Lopinavir
... was found to inhibit MERS-CoV replication in the low-micromolar range in cell cultures. In 2020, lopinavir/ritonavir ... Kaletra (lopinavir/ritonavir) capsules; (lopinavir/ritonavir) oral solution. Prescribing information. April 2009 Capparelli EV ... Lopinavir is highly bound to plasma proteins (98-99%). Reports are contradictory regarding lopinavir penetration into the ... a study of paired CSF-plasma samples from 26 patients receiving lopinavir/ritonavir found lopinavir CSF levels above the IC50 ...
Chloroquine and hydroxychloroquine during the COVID-19 pandemic
The WHO stated that "These interim trial results show that hydroxychloroquine and lopinavir/ritonavir produce little or no ... CYP3A4 inhibitors include Azithromycin, ritonavir, and lopinavir. On 27 April 2020 the Association of American Physicians and ... "WHO discontinues hydroxychloroquine and lopinavir/Ritonavir treatment arms for COVID-19". Portals: Medicine COVID-19 (Source ...
Parvesh Bhainswal
"Darunavir matches up to lopinavir in clash of the Titans". Inpharma Weekly (1666): 16. November 2008. doi:10.2165/00128413- ...
COVID-19 drug repurposing research
One study of lopinavir/ritonavir (Kaletra), a combination of the antivirals lopinavir and ritonavir, concluded that "no benefit ... The WHO included lopinavir/ritonavir in the international Solidarity trial. On 29 June, the chief investigators of the UK ... IFN-β 1b have been shown in an open label randomised controlled trial in combination with lopinavir/ ritonavir and ribavirin to ... IFN-β will be included in the international Solidarity Trial in combination with the HIV drugs Lopinavir and Ritonavir. as well ...
Ritonavir
Lopinavir/ritonavir was found not to work in severe COVID-19. Virtual screening followed by molecular dynamics analysis ... May 2006). "Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but ... Stader F, Khoo S, Stoeckle M, Back D, Hirsch HH, Battegay M, Marzolini C (October 2020). "Stopping lopinavir/ritonavir in COVID ... May 2020). "A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19". The New England Journal of Medicine. ...
Andy Harris (politician)
". "WHO discontinues hydroxychloroquine and lopinavir/Ritonavir treatment arms for COVID-19". Olson, Laura (December 28, 2020 ...
Umifenovir
A similar study comparing Umifenovir directly with Lopinavir/Ritonavir found no difference in fever duration between the two ... December 2020). "Efficacy and Safety of Lopinavir/Ritonavir or Arbidol in Adult Patients with Mild/Moderate COVID-19: An ... July 2020). "Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19". The Journal of Infection. 81 (1): ... 2020-02-21). "Efficacies of lopinavir/ritonavir and arbidol in the treatment of novel coronavirus pneumonia". Chinese Journal ...
Didier Raoult
". "WHO discontinues hydroxychloroquine and lopinavir/Ritonavir treatment arms for COVID-19". Olivia Recasens (1 January 2009 ...
Charles Flexner
In 2010, he studied age-related changes in plasma concentrations of the HIV protease inhibitor lopinavir. Results of this study ... "Age-Related Changes in Plasma Concentrations of the HIV Protease Inhibitor Lopinavir". AIDS Research and Human Retroviruses. 26 ...
AbbVie
March 2020). "A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19". New England Journal of Medicine. 382 ... This randomized trial found that lopinavir-ritonavir treatment added to standard supportive care was not associated with ... the brand name of lopinavir/ritonavir, a fixed dose combination medication for the treatment and prevention of HIV/AIDS which ...
Saquinavir
COVID-19 hospital
Some drug examples include chloroquine, phosphate, lopinavir or ritonavir, alpha interferon, ribavirin and arbidol. The dosage ...
COVID-19 drug development
It had also announced results for lopinavir/ritonavir which were published in October 2020. The lopinavir-ritonavir and ... The individual or combined drugs undergoing initial studied are 1) lopinavir-ritonavir combined, 2) lopinavir-ritonavir ... "No clinical benefit from use of lopinavir-ritonavir in hospitalised COVID-19 patients studied in RECOVERY" (PDF). RECOVERY ... The trial is examining different potential therapies for severe COVID-19 infection: lopinavir/ritonavir, low-dose dexamethasone ...
Protease inhibitor (pharmacology)
The drugs saquinavir, ritonavir, and lopinavir have been found to have anti-malarial properties. A cysteine protease inhibitor ... Jul 2007). "Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment- ... A combination of ritonavir and lopinavir was found to have some effectiveness against Giardia infection. ... 23 Amprenavir Atazanavir Darunavir Fosamprenavir Indinavir Lopinavir Nelfinavir Ritonavir Saquinavir Tipranavir Hepatitis C ...
Treatment and management of COVID-19
... lopinavir/ritonavir, ruxolitinib, chloroquine, hydroxychloroquine, interferon β-1a, and colchicine. As of 2021, favipiravir and ... lopinavir-ritonavir or colchicine and recommended conditionally against corticosteroids or ivermectin or fluvoxamine or ... such as hydroxychloroquine and lopinavir/ritonavir, but later research found them to be ineffective or even harmful, like ... nirmatrelvir and ritonavir WHO also strongly recommended against treating severe cases with hydroxychloroquine or lopinavir- ...
Oxycodone
Ralph S. Baric
"Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV". ...
Thiomer
Madgulkar, AR; Bhalekar, MR; Kadam, AA (2017). "Improvement of oral bioavailability of lopinavir without co-administration of ...
COVID-19 pandemic in Vietnam
Specifically, Lopinavir, ritonavir and interferon have been used effectively, with patients becoming virus-free in seven days. ...
Bupropion
... lopinavir/ritonavir, and efavirenz have been shown to decrease levels of bupropion and/or its metabolites. Ticlopidine and ...
Responses to the COVID-19 pandemic in May 2020
Hong Kong researchers have tested a three-drug cocktail consisting of lopinavir/ritonavir, ribavirin and interferon-beta on 127 ... The trial found that patients treated with this cocktail recovered faster than patients given just lopinavir-ritonavir. South ...
RECOVERY Trial
5 October 2020). "Lopinavir-ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open ... In June 2020, chief investigators of the trial reported there was no clinical benefit from use of lopinavir-ritonavir in 1,596 ... "No clinical benefit from use of lopinavir-ritonavir in hospitalised COVID-19 patients studied in RECOVERY" (PDF). RECOVERY ... Lopinavir-Ritonavir (an HIV medication) Hydroxychloroquine (used to treat malaria and rheumatism) Azithromycin (an antibiotic) ...
Pravastatin
Artemether
Plasma artemether level was found to be lower when the combination product was used with lopinavir/ritonavir. There is also ...
Colchicine
People with HIV/AIDS taking atazanavir, darunavir, fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, or saquinavir ...
Martin Landray
"Lopinavir-ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform ... Lopinavir/ritonavir, Azithromycin, Convalescent plasma, and Colchicine. The trial continues to study REGN-COV2 and Baricitinib ...
COVID-19 pandemic in Bhutan
Then the patient was put on lopinavir and ritonavir and the antibiotics were switched to meropenem and vancomycin. However, he ...
Etonogestrel
August 2014). "Effect of antiretroviral therapy including lopinavir/ritonavir or efavirenz on etonogestrel-releasing implant ...
Camostat
... decreased CRP levels better compared to Lopinavir/Ritonavir in a small study of mild COVID-19 patients. Camostat ... Lopinavir/Ritonavir) treatment in Korean mild COVID-19 pneumonic patients (Report). Infectious Diseases (except HIV/AIDS). doi: ...
Tipranavir
Like lopinavir and atazanavir, it is very potent and is effective in salvage therapy for patients with drug resistance. However ...