the significant CD4 cell depletion ...

*Apoptosis

... of the human immunodeficiency virus infection into AIDS is due primarily to the depletion of CD4+ T-helper lymphocytes in a ... In a healthy individual, the number of CD4+ lymphocytes is in balance with the cells generated by the bone marrow; however, in ... Judie B. Alimonti; T. Blake Ball; Keith R. Fowke (2003). "Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency ... In the case of HIV, CD4+ lymphocytes die at an accelerated rate through uncontrolled apoptosis, when stimulated. At the ...

*Systemic lupus erythematosus

The cytokines B-lymphocyte stimulator (BLys), interleukin 6, interleukin 17, interleukin 18, type I interferons, and tumor ... and depletion of ATP. Impaired clearance of dying cells is a potential pathway for the development of this systemic autoimmune ... B and T cell tolerance for apoptotic cells is abrogated, and the lymphocytes get activated by these autoantigens; inflammation ... Necrosis is increased in T lymphocytes. Tingible body macrophages (TBMs) - large phagocytic cells in the germinal centers of ...

*Anti-thymocyte globulin

Guinea pigs and injected it into normal mice he observed a marked depletion in the number of circulating mouse lymphocytes. ... Temporary depletion of the T-cell population at the time of the transplant also risks delayed acute rejection, which may be ... A similar trial of anti-lymphocyte globulin showed a trend in reduction of aGVH that was not statistically significant, but a ... rATG in particular effects large reductions (through cell lysis) in the number of circulating T-lymphocytes, hence preventing ( ...

*Purine nucleoside phosphorylase deficiency

In addition to the symptoms associated with immunodeficiency, such as depletion of T-cells, decline of lymphocyte activity, and ...

*Theralizumab

"CD4 depletion in HIV-infected haemophilia patients is associated with rapid clearance of immune complex-coated CD4+ lymphocytes ... The severe reactions in humans could have only occurred, they believe, in those with memory T lymphocytes. Animals raised in a ...

*Allan Victor Hoffbrand

... and showed for the first time that graft versus host disease could be prevented by depletion of donor marrow of T lymphocytes. ...

*Tyrosine phosphorylation

... negative signaling is of particular interest in view of the progressive depletion of the CD4+ subset of T lymphocytes by the ...

*Glucocorticoid

... s are also shown to play a role in the development and homeostasis of T lymphocytes. This has been shown in ... potassium depletion, and metabolic alkalosis. Glucocorticoids cause immunosuppression, decreasing the function and/or numbers ... The diminished amounts of IL-2 also cause fewer T lymphocyte cells to be activated. The effect of glucocorticoids on Fc ... This includes inhibitory effects on lymphocyte proliferation, as in the treatment of lymphomas and leukemias, and the ...

*Lactalbumin

To investigate the possible influence of dietary protein type on the supply of B lymphocytes, bone marrow lymphocyte production ... Depletion of this small molecule is a common consequence of increased formation of reactive oxygen species during increased ... 0.05) in the lymphocyte GSH levels in the supplemented group. No other changes were observed. Conclusion: The results show that ... Lymphocyte GSH also increased significantly in the Immunocal group (35.5 +/- 11.04%, P < 0.02), with no change in the placebo ...

*NEDD9

"Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance". J. ... NEDD9 depletion sensitizes breast tumor cell lines to the Aurora A inhibitor alisertib. Consideration of NEDD9 as a biomarker ... In lymphocytes, integrin or TCR signaling induces NEDD9 phosphorylation by tyrosine kinases Fyn and Lck (SRC family kinases), ... Ice RJ, McLaughlin SL, Livengood RH, Culp MV, Eddy ER, Ivanov AV, Pugacheva EN (2013). "NEDD9 depletion destabilizes Aurora A ...

*Calcium release activated channel

STIM1 is a crucial component of the CRAC influx mechanism in lymphocytes, acting as a sensor of low Ca2+ concentration in the ... STIM proteins sense the depletion of luminal Ca2+ from the ER and trigger activation of CRAC channels in the surface membrane ... Yarkoni and Cambier (2011) reported that STIM1 expression differs in murine T and B lymphocytes; mature T cells express about 4 ... The primary mechanism of extracellular Ca2+ entry in lymphocytes involves CRAC channels. ...

*FGL2

Rüegg C, Pytela R (1995). "Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein". ... it has been shown that depletion of the Treg cell population in murine models for disease lead to enhanced immune responses to ... 1998). "Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes". J. Immunol. 161 (1): 138- ... HCV's core protein has been found to increase the levels of expression of sFGL2 and cause virus-specific CD4+ T lymphocytes to ...

*Viral synapse

Recent study proposes that the fundamental "killing units" of CD4 T cells leading to CD4 T-cell depletion and ultimately ... 2003). "Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton". Science. 299: 1713-1716. doi: ... 2005). "Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes". ...