The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein ... Albers JJ, Cheung MC (2004). "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism". Curr. Opin ... Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene. ... "Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I". J. Lipid Res. 40 (4): 654-64. doi: ...
2006). "The discrete and combined effect of SREBP-2 and SCAP isoforms in the control of plasma lipids among familial ... Sterol regulatory element-binding protein cleavage-activating protein, also known as SREBP cleavage-activating protein or SCAP ... SCAP is a regulatory protein that is required for the proteolytic cleavage of the sterol regulatory element-binding protein ( ... In cholesterol-depleted cells, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their ...
... lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation". J. Lipid Res. 47 (2): 233 ... Many proteins can exist in a cell in various locations, and the addition of a farnesyl group targets proteins to the plasma ... The mechanism by which FTIs work is through inhibition of this enzyme, which adds a fatty acid molecule to proteins (such as ... LNK-754 inhibits the activity of a protein called farnesyl-transferase (FT). This class of molecules are called FTIs (or ...
... (PCTP), also known as StAR-related lipid transfer domain protein 2 (STARD2), is a specific ... This protein also founds the StarD2 subfamily of proteins. This subfamily consists of PCTP, StarD7, StarD10 and collagen type ... "Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2". J. Biol. Chem. ... This soluble protein is 214 amino acids long. It is almost entirely composed of a StAR-related transfer domain (START). X-ray ...
Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I". J. Lipid Res. 47 (4): 681-99. doi: ... Fighting parasitic disease by blocking protein farnesylation". J. Lipid Res. 47 (2): 233-40. doi:10.1194/jlr.R500016-JLR200. ... modify proteins by adding an isoprenoid lipid called a prenyl group to the carboxyl terminus of the target protein. This ... Most prenylated proteins are involved in cellular signaling, wherein membrane association is critical for function. ...
Membrane lipids also form a matrix in which membrane proteins reside. Historically lipids were thought to merely serve a ... The arrangements of lipids and various proteins, acting as receptors and channel pores in the membrane, control the entry and ... Formation of lipid rafts promotes aggregation of peripheral and transmembrane proteins including docking of SNARE and VAMP ... Homeoviscous adaptation Protein-lipid interaction R. B. Gennis. Biomembranes - Molecular Structure and Function. Springer- ...
Thus, they are able to inactivate sensitive proteins through electrophilic stress. The toxicity of lipid hydroperoxides to ... Lipid peroxidation is the chain of reactions of oxidative degradation of lipids. It is the process in which free radicals " ... The chemical products of this oxidation are known as lipid peroxides or lipid oxidation products (LOPs). Initiation is the step ... Lipid+peroxidation at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (All articles with dead external ...
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most ... Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene. ... 2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203-13. doi:10.1016/S0022-2275(20)31570-4. PMID ... This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind ...
2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203-13. doi:10.1016/S0022-2275(20)31570-4. PMID ... Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene. Oxysterols are byproducts of cholesterol ... Wang C, JeBailey L, Ridgway ND (Jan 2002). "Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and ... The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds ...
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most ... Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene. ... 2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203-13. doi:10.1016/S0022-2275(20)31570-4. PMID ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143-50. doi: ...
Lipids. 216: 132-141. doi:10.1016/j.chemphyslip.2018.09.002. PMID 30194925. S2CID 52179117. Review of a lipid visualization ... Hullin-Matsuda F.; Murate M.; Kobayashi T. (25 September 2018). "Protein Probes to Visualize Sphingomyelin and Ceramide ...
... translocon-assisted folding of membrane proteins, structure of fluid lipid bilayers, and MD simulations of lipid bilayers. His ... Membrane Protein Structure: Experimental Approaches (1994) ISBN 9780195071122 Cell Boundaries: How Membranes and Their Proteins ... He has focused his research on structure and folding of membrane proteins, with particular attention on protein structure ... Using a thermodynamic framework, he highlighted three main aspects of membrane protein folding energetics: protein binding and ...
Lomitapide is a microsomal triglyceride transfer protein inhibitor. PCSK9 inhibitors are monoclonal antibodies for refractory ... lipid lowering agent' be used for this class of drugs rather than the term 'hypolipidemic'. The several classes of lipid ... Lipid-lowering agents, also sometimes referred to as hypolipidemic agents, cholesterol-lowering drugs, or antihyperlipidemic ... Flaxseed oil Investigational classes of hypolipidemic agents: CETP inhibitors (cholesteryl ester transfer protein), 1 candidate ...
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most ... Oxysterol-binding protein-related protein 1 is a protein that in humans is encoded by the OSBPL1A gene. ... 2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203-13. doi:10.1016/S0022-2275(20)31570-4. PMID ... 2004). "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have ...
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most ... Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene. ... 2001). "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203-13. doi:10.1016/S0022-2275(20)31570-4. PMID ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
... s are composed entirely of protein; no lipids or carbohydrates have been detected. Gas vesicles occur primarily in ... Formation of gas vesicles are regulated by two Gvp proteins: GvpD, which represses the expression of GvpA and GvpC proteins, ... Larger vesicles can hold more air and use less protein making them the most economic in terms of resource use, however, the ... There are at least two proteins that compose a cyanobacterium's gas vesicle: GvpA, and GvpC. GvpA forms ribs and much of the ...
ROS can damage lipids, DNA, and proteins. Gradual but steady accretion of such damage can lead to the development of many ... Myricetin suppressed the release of IL-2 protein from mouse EL-4 T cells that had been stimulated with phorbol 12-myristate 13- ... pyrenes to DNA and protein native to epidermal skin cells. Myricetin also has been shown to inhibit the act of genetic mutation ... could have deleterious effects on the cell's capacity to transcribe and translate DNA and RNA to produce vital proteins for the ...
These structures contain proteins, proteoglycans, and lipids. Enamel lamellae should not be confused with two similar entities ...
The outer layer is a protein structure of 240 capsid proteins trimers, and the inner one is a proteinaceous lipid membrane ... It encodes about 30 proteins that are transcribed in operons. At least 9 structural proteins are present in the viron. The ... Lipids constitute a further 15% by weight. Carbohydrates are not present.[citation needed] Viral replication is cytoplasmic. ... Capsid proteins polymerize around a lipoprotein vesicle translocated in the cytoplasm by virion assembly factors. Mature virons ...
The proteins and lipids that make up the surfactant have both hydrophilic and hydrophobic regions. By adsorbing to the air- ... These are concentric rings of lipid and protein, about 1 µm in diameter. SP-A and SP-D are collectins. They confer innate ... Neutral lipids and cholesterol are also present. The components for these lipids diffuse from the blood into type II alveolar ... Half of this 10% is plasma proteins but the rest is formed by the apolipoproteins, surfactant proteins SP-A, SP-B, SP-C, and SP ...
Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. ... Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the ... The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is ... 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. ...
Lipids and Lipid Metabolism. 961 (1): 148-52. doi:10.1016/0005-2760(88)90141-5. PMID 3260112. Ghani F, Wu AH, Graff L, Petry C ... Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is ... Heart-type Fatty Acid-Binding Protein (H-FABP) is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ...
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most ... Oxysterol-binding protein-related protein 11 is a protein that in humans is encoded by the OSBPL11 gene. ... "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203-13. doi:10.1016/S0022-2275(20)31570-4. PMID ... Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein ...
... playing a role in rearranging lipids. However, proteins like GNLY and AOAH do not carry a SapA domain. While GNLY is ... The saposin domains refers to two evolutionally-conserved protein domains found in saposin and related proteins (SAPLIP). ... Saposins are small lysosomal proteins that serve as activators of various lysosomal lipid-degrading enzymes. They probably act ... Protein domains, Protein families, Peripheral membrane proteins). ...
Jansen H, Verhoeven AJ, Sijbrands EJ (September 2002). "Hepatic lipase: a pro- or anti-atherogenic protein?". Journal of Lipid ... take off free fatty acids from the plaques through the help of ABCL1 proteins. These proteins help transfer free fatty acids ... Mutated ApoA-I protein caused a decrease in HL release and thus decreased the amount of HL bound to HDL and released into the ... where mouse cells were created to have a mutated HL protein that has lost its function. They found that a build-up of ...
Journal of Lipid Research. 36 (6): 1247-53. doi:10.1016/S0022-2275(20)41132-0. PMID 7666002. Berni R, Malpeli G, Folli C, ... Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). RBP4 has a molecular ... Kanai M, Raz A, Goodman DS (September 1968). "Retinol-binding protein: the transport protein for vitamin A in human plasma". ... Naylor HM, Newcomer ME (March 1999). "The structure of human retinol-binding protein (RBP) with its carrier protein ...
Such complexes in cell nucleus are called ribonucleoproteins (RNPs). DNA-protein complexes: nucleosome. Protein-lipid complexes ... and of proteins within lipid bilayers. During assembly of the bacteriophage (phage) T4 virion, the morphogenetic proteins ... June 2004). "A structural perspective on protein-protein interactions". Current Opinion in Structural Biology. 14 (3): 313-324 ... protein, RNA, DNA, carbohydrate) or large non-polymeric biomolecules (lipid). The interactions between these biomolecules are ...
Journal of Lipid Research. 27 (2): 166-71. doi:10.1016/S0022-2275(20)38843-X. PMID 3754273. Harney JP, Smith LC, Simmen RC, ... Retinol-binding proteins (RBP) are a family of proteins with diverse functions. They are carrier proteins that bind retinol. ... Plasma retinol-binding protein, the retinol transport vehicle in serum. CRBP I/II, cellular-binding proteins involved in ... MacDonald PN, Bok D, Ong DE (June 1990). "Localization of cellular retinol-binding protein and retinol-binding protein in cells ...
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most ... Ngo M, Ridgway ND (Mar 2009). "Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that ... Wyles JP, Ridgway ND (Jul 2004). "VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein ... Oxysterol binding protein-like 9 is a protein that in humans is encoded by the OSBPL9 gene. ...
New Insights into Cellular Functions and Mechanisms of Protein Recognition". Lipid-mediated Protein Signaling. Advances in ... ApoE is a protein that is involved in the transport of many lipids, including cholesterol, and thus, regulates how much ... CD1a, CD1b, and CD1c subtypes present lipid antigens to T cells, while CD1d cells present lipids, glycolipids, and lipoproteins ... Research has shown that MAL may be involved in vesicular transport of sulfatide and other myelin proteins and lipids to the ...
Ideas regarding carbohydrates, lipids, and proteins. The Chemistry of Digestion, the Circulation, and the Excreto. The ... and that pepsin does not attack the CO-NH links in proteins. Textbook of Biochemistry, being the first concise and ...
S-palmitoylation can also modulate protein-protein interactions of SLC46A3 by changing the affinity of the protein for lipid ... As an MFS protein, SLC46A3 is a membrane transporter, mainly involved in the movement of substrates across the lipid bilayer. ... The protein contains a C-(X)2-C motif (CLLC), which is mostly present in metal-binding proteins and oxidoreductases. A sorting- ... Reithmeier RA (1996). "Assembly of proteins into membranes". Biochemistry of Lipids, Lipoproteins and Membranes. New ...
Lipid Res. 42 (6): 998-1002. doi:10.1016/S0022-2275(20)31625-4. PMID 11369809. Weeber EJ, Beffert U, Jones C, Christian JM, ... FE65 is an intracellular protein that binds to the NPXY motif of ApoER2 and plays a role in linking other proteins, such as ... ApoE binding leads to the cleavage of ApoER2 into secreted proteins by the actions of the plasma membrane protein gamma ... Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein ...
He pioneered the use of time-resolved biochemical and biophysical methods to study proteinlipid and proteinprotein ... "Exocytotic fusion pores are composed of both lipids and proteins". Nature Structural & Molecular Biology. 23 (1): 67-73. doi: ... Dong, M.; Yeh, F.; Tepp, W. H.; Dean, C.; Johnson, E. A.; Janz, R.; Chapman, E. R. (2006). "SV2 is the protein receptor for ... this approach to make numerous crucial contributions concerning the mechanism by which proteins catalyze the merger of lipid ...
Lipid uptake. Lipids are broken down by pancreatic lipase aided by bile, and then diffuse into the enterocytes. Smaller lipids ... These include broken down proteins, fats, and sugars, as well as water, electrolytes, vitamins, and bile salts. Enterocytes ... Bile that was released and not used in emulsification of lipids are reabsorbed in the ileum. Also known as the enterohepatic ... Peptidases in the glycocalyx cleave proteins to amino acids or small peptides. Enteropeptidase (also known as enterokinase) is ...
In particular, the values of Ka and Kb affect the ability of proteins and small molecules to insert into the bilayer. Bilayer ... Lipid bilayer mechanics is the study of the physical material properties of lipid bilayers, classifying bilayer behavior with ... Only certain classes of lipids can form bilayers. Two factors primarily govern whether a lipid will form a bilayer or not: ... "On the Computational Modeling of Lipid Bilayers Using Thin-Shell Theory". The Role of Mechanics in the Study of Lipid Bilayers ...
These lipoproteins shield the lipids from water by encapsulating them within a coating of polar lipids and proteins. ... Phospholipid transfer protein (PLTP) Palate, lung and nasal epithelium carcinoma-associated protein (PLUNC) These proteins ... Cholesteryl ester transfer protein (CETP) is a glycoprotein that facilitates the transfer of lipids (cholesteryl esters and ... Protein domains, Protein families, Peripheral membrane proteins, Water-soluble transporters). ...
... but lack lipids and proteins. Lipids can be synthesized from carbohydrates; however, proteins require nitrogen, which is not ... While N. deltocephalinicola has the smallest number of nucleotides, it has more protein-coding genes (137) than some bacteria. ...
1] - Lipid microdomain formation. [2] - Lipid microdomain clustering. [3] - Lipid microdomain signaling. SCIMP protein (Commons ... Wikimedia Commons has media related to Lipids. Biochemistry Essential fatty acid Lipid raft PIP2 domain Lipid signaling ... Lipid microdomains are formed when lipids undergo lateral phase separations yielding stable coexisting lamellar domains. These ... The question of whether such lipid microdomains observed in model lipid systems also exist in biomembranes had motivated ...
... and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence ... First, there is a fast initial binding to the protein and then a subsequent ligation to the heme iron. In the first step of the ... The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of ... The human thromboxane A (TXA) synthase is a 60 kDa cytochrome P450 protein with 533 amino acids and a heme prosthetic group. ...