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*  Diet-induced obesity model
High levels of leptin and insulin are produced; at the same time, the body becomes resistant to both. Insulin resistance in ... In addition to protein, Fructose, a carbohydrate, has impact on fat deposition, plasma insulin, leptin, thyroid, estradiol, and ...
*  Proopiomelanocortin
Cowley MA, Smart JL, Rubinstein M, Cerdán MG, Diano S, Horvath TL, Cone RD, Low MJ (May 2001). "Leptin activates anorexigenic ... "Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis". EMBO Reports. 13 ( ...
*  Agouti-related peptide
Adipocytes secrete leptin in response to food intake. This hormone acts in the arcuate nucleus and inhibits the AgRP/NPY neuron ... The appetite-stimulating effects of AgRP are inhibited by the hormone leptin and activated by the hormone ghrelin. ... "Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons". Cell Metabolism. 5 (3): ...
*  Leptin
... where leptin levels are elevated; but the leptin does not turn on the leptin receptor, hence the patient has functional leptin ... When leptin binds with the leptin receptor, it activates a number of pathways. Leptin resistance may be caused by defects in ... Serum level of leptin is reduced by sleep deprivation. Leptin levels are paradoxically increased in obesity. Leptin level is ... The placenta produces leptin. Leptin levels rise during pregnancy and fall after childbirth. Leptin is also expressed in fetal ...
*  Maria Leptin
"Maria Leptin appointed next Director of EMBO". Retrieved 25 November 2013. "An interview with Maria Leptin". Retrieved 26 ... In 1988, Maria Leptin was appointed as staff scientist at the same institution. She then went to Pat O'Farrell's lab at the ... Barrett, K.; Leptin, M.; Settleman, J. (1997). "The Rho GTPase and a Putative RhoGEF Mediate a Signaling Pathway for the Cell ... In 1994, Maria Leptin became Professor at the Institute of Genetics University of Cologne, Germany, where she still leads a ...
*  Leptin receptor
CRH1 domains is not essential for Leptin binding, but may have regulatory roles. Ig domain interacts with Leptin and is ... CRH2 is essential for leptin binding, deletion of this domain abolishes the leptin binding. FNIII domains are essential for ... of the leptin receptor by demonstrating that an apparent leptin receptor cloned from a choroid plexus library using leptin as ... "Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian ...
*  Teleost leptins
... are a family of peptide hormones found in fish (teleostei) that are orthologs of the mammalian hormone leptin. ... By contrast, however, studies in common carp demonstrated a peak in leptin-I(lepa1) and leptin-II (lepa2) in liver at 3 and 6 ... Injection of rainbow trout with recombinant trout leptin (rt-leptin) resulted in a significantly reduced appetite over two days ... Kurokawa T, Murashita K (April 2009). "Genomic characterization of multiple leptin genes and a leptin receptor gene in the ...
*  Apsines (sophist)
Leptin. p. 11; comp. Schol. ad Hermog. p. 402 Eunapius, Lives of the Sophists p. 113, ed. Antwerp. 1568 Eunapius, Lives of the ...
*  Aphepsion
Leptin. p. 453 Dem. c. Lept. p. 501 Wolf, Proleg. in Demosth. Lept. p. 48, &c., pp. 52-56 This article incorporates text from a ...
*  Douglas L. Coleman
Rosenbaum M (1998). "Leptin". The Scientist Magazine. Okie S (February 11, 2005). "Chapter 2: Obese Twins and Thrifty Genes". ... His work predicted that the ob gene encoded the hormone leptin, later co-discovered in 1994 by Jeffrey Friedman, Rudolph Leibel ... Friedman for the discovery of leptin. Coleman, DL (1978). "Obese and Diabetes: two mutant genes causing diabetes-obesity ...
*  European Molecular Biology Organization
Leptin, Maria (2010). "Spreading the Spirit of EMBO". Science. 327 (5962): 126-126. Bibcode:2010Sci...327..126L. doi:10.1126/ ... As of 2016[update] the Director of EMBO is Maria Leptin, a developmental biologist at the University of Cologne, Germany. EMBO ... Maria Leptin was appointed fifth Director of EMBO. In 2011, EMBO established the "Science Policy Programme" which interacts ...
*  Puberty
Leptin is a protein hormone produced by adipose tissue. Its primary target organ is the hypothalamus. The leptin level seems to ... Leptin might be the cause of the GnRH rise. Leptin has receptors in the hypothalamus which synthesizes GnRH. Individuals who ... The levels of leptin increase with the onset of puberty, and then decline to adult levels when puberty is completed. The rise ... Leptin levels rise throughout childhood and play a part in allowing the arcuate nucleus to resume operation. If the childhood ...
*  EMBO Membership
Leptin, Maria (2010). "Spreading the Spirit of EMBO". Science. 327 (5962): 126-126. Bibcode:2010Sci...327..126L. doi:10.1126/ ...
*  Neuropeptide Y
Meanwhile, obesity-induced insulin resistance and the mutation of the leptin receptor (ObRb) results in the abolition of ... mutation of leptin receptor; and an increase in NPY mRNA and NPY release. In obesity chronically elevated levels of NPY can be ... hypothalamic resistance to energy excess hormone signals such as leptin, that can be a result of a variety of reasons in the ... in rats fed on a high fat diet for 22 weeks and resulted in a genetic mutation increasing NPY release due to a defective leptin ...
*  MARCM
Baer, MM; Bilstein A; Leptin M. (2007-07-01). "A clonal genetic screen for mutants causing defects in larval tracheal ...
*  Parabiosis
After injecting leptin into the obese mouse of each pair, she found that leptin circulated between the conjoined animals, but ... Due to the discovery of leptin, she analyzed leptin concentrations of the mice in the parabiotic experiments. ... Harris concluded that leptin levels are increased in the obese animal, but other factors could also affect the animals. Also, ... Leptin seemed like a viable candidate. Starting in 1977, Ruth B.S. Harris, a graduate student under Hervey, repeated previous ...
*  Julio Licinio
... and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by ... "Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient ... "The Role of Leptin in Weight Loss". ABC News. 7 August 2002. Retrieved 25 March 2014. Licinio, J.; Caglayan, S.; Ozata, M.; ... He then administered daily leptin injections to each of them, and found that after ten months, the patients had lost half of ...
*  Inflammation
Stored fat secretes leptin to signal satiety. Leptin resistance plays a role in the process where appetite overrules the ... Higher than normal Angptl2 level in fat tissues develop inflammation as well as insulin and leptin resistance. ... It is possible that, as an inflammatory marker, leptin responds specifically to adipose-derived inflammatory cytokines. C- ... Insulin Blood glucose Leptin Low-grade chronic inflammation is characterized by a two- to threefold increase in the systemic ...
*  Michael Warren Schwartz
Key enzyme in leptin-induced anorexia. Nature. 413:794-795, 2001. Morton GJ, Blevins JE, Williams DL, Niswender KD, Gelling RW ... Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest. 115:703-710, 2005. Morton, ... Melanocortin receptors in leptin effects. Nature. 390:349, 1997. Schwartz MW, Seeley RJ, Weigle DS, Woods SC, Campfield LA, ... Cerebrospinal Fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nature Medicine. 2:589-93, 1996. ...
*  Melanocortin
Zhou, Yingjiang; Rui, Liangyou (2013-06-01). "Leptin signaling and leptin resistance". Frontiers of Medicine. 7 (2): 207-222. ... Leptin, the energy surfeit hormone, and Ghrelin, the hunger hormone, are upstream regulators of the melanocortin system in the ... Klok, M. D.; Jakobsdottir, S.; Drent, M. L. (2007-01-01). "The role of leptin and ghrelin in the regulation of food intake and ...
*  Breast development
Leptin has also been found to be an important factor in mammary gland development, and has been found to promote mammary ... 190-. ISBN 978-0-323-24147-2. Mechanisms of Leptin in Mammary Tumorigenesis. ProQuest. 2007. pp. 3-. ISBN 978-0-549-16664-1. ...
*  Pathophysiology of obesity
Thus a deficiency in leptin signaling, either via leptin deficiency or leptin resistance, leads to overfeeding and may account ... On the contrary Leptin expression was increased proposing the possibility of Leptin-resistance in human obesity. Since this ... In the ob/ob mouse, mutations in the leptin gene resulted in the obese phenotype opening the possibility of leptin therapy for ... Both groups of arcuate nucleus neurons are regulated in part by leptin. Leptin inhibits the NPY/AgRP group while stimulating ...
*  Hyperemesis gravidarum
"Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum". The Australian & New Zealand journal of ... Leptin may also play a role. Possible pathophysiological processes involved are summarized in the following table: Hyperemesis ...
*  DDX41
Leptin M (Feb 2000). "Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt". Curr Biol. 9 ( ...
*  Endocrine gland
... leptin and resistin). Endocrine glands derive from all three germ layers.[citation needed] The natural decrease in function of ...