Ligands[edit]. Ligands containing a chiral 2-oxazoline ring are used in asymmetric catalysis due to their facile synthesis, ... Trisoxazolinylborate ligands. Polymers[edit]. 2-Oxazolines, such as 2-ethyl-2-oxazoline, can undergo living cationic ring- ... McManus, Helen A.; Guiry, Patrick J. (2004). "Recent Developments in the Application of Oxazoline-Containing Ligands in ... Hargaden, Gráinne C.; Guiry, Patrick J. (2009). "Recent Applications of Oxazoline-Containing Ligands in Asymmetric Catalysis". ...
Phosphine ligands are usually "spectator" rather than "actor" ligands. They generally do not participate in reactions, except ... also function as ligands. Such ligands are less basic and have small cone angles. These complexes are susceptible to ... 1973). Transition Metal Complexes of Phosphorus, Arsenic, and Antimony Ligands. J. Wiley. ISBN 0-470-58117-4. .. . ... Phosphine ligands are also π-acceptors. Their π-acidity arises from overlap of P-C σ* anti-bonding orbitals with filled metal ...
Ligand[edit]. The primary ligand for P-selectin is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all ... However, PSGL-1 is not specific for P-selectin, as it can also function as a ligand for both E- and L-selectin.[17] ... Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase- ... Vestweber D, Blanks JE (January 1999). "Mechanisms that regulate the function of the selectins and their ligands". Physiol. Rev ...
Binding for ligands other than oxygen[edit]. Besides the oxygen ligand, which binds to hemoglobin in a cooperative manner, ... hemoglobin ligands also include competitive inhibitors such as carbon monoxide (CO) and allosteric ligands such as carbon ... A sixth position can reversibly bind oxygen by a coordinate covalent bond,[39] completing the octahedral group of six ligands. ... and fungi all have hemoglobin-like proteins whose known and predicted roles include the reversible binding of gaseous ligands. ...
Depending on its subunit composition, its ligands are glutamate and glycine (or D-serine). However, the binding of the ligands ... The extracellular domain contains two globular structures: a modulatory domain and a ligand-binding domain. GluN1 subunits bind ... While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel ... The allosteric site, which modulates receptor function when bound to a ligand, is not occupied. NMDARs require the binding of ...
Ligands[edit]. A number of ligands for FXR are known, of both natural and synthetic origin.[11][12][13] ... ligand-dependent nuclear receptor binding. • transcription factor activity, RNA polymerase II distal enhancer sequence-specific ... Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR ... RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. • bile acid receptor activity ...
Ligands[edit]. Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum ...
Ligands[edit]. GPER binds estradiol though not other endogenous estrogens, such as estrone or estriol, nor for other endogenous ...
Selective ligands[edit]. A number of selective ligands are available for NK3. NK3 receptor antagonists are being investigated ... Neurokinin B - endogenous peptide ligand, also interacts with other neurokinin receptors but has highest affinity for NK3 ... "Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands". Proceedings ...
The metal to ligand chemical bond is largely ionic. Ligands[edit]. Most organoscandium compounds have at least one ... 2 two allyl ligands are η3 coordinated and one allyl ligand is η1 coordinated. ... Chlorine can be replaced by a host of other ligands for example by an allyl group in reaction with allylmagnesium bromide: ScCp ... Cp2ScX compounds are dimers with X forming a bridging ligand. Dimerization is avoided in presence of coordinating solvent such ...
One of the ligands phenyl-groups can be replaced by propene, and the resulting diphenylpropylphosphine ligand can inhibit the ... Catalyst and ligands[edit]. The triphenylphosphine complexes are under reaction conditions potentially subject to hydrogenation ... Using chiral phosphine ligands, the hydroformylation can be tailored to favor one enantiomer.[11] Thus, for example, ... Bulky ligands exacerbate this steric hindrance. Hence, the mixed carbonyl/phosphine complexes offer a greater selectivity for ...
Many complexes feature coordination bonds between a metal and organic ligands. The organic ligands often bind the metal through ... However, if any of the ligands form a direct M-C bond, then complex is usually considered to be organometallic, e.g., [(C6H6)Ru ... For highly electropositive elements, such as lithium and sodium, the carbon ligand exhibits carbanionic character, but free ... refers to metal-containing compounds lacking direct metal-carbon bonds but which contain organic ligands. Metal β-diketonates, ...
... pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET". Journal of Medicinal ... azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a] ...
Ligands[edit]. Activating ligands[edit]. The following standard prostaglandins have the following relative affinities and ... Inhibiting ligands[edit]. The following compounds are selective receptor antagonists of and thereby inhibit the activation of ... Ligands that activate DP2 stimulate the in vitro chemotaxis (i.e. directed migration) of leukocytes active in mediating ... G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, ...
Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin) ...
Selective Ligands[edit]. Several selective ligands for NK2 are now available, and although most of the compounds developed so ... Bhogal N, Donnelly D, Findlay JB (Nov 1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis ...
Selective ligands[edit]. A range of selective ligands for the GHS-R receptor are now available and are being developed for ... One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the ghrelin ligand ...
Organofluorine ligands in transition metal chemistry[edit]. Organofluorine ligands have long been featured in organometallic ... 5.7 Organofluorine ligands in transition metal chemistry *5.7.1 C-F bond activation ... The organofluorine compounds can serve as a "sigma-donor ligand," as illustrated by the titanium(III) derivative [(C5Me5)2Ti(FC ... In an area where coordination chemistry and materials science overlap, the fluorination of organic ligands is used to tune the ...
Ligands[edit]. Agonists[edit]. *α-MSH - nonselective peptide full agonist. *β-MSH - nonselective peptide full agonist ...
2008). "Novel High-Affinity and Selective Biaromatic 4-Substituted gamma-Hydroxybutyric Acid (GHB) Analogues as GHB Ligands: ... November 2003). "Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but ...
Ligands[edit]. Antagonists. *A-315456[6]. *BMY 7378 (also α2C antagonist)[7] ...
... (abbreviated as en when a ligand) is the organic compound with the formula C2H4(NH2)2. This colorless liquid ... The salen ligands, some of which are used in catalysis, are derived from the condensation of salicylaldehydes and ... Related ligands[edit]. Related derivatives of ethylenediamine include tetramethylethylenediamine (TMEDA) and ... Ethylenediamine is a well-known bidentate chelating ligand for coordination compounds, with the two nitrogen atoms donating ...
Selective Ligands[edit]. The cholecystokinin B receptor responds to a number of ligands. ... Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin) ...
Ligands[edit]. Agonists[edit]. *Ergotamine (vasoconstrictor in migraine). *Oxymetazoline. *Sumatriptan (vasoconstrictor in ...
Ligands[edit]. Until comparatively recently, there were few pharmacological tools for the study of δ receptors. As a ... A showing of selective delta opioid ligands. Blue represents a common phenolic moiety, yellow a basic nitrogen, and red a ... Recent work indicates that exogenous ligands that activate the δ receptors mimic the phenomenon known as ischemic ... In the rat model, introduction of δ active ligands results in significant cardioprotection.[23] ...
Ligands[edit]. Many selective ligands for the CB2 receptor are now available.[48] ... Cannabinoid receptors and their ligands: beyond CB₁ and CB₂". Pharmacological Reviews. 62 (4): 588-631. doi:10.1124/pr. ... Feng W, Song ZH (Apr 2003). "Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the ... Pertwee RG (Apr 2006). "The pharmacology of cannabinoid receptors and their ligands: an overview". International Journal of ...
Systems, receptors and ligands[edit]. This section needs expansion. You can help by adding to it. (July 2019) ... 2009). Ligand-binding assays development, validation, and implementation in the drug development arena. Hoboken, N.J.: John ... The development of the ligand binding assay in 1945 allowed quantification of the binding affinity of drugs at chemical targets ... The major systems studied in pharmacology can be categorised by their ligands and include acetylcholine, adrenaline, glutamate ...
Not every ligand that binds to a receptor also activates that receptor. The following classes of ligands exist:. *(Full) ... Ligands[edit]. The ligands for receptors are as diverse as their receptors. Examples include:[11] ... Ligand-receptor complex. ]. {\displaystyle \left[\mathrm {Ligand} \right]\cdot \left[\mathrm {Receptor} \right]\;\;{\overset {K ... Ligand binding is an equilibrium process. Ligands bind to receptors and dissociate from them according to the law of mass ...
Complexes with simple ligands[edit]. TiCl4 is a Lewis acid as implicated by its tendency to hydrolyze. With the ether THF, TiCl ... TiCl4 reacts exothermically with donor solvents such as THF to give hexacoordinated adducts.[9] Bulkier ligands (L) give ... surrounded by four identical ligands. This configuration leads to highly symmetrical structures, hence the tetrahedral shape of ...
Ligands[edit]. Decay accelerating factor (DAF/CD55), a regulatory protein of the complement cascade, interacts with the first ... Mice lacking CD97 or its ligand CD55 have twice as many granulocytes as wild-type mice possibly due to enhanced granulopoiesis. ... The expression of CD97 on macrophage and the abundant presence of its ligand CD55 on fibroblast-like synovial cells suggest ... "Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". Journal of Neuroimmunology. 132 (1-2 ...