Leucine transaminase
... leucine 2-oxoglutarate transaminase, leucine aminotransferase, and leucine-alpha-ketoglutarate transaminase. This enzyme ... In enzymology, a leucine transaminase (EC 2.6.1.6) is an enzyme that catalyzes the chemical reaction L-leucine + 2-oxoglutarate ... Ikeda T, Konishi Y, Ichihara A (1976). "Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of ... The systematic name of this enzyme class is L-leucine:2-oxoglutarate aminotransferase. Other names in common use include L- ...
2-aminohexanoate transaminase
Other names in common use include norleucine transaminase, norleucine (leucine) aminotransferase, and leucine L-norleucine: 2- ... In enzymology, a 2-aminohexanoate transaminase (EC 2.6.1.67) is an enzyme that catalyzes the chemical reaction L-2- ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... Der Garabedian PA, Vermeersch JJ (1987). "Candida L-norleucine,leucine:2-oxoglutarate aminotransferase Purification and ...
Amino acid synthesis
The final step is the transamination of the α-ketoisocaproate by the action of a glutamate-leucine transaminase. Leucine, like ... The only definite method is the bacterium's ability to repress Transaminase C activity by either valine or leucine (see ilvEDA ... Because leucine is synthesized by a diversion from the valine synthetic pathway, the feedback inhibition of valine on its ... The leucine synthesis pathway diverges from the valine pathway beginning with α-ketoisovalerate. α-Isopropylmalate synthase ...
Alanine-oxo-acid transaminase
Other names in common use include L-alanine-alpha-keto acid aminotransferase, leucine-alanine transaminase, alanine-keto acid ... In enzymology, an alanine-oxo-acid transaminase (EC 2.6.1.12) is an enzyme that catalyzes the chemical reaction L-alanine + a 2 ... Wilson DG, King KW, Burris RH (1954). "Transaminase reactions in plants" (PDF). J. Biol. Chem. 208 (2): 863-874. Portal: ... ALTENBERN RA, HOUSEWRIGHT RD (1953). "Transaminases in smooth Brucella abortus, strain 19" (PDF). J. Biol. Chem. 204 (1): 159- ...
List of EC numbers (EC 2)
... cysteine transaminase EC 2.6.1.4: glycine transaminase EC 2.6.1.5: tyrosine transaminase EC 2.6.1.6: leucine transaminase EC ... D-amino-acid transaminase EC 2.6.1.11: acetylornithine transaminase EC 2.6.1.12: alanine-oxo-acid transaminase EC 2.6.1.13: ... neamine transaminase EC 2.6.1.94: 2′-deamino-2′-hydroxyneamine transaminase EC 2.6.1.95: neomycin C transaminase EC 2.6.1.96: 4 ... UDP-N-acetylbacillosamine transaminase EC 2.6.1.35: glycine-oxaloacetate transaminase EC 2.6.1.36: L-lysine 6-transaminase EC ...
Valine-pyruvate transaminase
This enzyme participates in valine, leucine and isoleucine biosynthesis. Falkinham JO 3rd (1979). "Identification of a mutation ... In enzymology, a valine-pyruvate transaminase (EC 2.6.1.66) is an enzyme that catalyzes the chemical reaction L-valine + ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... Other names in common use include transaminase C, valine-pyruvate aminotransferase, and alanine-oxoisovalerate aminotransferase ...
S)-3-amino-2-methylpropionate transaminase
... and beta-aminoisobutyrate-alpha-ketoglutarate transaminase. This enzyme participates in valine, leucine and isoleucine ... Other names in common use include L-3-aminoisobutyrate transaminase, beta-aminobutyric transaminase, L-3-aminoisobutyric ... In enzymology, a (S)-3-amino-2-methylpropionate transaminase (EC 2.6.1.22) is an enzyme that catalyzes the chemical reaction (S ... Kakimoto Y, Kanazawa A, Taniguchi K, Sano I (1968). "Beta-aminoisobutyrate-alpha-ketoglutarate transaminase in relation to beta ...
Beta-alanine-pyruvate transaminase
This enzyme participates in 4 metabolic pathways: alanine and aspartate metabolism, valine, leucine and isoleucine degradation ... In enzymology, a beta-alanine-pyruvate transaminase (EC 2.6.1.18) is an enzyme that catalyzes the chemical reaction L-alanine ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... Other names in common use include beta-alanine-pyruvate aminotransferase, and beta-alanine-alpha-alanine transaminase. ...
Branched chain amino acid transaminase 1
The respective reactions are: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate L-isoleucine + 2-oxoglutarate ... Branched chain amino acid transaminase 1 is a protein that in humans is encoded by the BCAT1 gene. It is the first enzyme in ... This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible ... July 2017). "The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast ...
Hypervalinemia
It is caused by a deficiency of the enzyme valine transaminase. Presenting in infancy, symptoms include lack of appetite, ... without related elevation of the branched-chain amino acids leucine and isoleucine. ...
List of MeSH codes (D08)
... glycine transaminase MeSH D08.811.913.477.700.535 - leucine transaminase MeSH D08.811.913.477.700.550 - l-lysine 6-transaminase ... transaminases MeSH D08.811.913.477.700.100 - alanine transaminase MeSH D08.811.913.477.700.120 - 2-aminoadipate transaminase ... beta-alanine-pyruvate transaminase MeSH D08.811.913.477.700.347 - d-alanine transaminase MeSH D08.811.913.477.700.470 - ... tryptophan transaminase MeSH D08.811.913.477.700.900 - tyrosine transaminase MeSH D08.811.913.555.150 - amidinotransferases ...
Acetolactate synthase
The ilvGMEDA operon encodes the ilvGM (ALS II) pair as well as a branched-chain-amino-acid transaminase (ilvE), dihydroxy-acid ... Both of these operons as well as the third, ilvIH, are regulated by leucine-responsive protein (Lrp). Inhibitors of ALS are ... ALS catalyzes the first step in the synthesis of the branched-chain amino acids (valine, leucine, and isoleucine). A human ... The resulting product of this reaction, acetolactate, eventually becomes valine, leucine, and isoleucine. All three of these ...
Branched-chain amino acid aminotransferase
Like other transaminase enzymes (as well as many enzymes of other classes), BCATs require the cofactor pyridoxal-5'-phosphate ( ... In synthetic organic chemistry, BCATs are typically used for the conversion of L-Leucine to 2-ketoglutarate. The anticonvulsant ... Aminotransferases (transaminases) in general have been used to create unnatural amino acids, important building blocks for ... branched-chain-amino-acid+transaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "RCSB Protein ...
GOT2
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane ... Mg2+ plus leucine versus citrate and malate". The Journal of Biological Chemistry. 260 (10): 6069-79. doi:10.1016/S0021-9258(18 ... "Entrez Gene: GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)". Ford GC, Eichele G, ... "Assignment of a gene necessary for the expression of mitochondrial glutamic-oxaloacetic transaminase in human-mouse hybrid ...
Biochemistry
Enzymes called transaminases can easily transfer the amino group from one amino acid (making it an α-keto acid) to another α- ... They cannot synthesize isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. Because they ...
Glutamate-glutamine cycle
Sarup A.; Larsson, O.M. & Schousboe A. (2003). GABA transporters and GABA transaminase as drug targets. Curr. Drug Targets CNS ... leucine and alanine. The amino acid moves in the opposite direction of glutamine. In the opposite direction of the amino acid, ... drugs such as vigabatrin that target both GABA transporters and the GABA metabolizing enzyme GABA-transaminase have been ... a corresponding molecule is transported; for alanine this molecule is lactate; for leucine, α-ketoisocaproate. The ammonia ...
Amino acid
Glycine and leucine were discovered in 1820. The last of the 20 common amino acids to be discovered was threonine in 1935 by ... This process involves transaminases, often the same as those used in amination during synthesis. In many vertebrates, the amino ... The oxidation pathway starts with the removal of the amino group by a transaminase; the amino group is then fed into the urea ... Other organisms use transaminases for amino acid synthesis, too. Nonstandard amino acids are usually formed through ...
Oxaloacetic acid
After that, oxaloacetate will be recycled to aspartate, as transaminases prefer these keto acids over the others. This ... Methionine, threonine, lysine, isoleucine, valine, and leucine are essential amino acids in humans and most vertebrates. Their ...
Index of molecular biology articles
... leucine zipper - leukemia - leukotriene-B4 20-monooxygenase - library - licodione synthase - ligase - linear epitope - linkage ... transaminase - p53 - package - palindromic sequence - palmitoyl acyltransferase - Parkinson's disease - pBR322 - PCR - pedigree ... 6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase - undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase - ...
Chromosome 12
... encoding protein Leucine-rich repeats and IQ motif containing 1 LRRK2: leucine-rich repeat kinase 2 MBOAT5: encoding enzyme ... encoding protein Branched chain amino acid transaminase 1 C12orf24: encoding protein FAM216A C12orf42: encoding protein ... encoding protein Leucine-rich repeat-containing protein 23 LRRIQ1: ...
Transamination
... and leucine. The two common types of aminotransferases are alanine aminotransferase (ALT) and aspartate aminotransferase (AST ... Transamination in biochemistry is accomplished by enzymes called transaminases or aminotransferases. α-ketoglutarate acts as ...
Wilson's disease
Most have slightly abnormal liver function tests such as raised aspartate transaminase, alanine transaminase, and bilirubin ... arginine to leucine at 778) is found more often. Relatively little is known about the relative impact of various mutations, ...
Enfuvirtide
"The Inhibitory Activity of an HIV Type 1 Peptide Correlates with Its Ability to Interact with a Leucine Zipper Structure". AIDS ... elevated hepatic transaminases; and possibly more severe reactions including respiratory distress, glomerulonephritis and/or ...
List of EC numbers (EC 5)
... leucine 2,3-aminomutase EC 5.4.3.8: glutamate-1-semialdehyde 2,1-aminomutase EC 5.4.3.9: glutamate 2,3-aminomutase EC 5.4.3.10 ... glutamine-fructose-6-phosphate transaminase (isomerizing) EC 5.3.1.20: ribose isomerase EC 5.3.1.21: corticosteroid side-chain- ...
Microcystin-LR
In female mice only changes in transaminases were observed at the highest dose. Mice showed neoplastic liver nodules after 100 ... In microcystin-LR these are leucine and arginine. More than 250 microcystins have been identified to date, representing ... leucine, methylaspartic acid and arginine leads to the coupled product. A nucleophilic attack of the nitrogen in the Adda ... and the leucine residue packs closely to another conserved tyrosine residue. Microcystin-LR is toxic for both humans and ...
Enzyme promiscuity
An example of a commonly evolved enzyme is ω-transaminase which can replace a ketone with a chiral amine and consequently ... an ancestral interconnection between leucine, arginine, and lysine biosynthesis". BMC Evolutionary Biology. 7 (Suppl 2): S3. ... Shin JS, Kim BG (August 2001). "Comparison of the omega-transaminases from different microorganisms and application to ...
ETV6
... an Aspartate transaminase), and ACSL6 (a Long-chain-fatty-acid-CoA ligase); h) transporter gene ARNT (binds to ligand-bound ... one family with a germline DNA substitution termed L349P that lead to replacing leucine with proline at amino acid 349 in the ...
Carnitine palmitoyltransferase II deficiency
speculate that mutation of serine to the bulkier, hydrophobic leucine alters a critical interaction with nearby Phe117, ... patients often have serum and/or urine screen positive for the presence of myoglobin and serum creatine kinase and transaminase ...
List of OMIM disorder codes
ABCA4 GABA-transaminase deficiency; 613163; ABAT Galactokinase deficiency with cataracts; 230200; GALK1 Galactose epimerase ... leucine-sensitive; 240800; ABCC8 Hypogonadism, hypogonadotropic; 146110; PROK2 Hypogonadotropic hypogonadism due to GNRH ...
Biosynthesis
"MetaCyc: L-lysine biosynthesis I". PETERKOFSKY, B; GILVARG, C (May 1961). "N-Succinyl-L-diaminopimelic-glutamic transaminase". ... The other amino acids, valine, methionine, leucine, isoleucine, phenylalanine, lysine, threonine and tryptophan for adults and ...