... soybean lipoxygenase L1 and L3, coral 8-lipoxygenase, human 5-lipoxygenase, rabbit 15-lipoxygenase and porcine leukocyte 12- ... erythrocyte type 15-lipoxygenase (or 15-lipoxygenase, erythrocyte type), reticulocyte type 15-lipoxygenase (or 15-lipoxygenase ... LOX-DB - LipOXygenases DataBase Lipoxygenases iron-binding region in PROSITE PDB: 1YGE​ - structure of lipoxygenase-1 from ... Certain types of the lipoxygenases, e.g. human and murine 15-lipoxygenase 1, 12-lipoxygenase B, and ALOXE3, are capable of ...

Linoleate+8R-lipoxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 1.13.11) ... Linoleate 8R-lipoxygenase (EC 1.13.11.60, linoleic acid 8R-dioxygenase, 5,8-LDS (bifunctional enzyme), 7,8-LDS (bifunctional ... 12-dienoate Linoleate 8R-lipoxygenase contains heme. Brodhun F, Göbel C, Hornung E, Feussner I (May 2009). "Identification of ...

... (EC 1.13.11.58, 9-lipoxygenase, 9S-lipoxygenase, linoleate 9-lipoxygenase, LOX1 (gene), 9S-LOX) is an ... Linoleate+9S-lipoxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 1.13.11) ... Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I (March 2009). "On the substrate binding of linoleate 9-lipoxygenases". ... Bannenberg G, Martínez M, Hamberg M, Castresana C (February 2009). "Diversity of the enzymatic activity in the lipoxygenase ...

Hamberg M, Su C, Oliw E (1998). "Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate ... In enzymology, a linoleate 11-lipoxygenase (EC 1.13.11.45) is an enzyme that catalyzes the chemical reaction linoleate + O2 ... This enzyme is also called linoleate dioxygenase, manganese lipoxygenase. This enzyme participates in linoleic acid metabolism ... Su C, Oliw EH (1998). "Manganese lipoxygenase. Purification and characterization". J. Biol. Chem. 273 (21): 13072-9. doi: ...

Linoleate+10R-lipoxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 1.13.11 ... Linoleate 10R-lipoxygenase (EC 1.13.11.62, 10R-DOX, (10R)-dioxygenase, 10R-dioxygenase) is an enzyme with systematic name ... 12-octadecadienoate Linoleate 10R-lipoxygenase is involved in biosynthesis of oxylipins. Garscha U, Oliw EH (May 2009). " ...

... (EC 1.13.11.61, NspLOX, (9R)-LOX, linoleate 9R-dioxygenase) is an enzyme with systematic name alpha- ... Linolenate+9R-lipoxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 1.13.11 ... Andreou AZ, Vanko M, Bezakova L, Feussner I (June 2008). "Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its ... Lang I, Göbel C, Porzel A, Heilmann I, Feussner I (March 2008). "A lipoxygenase with linoleate diol synthase activity from ...

... , also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms essential fatty acids (EFA) ... "5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes". J. ... "Alox5 - arachidonate 5-lipoxygenase". WikiGenes. Fahel JS, de Souza MB, Gomes MT, Corsetti PP, Carvalho NB, Marinho FA, de ...

Other names in common use include 8-lipoxygenase, and 8(R)-lipoxygenase. This enzyme participates in arachidonic acid ... Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ (1986). "Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian ... Arachidonate 8-lipoxygenase (EC 1.13.11.40) is an enzyme that catalyzes the chemical reaction arachidonate + O2 ⇌ {\ ...

Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in ... synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein". Biochemical and Biophysical Research ... 5-lipoxygenase-activating+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human ALOX5AP genome ... Musiyenko A, Correa L, Stock N, Hutchinson JH, Lorrain DS, Bain G, Evans JF, Barik S (November 2009). "A novel 5-lipoxygenase- ...

... s are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5- ... Lipoxygenase+inhibitors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82016859 ... 1. Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a ... Zileuton is a specific inhibitor of 5-lipoxygenase and thus inhibits leukotriene (LTB4, LTC4, LTD4, and LTE4) formation. Both ...

"Pfam entry: Lipoxygenase". Archived from the original on 2007-09-29. Retrieved 2007-01-25. PDBsum entry: Alpha Toxin "Pfam ...

... also termed arachidonate-5-lipoxygenase, 5-lipoxygenase, 5-LO, and 5-LOX). ALOX5 metabolizes arachidonic acid to its ... 12-Lipoxygenase (i.e. ALOX12) to metabolize 5(S)-HETE to 5(S),12(S)-diHETE. The activity of this product has not yet been fully ... by the arachidonate 15-Lipoxygenase-1-based or arachidonate 15-lipoxygenased-2-based metabolism of 5-oxo-ETE; and f) conversion ...

Arachidonate 5-lipoxygenase "Flavocoxid". livertox.nlm.nih.gov. Retrieved 2016-07-20. This article incorporates text from this ...

It is a lipoxygenase inhibitor. Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat ...

AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in ... "5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl ... "A Novel 5-Lipoxygenase-Activating Protein Inhibitor, AM679, Reduces Inflammation in the Respiratory Syncytial Virus-Infected ...

... possibly 15-lipoxygenase-2 (i.e. ALOX15B), 5-lipoxygenase (i.e. ALOX5), cyclooxygenase-2 (i.e. COX-2), and certain cytochrome ... The following oxygenase enzymes may be responsible for metabolizing PUFA to resolvins: 15-lipoxygenase-1 (i.e. ALOX15), ... range of cells and tissues by the initial metabolism of DHA to 7S-hydroperoxy-DHA and 4S-hydroperoxy-DHA by a 15-lipoxygenase ( ...

Lipoxygenase inhibitor "Zileuton (Oral Route)". MayoClinic. "Zyflo consumer information". Drugs.com. "Lethal Cancer Knocked ... Zileuton (trade name Zyflo) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, ... Krutetskaya ZI, Milenina LS, Naumova AA, Antonov VG, Nozdrachev AD (July 2016). "5-Lipoxygenase inhibitor zileuton inhibits Ca( ... Zileuton is an active oral inhibitor of the enzyme 5-lipoxygenase, which forms leukotrienes, 5-hydroxyeicosatetraenoic acid, ...

... a Potent 5-Lipoxygenase Inhibitor, Isolated from Ardisia sieboldii, and Degree of 5-Lipoxygenase Inhibitory Activity of Its ... Ardisiaquinones are of research interest because they possess 5-lipoxygenase (5-LOX) inhibitor activity and 5-LOX has clinical ... Fukuishi, N.; Takada, T.; Fukuyama, Y.; Akagi, M. (2001). "Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase ... "Naturally Occurring 5-Lipoxygenase Inhibitor. II. Structures and Syntheses of Ardisianones a and B, and Maesanin, Alkenyl-1,4- ...

Pinoresinol - inhibitor of 15-lipoxygenase. Uracil - isolated from the leaf of Fadogia homblei, significant as the first ...

Cho KJ, Seo JM, Kim JH (July 2011). "Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen ... Speed N, Blair IA (December 2011). "Cyclooxygenase- and lipoxygenase-mediated DNA damage". Cancer and Metastasis Reviews. 30 (3 ...

For example, 5-lipoxygenase (i.e. (ALOX5) in neutrophils and 15-lipoxygenase-1 (i.e. ALOX15) in immature erythrocytes and ... The double oxygenations may be conducted within a single cell type which possesses ALOX5 and an enzyme with 15-lipoxygenase ... A lipoxin (LX or Lx), an acronym for lipoxygenase interaction product, is a bioactive autacoid metabolite of arachidonic acid ... This step is catalyzed by enzymes with 15-lipoxygenase activity which in humans includes ALOX15, ALOX12, aspirin-treated ...

Epidermis-type lipoxygenase 3 (ALOXE3 or eLOX3) is a member of the lipoxygenase family of enzymes; in humans, it is encoded by ... The epidermis-type lipoxygenases are now regarded as a distinct subclass within the multigene family of mammalian lipoxygenases ... "Entrez Gene: ALOXE3 arachidonate lipoxygenase 3". Schneider C, Brash AR (August 2002). "Lipoxygenase-catalyzed formation of R- ... "Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE ...

15-Lipoxygenase-2: Cells also used 15-lipoxygenase 2 (i.e. 15-LOX-2 or ALOX15B) to make 15(S)-HpETE and 15(S)-HETE. However ... 15-Lipoxygenase-1: Cells metabolize arachidonic acid with 15-lipoxygenase-1 (i.e., 15-LO-1, ALOX15) to form 15(S)-HpETE as a ... inhibitor of 12-lipoxygenase but not other human lipoxygenases. This effect could also have anti-inflammatory and anti- ... Oxygenated by 5-lipoxygenase (ALOX5 to form its 5,6-trans epoxide derivative which may then rearrange to the lipoxins (LX), ...

Lipoxygenase homology domains 1 is a protein in humans that is encoded by the LOXHD1 gene. This gene encodes a highly conserved ... "Entrez Gene: Lipoxygenase homology domains 1". Retrieved 2012-04-10. Grillet N, Schwander M, Hildebrand MS, Sczaniecka A, ... protein consisting entirely of PLAT (polycystin/lipoxygenase/alpha-toxin) domains, thought to be involved in targeting proteins ...

The murine homolog of human 15(S)-lipoxygenase-2 (ALOX15B), 8(S)-lipoxygenase, while preferring arachidonic acid over linoleic ... However, ALOX15B, similar to human 15-lipoxygenase-1 (ALOX15), metabolizes linoleic acid to 13(S)-HODE but not to 9(S)-HODEs. ... Cho, K. J.; Seo, J. M.; Kim, J. H. (2011). "Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive ... Speed, N.; Blair, I. A. (2011). "Cyclooxygenase- and lipoxygenase-mediated DNA damage". Cancer and Metastasis Reviews. 30 (3-4 ...

The 15-lipoxygenases (particularly ALOX15) may also act in series with 5-lipoxygenase, 12-lipoxygenase, or aspirin-treated COX2 ... The enzymes 15-lipoxygenase-1 (15-LO-1 or ALOX15) and 15-lipoxygenase-2 (15-LO-2, ALOX15B) metabolize arachidonic acid to the S ... Other reactions of lipoxygenases generate cellular damage; murine models implicate 15-lipoxygenase in the pathogenesis of ... Lipoxygenases (LOXs): 5-Lipoxygenase (5-LOX or ALOX5) initiates the metabolism of arachidonic acid to 5- ...

... cyclooxygenases and lipoxygenases. In addition to the maresins, this class of mediators includes: the 15-lipoxygenase (i.e. ... certain 15-lipoxygenase-derived Resolvin D series metabolites of DHA; certain other 15-lipoxygenase-derived protectin D1 and ... Maresin 1, and more recently defined maresins, are 12-lipoxygenase-derived metabolites of the omega-3 fatty acid, ... Studies implicate the following pathway in its formation: 12-lipoxygenase converts DHA to its 14-hydroxperoxy intermediate, 14( ...

12-lipoxygenase gene, see lipoxygenase#Mouse lipoxygenases) are resistant to a) streptozotocin-induced, b) high fat diet- ... express platelet type 12-lipoxygenase but also a leukocyte type 12-lipoxygenase (also termed 12/15-lipoxygenase, 12/15-LOX or ... In humans, Arachidonate 12-lipoxygenase (12-LO, 12-LOX, ALO12, or platelet type 12-lipoxygenase) is encoded by the ALOX12 gene ... "CDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin". Biochimica et ...

Delta12-lipoxygenase, 12Delta-lipoxygenase, and C-12 lipoxygenase. ALOX12, often termed plate platelet-type 12-lipoxygenase, is ... ALOX12 (EC 1.13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a ... "Entrez Gene: ALOX12 arachidonate 12-lipoxygenase". Yamamoto S, Suzuki H, Ueda N (March 1997). "Arachidonate 12-lipoxygenases". ... Other systematic names for ALOX12 include 12S-Lipoxygenase, platelet-type 12-lipoxygenase, arachidonate:oxygen 12- ...

Compositae) on soybean lipoxygenase and prostaglandin synthetase". General Pharmacology: The Vascular System. 26 (4): 815-9. ...