... is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor (LIF) is a polyfunctional cytokine ... Boulton TG, Stahl N, Yancopoulos GD (April 1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/ ... including the ciliary neurotrophic factor, growth hormone and prolactin. Leukemia inhibitory factor receptor has been shown to ... "Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor". Journal of ...

Leukemia inhibitory factor (LIF) was removed from all the cell lines. LIF inhibits cell differentiation, and its removal allows ... The removal of leukemia inhibitory factor (LIF) triggers differentiation. Representative data of the histone modifications at ... three of the four Yamanaka factors - Oct4, Sox2, KLF4, c-Myc) works together with other transcription factors to change the ... Okamoto K, Okazawa H, Okuda A, Sakai M, Murmatsu M, Hamada H (1990). "A novel octamer binding transcription factor is ...

Salleh, Naguib; Giribabu, Nelli (2014). "Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal ... Hoxa11 mutations alter the endometrial gland development and reduce the secretion of Leukaemia-Inhibitory factor (LIF) which is ... Modifiable risk factors include smoking, alcohol consumption and BMI. Women with RIF should be advised to abstain from both ... Endometrial polyps are benign tumours found in the endometrium which factor into female infertility. There has been limited ...

Chen HF, Shew JY, Ho HN, Hsu WL, Yang YS (October 1999). "Expression of leukemia inhibitory factor and its receptor in ... Ogawa described the early acting growth factors, intermediate acting growth factors and late acting growth factors. Classic ... Macrophage migration inhibitory factor (MIF) was identified simultaneously in 1966 by John David and Barry Bloom. In 1969, ... "Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an ...

2004). "GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor". J. Biol. Chem. 278 (50): ...

"Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, ... Ichihara M, Hara T, Kim H, Murate T, Miyajima A (July 1997). "Oncostatin M and leukemia inhibitory factor do not use the same ... Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. As yet poorly ... Thoma B, Bird TA, Friend DJ, Gearing DP, Dower SK (February 1994). "Oncostatin M and leukemia inhibitory factor trigger ...

Cytokine leukemia inhibitory factors are associated with the maintenance of mouse ESCs in an undifferentiated state. This is ... Virally induced expression of four transcription factors Oct4, Sox2, c-Myc, and Klf4 (Yamanaka factors) is sufficient to create ... There are also factors in the cell that inhibit non-muscle myosin II, such as blebbistatin. This makes the cell effectively ... Three transcription factors, OCT4, SOX2, and NANOG - the first two of which are used in induced pluripotent stem cell (iPSC) ...

"Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor". ... This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved ... Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. WIF1 is a lipid-binding protein that binds to ... Liepinsh E, Bányai L, Patthy L, Otting G (2006). "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1". J. Mol ...

1997). "Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular ... and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling". J. Biol. Chem. 271 (46): 29415 ... Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling". J. Biol. Chem. 271 (16): 9287-90. doi:10.1074/jbc. ... 1996). "Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. ...

... and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling". J. Biol. Chem. 271 (46): 29415 ... Hanna AN, Chan EY, Xu J, Stone JC, Brindley DN (1999). "A novel pathway for tumor necrosis factor-alpha and ceramide signaling ... van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (2000). "Stem cell factor induces ... Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87-94. doi: ...

... leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation". J. Immunol. 165 (5): ... Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F (2000). "SOCS3 exerts its inhibitory function on interleukin-6 signal ... SOCS3 has been shown to interact with: Erythropoietin receptor, Glycoprotein 130, Insulin-like growth factor 1 receptor, Janus ... binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. ...

"Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction". J. ... sequences in the zeta chain of the T-cell receptor is thought to relieve an inhibitory restraint on the kinase domain, leading ... inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells. ...

... leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms". The Journal of Biological ... "Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in ... Machiyama T, So T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Harigae H, Ishii N (May 2018). "TNF receptor associated factor 5 ... OSMR activates STAT3 and transforming growth factor β (TGF-β) effector SMAD3 to regulate expression of genes responsible for ...

... cardiotrophin-1 and leukemia inhibitory factor. Sclerostin production is increased by calcitonin. Thus, osteoblast activity is ... "Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in ... January 2007). "Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation ... August 2004). "Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex". The Journal of ...

... leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and IL-11. There are also several ... Glycoprotein 130 has been shown to interact with: Grb2, HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, ... leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation". J. Immunol. 165 (5): ... "Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated ...

... leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation". Journal of Immunology. ... Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. This phosphatase, along with its ... PTPN11 has been shown to interact with CagA, Cbl gene, CD117, CD31, CEACAM1, Epidermal growth factor receptor, Erk FRS2, GAB1, ... Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (August 1997). "LAIR-1, a novel inhibitory ...

The CNTF family of neurotrophic factors includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), ... It is structurally related to leukemia inhibitory factor (LIF), interleukin 6 (IL-6), and oncostatin M (OSM). CNTF prevents ... glia maturation factor, insulin, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), fibroblast ... Most neurotrophic factors belong to one of three families: (1) neurotrophins, (2) glial cell-line derived neurotrophic factor ...

... transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and leukemia inhibitory factor (LIF)). The ... Mouse embryonic stem cells (mESCs) undergo self-renewal in the presence of the cytokine leukemia inhibitory factor (LIF). ... However, brief expression of a single transcription factor, the ELT-7 GATA factor, can convert the identity of fully ... Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, et al. (May 2013). "Transcription factor-mediated ...

In the presence of Ngn1, the leukemia inhibitory factor (LIF) pathway is inhibited by Ngn1 blocking STAT activation. Normally, ... Another transcription factor that may be a downstream target of Ngn3 is Nkx2.2 because it is often coexpressed with it. Studies ... Since Ngn1 is the limiting factor, CBP/p300/Smad1 is able to interact with STAT1/3 and induce gliogenesis. Activation of the ... Binding of Ngn1, to the enhancer box, induces the transcription factor NeuroD to bind to its own enhancer boxes, inducing the ...

... leukemia inhibitory factor and colony-stimulating factor. Human chorionic gonadotropin (hCG) not only acts as an ... Leukemia inhibitory factor (LIF) is a pro-inflammatory cytokine expressed in the endometrium during the luteal phase of the ... Xiao Y, Sun X, Yang X, Zhang J, Xue Q, Cai B, Zhou Y (June 2010). "Leukemia inhibitory factor is dysregulated in the ... Lytic factors in the uterine cavity, as well as factors from the blastocyst itself are essential for the breakdown of the egg- ...

... by regulating Leukemia Inhibitory Factor has been shown to facilitate implantation in the mouse and possibly humans ... Thus, it may be an important factor in aging. It can arrest growth by holding the cell cycle at the G1/S regulation point on ... Mechanical signals such as hypoxia affect levels of p53 in these niche cells through the hypoxia inducible factors, HIF-1α and ... Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE (January 2003). "Cyclin G1 has growth inhibitory ...

1996). "Binding interactions of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their ... Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor. Ciliary neurotrophic factor ... Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. The protein encoded by this gene is a ... Like CNTF it is a neurotrophic factor, and may stimulate nerve cells to survive. It was tested in the 1990s as a treatment for ...

2005). "Leukemia inhibitory factor as an anti-apoptotic mitogen for pluripotent mouse embryonic stem cells in a serum-free ... Lane MA, Chen AC, Roman SD, Derguini F, Gudas LJ (November 1999). "Removal of LIF (leukemia inhibitory factor) results in ... Testa U, Riccioni R, Diverio D, Rossini A, Lo Coco F, Peschle C (February 2004). "Interleukin-3 receptor in acute leukemia". ... Nemetz C, Hocke GM (March 1998). "Transcription factor Stat5 is an early marker of differentiation of murine embryonic stem ...

The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor ... It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the IL-6 cytokine family. CT-1 is associated with the ... In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor ...

The proinflammatory cytokines, interleukin-6 and leukemia inhibitory factor, can also induce peripherin expression through the ... Nerve growth factor (NGF) plays the major role in the regulation of peripherin. It is both a transcriptional inducer and post- ... The 5' flanking regions and regulatory sequences were also very similar and a nerve growth factor negative regulatory element, ...

Instead, it causes astrocytes to secrete cytokine leukemia inhibitory factor (LIF), a regulatory protein that promotes the ... Just as with neuronal cell specification, canonical signaling factors like sonic hedgehog (SHH), fibroblast growth factor (FGFs ... and down-regulated by a number of different factors. One factor at the forefront of recent research is in the pain-potentiating ... These factors increase the responsiveness of the dorsal horn pain-projection neurons to ensuing stimuli, termed "spinal ...

"Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous ... This compound has a Ki inhibitory binding value (see Biochemistry#Receptor/ligand binding affinity) of 150 nM compared to that ... and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung ... human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor ...

Signaling of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor ... Glerup, S.; Nykjaer, A.; Vaegter, C. B. (2014), "Sortilins in Neurotrophic Factor Signaling", Neurotrophic Factors, Springer ... Examples of ligands are neurotrophic factors, amyloid precursor protein (APP), lipoproteins, and cytokines. In addition to ... brain-derived neurotrophic factor) and TrkB (BDNF receptor tyrosine kinase) inside neurons in the hippocampal region of the ...

C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells ...

... leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 ( ... Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3 ... 1999). "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family". Proc. Natl. Acad. Sci. U.S.A. 96 (20 ... "Entrez Gene: CLCF1 cardiotrophin-like cytokine factor 1". Senaldi G, Varnum BC, Sarmiento U, Starnes C, Lile J, Scully S, Guo J ...

Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Source of Recombiant Leukemia Inhibitory Factor ... "The gene for human leukemia inhibitory factor (LIF) maps to 22q12". Leukemia. 3 (1): 9-13. PMID 2491897. Mori M, Yamaguchi K, ... Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. ... Králícková M, Síma P, Rokyta Z (2005). "Role of the leukemia-inhibitory factor gene mutations in infertile women: the embryo- ...

2005). "Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific ...