Generally, the common names of ligases include the word "ligase", such as in DNA ligase, an enzyme commonly used in molecular ... such as DNA ligase EC 6.6 includes ligases used to form nitrogen-metal bonds, as in the chelatases Some ligases associate with ... Ligases can be further classified into six subclasses: EC 6.1 includes ligases used to form carbon-oxygen bonds EC 6.2 includes ... Commonly, the two terms are used interchangeably and are both used to describe ligases. Ligases are classified as EC 6 in the ...

Stage two involves four key Mur ligase enzymes: MurC, MurD, MurE (EC) and MurF (EC). These four Mur ligases are responsible for ... 6-diaminopimelate ligase (MurE), and UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (MurF). This entry also includes ... All four Mur ligases are topologically similar to one another, even though they display low sequence identity. They are each ... The conserved sequence motifs found in the four Mur enzymes also map to other members of the Mur ligase family, including ...

Other examples of RNA ligases include the L1 ligase (Robertson and Ellington), the R3C ligase (Joyce), the DSL ligase (Inoue). ... The most active ligase known to date is the Class I ligase, isolated from random sequence (work of David Bartel, while in the ... Ligase ribozymes may have been part of such a pre-biotic RNA world. In order to copy RNA, fragments or monomers (individual ... The RNA Ligase ribozyme was the first of several types of synthetic ribozymes produced by in vitro evolution and selection ...

... is used in both DNA repair and DNA replication (see Mammalian ligases). In addition, DNA ligase has extensive use in ... units of ligase. The optimal incubation temperature for T4 DNA ligase is 16 °C. Bacteriophage T4 ligase mutants have increased ... it has been recognized as another DNA ligase and it is the reason for the unusual nomenclature of DNA ligases. DNA ligase from ... coli DNA ligase The DNA ligase from bacteriophage T4 (a bacteriophage that infects Escherichia coli bacteria). The T4 ligase is ...

The E3 ligases are classified into four families: HECT, RING-finger, U-box, and PHD-finger. The RING-finger E3 ligases are the ... A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has ... Quips article describing E3 Ligase function Archived 2012-11-30 at the Wayback Machine at PDBe Ubiquitin-Protein+Ligases at the ... The human genome encodes over 600 putative E3 ligases, allowing for tremendous diversity in substrates. The ubiquitin ligase is ...

Heme+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 4.99.1). ... Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+: ... ferriprotoporphyrin IX ligase (β-hematin-forming). This enzyme catalyses the following reaction: 2 ferriprotoporphyrin IX ⇌ {\ ...

Other names in common use include phenylacetyl-CoA ligase, PA-CoA ligase, and phenylacetyl-CoA ligase (AMP-forming). This ... This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The ... In enzymology, a phenylacetate-CoA ligase is an enzyme (EC 6.2.1.30) that catalyzes the chemical reaction ATP + phenylacetate ... "Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the ...

Pyrrolysine---tRNAPyl+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 6.1.1 ... Pyrrolysine-tRNAPyl ligase (EC 6.1.1.26, PylS, pyrrolysyl-tRNA synthetase) is an enzyme with systematic name L-pyrrolysine: ... tRNAPyl ligase (AMP-forming). This enzyme catalyses the following chemical reaction ATP + L-pyrrolysine + tRNAPyl ⇌ {\ ...

... ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (AMP-forming). Other names in ... In enzymology, an aspartate-ammonia ligase (EC 6.3.1.1) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ...

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases ( ... In enzymology, a diphthine-ammonia ligase (EC 6.3.1.14, diphthamide synthase, diphthamide synthetase) is an enzyme that ... peptide synthases). The systematic name of this enzyme class is diphthine:ammonia ligase (ADP-forming). Other names in common ...

... (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl ... THCA-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta- ... Cholate---CoA+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 6.2.1). ... Wheeler JB, Shaw DR, Barnes S (December 1997). "Purification and characterization of a rat liver bile acid coenzyme A ligase ...

... (EC 2.7.7.63, LplA, lipoate protein ligase, lipoate-protein ligase A, LPL, LPL-B) is an enzyme with ... Lipoate---protein+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 2.7.7). ... Kim DJ, Kim KH, Lee HH, Lee SJ, Ha JY, Yoon HJ, Suh SW (November 2005). "Crystal structure of lipoate-protein ligase A bound ... Green DE, Morris TW, Green J, Cronan JE, Guest JR (August 1995). "Purification and properties of the lipoate protein ligase of ...

In enzymology, an aspartate-tRNA ligase (EC 6.1.1.12) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... The systematic name of this enzyme class is L-aspartate:tRNAAsp ligase (AMP-forming). Other names in common use include ... Portal: Biology v t e (EC 6.1.1, Enzymes of known structure, All stub articles, Ligase stubs). ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ...

The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming). Drake JC, Baram J, Allegra CJ (1990). " ... In enzymology, a formate-dihydrofolate ligase (EC 6.3.4.17) is an enzyme that catalyzes the chemical reaction ATP + formate + ... Portal: Biology v t e (EC 6.3.4, Enzymes of unknown structure, All stub articles, Ligase stubs). ... This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. ...

... , also known as xenobiotic/medium-chain fatty acid-ligase (XM-ligase), is an enzyme (EC 6.2.1.2) that ... This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme ... 3-hydroxybutyryl CoA ligase, xenobiotic/medium-chain fatty acid ligase, and short-chain acyl-CoA synthetase. ACSM1 ACSM2A ... This reaction is catalyzed by the HXM-A and HXM-B medium-chain acid:CoA ligases and requires energy in the form of ATP. ... The ...

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ... In enzymology, a tryptophan-tRNA ligase (EC 6.1.1.2) is an enzyme that catalyzes the chemical reaction ATP + L-tryptophan + ... The systematic name of this enzyme class is L-tryptophan:tRNATrp ligase (AMP-forming). Other names in common use include ... Portal: Biology v t e (EC 6.1.1, Enzymes of known structure, All stub articles, Ligase stubs). ...

DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, ... DNA ligase (NAD+) (EC 6.5.1.2, polydeoxyribonucleotide synthase (NAD+), polynucleotide ligase (NAD+), DNA repair enzyme, DNA ... DNA ligase Zimmerman SB, Little JW, Oshinsky CK, Gellert M (June 1967). "Enzymatic joining of DNA strands: a novel reaction of ... ligase (AMP-forming, NMN-forming). This enzyme catalyses the following chemical reaction NAD+ + (deoxyribonucleotide)n + ( ...

The systematic name of this enzyme class is L-alanine:tRNAAla ligase (AMP-forming). Other names in common use include alanyl- ... In enzymology, an alanine-tRNA ligase (EC 6.1.1.7) is an enzyme that catalyzes the chemical reaction ATP + L-alanine + tRNAAla ... Portal: Biology v t e (EC 6.1.1, Enzymes of known structure, All stub articles, Ligase stubs). ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ...

2-aminobenzoate-CoA ligase, 2-aminobenzoate-coenzyme A ligase, and 2-aminobenzoate coenzyme A ligase. This enzyme participates ... This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The ... In enzymology, an anthranilate-CoA ligase (EC 6.2.1.32) is an enzyme that catalyzes the chemical reaction ATP + anthranilate + ... Portal: Biology v t e (EC 6.2.1, Enzymes of unknown structure, Anthranilates, All stub articles, Ligase stubs). ...

The systematic name of this enzyme class is L-valine:tRNAVal ligase (AMP-forming). Other names in common use include valyl-tRNA ... In enzymology, a valine-tRNA ligase (EC 6.1.1.9) is an enzyme that catalyzes the chemical reaction ATP + L-valine + tRNAVal ... Portal: Biology v t e (EC 6.1.1, Enzymes of known structure, All stub articles, Ligase stubs). ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ...

... belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA ... In enzymology, a histidine-tRNA ligase (EC 6.1.1.21) is an enzyme that catalyzes the chemical reaction ATP + L-histidine + ... The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include ... Portal: Biology v t e (EC 6.1.1, Enzymes of known structure, All stub articles, Ligase stubs). ...

In enzymology, a methionine-tRNA ligase (EC 6.1.1.10) is an enzyme that catalyzes the chemical reaction ATP + L-methionine + ... The systematic name of this enzyme class is L-methionine:tRNAMet ligase (AMP-forming). Other names in common use include ... During oxidative stress, methionine-tRNA ligase might be phosphorylated, which results in promiscuity of this enzyme, where it ... Portal: Biology v t e (EC 6.1.1, Enzymes of known structure, All stub articles, Ligase stubs). ...

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The ... In enzymology, a citrate-CoA ligase (EC 6.2.1.18) is an enzyme that catalyzes the chemical reaction ATP + citrate + CoA ⇌ {\ ... CoA ligase, and citrate thiokinase. This enzyme participates in citric acid cycle. Lill U, Schreil A, Eggerer H (1982). " ... systematic name of this enzyme class is citrate:CoA ligase (ADP-forming). Other names in common use include citryl-CoA ...

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The ... In enzymology, a propionate-CoA ligase (EC 6.2.1.17) is an enzyme that catalyzes the chemical reaction ATP + propanoate + CoA ... Portal: Biology v t e (EC 6.2.1, Enzymes of unknown structure, All stub articles, Ligase stubs). ... systematic name of this enzyme class is propanoate:CoA ligase (AMP-forming). This enzyme is also called propionyl-CoA ...

In enzymology, an isoleucine-tRNA ligase (EC 6.1.1.5) is an enzyme that catalyzes the chemical reaction ATP + L-isoleucine + ... The systematic name of this enzyme class is L-isoleucine:tRNAIle ligase (AMP-forming). Other names in common use include ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ... isoleucine-transfer RNA ligase, isoleucine-tRNA synthetase, and isoleucine translase. This enzyme participates in valine, ...

In enzymology, a glutamate-tRNA ligase (EC 6.1.1.17) is an enzyme that catalyzes the chemical reaction ATP + L-glutamate + ... The systematic name of this enzyme class is L-glutamate:tRNAGlu ligase (AMP-forming). Other names in common use include ... Portal: Biology v t e (EC 6.1.1, Enzymes of known structure, All stub articles, Ligase stubs). ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ...

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases ( ... In enzymology, an ubiquitin-calmodulin ligase (EC 6.3.2.21) is an enzyme that catalyzes the chemical reaction n ATP + ... peptide synthases). The systematic name of this enzyme class is calmodulin:ubiquitin ligase (AMP-forming). Other names in ...

The systematic name of this enzyme class is L-arginine:tRNAArg ligase (AMP-forming). Other names in common use include arginyl- ... In enzymology, an arginine-tRNA ligase (EC 6.1.1.19) is an enzyme that catalyzes the chemical reaction ATP + L-arginine + ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ...

RNA ligase, polyribonucleotide ligase, and ribonucleic ligase. As of late 2007, two structures have been solved for this class ... In enzymology, an RNA ligase (ATP) (EC 6.5.1.3) is an enzyme that catalyzes the chemical reaction ATP + (ribonucleotide)n + ( ... The systematic name of this enzyme class is poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming). Other names in ... Silber R, Malathi VG, Hurwitz J (1972). "Purification and properties of bacteriophage T4-induced RNA ligase". Proc. Natl. Acad ...

The systematic name of this enzyme class is L-serine:tRNASer ligase (AMP-forming). Other names in common use include seryl-tRNA ... In enzymology, a serine-tRNA ligase (EC 6.1.1.11) is an enzyme that catalyzes the chemical reaction ATP + L-serine + tRNASer ... Portal: Biology v t e (EC 6.1.1, Enzymes of known structure, All stub articles, Ligase stubs). ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ...

The systematic name of this enzyme class is phytanate:CoA ligase (AMP-forming). This enzyme is also called phytanoyl-CoA ligase ... This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. ... In enzymology, a phytanate-CoA ligase (EC 6.2.1.24) is an enzyme that catalyzes the chemical reaction ATP + phytanate + CoA ... Portal: Biology v t e (EC 6.2.1, Enzymes of unknown structure, All stub articles, Ligase stubs). ...

The ligase chain reaction (LCR) is an amplification process that differs from PCR in that it involves a thermostable ligase to ... A mismatch at the 3′ end of the discriminating primer prevents the DNA ligase from joining the two fragments together. By using ... Gene amplification Wiedmann, M; Wilson, WJ; Czajka, J; Luo, J; Barany, F; Batt, CA (Feb 1994). "Ligase chain reaction (LCR)-- ... Barany, F (Jan 1991). "Genetic disease detection and DNA amplification using cloned thermostable ligase". Proc Natl Acad Sci U ...