... leading to a reduction in carbohydrate metabolism in vitro. In a study in Zucker rats, which are genetically predisposed to ... Laboratory and animal studies of HCA have produced results that indicate a potential for modulation of lipid metabolism. ... "High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly ... hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days". Mol. Cell. ...
Caron A, Richard D, Laplante M (2015). "The Roles of mTOR Complexes in Lipid Metabolism". Annual Review of Nutrition. 35: 321- ... July 2016). "Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing ... The metabolism of HMB is catalyzed by an uncharacterized enzyme which converts it to β-hydroxy β-methylbutyryl-CoA (HMB-CoA). ... Leucine metabolism occurs in many tissues in the human body; however, most dietary leucine is metabolized within the liver, ...
Zucker diabetic fatty rats by NMR analysis of plasma glucose". American Journal of Physiology. Endocrinology and Metabolism. ... of Acetyl-CoA Carboxylase 1 in β-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism". The ... "The involvement of pyruvate cycling in the metabolism of aspartate and glycerate by the perfused rat kidney". The Biochemical ... "Role of excess glycogenolysis in fasting hyperglycemia among pre-diabetic and diabetic Zucker (fa/fa) rats". Diabetes. 56 (3): ...
Smoller, JW; Truett, GE; Hirsch, J; Leibel, RL (1993). "A molecular genetic method for genotyping fatty (fa/fa) rats". Am J ... Smoller, JW; Truett, GE; Hirsch, J; Leibel, RL (1993). "The Zucker fatty (fa) gene is not a mutation of corticotropin-releasing ... Kolata, Gina (9 March 1995). "Metabolism Found to Adjust For a Body's Natural Weight". The New York Times. Parker-Pope, Tara ( ... J Lipid Res. 31 (8): 1423-31. doi:10.1016/S0022-2275(20)42613-6. PMID 2280183. Leibel, RL; Forse, RA; Hirsch, J (1989). " ...
Lipids and Lipid Metabolism. 1391 (1): 7-12. doi:10.1016/s0005-2760(97)00214-2. PMID 9518531. McDonnell, M; Davis Jr, W; Li, H ... "Impaired arachidonic acid-mediated dilation of small mesenteric arteries in Zucker diabetic fatty rats". AJP: Heart and ... Lipids and Lipid Metabolism. 1166 (2-3): 258-63. doi:10.1016/0005-2760(93)90106-j. PMID 8443245. Schneider, C; Boeglin, W. E.; ... Lipids and Lipid Metabolism. 1300 (3): 240-6. doi:10.1016/0005-2760(96)00003-3. PMID 8679690. Cabral, M; Martín-Venegas, R; ...
... improves insulin tolerance but not glucose tolerance in obese Zucker rats". Biomedicine & Pharmacotherapy. 64 (9): 647-51. doi: ... Li H, Liu Y, Xiao J, Huang J, Zhang Y (May 2023). "Preclinical pharmacokinetics and metabolism study of SCO-267, a GPR40 full ... Other Lipid Mediators. 89 (3-4): 82-8. doi:10.1016/j.prostaglandins.2009.05.003. PMID 19460454. Al Mahri S, Malik SS, Al ... 2) The FFAR1 agonist SCO-267 reduced the food intake and body weights in diet-induced obese rats, in rats made diabetic by ...
... and Zucker fatty (fa/fa) rats (Zucker rat) display similar obesity phenotypes. Work on characterizing rodent obesity syndromes ... The brain contains high concentrations of lipids than any other organ in the body with the most prominent type being ... Individuals with eating disorders such as bulimia and anorexia show lower neural metabolism of glucose, possibly due to neural ... Sham-feeding rat models have been used to present the defect in the satiety mechanisms in BN due to vomiting or purging after ...
As a crossroad between carbohydrate and lipid metabolism, pyruvate carboxylase expression in gluconeogenic tissues, adipose ... "Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats ... In rats and mice, alteration of nutrition status has been shown to affect hepatic PC activity. Fasting promotes hepatic glucose ... In type 2 diabetic rats, chronic exposure of β-cells to glucose due to peripheral insulin resistance results in decreased PC ...
Tocco-Bradley, R.; Kluger, M. J.; Kauffman, C. A. (1985). "Effect of age on fever and acute-phase response of rats to endotoxin ... When internal resources are limited (such as in winter), and the ability to afford high expenditure on increased metabolism is ... Prendergast, B. J.; Freeman, D. A.; Zucker, I.; Nelson, R. J. (2002). "Periodic arousal from hibernation is necessary for ... proteins and lipids, and result in cell senescence and death. A cost exists in creating or obtaining these antioxidants. This ...
... and its expression is reduced in high-fat diet fed mice and Zucker fatty rats. In heart, the embryonic combined MFN1/MFN2 ... In turn, MFN2 down-regulation activates JNK pathway, favouring the formation of lipid intermediates that lead to insulin ... May 2003). "Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory ... Cell Metabolism. 17 (4): 491-506. doi:10.1016/j.cmet.2013.03.002. PMC 5967396. PMID 23562075. PDB: 6JFL​; Li YJ, Cao YL, Feng ...
The carbon metabolism of cyanobacteria include the incomplete Krebs cycle, the pentose phosphate pathway, and glycolysis. There ... Kettler GC, Martiny AC, Huang K, Zucker J, Coleman ML, Rodrigue S, et al. (December 2007). "Patterns and implications of gene ... They are not bounded by lipid membranes, but by a protein sheath. Some cyanobacteria can fix atmospheric nitrogen in anaerobic ... Cyanobacteria's photosynthetic output of sugar and oxygen has been demonstrated to have therapeutic value in rats with heart ...
"Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis". Science Translational ... Zucker, Catherine; Goodman, Alyssa A.; Alves, João; Bialy, Shmuel; Foley, Michael; Speagle, Joshua S.; Großschedl, Josefa; ... "Forget mammoths, study shows how to resurrect Christmas Island rats". phys.org. Retrieved 19 April 2022. Lin, Jianqing; Duchêne ... "Calorie restriction rewires metabolism, immunity for longer health span". Science Daily. 10 February 2022. Retrieved 23 ...
Obese Zucker rats have high levels of lipids and cholesterol in their bloodstream, are resistant to insulin without being ... Thermoregulation in the rat tail has been used to study metabolism. A "strain", in reference to rodents, is a group in which ... Zucker, pioneer researchers in the study of the genetics of obesity. There are two types of Zucker rat: a lean Zucker rat, ... Zucker rat or Zucker diabetic fatty rat (ZDF rat), which is actually a recessive trait (fa/fa) of the leptin receptor, capable ...
... and is essential for hepatic lipid metabolism under starvation. Nitric oxide is a potential therapeutic intervention in acute ... "Cannabinoid/agonist WIN 55,212-2 reduces cardiac ischaemia-reperfusion injury in Zucker diabetic fatty rats: role of CB2 ... which produces lung tissue-damaging superoxide and hinders NOS metabolism. This vasodilation does not decrease the volume of ... "Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-κB activation in rat ...
Experiments with rats showed that the feeding of sucrose led to impaired glucose tolerance (results with human subjects were ... Der Zucker-Report". Hoffmann und Campe. "Az Edes-vezdes Cukor". Tenyek es Tevhitek. Retrieved 22 January 2019. "Puro, bianco ma ... Fructose appears to be responsible for most of the metabolic risks, including high production of lipids, increased ... had shown that their metabolism is significantly different. The need for carbohydrate as a component of the diet can be ...
"Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats". European Journal of ... Carnitine Mildronate Carnitine biosynthesis Beta Oxidation Fatty acid metabolism Stevens rearrangement GRCh38: Ensembl release ... Molecular and Cell Biology of Lipids. 1441 (1): 85-92. doi:10.1016/s1388-1981(99)00135-3. PMID 10526231. Rigault C, Le Borgne F ... Galland S, Le Borgne F, Guyonnet D, Clouet P, Demarquoy J (Jan 1998). "Purification and characterization of the rat liver gamma ...