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*  CTL-mediated cytotoxicity
Cytotoxic T lymphocytes (CTLs) are generated by immune activation of cytotoxic T cells (Tc cells). They are generally CD8+, ... In the first phase, functional effector CTLs are generated from naive Tc cells through activation and differentiation. In the ... Instead it involves Interleukin-1β converting enzyme (ICE; also known as Caspase 1) activation, which is similar to granzyme B ...
*  Signalling lymphocyte activation molecule family
The signalling lymphocyte activation molecule family (SLAMF) of cell-surface molecules has been identified as a group of ... receptors that modulates the activation and differentiation of a wide array of cell types involved in both innate and adaptive ...
*  Vedolizumab
"Lymphocyte activation antigens. I. A monoclonal antibody, anti-Act I, defines a new late lymphocyte activation antigen". J. ... Although the antibody did not block primary activation of T lymphocytes, it appeared late after activation with a number of ... T lymphocytes originally isolated from blood lymphocytes. The cell lines were created in Dr. Jim T. Kurnick's lab. ... Atul Bhan's group showed that it stained tissue lymphocytes but did not react with non-lymphoid tissues. Although Act-1 had ...
*  IGSF2
Role in T-lymphocyte activation". Tissue Antigens. 50 (5): 439-48. doi:10.1111/j.1399-0039.1997.tb02898.x. PMID 9389317. Soares ... 1995). "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional ... 1995). "V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and ...
*  Isotype (immunology)
"Helper T Cells and Lymphocyte Activation". Chandra, Vivek; Bortnick, Alexandra; Murre, Cornelis (2015-09-01). "AID targeting: ... Class-switching is mediated by the AID (activation-induced cytidine deaminase) enzyme and only occurs after the B cell binds an ... The levels of surface expression of IgD isotype has been associated with differences in B cell activation status but their role ... and activation of complement cascade. As IgM antibodies are expressed early in a B cell response, they are rarely highly ...
*  IL2RB
Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM (1988). "Lymphocyte activation by HIV-1 envelope glycoprotein". Nature ... Activation of the receptor increases proliferation of CD8+ effector T cells. IL2RB has been shown to interact with: CISH, HGS, ... "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045-7. doi: ... "The role of interleukin-2 during homeostasis and activation of the immune system". Nat Rev Immunol. 12 (3): 180-190. doi: ...
*  Common gamma chain
Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM (September 1988). "Lymphocyte activation by HIV-1 envelope ... Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals ... The common gamma chain partners with other proteins to direct blood-forming cells to form lymphocytes (a type of white blood ... The γc glycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) ...
*  Scaffold protein
Xavier, R., et al., Discs large (Dlg1) complexes in lymphocyte activation. J Cell Biol, 2004. 166(2): p. 173-8. Hanada, T., et ... Such changes may be able to enhance or inhibit the activation of these signaling proteins. An example is the Ste5 scaffold in ... Huang, G.N., et al., NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science, ... Claperon, A. and M. Therrien, KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Oncogene, 2007. 26(22): p. ...
*  TJAP1
2004). "Discs large (Dlg1) complexes in lymphocyte activation". J. Cell Biol. 166 (2): 173-8. doi:10.1083/jcb.200309044. PMC ...
*  Belimumab
... or B lymphocyte stimulator). Six years later, the key role of BLyS in B cell differentiation, survival and activation was ... "The role of APRIL and BAFF in lymphocyte activation". Curr. Opin. Immunol. 17 (3): 282-9. doi:10.1016/j.coi.2005.04.005. PMID ... B lymphocytes (B cells) are one of the immune cells responsible for the damage in autoimmune disease. B cells develop in the ... It blocks activation of TACI by APRIL and BLyS. It failed a phase II trial for multiple sclerosis. Blisibimod, an inhibitor of ...
*  Biochemical cascade
Syk kinase is specific of lymphocytes B and Zap-70 is present in T cells. After activation of these enzymes, some adaptor ... like activation o PI3 Kinase. PIP3 then is responsible for activation of several proteins, like vav (leads to activation of JNK ... "Signal Transduction Events Involved in Lymphocyte Activation and Differentiation". Retrieved 2014-01-08. Le Gallou, S; Caron, G ... ERK also leads to actin polymerization trough activation of cPLA2. Recruitment of FAK by integrin leads to Akt activation and ...
*  TCEAL4
Lu XW, Yin JY, Cui LX (2004). "[Cloning of human B lymphocyte activation-related novel gene]". Zhongguo Yi Xue Ke Xue Yuan Xue ...
*  Chemorepulsion
Bacon, K.B. (1997). "Analysis of signal transduction following lymphocyte activation by chemokines". Methods Enxymol. Methods ... For example, lymphocytes can migrate away from a high concentration of the chemokine SDF-1 rather than be attracted by lower ... 2001). "Activation of RhoA and ROCK are essential for detachment of migrating leukocytes". Mol. Biol. Cell. 12 (7): 2137-2145. ... 2004). "Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1". Nature. 427 (6972): 355- ...
*  CD48
... also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein ... Staunton DE, Thorley-Lawson DA (December 1987). "Molecular cloning of the lymphocyte activation marker Blast-1". EMBO J. 6 (12 ... signaling lymphocyte activation molecules) proteins, such as CD84, CD150, CD229 and CD244. CD48 is found on the surface of ... lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation ...
*  Marginal zone B-cell
Marginal zone B cells in lymphocyte activation and regulation. Curr Opin Immunol. 2005; 17(3):244-250. ... MZ B cells also display a lower activation threshold than their FO B cell counterparts with heightened propensity for plasma ... Hardy, Richard (2008). "Chapter 7: B Lymphocyte Development and Biology". In Paul, William. Fundamental Immunology (Book) (6th ...
*  Javed Agrewala
Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic. Springer Science & Business Media. pp. 113 ... Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic. Springer Science & Business Media. pp. 113 ... "Induction of the activation of innate and adaptive immunity by lipidated peptide vaccine: robust and enduring protective memory ... "CD40 Signaling Synergizes with TLR-2 in the BCR Independent Activation of Resting B Cells". PLoS One. doi:10.1371/journal.pone. ...
*  Margatoxin
Kv1.3-channels are important for the activation of T-lymphocytes, and thus for the activation of macrophages. The disturbance ... Ion channels play a key role in lymphocyte signal transduction. Potassium channels are required for the activation of T-cells. ... The membrane potential exerts powerful effects on the lymphocyte activation. The resting potential results primarily from a ... Upon activation of muscarinic ACh receptors with bethanechol, margatoxin-sensitive current was suppressed. Therefore, it was ...
*  CCL4L1
1991). "Cloning and expression of a lymphocyte activation gene (LAG-1)". Mol. Immunol. 27 (11): 1091-102. doi:10.1016/0161-5890 ... 1989). "Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new ... Miller MD, Hata S, De Waal Malefyt R, Krangel MS (1989). "A novel polypeptide secreted by activated human T lymphocytes". J. ... Lu J, Honczarenko M, Sloan SR (2004). "Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes ...
*  Endocrinology of reproduction
Clemens, L., Siiteri, P., & Stites, D. (1979). Mechanism of immunosuppression of progesterone on maternal lymphocyte activation ... hCG secreted by cytotrophoblastic cells of the blastocyst controls endometrial tissue remodeling by both activation of matrix ... High levels of progesterone produced by the embryonic placenta regulate lymphocyte proliferation at the maternal-fetal ...
*  GPR81
"T lymphocyte activation gene identification by coregulated expression on DNA microarrays". Genomics. 83 (6): 989-99. doi: ... "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81". The Journal of ...
*  IDH2
"Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation". Journal of Cellular ...
*  KCNA3
"Voltage-gated potassium channels are required for human T lymphocyte activation". J. Exp. Med. 160 (2): 369-85. doi:10.1084/jem ... Upon activation, naive and central memory T cells increase expression of the KCa3.1 channel to approximately 500 channels per ... It plays an essential role in T cell proliferation and activation. This gene appears to be intronless and is clustered together ... Kv1.3 has been reported to be expressed in the inner mitochondrial membrane in lymphocytes. The apoptotic protein Bax has been ...
*  CCL4
1991). "Cloning and expression of a lymphocyte activation gene (LAG-1)". Mol. Immunol. 27 (11): 1091-102. doi:10.1016/0161-5890 ... 1989). "Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new ... Miller MD, Hata S, De Waal Malefyt R, Krangel MS (1989). "A novel polypeptide secreted by activated human T lymphocytes". J. ... 1989). "Identification, cloning, and characterization of an immune activation gene". Proc. Natl. Acad. Sci. U.S.A. 85 (24): ...
*  GMDS (gene)
2002). "The FX enzyme is a functional component of lymphocyte activation". Cell. Immunol. 213 (2): 141-148. doi:10.1006/cimm. ...
*  MALT1
Ruefli-Brasse AA, French DM, Dixit VM (2003). "Regulation of NF-kappaB-dependent lymphocyte activation and development by ... this suggests that paracaspase-mediated A20 cleavage in T lymphocytes is necessary for a proper NF-κB activation. By targeting ... "Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines". Proc Natl Acad ... It has an important role in the activation of the transcription factor NF-κB, in the production of interleukin-2 (IL-2) and in ...
*  GNLY
Donlon TA, Krensky AM, Clayberger C (1990). "Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome ... Granulysin is present in cytolytic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granulysin is made ... 1993). "Genomic structure of NKG5, a human NK and T cell-specific activation gene". Immunogenetics. 37 (2): 102-7. doi:10.1007/ ... 9kD granulysin is also a chemoattractant for T lymphocytes, monocytes, and other inflammatory cells and activates the ...
*  IMP321
"A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells ... "Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223)". J. Immunol. 168 (8): 3874-80. ... March 1, 1999). "Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and ... Li B, VanRoey M, Triebel F, Jooss K (June 1, 2008). "Lymphocyte activation gene-3 fusion protein increases the potency of a ...