*B-Cell Prolymphocytic Leukemia

"Leukemia - B-cell Prolymphocytic Leukemia and Hairy Cell Leukemia: Treatment Options , Cancer.Net". Cancer.Net. 2012-06-25. ... B-cell prolymphocytic leukemia, referred to as B-PLL, is a rare blood cancer. Specifically, B-PLL is a prolymphocytic leukemia ... "B-cell Prolymphocytic Leukemia (B-PLL) , Chronic Lymphocytic Leukemia". www.knowcancer.com. Retrieved 2016-10-30. Melo, J. V.; ... "B-cell prolymphocytic leukemia: a specific subgroup of mantle cell lymphoma". Blood. 124 (3): 412-419. doi:10.1182/blood-2013- ...

*T-cell prolymphocytic leukemia

... type of T-cell leukemia, and T-prolymphocytic leukemia/T-cell lymphocytic leukemia. People affected by T-cell prolymphocytic ... Most patients with T-cell prolymphocytic leukemia require immediate treatment. T-cell prolymphocytic leukemia is difficult to ... T-cell-prolymphocytic leukemia (T-PLL) is a mature T-cell leukemia with aggressive behavior and predilection for blood, bone ... Matutes Estella (1998). "T-cell prolymphocytic leukemia, a rare variant of mature post-thymic T-cell leukemias, has distinct ...

*Cladribine

... has been studied as part of a multi-drug chemotherapy regimen for drug-resistant T-cell prolymphocytic leukemia. ... is a medication used to treat hairy cell leukemia (HCL, leukemic reticuloendotheliosis) and B-cell chronic lymphocytic leukemia ... Cladribine is used for as a first and second-line treatment for symptomatic hairy cell leukemia and for B-cell chronic ... "Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia". Science Translational Medicine. 7 (293): ...

*Prolymphocyte

Pluripotential hemopoietic stem cell Prolymphocytic leukemia Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier. ... Today it is believed that the differentiation of cells in the lymphocyte line is not always simply chronologic but rather ... In the 20th century it was believed that a sequence of general maturation changed cells from lymphoblasts to prolymphocytes and ... A prolymphocyte is a white blood cell with a certain state of cellular differentiation in lymphocytopoiesis. ...

*CD20

Tamayose K, Sato N, Ando J, Sugimoto K, Oshimi K (December 2002). "CD3-negative, CD20-positive T-cell prolymphocytic leukemia: ... It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. The ... it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells ... Because CD20 remains present on the cells of most B-cell neoplasms, and is absent on otherwise similar appearing T-cell ...

*Leukemia

"T-cell prolymphocytic leukemia, a rare variant of mature post-thymic T-cell leukemias, has distinct clinical and laboratory ... Large granular lymphocytic leukemia may involve either T-cells or NK cells; like hairy cell leukemia, which involves solely B ... T-cell prolymphocytic leukemia (T-PLL) is a very rare and aggressive leukemia affecting adults; somewhat more men than women ... Most patients with T-cell prolymphocytic leukemia, a rare and aggressive leukemia with a median survival of less than one year ...

*Chronic lymphocytic leukemia

B cell prolymphocytic leukemia, and lymphoplasmacytic lymphoma. B cell prolymphocytic leukemia, a related, but more aggressive ... One week after the T cells were injected, the leukemia cells in his blood had disappeared. The T cells were still found in the ... the development of fast-growing diffuse large B cell lymphoma, prolymphocytic leukemia, Hodgkin's lymphoma, or acute leukemia ... but the neoplastic cells have a distinct morphology under the microscope (hairy cell leukemia cells have delicate, hair-like ...

*MTCP1

"A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia". Leukemia ... Fisch P, Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro- ... "The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation ... a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations ...

*TCL1A

... an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology". Structure. 6 (2): 147-55 ... "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia". Jpn. J. Cancer Res. 89 (7): 712- ... T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene. TCL1A has been shown to interact ... Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638-43. doi:10.1038/sj. ...

*Prolymphocytic leukemia

... is divided into two types according to the kind of cell involved: B-cell prolymphocytic leukemia and T- ... cell prolymphocytic leukemia. It is usually classified as a kind of chronic lymphocytic leukemia.. ...

*Cerebriform nuclei

... such as the nuclei seen in T-cells in T-cell prolymphocytic leukemia or Sézary's disease.. ... In pathology, cerebriform nuclei refers to convoluted ("brain-like") cell nuclei, ...

*Tower Cancer Research Foundation

Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays ... suppresses translation of cyclin D1 in mantle cell lymphoma cells, Blood, 1 October 2007, Vol. 110, No. 7, pp. 2667-2673 ; ... A Phase 2 Trial of Immunotherapy With Mitumprotimut-T (Id-KLH) and GM-CSF Following Rituximab in Follicular B-cell Lymphoma - ... open-label study of pralatrexate in patients with aggressive relapsed or refractory b-cell non-Hodgkin's lymphoma (NHL): Study ...

*B-cell leukemia

B-cell prolymphocytic leukemia 9835/3-9836/3 - Precursor B lymphoblastic leukemia 9940/3 - Hairy cell leukemia T-cell leukemia ... A B-cell leukemia is any of several types of lymphoid leukemia which affect B cells. Types include (with ICD-O code): 9823/3 - ... B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma 9826/3 - Acute lymphoblastic leukemia, mature B-cell type 9833/3 ...

*Fam158a

"Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T-prolymphocytic leukemia and T-cell leukemias in ... T-Lymphocytic Leukemia with or without ataxia telangiectasia has been associated with inversions and tandem translocations of ... The MPN superfamily contributes to ubiquitination and de-ubiquitination activity within the cell. The UPF0172 subset no longer ...

*Comparative genomic hybridization

... affected with either Downs syndrome or T-cell prolymphocytic leukemia as well as cells of a renal papillary carcinoma cell line ... Array CGH is also frequently used in research and diagnostics of B cell malignancies, such as chronic lymphocytic leukemia Cri ... in 1997 using tumor cells and Pinkel et al. in 1998 by use of breast cancer cells. This was made possible by the Human Genome ... Colchicine is added to arrest the cells in mitosis, the cells are then harvested and treated with hypotonic potassium chloride ...

*CKAP2

B-cell prolymphocytic leukemia, non-Hodgkin lymphoma, and in more than half cases of B-cell chronic lymphocytic leukemia. Human ... Cell. Biol. 27 (10): 3667-81. doi:10.1128/MCB.01386-06. PMC 1900002 . PMID 17339342. Seki A, Fang G (2007). "CKAP2 is a spindle ... Its high transcriptional activity has been observed in the testes, thymus, and diffuse B-cell lymphomas. The gene codes for a ... 2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629-34. ...

*TCL1 MTCP1 protein domain

These are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the ... They are, T-cell leukemia/lymphoma protein 1A TCL1A encoded by oncogene TCL-1 SWISSPROT and Protein p13 MTCP-1 encoded by MTCP- ... Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol Cell. 6 (2): ... Once Akt is activated this will in turn trigger cell survival. Further more it helps to stabilise mitochondrial membrane ...

*T-cell leukemia

Types include: Large granular lymphocytic leukemia Adult T-cell leukemia/lymphoma T-cell prolymphocytic leukemia In practice, ... T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. ... it can be hard to distinguish T-cell leukemia from T-cell lymphoma, and they are often grouped together.. ...

*Janus kinase 3

T-cell prolymphocytic leukemia, and juvenile myelomonocytic leukemia and natural killer T-cell lymphoma (NK/T-lymphoma). Most ... It is most commonly expressed in T cells and NK cells, but has also been found in intestinal epithelial cells. JAK3 is involved ... "JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse ... which indicates the absence of T cells and NK cells. Although B cells are present, they are non-functional due to defective B ...

*Large granular lymphocytic leukemia

... in common with other T cell leukemias such as T-cell prolymphocytic leukemia, T-cell chronic lymphocytic leukemia. This disease ... T-cell LGL leukemia (T-LGLL) and natural-killer (NK)-cell LGL leukemia (NK-LGL)L. As the name suggests, T-cell large granular ... The postulated cells of origin of T-LGLL leukemia are transformed CD8+ T-cell with clonal rearrangements of β chain T-cell ... The neoplastic cells of this disease display a mature T-cell immunophenotype, with the majority of cases showing a CD4-/CD8+ T- ...

*Hematologic disease

T-cell prolymphocytic leukemia (T-PLL) B-cell prolymphocytic leukemia (B-PLL) Chronic neutrophilic leukemia (CNL) Hairy cell ... leukemia (HCL) T-cell large granular lymphocyte leukemia (T-LGL) Aggressive NK-cell leukemia Hemochromatosis Asplenia ... inherited pure red cell aplasia) Acquired pure red cell aplasia Decreased numbers of cells Myelodysplastic syndrome ... lymphoma Anaplastic large cell lymphoma Splenic marginal zone lymphoma Hepatosplenic T-cell lymphoma Angioimmunoblastic T-cell ...

*Cancer immunotherapy

... cutaneous T-cell lymphoma, peripheral T-cell lymphoma and T-cell prolymphocytic leukemia. CD52 is found on >95% of peripheral ... Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and ... Adoptive T-cell therapy is a form of passive immunization by the transfusion of T-cells (adoptive cell transfer). They are ... In normal physiology T-cells are activated by two signals: the T-cell receptor binding to an antigen-MHC complex and T-cell ...

*Leukemia cutis

... acute lymphoblastic leukemia, chronic lymphocytic leukemia, acute myeloid leukemia, and prolymphocytic leukemia. Granulocytic ... but which are not related to leukemic cell infiltration. Leukemia cutis can occur in most forms of leukemia, including chronic ... Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the skin resulting in clinically ... This condition may be contrasted with leukemids, which are skin lesions that occur with leukemia, ...

*International Classification of Diseases for Oncology

NOS M9832/3 Prolymphocytic leukemia, NOS M9833/3 B-cell prolymphocytic leukemia M9834/3 T-cell prolymphocytic leukemia M9835/3 ... M9800/3 Leukemia, NOS M9801/3 Acute leukemia, NOS Blast cell leukemia Undifferentiated leukemia Stem cell leukemia M9805/3 ... Adult T-cell lymphoma/leukemia M9831/1 T-cell large granular lymphocytic leukemia T-cell large granular lymphocytosis NK-cell ... cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell ...

*List of MeSH codes (C04)

... prolymphocytic MeSH C04.557.337.428.550.800 --- leukemia, T-Cell, chronic MeSH C04.557.337.428.580 --- leukemia, t-cell MeSH ... leukemia, b-cell MeSH C04.557.337.428.500.100 --- leukemia, b-cell, acute MeSH C04.557.337.428.500.125 --- leukemia, B-Cell, ... leukemia, mixed-cell MeSH C04.557.337.428.511.550 --- leukemia, null-cell MeSH C04.557.337.428.511.800 --- leukemia, t-cell, ... leukemia, t-cell, htlv-ii-associated MeSH C04.557.337.440 --- leukemia, mast-cell MeSH C04.557.337.539 --- leukemia, myeloid ...