*Serum protein electrophoresis

Transferrin and beta-lipoprotein (LDL) comprises the beta-1. Increased beta-1 protein due to the increased level of free ... Even staining in this zone is due to alpha-1 lipoprotein (high density lipoprotein - HDL). Decrease occurs in severe ... Beta lipoprotein forms an irregular crenated band in this zone. High levels are seen in type II hypercholesterolaemia, ... Increased beta-1 protein due to LDL elevation occurs in hypercholesterolemia. Decreased beta-1 protein occurs in acute or ...

*Sitosterolemia

This is coupled with significantly increased low-density lipoprotein (LDL) receptor expression. The disorder is treated by ...

*Lipoprotein-associated phospholipase A2

In the blood it travels mainly with low-density lipoprotein (LDL). Less than 20% is associated with high-density lipoprotein ... Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a ... It is an enzyme produced by inflammatory cells and hydrolyzes oxidized phospholipids in LDL. Lp-PLA2 is platelet-activating ... The Lp-PLA2 Studies Collaboration (2010). "Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and ...

*Michael Stuart Brown

Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE (Mar 1988). "Overexpression of low density lipoprotein (LDL) receptor ... Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that ... Lehrman MA, Goldstein JL, Russell DW, Brown MS (Mar 1987). "Duplication of seven exons in LDL receptor gene caused by Alu-Alu ... Russell DW, Schneider WJ, Yamamoto T, Luskey KL, Brown MS, Goldstein JL (Jun 1984). "Domain map of the LDL receptor: sequence ...

*Nutrition

Elevated amounts of Low-density lipoprotein (LDL) cholesterol, is the primary factor in heart disease. In order to avoid all ... Both sugar intake and fatty tissue increase the probability of elevated LDL cholesterol in the bloodstream. ...

*Atherosclerosis

Low-density lipoprotein (LDL) particles in blood plasma invade the endothelium and become oxidized, creating risk of ... Aviram M, Fuhrman B (1998). "LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and ... The process is worsened if there is insufficient high-density lipoprotein (HDL), the lipoprotein particle that removes ... Cholesterol is delivered into the vessel wall by cholesterol-containing low-density lipoprotein (LDL) particles. To attract and ...

*Nut (fruit)

Eating various nuts such as almonds and walnuts can lower serum low density lipoprotein (LDL) concentrations. Although nuts ...

*Endocytic cycle

Low-density lipoprotein (LDL) originates in the liver and is transported around the body by the blood stream. From there it is ... LDL in the blood binds to LDL receptors on the surface of fibroblasts; these receptors concentrate in coated pits (they are ... It is now ready for another round of LDL clearance. High levels of LDL in the blood are observed in atherosclerosis and ... Like the LDL receptor, the transferrin receptor is internalised into a coated vesicle. The iron is released inside the cell and ...

*ACVRL1

... directly interacts with low-density lipoprotein (LDL), which implies that it might initiate the early phases of ... "Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells". Nature Communications. 7: ...

*Zaragozic acid

Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels. ... LDL receptor, and cholesterol 7 alpha hydroxylase". Arch. Biochem. Biophys. 311 (2): 277-85. doi:10.1006/abbi.1994.1238. PMID ...

*Adrenal gland

LDL). LDL enters the cells through receptor-mediated endocytosis. The other source of cholesterol is synthesis in the cell's ... The main source is through dietary cholesterol transported via the blood as cholesterol esters within low density lipoproteins ... Synthesis can compensate when LDL levels are abnormally low. In the lysosome, cholesterol esters are converted to free ...

*Pravastatin

... which are the precursor to low-density lipoproteins (LDL). These reductions increase the number of cellular LDL receptors, thus ... Overall, the result is a reduction in circulating cholesterol and LDL. A minor reduction in triglycerides and an increase in ... Pravastatin acts as a lipoprotein-lowering drug through two pathways. In the major pathway, pravastatin inhibits the function ... Pravastatin also inhibits the synthesis of very-low-density lipoproteins, ...

*Ipomoea

"Sweet potato (Ipomoea batatas L.) leaves suppressed oxidation of low density lipoprotein (LDL) in vitro and in human subjects ...

*Monounsaturated fat

Foods containing monounsaturated fats reduce low-density lipoprotein (LDL) cholesterol, while possibly increasing high-density ... Fat composition in different foods view talk edit High density lipoprotein Saturated fat Unsaturated fat Polyunsaturated fat ... lipoprotein (HDL) cholesterol.[citation needed] Levels of oleic acid along with other monounsaturated fatty acids in red blood ...

*Atheroma

... that have taken up oxidized low-density lipoprotein (LDL). After they accumulate large amounts of cytoplasmic membranes (with ... such as lipoproteins, more importantly lipoprotein subclass analysis, blood sugar levels and hypertension are best known and ... Coronary circulation Coronary catheterization EBT Hemorheologic-Hemodynamic Theory of Atherosclerosis Lipoprotein LDL, HDL, IDL ...

*Colestipol

... specifically low-density lipoprotein (LDL). It is also used to reduce stool volume and frequency, and in the treatment of ... increased LDL receptor expression, and decreasing LDL in blood. The following notable side effects may occur: gastrointestinal ...

*Sterol ester

Plant sterol esters have been shown to reduce the level of low-density lipoprotein (LDL) cholesterol in blood when ingested. ... Studies have indicated that consumption of about 2 grams per day of phytosterol esters provides a reduction in LDL cholesterol ...

*Jawahar L. Mehta

His current research is on the uptake of oxidized low density lipoprotein (LDL) by specialized receptors LOX-1 (OLR1). Mehta ... Lectin-like ox-LDL receptor-1 (LOX-1) - toll-like receptor 4 (TLR4) interaction and autophagy in CATH.a differentiated cells ... Antisense to LOX-1 inhibits ox-LDL-mediated upregulation of MCP-1 expression and monocyte adhesion to human coronary artery ...

*Simvastatin

... is an effective lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%.[citation ... Statins are more effective than other lipid-regulating drugs at lowering LDL-cholesterol concentration, but they are less ... Pedersen, TR (2010). "Pleiotropic effects of statins: Evidence against benefits beyond LDL-cholesterol lowering". American ... or stroke but having relatively low LDL cholesterol. In this trial, which lasted 5.4 years, overall mortality was reduced by 13 ...

*Vein graft disease

... vascular surgery Lipoprotein LDL, HDL, IDL and VLDL "Saphenous vein graft disease: review of pathophysiology, prevention, and ...

*Torcetrapib

... the drug not only lowered low-density lipoproteins (LDL and VLDL) but also raised levels of high density, "good" lipoproteins ( ... which normally transfers cholesterol from HDL cholesterol to very low density or low density lipoproteins (VLDL or LDL). ... A 2004 trial (19 subjects, non-randomised) showed that torcetrapib could increase HDL and lower LDL with and without an added ... Keene, D; Price, C; Shun-Shin, MJ; Francis, DP (Jul 18, 2014). "Effect on cardiovascular risk of high density lipoprotein ...

*Oleic acid

Monounsaturated fat consumption has been associated with decreased low-density lipoprotein (LDL) cholesterol, and possibly ... increased high-density lipoprotein (HDL) cholesterol. However, its ability to raise HDL is still debated. Oleic acid may be ...

*Varespladib methyl

Furthermore, sPLA2 remodels lipoproteins, notably low-density lipoproteins (LDL) and their receptors, which are responsible for ... This remodeling can lead to increased deposition of LDL and cholesterol in the artery wall. In combination with chronic ... Two other Phase II trials, conducted in patients with coronary artery disease, found significant decreases in sPLA2 and LDL ... Varespladib methyl has also been shown to further reduce LDL and inflammatory biomarker levels when administered in conjunction ...

*Low-carbohydrate diet

... as well as an increase in high-density lipoprotein cholesterol (HDL). Low-density lipoprotein cholesterol (LDL) and creatinine ... Potential favorable changes in triglyceride and high-density lipoprotein cholesterol values should be weighed against potential ... unfavorable changes in low-density lipoprotein cholesterol and total cholesterol values when low-carbohydrate diets to induce ...

*Hepatic lipase

... to low-density lipoprotein (LDL). LIPC encodes hepatic triglyceride lipase (HTGL), which is expressed in liver. LIPC has the ... "Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to ... Santamarina-Fojo S, Haudenschild C, Amar M (Jun 1998). "The role of hepatic lipase in lipoprotein metabolism and ... Hepatic lipase deficiency is a rare, autosomal recessive disorder that results in elevated high density lipoprotein (HDL) ...

*Apolipoprotein C4

2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or ... 2008). "Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of ... 2007). "Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF". ... 2003). "Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins". J. ...