Linkage disequilibrium
The level of linkage disequilibrium between A and B can be quantified by the coefficient of linkage disequilibrium D A B {\ ... The coefficient of linkage disequilibrium D {\displaystyle D} is not always a convenient measure of linkage disequilibrium ... In spite of its name, linkage disequilibrium may exist between alleles at different loci without any genetic linkage between ... and genetic linkage. As a result, the pattern of linkage disequilibrium in a genome is a powerful signal of the population ...
Linkage disequilibrium score regression
Here, the "linkage disequilibrium score" for a SNP "is the sum of LD r2 measured with all other SNPs". LDSC can be used to ... In statistical genetics, linkage disequilibrium score regression (LDSR or LDSC) is a technique that aims to quantify the ... The approach involves using regression analysis to examine the relationship between linkage disequilibrium scores and the test ... "Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood". The ...
PLINK (genetic tool-set)
Linkage disequilibrium (LD) calculation; Identity by descent (IBD) and identity by state (IBS) matrix calculation; population ... a toolset for whole-genome association and population-based linkage analysis". American Journal of Human Genetics. 81 (3): 559- ...
Tomoko Ohta
Slatkin, Montgomery (2008). "Linkage disequilibrium - understanding the evolutionary past and mapping the medical future". ... Ohta, T. (May 1982). "Linkage disequilibrium with the island model". Genetics. 101 (1): 139-155. doi:10.1093/genetics/101.1.139 ...
Detlef Weigel
"Recombination and linkage disequilibrium in Arabidopsis thaliana". Nat. Genet. 39 (9): 1151-1155. doi:10.1038/ng2115. PMID ...
Race and genetics
May 2005). "Linkage disequilibrium patterns vary substantially among populations". European Journal of Human Genetics. 13 (5): ...
Biological network
Another measure of correlation is linkage disequilibrium. Linkage disequilibrium describes the non-random association of ... Linkage Disequilibrium - ISOGG Wiki, International Society of Genetic Genealogy, https://isogg.org/wiki/Linkage_disequilibrium ... Two nodes are connected by an edge if their linkage disequilibrium is greater than the average across all 81 genomic windows. ... It then pulls nodes together using linear interpolation by their linkage as a percentage. The figure illustrates strong ...
Genetic isolate
The presence of disequilibrium linkage in disease alleles enhances linkage analysis and aids in determining the precise ... Language isolate Linkage disequilibrium Tóth, Endre Gy; Tremblay, Francine; Housset, Johann M.; Bergeron, Yves; Carcaillet, ... Besides that, most cases are caused by the same mutation, and diseased alleles expose the linkage of disequilibrium with ... and families with numerous sick members become common enough to be employed in locus-identifying linkage analyses. ...
Hannu Toivonen (professor)
"Data mining applied to linkage disequilibrium mapping". Google Scholar. Retrieved 8 November 2016. "Hannu Toivonen". Google ...
Drosophila subobscura
Studies on linkage disequilibrium in four natural populations. Genetics. 1979;93:497-523". Genetics. 93 (2): 497-523. doi: ... allowing for the finding of more than 600 different linkages and genetic markers, which encompass a majority of the euchromatic ...
Mitochondrion
Awadalla P, Eyre-Walker A, Smith JM (December 1999). "Linkage disequilibrium and recombination in hominid mitochondrial DNA". ...
Martin Kreitman
"The extent of linkage disequilibrium in Arabidopsis thaliana". Nature Genetics. 30 (2): 190-193. doi:10.1038/ng813. PMID ...
Paternal mtDNA transmission
Awadalla P, Eyre-Walker A, Smith JM (December 1999). "Linkage disequilibrium and recombination in hominid mitochondrial DNA". ...
Transmembrane protein 151A
TMEM151A is in linkage disequilibrium with gene CACNA1C; CACNA1C mutation is significantly associated with bipolar disorder p ...
Complete linkage
"Asymmetric linkage disequilibrium: Tools for assessing multiallelic LD". Human Immunology. 77 (3): 288-94. doi:10.1016/j.humimm ... Linkage mapping can also be useful in determining the inheritance patterns of traits such as psychological disease. Linkage ... "Mapping quantitative trait loci using linkage disequilibrium: marker- versus trait-based methods". Behavior Genetics. 35 (2): ... Being able to determine linkage between genes can also have major economic benefits. Learning about linkage of traits in sugar ...
Haplotype block
According to the haplotype-block model, such blocks should show high levels of linkage disequilibrium and be separated from one ... Wall, Jeffrey D.; Pritchard, Jonathan K. (1 August 2003). "Haplotype blocks and linkage disequilibrium in the human genome". ... one based on whether a given genomic sequence displays higher linkage disequilibrium than a predetermined threshold, and one ...
Finnish heritage disease
Linkage and linkage disequilibrium in the Finnish disease heritage]". Duodecim; Lääketieteellinen Aikakauskirja (in Finnish). ...
Locus heterogeneity
Wang D, Huang J (May 2006). "Detecting linkage disequilibrium in the presence of locus heterogeneity". Annals of Human Genetics ... of causal genes for diseases impacted by locus heterogeneity is difficult with genetic analysis methods such as linkage ...
Matthew Stephens (statistician)
He then went on to develop the influential Li and Stephens model as an efficient model for linkage disequilibrium. Stephens was ... Song, Yun S. (1 July 2016). "Na Li and Matthew Stephens on Modeling Linkage Disequilibrium". Genetics. 203 (3): 1005-1006. doi: ...
Non-coding DNA
The association is referred to as tight linkage disequilibrium.) About 12% of these polymorphisms are found in coding regions; ... The association establishes a linkage that helps map the DNA region responsible for the trait but it doesn't necessarily ... Genome-wide association studies (GWAS) identify linkages between alleles and observable traits such as phenotypes and diseases ...
Eukaryote hybrid genome
Methods based on linkage disequilibrium decay or methods inferring ancestry tracts can be used to date recent admixture or ... It is also possible to gain more power by combining information from linkage disequilibrium decay patterns and the allele ... "Inferring admixture histories of human populations using linkage disequilibrium". Genetics. 193 (4): 1233-54. doi:10.1534/ ... and linkage among incompatibilities to each other and to adaptive variants. Extrinsic ecological barriers against parent ...
Sagiv Shifman
Shifman, Sagiv; Kuypers, Jane; Kokoris, Mark; Yakir, Benjamin; Darvasi, Ariel (2003-04-01). "Linkage disequilibrium patterns of ...
Richard Lewontin
Lewontin later introduced the D' measure of linkage disequilibrium. In 1966, he and J. L. Hubby published a paper that studied ... Lewontin, R. C. (1964). "The interaction of selection and linkage. I. General considerations; heterotic models". Genetics 49: ...
Polygenic score
SNPs that are physically close to each other are more likely to be in linkage disequilibrium, meaning they are often inherited ... October 2015). "Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores". American Journal of Human ... One of the most popular modern Bayesian methods uses "linkage disequilibrium prediction" (LDpred for short). Many other ... higher degrees of linkage disequilibrium among individuals, and a higher average genetic relatedness among individuals within a ...
Host microbe interactions in Caenorhabditis elegans
Barrière A, Félix MA (2007). "Temporal dynamics and linkage disequilibrium in natural Caenorhabditis elegans populations". ...
GABRB3
Scapoli L, Martinelli M, Pezzetti F, Carinci F, Bodo M, Tognon M, Carinci P (January 2002). "Linkage disequilibrium between ... "Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers". American Journal of Human Genetics. 62 (5): 1077- ... "Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13". Journal of ...
Homologous recombination
COVID-19 pandemic on Diamond Princess
Linkage disequilibrium analysis confirmed that RNA recombination with the 11083G > T mutation also contributed to the increase ...
Transmission disequilibrium test
McGinnis RE, Ewens WJ, Spielman RS (1995). "The TDT reveals linkage and linkage disequilibrium in a rare disease". Genet ... Spielman RS, Ewens WJ (Nov 1996). "The TDT and other family-based tests for linkage disequilibrium and association". Am J Hum ... Beagle Spielman RS, McGinnis RE, Ewens WJ (Mar 1993). "Transmission test for linkage disequilibrium: the insulin gene region ... The transmission disequilibrium test (TDT) was proposed by Spielman, McGinnis and Ewens (1993) as a family-based association ...
Dopamine transporter
"Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder". American Journal of Medical ...