It is located on chromosome 1p13 and expressed in lymphocytes. It acts as a negative regulator of T-cell activation. Mutation ... Microscopic examination will show infiltration of lymphocytes and plasma cells. The lymphocytes are predominately T-lymphocytes ... Thyroid autoantibodies appear mostly with the presence of lymphocytes in the targeted organ. Lymphocytes produce antibodies ... It is also characterized by invasion of the thyroid tissue by leukocytes, mainly T-lymphocytes. A rare but serious complication ...

October 2011). "Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation". Cell. 147 (3 ... This is not to say that ligand-dependent AhR activation is not needed for the AhR to function in those cases, but that, if a ... The mammalian AhR needs no exogenous ligand-dependent activation to be functional, and this appears to be the case for its role ... AhR activation seems to be also important for immunological responses and inhibiting inflammation through upregulation of ...

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation ". Proceedings of the National ... T lymphocytes are cells of the immune system that attack and destroy virus-infected cells, tumor cells and cells from ... Tumor antigens recognized by T lymphocytes ". Annual Review of Immunology. 12: 337-365. Coulie P., Van den Eynde B.J., van der ... In other instances, the normal peptide is presented at the cell surface and consequently the T lymphocytes that recognize the ...

Arrest of the 'rolling' cell by activation step. Further interactions between proteins or activation via chemokines cause more ... While this may be the case to some extent, it is now widely held that the main driver in lymphocyte homing is the interactions ... Cellular activation causes a conformational change which results in the cell flattening against the vessel wall. Once flattened ... The most convincing argument is that by targeting the lymphocytes to the region in which they were activated it is more likely ...

Donlon TA, Krensky AM, Clayberger C (1990). "Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome ... Krensky AM (February 2000). "Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells". ... Dotiwala F, Lieberman J (October 2019). "Granulysin: killer lymphocyte safeguard against microbes". Current Opinion in ... is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic ...

... a phosphorylated human lymphocyte differentiation and activation antigen". Eur J Immunol. 20 (11): 2417-23. doi:10.1002/eji. ... Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene. This gene encodes an intracellular F- ... "Entrez Gene: LSP1 lymphocyte-specific protein 1". Jongstra-Bilen J, Young AJ, Chong R, Jongstra J (1990). "Human and mouse LSP1 ... 1993). "Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family". Genomics. 15 (3): 515-20. doi: ...

"The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity". Immunity. 29 (2): ... "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". Journal of Immunology. 178 (9): 5496-504. doi: ...

Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology. Vol. 365. pp. 167- ... Aramburu J, Azzoni L, Rao A, Perussia B (Sep 1995). "Activation and expression of the nuclear factors of activated T cells, ... "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature. 369 (6480): 497-502. Bibcode: ... elements of the NFATc2 protein and the fusion of the N terminal region of the EWSR1 gene conferred constant activation of the ...

"HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. ... Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in ... "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. ... levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes". J. ...

"HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. ... Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in ... "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. ...

2004). "Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk". BMC Immunol. 2: 3. doi:10.1186/ ... 2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". J. Exp. Med. 190 (11): 1657- ... Schneider H, Guerette B, Guntermann C, Rudd CE (2000). "Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in ... Schneider H, Schwartzberg PL, Rudd CE (1998). "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates ...

The defect in lymphocyte activation and protective immunity suggested that caspase-8 had additional signaling roles in ... "Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency". Nature. 419 (6905 ... and lymphocyte activation. Patients with CEDS have hypogammaglobulinemia, make poor antibody responses to pneumococcal ... Cell death counters proliferation of lymphocytes, allowing the immune system to achieve dynamic homeostasis whereby it can ...

ConA was found to partially inhibit tumor nodule growth independent of its lymphocyte activation; the eradication of the tumor ... ConA is a lymphocyte mitogen. Similar to phytohemagglutinin (PHA), it is a selective T cell mitogen relative to its effects on ... ConA can also initiate cell division (mitogenesis), primarily acting on T-lymphocytes, by stimulating their energy metabolism ... ConA-mediated agglutination of other cell types has been reported, including muscle cells , B-lymphocytes (through surface ...

"HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". Journal of ... "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016-7. doi:10.1097/00002030-199407000- ... "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proceedings ...

"HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". Journal of ... "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes". ... "MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes". ... "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016-7. doi:10.1097/00002030-199407000- ...

Engel P, Zhou LJ, Ord DC, Sato S, Koller B, Tedder TF (July 1995). "Abnormal B lymphocyte development, activation, and ... Haas KM, Tedder TF (2005). Mechanisms of Lymphocyte Activation and Immune Regulation X. Advances in Experimental Medicine and ... B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell ... CD19 signaling involves the recruitment and activation of phosphoinositide 3-kinase (PI3K) and later downstream, the activation ...

"HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". Journal of ... "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016-7. doi:10.1097/00002030-199407000- ... "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proceedings ...

... activation of T lymphocytes by allogenic cells (PhD thesis). University of Newcastle upon Tyne. OCLC 35217792. EThOS uk.bl. ...

"Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes". Journal of Immunology. 169 (1): 15-21. ...

The decrease in lymphocyte count lasts for approximately 14 days after treatment discontinuation. Unlike fingolimod, it does ... not require phosphorylation for activation, nor does it demonstrate cardiac abnormalities or hepatotoxicity. Ozanimod was ... The 1 mg dose showed a slight increase in rate of clinical remission of ulcerative colitits and total lymphocyte decrease as ... Both doses of ozanimod reached anticipated range of 60-70% decreased lymphocyte count, and were well tolerated, with a safety ...

Vitamin K in the nervous system is responsible for the activation of enzymes that are essential for the biosynthesis of brain ... Sulfatide also associates with myelin and lymphocyte protein (MAL). Research has shown that MAL may be involved in vesicular ... Sulfatide binding to laminin also causes c-src/fyn kinase activation and initiation of basement membrane formation. ... However, sulfatide may mediate suppression of type II diabetes through the activation of potassium protein channels. Elevated ...

... expression was observed to be dependent on IL-6 amplifier activation, which is dependent on NF-κB and STAT3 activation. ... Chemotactic activity for lymphocytes and gene localization on chromosome 2". J. Biol. Chem. 272 (9): 5846-5853. doi:10.1074/jbc ... Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier , author = Arima, ... Chemotactic activity for lymphocytes and gene localization on chromosome 2". J. Biol. Chem. 272 (9): 5846-5853. doi:10.1074/jbc ...

Reif K, Cyster J (2002). "The CDM protein DOCK2 in lymphocyte migration". Trends Cell Biol. 12 (8): 368-73. doi:10.1016/S0962- ... Lu M, Ravichandran KS (2006). "Dock180-ELMO cooperation in Rac activation". Methods Enzymol. Methods in Enzymology. 406: 388- ...

1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. ... 1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016-7. doi:10.1097/00002030- ... 1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc ... by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene". Oncogene. 21 (51): 7872-82. doi: ...

"Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction". Journal of ... This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by ... a receptor expressed on T lymphocytes". In the cluster of differentiation terminology it is classified as CD258. The protein ...

2058 Litzman J, Vlková M, Pikulová Z, Stikarovská D, Lokaj J (February 2007). "T and B lymphocyte subpopulations and activation ... but it does not present the same lymphocyte subpopulation abnormalities. IgA-deficient patients may progress to ...

Schwarz H, Tuckwell J, Lotz M (December 1993). "A receptor induced by lymphocyte activation (ILA): a new member of the human ... Schwarz H, Tuckwell J, Lotz M (December 1993). "A receptor induced by lymphocyte activation (ILA): a new member of the human ... and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule, ... "CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers". Journal of ...

KLHL5: Kelch-like 5, its protein is thought to have a role in lymphocyte activation. NOXP20 is over-expressed in the brain, ... TLR6: Toll-like receptor (TLR) 6 plays a role in pathogen recognition and activation of innate immunity. TMEM156: The gene ... 1 plays a role in pathogen recognition and activation of innate immunity. ...

"Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation". Molecular ... B-lymphocytes and neutrophils. Recent observations suggest that cytonemes have also an important role during vertebrate ...

1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. ... 1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016-7. doi:10.1097/00002030- ... 1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc ...