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*  Angiotensin II receptor blocker
... irbesartan and losartan in mild-to-moderate hypertension. Irbesartan/Losartan Study Investigators". Am J Hypertens. 11 (4 Pt 1 ... Losartan and other ARBs regress liver, heart, lung and kidney fibrosis.[citation needed] A 2003 study using candesartan and ... Dang A, Zhang Y, Liu G, Chen G, Song W, Wang B (January 2006). "Effects of losartan and irbesartan on serum uric acid in ... Irbesartan and losartan have trial data showing benefit in hypertensive patients with type II diabetes,[citation needed] and ...
*  Losartan
Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via ... Using losartan while pregnant could result in fetal injury or death. The most common side effects for losartan are upper ... Losartan is a uricosuric. As a specific inhibitor of the urate transporter 1 (SLC22A12, URAT1), losartan blocks the uptake of ... Losartan should not be taken by people who are diabetic and taking aliskiren. Losartan is a selective, competitive angiotensin ...
*  Losartan/hydrochlorothiazide
... is a combination drug used as an antihypertensive, consisting of losartan (an angiotensin II ... will vary between losartan-hydrochlorothiazide 50 mg/12.5 mg and losartan-hydrochlorothiazide 100 mg/25 mg once a day. Based on ... With each change in dosage, it may take up to a month to see the full effect of losartan-hydrochlorothiazide on lowering blood ... The recommended dosage of losartan-hydrochlorothiazide for adults with high blood pressure (hypertension) ...
*  DMOZ - Health: Pharmacy: Drugs and Medications: L: Losartan
Losartan potassium and losartan potassium with hydrochlorothiazide. Features hypertension resources, prescribing information, ...
*  Discovery and development of angiotensin receptor blockers
Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is ... a metabolite of losartan (MK954, DuP753) is more potent than losartan in blocking the angiotensin ll-induced responses in ... In 1995 losartan was approved for clinical use in the United States and since then six additional ARBs have been approved. ... Losartan has the least affinity. ARBs' affinity for the AT2 receptor is generally much lower (or around 10,000 times less) than ...
*  Forasartan
Research demonstrates that forasartan is also significantly less potent than losartan. Discovery and development of angiotensin ...
*  Membrane fluidity
Some drugs, e.g. Losartan, are also known to alter membrane viscosity. Another way to change membrane fluidity is to change the ...
*  Lercanidipine
Lin T, Voon W, Yen H, Huang C, Su H, Lai W, Sheu S (2006). "Lercanidipine and losartan effects on blood pressure and ...
*  Fine chemical
... losartan) and Diovan (valsartan). A vast array of pharmaceuticals and agrochemicals are based on pyrimidines, such as Vitamin ...
*  Marfan syndrome
R.V. Lacro et al.: Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome. The New England Journal of ... However, a recent study published in NEJM demonstrated similar cardiac outcomes between the ARB, losartan, and the more ... Prior to modern cardiovascular surgical techniques and drugs such as losartan, and metoprolol, the prognosis of those with ...
*  Tetrazole
Angiotensin II receptor blockers - such as losartan and candesartan, often are tetrazoles. A well-known tetrazole is dimethyl ...
*  Loeys-Dietz syndrome
Therefore, losartan also holds promise for the treatment of Loeys-Dietz syndrome. In those patients in which losartan is not ... A large clinical trial sponsored by the National Institutes of Health is currently underway to explore the use of losartan to ... Previous research in laboratory mice has suggested that the angiotensin II receptor antagonist losartan, which appears to block ...
*  Antihypertensive drug
Gout may be worsened by thiazide diuretics, while losartan reduces serum urate. Kidney stones may be improved with the use of ... Würzner G,"Comparative effects of losartan and irbesartan on serum uric acid in hypertensive patients with hyperuricaemia and ... azilsartan candesartan eprosartan irbesartan losartan olmesartan telmisartan valsartan Fimasartan Whether angiotensin receptor ...
*  Camurati-Engelmann disease
Elimination of pain and improvement of exercise capacity in Camurati-Engelmann disease with losartan. The Journal of Clinical ...
*  Grapefruit-drug interactions
Losartan (Cozaar) Methadone: Inhibits the metabolism of methadone and raises serum levels. Omeprazole (Losec, Prilosec) ...
*  Transforming growth factor beta
April 2006). "Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome". Science. 312 (5770): ...
*  Uricosuric
In some persons with loss-of-function mutations of URAT1, the uricosurics benzbromarone and losartan had no effect, suggesting ... Drugs with other primary uses, that have known uricosuric properties, include losartan, atorvastatin, and fenofibrate. Although ... Amlodipine Atorvastatin (lowers cholesterol) Fenofibrate (lowers triglycerides, raises HDL) Losartan Adrenocorticotropic ... "Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients". Am. J. Hypertens. ...
*  Enalapril
... versus losartan for adults with chronic kidney disease: a systematic review and meta-analysis. Nephrology (Carlton). ...
*  CYP2C9*13
"Effects of the CYP2C9*13 allele on the pharmacokinetics of losartan in healthy male subjects". Xenobiotica. 39: 788-793. doi: ... "Genetic Variations of CYP2C9 in 724 Japanese Individuals and Their Impact on the Antihypertensive Effects of Losartan". ...
*  Øyvind Ellingsen
Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan. Cardiovasc Res ... Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart ...
*  Alp Ikizler
Hyperbaric oxygen treatment augments the efficacy of a losartan regime in an experimental nephrotic syndrome model. Nephron Exp ...
*  Andrew Stewart Coats
Effects of losartan and captopril on mortality and morbidity after acute myocardial infarction: The OPTIMAAL randomized trial. ...
*  Raynaud syndrome
Losartan can, and topical nitrates may, reduce the severity and frequency of attacks, and the phosphodiesterase inhibitors ... December 1999). "Losartan therapy for Raynaud's phenomenon and scleroderma: clinical and biochemical findings in a fifteen-week ... often losartan) reduce frequency and severity of attacks, and possibly better than nifedipine. The prostaglandin iloprost is ... losartan) in primary Raynaud's phenomenon". Journal of Internal Medicine. 242 (5): 373-6. doi:10.1046/j.1365-2796.1997.00219.x ...
*  Lisinopril
"Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertensive patients". ...
*  Sucroferric oxyhydroxide
2014). "Drug−drug interactions between sucroferric oxyhydroxide and losartan, furosemide, omeprazole, digoxin and warfarin in ... Phase 3 studies showed no clinically relevant interaction of sucroferric oxyhydroxide with the systemic exposures to losartan, ...