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*  Leukemia inhibitory factor
"Molecular cloning of rat leukemia inhibitory factor receptor alpha-chain gene and its expression during pregnancy". Biochimica ... receptor: molecular cloning of the mouse OSM receptor beta subunit". Blood. 93 (3): 804-15. PMID 9920829. Nakashima K, ... Leukemia Inhibitory Factor at the US National Library of Medicine Medical Subject Headings (MeSH) Source of Recombiant Leukemia ... "The gene for human leukemia inhibitory factor (LIF) maps to 22q12". Leukemia. 3 (1): 9-13. PMID 2491897. Mori M, Yamaguchi K, ...
*  Oncostatin M
"Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction". J. ... "Influence of subunit combinations on signaling by receptors for oncostatin M, leukemia inhibitory factor, and interleukin-6". J ... specific receptor but not leukemia inhibitory factor/OM receptor or interleukin-6 receptor. Complete block of OM-induced KS ... "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric ...
*  Leukemia inhibitory factor receptor
LIF Receptor alpha Subunit at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates ... is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that ... LIFR leukemia inhibitory factor receptor alpha". Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G (June 2002). "A ... "The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome ...
*  Interleukin 31
This family includes IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor ( ... IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. ... The receptor for IL-31 is a heterodimer of the interleukin 31 receptor alpha (IL-31RA) and OSMR. IL-31RA was originally ... These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31RA binds IL-31 through ...
*  Glycoprotein 130
"Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated ... It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common ... Glycoprotein 130 has been shown to interact with: Grb2, HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, ... leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation". J. Immunol. 165 (5): ...
*  Protein kinase R
Active PKR is also able to mediate the activation of the transcription factor NFkB, by phosphorylating its inhibitory subunit, ... or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 ... PKR contributes to this response by interacting with several inflammatory kinases such as IKK, JNK, ElF2α, insulin receptor and ... This leads to cancers such as Burkitt's lymphoma, Hodgkin's Disease, nasopharyngeal carcinoma and various leukemias. PKR ...
*  PIK3R1
... and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling". J. Biol. Chem. 271 (46): 29415 ... Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene. ... Serve H, Hsu YC, Besmer P (1994). "Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of ... Zhang S, Broxmeyer HE (1999). "p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, ...
*  Eukaryotic translation elongation factor 1 alpha 1
... muscarinic acetylcholine receptor, α2 subunit of GlyR, and SAMHD1. GRCh38: Ensembl release 89: ENSG00000156508 - Ensembl, May ... "Effects of two elongation factor 1A isoforms on the formation of gephyrin clusters at inhibitory synapses in hippocampal ... In the case of acute T lymphocytic leukemia, knocking down the eEF1A1 gene produces inhibited proliferation and induced ... The eEF1A1 protein is an isoform of the eEF-1 complex alpha subunit, an elongation factor protein, a GTPase, and an actin ...
*  Chromosome 14 (human)
... encoding protein TMEM260 TRAJ56 encoding protein T cell receptor alpha joining 56 TSHR: thyroid stimulating hormone receptor ... coagulation factor C homolog, cochlin (Limulus polyphemus) CRIP2: Cysteine-rich protein 2 DDX24: encoding enzyme ATP-dependent ... encoding protein Melanoma inhibitory activity protein 2 MIR494 encoding protein MicroRNA 494 MIR3173: encoding protein MicroRNA ... encoding protein T-cell leukemia/lymphoma protein 1B TIMM9: encoding enzyme Mitochondrial import inner membrane translocase ...
*  STAT3
A direct connection between the PTEN-Akt-FOXO axis (suppressive) and the leukemia inhibitory factor receptor beta (LIFRbeta)- ... Kim J, Kim D, Chung J (2000). "Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its ... Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y (May 2003). "Opposing effects of PML and PML/RAR alpha ... In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), form homo- or ...
*  Ciliary neurotrophic factor
... of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors". J ... "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... 2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharmaceutica acta Helvetiae. 74 (2-3): 265-72. doi: ... Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor. Axokine Ciliary neurotrophic ...
*  Index of immunology articles
Lck Lectin Leukemia inhibitory factor Leukemia inhibitory factor receptor Leukocyte extravasation Leukocyte-promoting factor ... alpha subunit Interleukin 23 subunit alpha Interleukin 28 receptor, alpha subunit Interleukin 34 Interleukin 35 Interleukin 6 ... necrosis factor alpha Tumor necrosis factor receptor Tumor necrosis factors Type I cytokine receptor Type II cytokine receptor ... 4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin-7 receptor-α Interleukin-8 receptor ...
*  CLCF1
... induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor ... 2001). "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional ... specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component". J. Biol. Chem. 276 ( ... 2007). "Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes". Am ...
*  Adoptive cell transfer
BCMA is a tumor necrosis factor receptor family protein expressed on mature B cells and plasma cells and can be targeted on ... chronic lymphocytic leukemia and acute lymphoblastic leukemia. Toxicity against CD19 results in B cell loss in circulation and ... The latter targets the epsilon subunit within the human CD3 complex of the TCR. 5-6 weeks after resecting the tumor, up to 1011 ... T cells can be redirected by the integration of genes encoding either conventional alpha-beta TCRs or CARs. CARs (Chimeric ...
*  NFKB1
"Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations ... Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development". Leukemia. 16 (6): ... the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha". Proc Natl Acad Sci U S A. 88 (3 ... "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105". Nature. 397 (6717): 363-8. doi: ...
*  Prostaglandin EP1 receptor
"Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous ... EP1 mobilizes G proteins containing the Gq alpha subunit (Gαq/11)-G beta-gamma complex. These two subunits in turn stimulate ... Prostaglandin receptors Prostanoid receptors Prostaglandin E2 receptor 2 (EP2) Prostaglandin E2 receptor 3 (EP3) Prostaglandin ... of available EP1 receptors) is ~20 nM and that of PGE1 ~40 for the mouse receptor and ~25 nM for PGE2 with the human receptor. ...
*  Interleukin 11
As a signaling molecule, interleukin 11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; ... It is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. The human IL-11 gene, consisting of 5 ... Signal specificity is provided by the IL-11Rα subunit. Signal transduction is initiated upon binding of IL-11 to IL-11Ralpha ... acute myeloid leukemia and bone marrow failure syndromes". Leuk. Lymphoma. 48 (1): 9-15. doi:10.1080/10428190600909115. PMID ...
*  CD90
Crosslinking anti-Thy-1 Ab can promote neurite outgrowth which is dependent on G{alpha}i and L- and N-type calcium channel ... Thy-1 has been suggested to interact with G inhibitory proteins, the Src family kinase (SFK) member c-fyn, and tubulin within ... Thy-1 was discovered by Reif and Allen in 1964 during a search for heterologous antisera against mouse leukemia cells, and was ... Some believe that there may be a functional significance of both this gene and CD3 delta subunit (T3D) mapping to chromosome ...
*  Mdm2
"Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ... Chen D, Li M, Luo J, Gu W (April 2003). "Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function". The Journal ... Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE (January 2003). "Cyclin G1 has growth inhibitory ... Zhu H, Wu L, Maki CG (December 2003). "MDM2 and promyelocytic leukemia antagonize each other through their direct interaction ...
*  Proteasome
The second ubiquitin receptor identified to date, Rpn10, is positioned at the periphery of the lid, near subunits Rpn8 and Rpn9 ... Degradation of Aux/IAA proteins derepresses transcription factors in the auxin-response factor (ARF) family and induces ARF- ... which serve as docking domains for the regulatory particles and the alpha subunits N-termini form a gate that blocks ... for B-cell acute lymphoblastic leukemia Proteasome inhibitor can kill some types of cultured leukemia cells that are resistant ...
*  PIAS3
Sentis S, Le Romancer M, Bianchin C, Rostan MC, Corbo L (2005). "Sumoylation of the estrogen receptor alpha hinge region ... was isolated and characterized as an inhibitory domain that binds and inhibits both the MITF and STAT3 transcription factors. ... "Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of ... Leukemia Research. 28 (1): 71-82. doi:10.1016/S0145-2126(03)00158-9. PMID 14630083. Long J, Wang G, Matsuura I, He D, Liu F ( ...
*  Stem cell marker
"The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells". Leukemia. 14 (10): ... 2005). "Leukemia inhibitory factor as an anti-apoptotic mitogen for pluripotent mouse embryonic stem cells in a serum-free ... April 2005). "Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID". Genes & Development. 19 (7): ... Lane MA, Chen AC, Roman SD, Derguini F, Gudas LJ (November 1999). "Removal of LIF (leukemia inhibitory factor) results in ...
*  Thyroid hormone receptor beta
THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)". Sakurai A, Nakai A, ... detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit ... "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by ... "Entrez Gene: THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)". Monden T ...
*  Activity-regulated cytoskeleton-associated protein
... nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF), glutamate acting at NMDA receptors, dopamine through ... Gao Y, Tatavarty V, Korza G, Levin MK, Carson JH (2008). "Multiplexed dendritic targeting of alpha calcium calmodulin-dependent ... and inhibitory avoidance. The mRNA is notably upregulated following electrical stimulation in LTP-induction procedures such as ... but express higher levels of the GluR1 subunit and increased miniature excitatory postsynaptic currents (mEPSCs) in addition to ...
*  P21
"A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome ... "A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA ... Almond JB, Cohen GM (April 2002). "The proteasome: a novel target for cancer chemotherapy". Leukemia. 16 (4): 433-43. doi: ... vitamin D receptor and cyclin-dependent kinase inhibitors, p21 and p27". Nephrol. Dial. Transplant. 18 Suppl 3: iii9-12. doi: ...
*  FYN
Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D (April 2002). "NMDA receptor function is regulated by the inhibitory ... Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A (April 2001). "alpha 7 nicotinic receptor ... Ma J, Zhang GY (September 2003). "Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its ... growth factor and cytokine receptor signaling, platelet activation, ion channel function, cell adhesion, axon guidance, ...