Campbell, Chantel D.; Vederas, John C. (23 June 2010). "Biosynthesis of lovastatin and related metabolites formed by fungal ... as a side chain of lovastatin formed by its diketide synthase (LovF) during its biosynthesis-this result constitutes the first ...

Some examples of secondary metabolites are penicillin, cyclosporin A, gibberellin, and lovastatin. Primary metabolites are ...

Acosta, MT; Kardel, PG; Walsh, KS; Rosenbaum, KN; Gioia, GA; Packer, RJ (Oct 2011). "Lovastatin as treatment for neurocognitive ... Sebti, SM; Tkalcevic, GT; Jani, JP (1991). "Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human H- ... They discovered that Lovastatin, a statin that crosses the blood-brain barrier, at a dose that does not affect control mice, ... "Lovastatin regulates brain spontaneous low-frequency brain activity in neurofibromatosis type 1". Neurosci. Lett. 515 (1): 28- ...

"Efficacy and tolerability of lovastatin in hypercholesterolemia in patients with systemic hypertension". The American Journal ...

Lovastatin (also known as mevinolin) is produced by Aspergillus terreus Gent, Janneane F; Ren, Ping; Belanger, Kathleen; Triche ... Several statin cholesterol-lowering drugs (such as lovastatin, from Aspergillus terreus) are derived from molds. The ...

Soon after, lovastatin, the first commercial statin, was found in the Aspergillus mold. Although mevastatin never became an ...

The PKS unit is hypothesized to cyclize by a Diels-Alder-like addition similar to other natural products such as lovastatin and ... "Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue". Journal of the ...

Mevacor (lovastatin) is the first and most influential statin in the American market. The 1991 launch of Pravachol (pravastatin ... lovastatin, pravastatin, and simvastatin Pharmaceuticals may also be described as "specialty", independent of other ...

Roze, LV; Linz, JE (November 1998). "Lovastatin triggers an apoptosis-like cell death process in the fungus Mucor racemosus". ... In addition to commonly used antifungal agents, biological compounds like Lovastatin, Aleuria aurantia lectin (AAL) and ...

Contrary to lovastatin, simvastatin and atorvastatin, fluvastatin has no relevant interactions with drugs that inhibit the ... lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463-74. doi:10.2165/00003088-200847070-00003. PMID ...

Addition of cholesterol to Lovastatin-treated cells does not undo the arrest affect, so Lovastatin appears to inhibit the ... It involves Lovastatin, a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an enzyme vital ... "Synchronization of Tumor and Normal Cells from G1 to Multiple Cell Cycles by Lovastatin". Cancer Research. 51 (13): 3602-3609. ...

In 1979, Merck scientists developed lovastatin (Mevacor), the first drug of the statin class. Merck scientist William C. ...

At the time of acquisition Kos marketed Niaspan (extended release niacin), and Advicor (niacin/lovastatin). In 2007 the company ...

... has been found to contain the cholesterol-lowering drug lovastatin. In one study, among 11 other commonly cultivated or foraged ... "Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin". Exp. Mycol. 19 ...

The naturally occurring lovastatins and analogs are called monacolins K, L, J, and also occur in their hydroxyl acid forms ... Ali (2010) Optimization of fermentation parameters for higher lovastatin production in red mold rice through co-culture of ... along with dehydroxymonacolin and compactin (mevastatin). The prescription drug lovastatin, identical to monacolin K, is the ...

This risk also appears to increase among patients who received gemfibrozil or lovastatin concomitantly, and there is a known ... The inhibitory activity of cerivastatin was compared to that of other statins, specifically lovastatin, simvastatin and ... which is over 100 times lower than the inhibitory constant of lovastatin, known to be 150 x 10-9 M. To compare cerivastatin ... cerivastatin was combined with lovastatin. The reporting rate of fatal rhabdomyolysis in association with cerivastatin ...

Other industrially important polyketides are sirolimus (immunosuppressant), erythromycin (antibiotic), lovastatin ( ...

Salins P, Shawesh S, He Y, Dibrov A, Kashour T, Arthur G, Amara F (Feb 2007). "Lovastatin protects human neurons against Abeta- ...

When the patent of the cholesterol-lowering drug lovastatin expired in 2001, Biocon got involved in its development. Then the ...

The most active of these is monacolin K, or lovastatin (previously sold under the trade name Mevacor, and now available as ... These drugs include rosuvastatin (CRESTOR), lovastatin (Mevacor), atorvastatin (Lipitor), pravastatin (Pravachol), fluvastatin ... generic lovastatin). Vytorin is drug that combines the use simvastatin and ezetimibe, which slows the formation of cholesterol ...

Warner-Lambert management was concerned that atorvastatin was a me-too version of rival Merck & Co.'s orphan drug lovastatin ( ... December 2000). "Comparative efficacy study of atorvastatin vs simvastatin, pravastatin, lovastatin and placebo in type 2 ... lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)". The American Journal of Cardiology. 81 ( ...

... lovastatin, and simvastatin, among others. The U.S. National Institutes of Health report that BHA is reasonably anticipated to ...

In 2001 Biocon became the first Indian company to be approved by USFDA for the manufacture of lovastatin; PlaFractor is granted ...

It appears that this other mechanism may predominate when the lactone form of statins, particularly lovastatin, is administered ...

In addition, there has been evidence of the production of lovastatin from the environmental isolate of P. commune. Along with ...

Research into the effects of Lovastatin was linked with Alcino Silva, who presented his findings at the 2007 symposium. Silva ... Another medication that affects H-Ras is Lovastatin, which is planned as a treatment for neurofibromatosis type I. When this ...

Pahan K, Sheikh FG, Namboodiri AM, Singh I (December 1997). "Lovastatin and phenylacetate inhibit the induction of nitric oxide ... both lovastatin and sodium phenylacetate were found to inhibit TNF-α, IL-1β, and IL-6 in rat microglia. This shows that the ...

2003). "Effects of a dietary portfolio of cholesterol-lowering foods vs Lovastatin on serum lipids and C-reactive protein". ...

"Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia ...

It is mixed as follows: to make 250 ml: Grind up lovastatin tablets 5g (10-20-40-80 mg); mix with cholesterol NF powder (NDC# ...