... (/ˈlaɪpeɪs, ˈlaɪpeɪz/ LY-payss, LY-payz) is a family of enzymes that catalyzes the hydrolysis of fats. Some lipases ... Other lipases include LIPH, LIPI, LIPJ, LIPK, LIPM, LIPN, MGLL, DAGLA, DAGLB, and CEL. In the commercial sphere, lipases are ... Lipases are generally animal sourced, but can also be sourced microbially[citation needed]. Blood tests for lipase may be used ... Measured serum lipase values may vary depending on the method of analysis.[citation needed] Lipase assist in the breakdown of ...
It has a pH optimum of 3-6. Gastric lipase, together with lingual lipase, comprise the two acidic lipases. These lipases, ... This leaves the acidic lipases less efficient than alkaline lipases. Gastric lipase is a polypeptide of 371 residues in length ... with gastric lipase contributing the most of the two acidic lipases. In neonates, acidic lipases are much more important, ... Gastric lipase, also known as LIPF, is an enzymatic protein that, in humans, is encoded by the LIPF gene. Gastric lipase is an ...
... triglyceride lipase, liver lipase, hepatic monoacylglycerol acyltransferase). Pancreatic lipase Gastric lipase Lingual lipase ... meito Sangyo OF lipase, hepatic lipase, lipazin, post-heparin plasma protamine-resistant lipase, salt-resistant post-heparin ... This family was also called class 3 lipases as they are only distantly related to other lipase families. DAGLA; DAGLB; ... The enzyme triacylglycerol lipase (also triglyceride lipase, EC 3.1.1.3;systematic name triacylglycerol acylhydrolase) ...
... are substances used to reduce the activity of lipases found in the intestine. Lipases are secreted by the ... Lipase inhibitors covalently bond to the active serine site on lipases. This covalent bond is strong, meaning the lipase ... Likewise, lipase inhibitors are not absorbed into the bloodstream. Lipase inhibitors bind to lipase enzymes in the intestine, ... Lipase inhibitors can be found naturally in plants and can also be produced as pharmaceutical drugs. Some lipase inhibitors ...
... is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water- ... "Entrez Gene: LPL lipoprotein lipase". Wang H, Eckel RH (2009). "Lipoprotein lipase: from gene to obesity". Am J Physiol ... GeneReviews/NCBI/NIH/UW entry on Familial Lipoprotein Lipase Deficiency Gene therapy for lipoprotein lipase deficiency ... Lipoprotein lipase has been shown to interact with LRP1. It is also a ligand for α2M, GP330, and VLDL receptors. LPL has been ...
... , also known as DAG lipase, DAGL, or DGL, is an enzyme that catalyzes the hydrolysis of diacylglycerol, ... Diacylglycerol lipase uses a Serine-Aspartate-Histidine catalytic triad to hydrolyze the ester bond of an acyl chain from ... Diacylglycerol lipase has been identified as a tunable target in the endocannabinoid system. It has been the subject of ... Diacylglycerol+Lipase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 3.1.1.116 Portal: Biology ( ...
... (HL), also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, ... Hepatic lipase is coded by chromosome 15 and its gene is also often referred to as HTGL or LIPC. Hepatic lipase is expressed ... Hegele RA, Little JA, Connelly PW (August 1991). "Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase ... mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21". Genomics. 1 (2): 138-44. doi:10.1016/0888-7543(87) ...
... (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol ... Monoacylglycerol lipase catalyzes a reaction that uses water molecules to break the glycerol monoesters of long-chain fatty ... Monoacylglycerol+lipases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 3.1.1.23 Monoglyceride ... Monoacylglycerol lipase is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). It converts ...
... , together with gastric lipase, comprise the two acidic lipases. Lingual lipase uses a catalytic triad consisting ... Lingual lipase is a member of a family of digestive enzymes called triacylglycerol lipases, EC 3.1.1.3, that use the catalytic ... of total lipase activity in duodenum. This can be attributed to the fact that lingual lipase has a low pH optimum and can thus ... which can be attributed to low pancreatic lipase activity. Furthermore, milk fat is not a good substrate for pancreatic lipase ...
... is a form of lipase which functions intracellularly, in the lysosomes. The primary function of lysosomal ... Chlorpromazine is an inhibitor of lysosomal lipase. A genome wide survey suggests that lysosomal lipase A (located at ... lysosomal+acid+lipase,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with ... Lysosomal lipases function optimally at an acidic pH which are complementary with the environment found in the lysosomal lumen ...
... (LIPG) is a form of lipase secreted by vascular endothelial cells in tissues with high metabolic rates and ... Endothelial lipase is secreted from vascular endothelial cells, being the only lipase to date. The primary secretion is that of ... Endothelial lipase is a protein that belongs triglyceride lipase category. This protein is encoded by the LIPG gene. ... Unlike the lipases that hydrolyze Triglycerides, endothelial lipase primarily hydrolyzes phospholipids. Due to the hydrolysis ...
"Entrez Gene: LIPE lipase, hormone-sensitive". Kraemer FB, Shen WJ (October 2002). "Hormone-sensitive lipase: control of ... Hormone-sensitive lipase (EC 3.1.1.79, HSL), also previously known as cholesteryl ester hydrolase (CEH), sometimes referred to ... Hormone-Sensitive+Lipase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (CS1 errors: missing ... Although Hormone-Sensitive Lipase (HSL) is able to catalyze hydrolysis of triglycerides and diglycerides, another enzyme found ...
... is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads ... More than 220 mutations in the LPL gene have been found to cause familial lipoprotein lipase deficiency so far.[citation needed ... "Familial lipoprotein lipase deficiency: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 17 April 2019. Burnett, ... Familial lipoprotein lipase deficiency. Retrieved October 15, 2012. {{cite book}}: ,work= ignored (help) Gaudet, D; de Wal, J; ...
These lipases are closely related to each other and to lipoprotein lipase (EC 3.1.1.34), which hydrolyses triglycerides of ... Triglyceride lipases (EC 3.1.1.3) are a family of lipolytic enzymes that hydrolyse ester linkages of triglycerides. Lipases are ... Pancreatic lipase, also known as pancreatic triacylglycerol lipase or steapsin, is an enzyme secreted from the pancreas. As the ... Freie AB, Ferrato F, Carrière F, Lowe ME (2006). "Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase- ...
... occurs when the enzyme lysosomal acid lipase that is needed to break down certain fats that are normally ... In acid lipase disease the lysosomal acid lipase enzyme is either lacking or missing. In both CESD and Wolman's disease there ... "lysosomal acid lipase deficiency , Counsyl". Counsyl. Retrieved 2017-11-08. NINDS. Acid Lipase Disease Information Page (All ... Three rare lipid storage diseases are caused by the deficiency of the enzyme lysosomal acid lipase: Lysosomal acid lipase ...
June 2020). "Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical ... June 2007). "Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell ... June 2007). "Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin- ... Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that ...
Lipase family member N is a protein that in humans is encoded by the LIPN gene. The gene encodes a lipase that is highly ... "Entrez Gene: Lipase family member N". Retrieved 2019-12-02. v t e This article incorporates text from the United States ...
Triacylglycerol lipase can refer to: Triacylglycerol lipase pancreatic lipase gastric lipase lingual lipase This disambiguation ... page lists articles associated with the title Triacylglycerol lipase. If an internal link led you here, you may wish to change ...
National Organization for Rare Disorders (NORD) Article - LYSOSOMAL ACID LIPASE/NIH.gov Article - LYSOSOMAL ACID LIPASE ... Lysosomal acid lipase deficiencies occur when a person has defects (mutations) in both copies of the LIPA gene. Each parent of ... Lysosomal acid lipase deficiency is a genetic disease that is autosomal recessive. It is an inborn error of metabolism that ... Lysosomal acid lipase deficiency (LAL deficiency or LAL-D) is an autosomal recessive inborn error of metabolism that results in ...
... (or BSDL), also known as carboxyl ester lipase (or CEL) is an enzyme produced by the adult pancreas ... "Effect of pancreatic phospholipase A2 and gastric lipase on the action of pancreatic carboxyl ester lipase against lipid ... Bile salt-stimulated lipase (or BSSL) is an equivalent enzyme found within breast milk. BSDL has been found in the pancreatic ... 1991). "Carboxyl ester lipase: a highly polymorphic locus on human chromosome 9qter". Genomics. 10 (2): 425-31. doi:10.1016/ ...
... is a protein that in humans is encoded by the LIPA gene. This gene encodes lipase A, the ... "Entrez Gene: Lipase A, lysosomal acid type". Retrieved 2018-08-22. Riemenschneider M, Mahmoodzadeh S, Eisele T, Klopp N, ... Wang F, Wang W, Wähälä K, Adlercreutz H, Ikonen E, Tikkanen MJ (December 2008). "Role of lysosomal acid lipase in the ... von Trotha KT, Heun R, Schmitz S, Lütjohann D, Maier W, Kölsch H (July 2006). "Influence of lysosomal acid lipase polymorphisms ...
"Physiology of Gastrointestinal Lipolysis and Therapeutical Use of Lipases and Digestive Lipase Inhibitors". Lipases and ... The pancreatic lipase is secreted to the small intestine where it is most active, at pH 7-7,5. Pancreatic lipase hydrolyses ... Gastric- and lingual lipases are the two acidic lipolytic enzymes that origin preduodenal but the gastric lipase is in much ... The pancreatic lipase consists of 465 amino acids. Schematic picture of pancreatic lipase is shown in figure 2. Pancreatic and ...
Osório, N. M.; Dubreucq, E.; Da Fonseca, MM R.; Ferreira-Dias, S. (2009), "Operational Stability of Immobilized Lipase/ ... Enzymes most suitable for this process are esterase; lipase; acylase; those enzymes that facilitate acidolysis reactions, ... Factors Influencing the Choice of Support for Immobilized Lipase.", Enzyme and Microbial Technology, 6 (10): 443-446, doi: ...
An increase in lipase activity has been reported in barley by MacLeod and White (1962), as cited by Chavan and Kadam (1989). ... Barley Lipase". Journal of the Institute of Brewing. 68 (6): 487-495. doi:10.1002/j.2050-0416.1962.tb01894.x. Shipard, Isabell ...
... amylase and lipase. A similar mixture of enzymes is sold as pancrelipase, which contains more active lipase enzyme than does ... Due to this association a maximum dose of 10,000 IU of lipase per kilogram per day is recommended. Though never reported there ... It is composed of amylase, lipase and protease. This mixture is used to treat conditions in which pancreatic secretions are ... "Pancrelipase Amylase; Pancrelipase Lipase; Pancrelipase Protease - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022. ...
Svendsen A (2000). "Lipase protein engineering". Biochim Biophys Acta. 1543 (2): 223-228. doi:10.1016/S0167-4838(00)00239-9. ... Some examples of degradative enzymes: Lipase, which digests lipids, Carbohydrases, which digest carbohydrates (e.g., sugars), ...
The degradation of triacylglycerides by hormone-sensitive lipase produces free fatty acids that are eventually converted to ... Kraemer, Fredric B.; Shen, Wen-Jun (2002). "Hormone-sensitive lipase". Journal of Lipid Research. 43 (10): 1585-1594. doi: ... a condition called ketoacidosis may develop because decreased insulin levels increase the activity of hormone sensitive lipase ...
APOE Lipoprotein lipase deficiency; 238600; LPL Lissencephaly 3; 611603; TUBA1A Lissencephaly syndrome, Norman-Roberts type; ... TP63 Lipase deficiency, combined; 246650; LMF1 Lipodystrophy, congenital generalized, type 1; 608594; AGPAT2 Lipodystrophy, ...
"triacylglycerol lipase - Homo sapiens". BRENDA. Technische Universität Braunschweig. Retrieved 25 May 2015. Tilg H, Moschen AR ... In humans, the butyrate precursor tributyrin, which is naturally present in butter, is metabolized by triacylglycerol lipase ...
... lipases; xylanases; pectinases; chitinases and their metabolites, including: 2-phenylamine; carotenoids; siderophores; cholic ...