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*  Norepinephrine
The locus coeruleus is quite small in absolute terms-in primates it is estimated to contain around 15,000 neurons, less than ... Sara SJ (2015). "Locus Coeruleus in time with the making of memories". Curr. Opin. Neurobiol. 35: 87-94. doi:10.1016/j.conb. ... The most important of these nuclei is the locus coeruleus, located in the pons. Outside the brain, norepinephrine is used as a ... The level of activity in the locus coeruleus correlates broadly with vigilance and speed of reaction. LC activity is low during ...
*  Dorsal raphe nucleus
The nucleus raphes dorsalis have been known to project to the lateral hypothalamus, along with the locus coeruleus and the ...
*  Imidazoline receptor
They are notably not expressed in the cerebral cortex or locus coeruleus. Animal research suggests that much of the ...
*  Locus coeruleus
The locus coeruleus (\-si-ˈrü-lē-əs\, also spelled locus caeruleus or locus ceruleus) is a nucleus in the pons of the brainstem ... The locus coeruleus is the principal site for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the ... The locus coeruleus is responsible for mediating many of the sympathetic effects during stress. The locus coeruleus is ... name locus coeruleus is actually a Latin expression consisting of the noun, locus, place or spot and the adjective coeruleus, ...
*  Pre-locus coeruleus
... the locus coeruleus, which is commonly abbreviated "LC". The pre-locus coeruleus was first formally defined during the course ... Pre-locus coeruleus is a small nucleus in the brainstem. This small cluster of neurons also is referred to by the abbreviation ... Based on these observations, the pre-locus coeruleus ("pre-LC") was defined as the cluster of neurons which: (1) are found in a ... However, it should be noted that FoxP2 expression is found in several nearby brain regions (not including the locus coeruleus, ...
*  Johann Christian Reil
In 1809, he was the first to describe the white fibre tract now called the arcuate fasciculus and the locus coeruleus. From ... PMID 18614162 Maeda T. (2000). The Locus coeruleus: history. Journal of Chemical Neuroanatomy. 18:57-64. PMID 10708919 https:// ...
*  Brain
Norepinephrine, which is involved in arousal, comes exclusively from a nearby small area called the locus coeruleus. Other ... ISBN 0-397-51820-X. Mehler, MF; Purpura, DP (2009). "Autism, fever, epigenetics and the locus coeruleus". Brain Research ...
*  Causes of autism
Autism, fever, epigenetics and the locus coeruleus. Brain Res Rev. 2009;59(2):388-92. doi:10.1016/j.brainresrev.2008.11.001. ... Based on these studies, there are predicted to be 130-234 ASD-related CNV loci. The first whole genome sequencing study to ... behaviors depend at least in part on a developmental dysregulation that results in impaired function of the locus coeruleus- ... A further 5-10% of cases have inherited structural variation at loci known to be associated with autism, and these known ...
*  Optogenetics
"Tuning arousal with optogenetic modulation of locus coeruleus neurons". Nature Neuroscience. 13 (12): 1526-33. doi:10.1038/nn. ...
*  Serotonin-norepinephrine reuptake inhibitor
These regions are called locus coeruleus and the lateral tegmental. With administration of selective NRIs, neuronal activity in ... "Comparative study of the effects of desipramine and reboxetine on locus coeruleus neurons in rat brain slices". ... locus coeruleus region is induced because of increased concentration of norepinephrine in the synaptic cleft. This results in ...
*  Rett syndrome
However, locus coeruleus cells are not dying, but are more likely losing their fully mature phenotype, since no apoptotic ... Using immunoquantitative techniques, a decrease of Th protein staining level, number of locus coeruleus TH-expressing neurons ... Berridge, Craig W; Waterhouse, Barry D (2003). "The locus coeruleus-noradrenergic system: Modulation of behavioral state and ... we hypothesize that the locus coeruleus is a critical site at which loss of MECP2 results in CNS dysfunction." The restoration ...
*  Alzheimer's disease
Degeneration is also present in brainstem nuclei like the locus coeruleus. Studies using MRI and PET have documented reductions ... Lambert JC (December 2013). "Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease ...
*  Arecoline
Yang YR, Chang KC, Chen CL, Chiu TH (2000). "Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic ...
*  Metalearning (neuroscience)
1999). "The Role of Locus Coeruleus in the Regulation of Cognitive Performance". Science. Retrieved 2013-08-04. Hasselmo, ...
*  Jackie Hunter
"Orexin a activates locus coeruleus cell firing and increases arousal in the rat". Proceedings of the National Academy of ...
*  Attention deficit hyperactivity disorder
The dopamine and norepinephrine pathways that originate in the ventral tegmental area and locus coeruleus project to diverse ... NOTE: DA: dopamine, LC: locus coeruleus, VTA: ventral tegmental area, 5HT: serotonin (5-hydroxytryptamine) Castellanos FX, ... Current models involve the mesocorticolimbic dopamine pathway and the locus coeruleus-noradrenergic system. ADHD ...
*  Attentional blink
According to the LC-NE hypothesis, when a salient, or meaningful stimulus is presented, neurons in the locus coeruleus release ... Nieuwenhuis S, Gilzenrat MS, Holmes BD, Cohen JD (August 2005). "The role of the locus coeruleus in mediating the attentional ... Eventually the neurons in the locus coeruleus enter a refractory period, due to the auto-inhibitory effect of norepinephrine. ...
*  Nociceptin receptor
"Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro". British Journal of ...
*  Sopite syndrome
The sopite syndrome is therefore linked to inhibition of the locus coeruleus-noradrenergic pathways. As such, noradrenaline ... The locus coeruleuses of these animals are apparently deactivated. ...
*  Sodium nitroprusside
"Immunohistochemical evidence for impaired nitric oxide signaling of the locus coeruleus in bipolar disorder". Brain Research. ...
*  Reticular formation
Locus coeruleus Pedunculopontine nucleus Medial pontine reticular formation Midbrain reticular formation Purves, Dale (2011). ... noradrenergic locus coeruleus (LC), serotonergic (5-HT) Raphe nuclei and dopaminergic ventral tegmental area (VTA), substantia ... the ascending arousal system promotes wakefulness through a network composed of the monaminergic neurons in the locus coeruleus ... decrease in the number of locus coeruleus (LC) neurons, resulting is increased disinhibition of the PPN. Progressive ...
*  Psychopharmacology
The pathways begin in the locus coeruleus (noradrenaline) and the nucleus of raphe (serotonin). Similar to other abused ...
*  Visual selective attention in dementia
It is associated with the degeneration of neurons in the substantia nigra and locus coeruleus. Clinical symptoms of PD include ... locus coeruleus, temporal, parietal and frontal lobes, and the limbic system, especially the hippocampus and amygdala, are ... locus coeruleus, and components of the basal forebrain cholinergic system. Clinical features include a cortical dementia and ... is characterised by degeneration of the substantia nigra within the basal ganglia and the locus coeruleus. These regions are ...
*  6-Fluoronorepinephrine
Stone EA, Lin Y, Sarfraz Y, Quartermain D (2009). "Marked behavioral activation from inhibitory stimulation of locus coeruleus ... Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing ...
*  Nisoxetine
In humans, 3H-NIS is used to measure uptake sites in the locus coeruleus (LC). The LC, a source of norepinephrine axons, has ... Samuels, E.R.; Szabadi, E. (September 2008). "Functional neuroanatomy of the noradrenergic locus coeruleus: Its roles in the ... "Effect of age on 3H-nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus of humans". Brain Research. ... Physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans". Current ...
*  Solitary nucleus
... the locus coeruleus, the dorsal raphe nucleus, and other visceral motor or respiratory networks). The signals projected from ...
*  Arousal
The noradrenergic system is a bundle of axons that originate in the locus coeruleus and ascends up into the neocortex, limbic ... The activation of the locus coeruleus and release of norepinephrine causes wakefulness and increases vigilance. The neurons ... Samuels, E. R., & Szabadi, E. (2008, September). Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the ... The hypothalamic projection involves noradrenergic neurons of the locus coeruleus (LC) and serotoninergic neurons of the dorsal ...