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*  Familial partial lipodystrophy
Six types (1-6) have been described. Types 1-5 are inherited in an autosomal dominant fashion. Type 1 (Kobberling variety, FPL1 ... Mutations associated with FPL have been reported in LMNA (lamin A/C), PPARG (PPARγ), AKT2 (AKT serine/threonine kinase 2), ... Type 3 is due to mutations in the PPARG gene. It is rare with approximately 30 cases reported to date. It is similar to type 2 ... Type 4 is due to mutations in the PLIN1 gene. It is rare with only a small number of cases reported. Fat loss tends to affect ...
*  Lamin
... and B-type lamins have found that the positions of introns/exons in B-type lamins have been conserved in A-type lamins, with ... As with A-type lamins, there are multiple isoforms of B-type lamins, the most common being lamins B1 and B2. They are produced ... This suggests that the common ancestor of these lamin types was a B-type lamin. Due to their properties as a type of IF protein ... of B-type lamins across multiple species have found evidence that supports that B-type lamins existed before A-type lamins. ...
*  Dunnigan familial partial lipodystrophy
Dunnigan-type familial partial lipodystrophy, also known as FPLD Type II and abbreviated as (FPLD2), is a rare monogenic form ... FPLD results from mutations in LMNA gene, which is the gene that encodes nuclear lamins A and C. Familial partial lipodystrophy ... October 2005). "Hepatic steatosis in Dunnigan-type familial partial lipodystrophy". The American Journal of Gastroenterology. ... glucose intolerance and diabetes usually type 2, dyslipidemia, hypertension, and early endpoints of atherosclerosis. It can ...
*  Intermediate filament
A-type lamins are only expressed following gastrulation. Lamin A and C are the most common A-type lamins and are splice ... B-type lamins are present in every cell. B type lamins, B1 and B2, are expressed from the LMNB1 and LMNB2 genes on 5q23 and ... Most types of intermediate filaments are cytoplasmic, but one type, the lamins, are nuclear. Unlike microtubules, IFs ... a type VI intermediate filament protein. Limited co-assembly in vitro to form heteropolymers with type III vimentin and type IV ...
*  Thymopoietin
Furukawa K, Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". ... Furukawa K, Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". ... "Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins". Journal of Cell Science. 113 Pt 19 (19): 3473-84. PMID ... "Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins". Journal of Cell Science. 113 Pt 19 (19): 3473-84. PMID ...
*  LMNA
Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. ... Lamin A/C also known as LMNA is a protein that in humans is encoded by the LMNA gene. Lamin A/C belongs to the lamin family of ... Mounkes LC, Burke B, Stewart CL (2001). "The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and ... Cao H, Hegele RA (2002). "Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial ...
*  Lamin B1
Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Lamin B, along with ... Furukawa K, Kondo T (1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". Eur. J. ... 1997). "A- and B-type lamins are differentially expressed in normal human tissues". Histochem. Cell Biol. 107 (6): 505-17. doi: ... During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are ...
*  Senescence
Mounkes LC; Kozlov S (2003). "A progeroid syndrome in mice is caused by defects in A-type lamins" (PDF). Nature. 423 (6937): ... While there may be some validity to the idea that for various types of specific damage detailed below that are by-products of ... For a critique of the Rate of Living Hypothesis see Living fast, dying when?) With respect to specific types of chemical damage ... Horvath S (2013). "DNA methylation age of human tissues and cell types". Genome Biology. 14: R115. doi:10.1186/gb-2013-14-10- ...
*  Progeria
In progeria, the inability to adequately repair DNA damages due to defective A-type lamin may cause aspects of premature aging ... After cleavage by the protease, prelamin A is referred to as lamin A. Lamin A, along with lamin B and lamin C, makes up the ... link) Cao H, Hegele RA; Hegele (2002). "Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial ... November 29, 1999). "Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy". J. ...
*  DNA damage theory of aging
A-type lamins promote genetic stability by maintaining levels of proteins that have key roles in the DNA repair processes of ... "A dual role for A-type lamins in DNA double-strand break repair". Cell Cycle. 10 (15): 2549-60. doi:10.4161/cc.10.15.16531. PMC ... The initial study of this type, by Hart and Setlow, showed that the ability of skin fibroblasts of seven mammalian species to ... Numerous studies of this type have indicated that oxidative damage to DNA is particularly important. The loss of expression of ...
*  ZMPSTE24
"A dual role for A-type lamins in DNA double-strand break repair". Cell Cycle. 10 (15): 2549-60. doi:10.4161/cc.10.15.16531. PMC ... It is involved in the processing of lamin A. Defects in the ZMPSTE24 gene lead to similar laminopathies as defects in lamin A, ... As shown by Liu et al., lack of Zmpste24 prevents lamin A formation from its precursor farnesyl-prelamin A. Lack of Zmpste24 ...
*  Progeroid syndromes
In HGPS, the inability to adequately repair DNA damages due to defective A-type lamin may cause aspects of premature aging (see ... There are eight types of XP (XP-A through XP-G), plus a variant type (XP-V), all categorized based on the genetic cause. XP can ... A-type lamins promote genetic stability by maintaining levels of proteins which have key roles in NHEJ and HR. Mouse cells ... "A dual role for A-type lamins in DNA double-strand break repair". Cell Cycle. 10 (15): 2549-60. doi:10.4161/cc.10.15.16531. PMC ...
*  Laminopathy
A-type lamins promote genetic stability by maintaining the levels of proteins that have key roles in DNA double-strand break ... Most lamin B mutations appear to be lethal with mutations in lamin B1 causing death at birth in mice. In 2006, lamin B2 ... The inability to adequately repair DNA damages when A-type lamins are defective is likely responsible for some of the aspects ... Cao H, Hegele RA (2002). "Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial ...
*  Nuclear lamina
The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type(lamin B1, B2) ... LA are considered homologous to lamin A and LIII as a B-type lamin. A fourth type exists and is germ cell specific. In the ... the only lamins present are B-type lamins. In further stages, the expression pattern of lamin B1 decreases and there is a ... In the latter case as well it is the B-type lamins that are expressed in the early stages. Lamin B1 reaches the highest ...
*  Inner nuclear membrane protein
González, Jose M.; Andrés, Vicente (2011). "Synthesis, transport and incorporation into the nuclear envelope of A-type lamins ... As mutations in lamins cause the autosomal dominant form of Emery-Dreifuss muscular dystrophy, and lamins and emerin are known ... Lamins and chromatin found at the nuclear envelope are organised with the assistance of proteins embedded in the INM. INM ... For example, lamin B receptor, lamina-associated polypeptide 1 and lamina-associated polypeptide 2 are targets for different ...
*  Fluorescence-lifetime imaging microscopy
"The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers". ... has also been used to show the interaction of both types of nuclear intermediate filament proteins lamins A and B1 in distinct ...
*  Nuclear prelamin A recognition factor
The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is ... translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin ...
*  TOR1AIP1
"The inner nuclear membrane protein LAP1 forms a native complex with B-type lamins and partitions with spindle-associated ... "Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic ...
*  MLIP (gene)
Muscular LMNA interacting protein has a number of aliases including MLIP, C6orf142, CIP and Muscle-enriched A-type Lamin- ... muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) ... "Identification of a novel muscle A-type lamin-interacting protein (MLIP)". The Journal of Biological Chemistry. 286 (22): 19702 ... It interacts with the nuclear envelope proteins lamin A/C, which is what led to its discovery. It also interacts with Islet1 ...
*  Cell nucleus
"Mistargeting of B-type lamins at the end of mitosis: implications on cell survival and regulation of lamins A/C expression". J ... The nuclear lamina is composed mostly of lamin proteins. Like all proteins, lamins are synthesized in the cytoplasm and later ... The destruction of the lamin networks is controlled by specialized apoptotic proteases called caspases, which cleave the lamin ... Lamins found on the cytosolic face of the membrane, such as emerin and nesprin, bind to the cytoskeleton to provide structural ...
*  List of MeSH codes (D12.776.660)
... lamin type a MeSH D12.776.660.650.875.750 -- lamin type b. ...
*  Lamin B2
... is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is ... Lamin B receptor Barraquer-Simons disease Pelger-Huet anomaly Lamin B at the US National Library of Medicine Medical Subject ... Model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2tm1a(KOMP)Wtsi ...
*  Insulin resistance
... Cao, H. (2000-01-01). "Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial ... Some types of polyunsaturated fatty acids (omega-3) may moderate the progression of insulin resistance into type 2 diabetes, ... It is a type of glucose clamp technique. The test rarely is performed in clinical care, but is used in medical research, for ... Certain cell types such as fat and muscle cells require insulin to absorb glucose. When these cells fail to respond adequately ...
*  Keratin
Nematodes and many other non-chordate animals seem to only have type VI intermediate filaments, lamins, which have a long rod ... Keratins (also described as cytokeratins) are polymers of type I and type II intermediate filaments, which have only been found ... Fibrous proteins are characterized by a single type of secondary structure: a keratin is a left-handed coil of two a helices ... In many other cell types, such as cells of the dermis, keratin filaments and other intermediate filaments function as part of ...
*  Lamin B receptor
Ye Q, Callebaut I, Pezhman A, Courvalin JC, Worman HJ (June 1997). "Domain-specific interactions of human HP1-type chromodomain ... Lamin-B receptor is a protein, and in humans, it is encoded by the LBR gene. The protein encoded by this gene belongs to the ... Lamin B receptor has been shown to interact with CBX3 and CBX5. LBR also interacts with long non-coding RNA XIST in mouse cells ... "Entrez Gene: LBR lamin B receptor". Online Mendelian Inheritance in Man (OMIM) 215140 Online Mendelian Inheritance in Man (OMIM ...
*  Histone H2B
... is modified by a combination of several types of post-translational modifications. These modifications affect the ... "Prepatterning of Differentiation-Driven Nuclear Lamin A/C-Associated Chromatin Domains by GlcNAcylated Histone H2B". Genome ... have different types and numbers of post-translational modifications, and are more or less stable than regular histone H2B. All ...
*  Pelger-Huet anomaly
It is characterized by a white blood cell type known as a neutrophil whose nucleus is hyposegmented.[citation needed] It is a ... Pelger-Huët anomaly (pronunciation: [pel′gər hyo̅o̅′ət]) is a blood laminopathy associated with the lamin B receptor. ... Is a benign dominantly inherited defect of terminal neutrophil differentiation as a result of mutations in the lamin B receptor ... "Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly ...