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*  Ligand binding assay
If ligand is unbound, it will have a large depolarization (ligand is free to spin rapidly, rotating the light). If the ligand ... Ligand binding assays (LBA) is an assay, or an analytic procedure, whose procedure or method relies on the binding of ligand ... Many ligand binding assays require a filtration step to separate bound and unbound ligands before screening. A method called ... There are numerous types of ligand binding assays, both radioactive and non-radioactive. As such, ligand binding assays are a ...
*  Protein primary structure
"Normalization of nomenclature for peptide motifs as ligands of modular protein domains". FEBS Letters. 513 (1): 141-144. doi: ...
*  Josiphos ligands
Figure 2: Xyliphos ligand The ligands are also used in non-enantioselective reactions. They have been good ligands in Pd- ... Ligands can also influence the chemoselectivity of the catalyst. The Josiphos ligands, often called privileged ligands, are ... Josiphos ligands were developed in the 1990s by Antonio Togni in studies on ferrocenyl ligands previously discovered by T. ... Diphosphine ligands were prepared with secondary phosphines, they are today known as Josiphos ligands family, which gets the ...
*  Tm ligands
... tripodal ligand topologically similar to the more common Tp ligands, but the two classes of ligands differ in several ways. ... They are examples of scorpionate ligands. Various ligands in this family are known, differing in what substituents are on the ... The TmR anion simulates the environment provided by three facial thiolate ligands but without the 3- charge of a facial ... In coordination chemistry, Tm is an abbreviation for anionic tridentate ligand based on three imidazole-2-thione groups bonded ...
*  Phosphinimide ligands
... , also known as phosphorane iminato ligands, are any of a class of organic compounds of the general ... The phosphinimide ligand is isoelectronic with ligands such as OPR3, [OSiR3]−, [CSiR3]3− and [NSiR3]2−, and often has ... These dimeric complexes yield different M-N bond lengths depending on the ligands present in the rest of the ligand sphere of M ... An alternative to the Cp ligand is the tropinyl ligand. If this is preferable, tropinyl can be added through the substitution ...
*  Dialkylbiaryl phosphine ligands
Today, these ligands are widely used in both academia and industry. All of the Buchwald ligands are air-stable crystalline ... This ligand helps promote the coupling of weak nucleophiles with aryl halides. Notably, this ligand is highly selective for the ... SPhos was first reported in 2004 as an extremely competent ligand in catalyzing Suzuki-Miyaura coupling reactions This ligand ... AlPhos is one of the newest commercially available Dialkylbiaryl phosphine ligands. Reported in 2015, this ligand allows for ...
*  C2-Symmetric ligands
C2-symmetric diene ligand. Both bi- and tridentate bis(oxazoline) ligands are used in organic synthesis The first such ligand ... Such ligands have proven valuable in catalysis and drug design. C2-Symmetric Ligands The C2-symmetric diphosphine DIOP is ... DuPhos ligands are a class of C2-symmetric ligands for asymmetric hydrogenation. Oxaliplatin, containing the C2-symmetric R,R- ... This ligand was used in the industrial production of L-DOPA. C2-symmetric ligands can strongly influence the enantioselectivity ...
*  GDNF family of ligands
The primary ligands for the co-receptors GFRα1, GFRα2, GFRα3, and GFRα4 are GDNF, NRTN, ARTN, and PSPN, respectively. Upon ... However, natural GDNF ligands are of a limited clinical use. As positively charged polypeptides GFLs are unable to penetrate ... GDNF Family Ligands at the US National Library of Medicine Medical Subject Headings (MeSH). ... The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), ...
*  Ligand
... field theory DNA binding ligand Inorganic chemistry Josiphos ligands Ligand dependent pathway Ligand field theory Ligand ... A ligand exchange (also ligand substitution) is a type of chemical reaction in which a ligand in a compound is replaced by ... Example is alkoxy ligands( which is regularly known as X ligand too). L ligands are derived from charge-neutral precursors and ... Binucleating ligands bind two metals. Usually binucleating ligands feature bridging ligands, such as phenoxide, pyrazolate, or ...
*  Pincer ligand
Many tridentate ligands types occupy three contiguous, coplanar coordination sites. The most famous such ligand is terpyridine ... Most pincer ligands contain phosphines. Reactions of metal-pincer complexes are localized at three sites perpendicular to the ... Many pincer ligands also feature nitrogenous donors at the central coordinating group position (see figure), such as pyridines ... In chemistry, a pincer ligand is a type of chelating agent that binds tightly to three adjacent coplanar sites, usually on a ...
*  Ligand efficiency
... ligand lipophilicity index (LLEAT) ligand efficiency dependent lipophilicity (LELP), fit quality scaled ligand efficiency (LE_ ... Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or ... Mathematically, ligand efficiency (LE) can be defined as the ratio of Gibbs free energy (ΔG) to the number of non-hydrogen ... Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal ...
*  Tetradentate ligand
In addition to shape, tetradentate ligands can be classified by the ligating atoms on the ligand. For linear ligands the order ... Tetradentate ligands are common in nature in the form of chlorophyll which has a core ligand called chlorin, and heme with a ... Tetradentate ligands are ligands that bind with four donor atoms to a central atom to form a coordination complex. This number ... A linear tetradetate ligand bound to a metal in tetrahedral coordination can only connect in one way. If the ligand is ...
*  Chiral ligand
This ligand was used in the industrial production of L-DOPA. Many chiral ligands have been prepared. Certain classes of ligand ... In chemistry a chiral ligand is a specially adapted ligand used for asymmetric synthesis. This ligand is an enantiopure organic ... Design of chiral ligands for asymmetric catalysis: From C2-symmetric P,P- and N,N-ligands to sterically and electronically ... Note that when the ligand is replaced by its mirror image the other enantiomer will form and that a racemic mixture of ligand ...
*  Salen ligand
Related to salen ligands but based on non-aromatic precursors are the acacen ligands. These dianionic tetradentate ligands are ... As an anionic tetradendate ligand, salen2− resembles tetradentate ligands including those that are macrocyclic, such as ... The ligand is a bright yellow micaceous solid that is soluble in polar organic solvents. H2salen is commercially available. It ... Chiral Salen-based ligands are widely used in the field of asymmetric catalysis in organic chemistry. The diphenol H2salen is ...
*  Ligand (biochemistry)
High-affinity ligand binding implies that a relatively low concentration of a ligand is adequate to maximally occupy a ligand- ... In the example shown to the left, ligand-binding curves are shown for two ligands with different binding affinities. Ligand ... affinity ligand binding results from greater intermolecular force between the ligand and its receptor while low-affinity ligand ... In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. ...
*  Trost ligand
Other C2-symmetric ligands derived from trans-1,2-diaminocyclohexane (DACH) have been developed, such as the (R,R)-DACH- ... naphthyl ligand derived from 2-diphenylphosphino-1-naphthalenecarboxylic acid. Related bidentate phosphine-containing ligands ... The Trost ligand is an diphosphine used in the palladium-catalyzed Trost asymmetric allylic alkylation. ... Sigma-Aldrich: Trost Ligands Trost Research Group. ...
*  Phosphoramidite ligand
The ligands for this transformation require generating a chiral center on the amine portion of the ligand. These ligands afford ... A phosphoramidite ligand is a chiral monodentate phosphine ligand, widely used for enantioselective synthesis. They were ... It is worth noting that the ligand shown (Figure 4.) is the only ligand known to afford greater than 90% enantioslectivity for ... This paradigm shift using monodentate phosphine ligands challenged the belief that a tight metal-ligand complex is necessary ...
*  Spectator ligand
Instead, spectator ligands (vs "actor ligands") occupy coordination sites. Spectator ligands tend to be of polydentate, such ... In coordination chemistry, a spectator ligand is a ligand that does not participate in chemical reactions of the complex. ... Several different classes of ligand that can be considered spectator ligands. A few examples oinclude trispyrazolylborates (Tp ... cyclopentadienyl ligands (Cp), and many chelating diphosphines such as 1,2-bis(diphenylphosphino)ethane ligands (dppe). Varying ...
*  Macrocyclic ligand
A challenge with templated synthesis of macrocyclic ligands is difficulting in removing the templating metal from the ligand. ... In chemistry, a macrocyclic ligand is a macrocycle with a ring size of at least nine (including all hetero atoms) and three or ... Macrocyclic ligands occur in many cofactors in proteins and enzymes. Of particular interest are tetraazamacrocycles. Heme, the ... The high affinity of macrocyclic ligands is thought to be a combination of the entropic effect seen in the chelate effect, ...
*  Smart ligand
Smart ligands are affinity ligands selected with pre-defined equilibrium ( K d {\displaystyle K_{d}} ), kinetic ( k o f f {\ ... Smart ligands can find a set of unique applications in biomedical research, drug discovery and proteomic studies. For example, ... Ligands with desired parameters can be selected from large combinatorial libraries of biopolymers using instrumental separation ... Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed. ...
*  Bridging ligand
Ligands that are not bridging, are called terminal ligands (see figure). Virtually all ligands are known to bridge, with the ... In coordination chemistry, a bridging ligand is a ligand that connects two or more atoms, usually metal ions. The ligand may be ... In triiron dodecarbonyl, two CO ligands are bridging and ten are terminal ligands. The terminal and bridging CO ligands ... Common inorganic bridging ligands include most of the common anions. Many simple organic ligands form strong bridges between ...
*  Tripodal ligand
Tripodal ligands are tri- and tetradentate ligands with C3 symmetry. They are popular in research in the areas of coordination ... Tripodal ligands are often able to coordinately saturate metal ions with lower coordination numbers. One tripodal ligand of ... The Kläui ligand, a dianionic organometallic ligand. Verkade, J. G., "Atranes: new examples with unexpected properties", Acc. ... When bound to four- and five-coordinate metal centres, these ligands impose C3 symmetry, which can lead to uncommon ligand ...
*  Z-Ligand
A Z-ligand is usually accompanied by an L-ligand, as the presence of the L-ligand adds stability to the complex. As the ... if one Z-ligand is accompanied by one L type ligand, it can be written as a complex containing two X type ligands; i.e. MLZ ... and L-type ligands, which form a bond with the ligand donating two electrons. Typically, these Z-type ligands are Lewis acids, ... a Z-type ligand refers to a ligand that accepts two electrons from the metal center. This is in contrast to X-type ligands, ...
*  Ligand isomerism
... is a type of structural isomerism which arises from the presence of ligands which can adopt different isomeric ... The position isomer of ligand gives ligand isomerism.. ...
*  Kläui ligand
The Kläui ligand is the anion {(C5H5)Co[(CH3O)2PO]3}−. The ligand, popularized by Wolfgang Kläui, binds metals and metalloids ... Related tridentate anionic ligands include trispyrazolylborate and cyclopentadienyl anions. The ligand is derived from the ... Using other phosphites and other cyclopentadienyl ligands, a large variety of derivatives are possible. The parent acid {(C5H5) ...