Aminoadipate-semialdehyde dehydrogenase
"Entrez Gene: Aminoadipate-semialdehyde dehydrogenase". Retrieved 2017-01-02. Wang L, Jil C, Xu Y, Xu J, Dai J, Wu Q, Wu M, Zou ... Aminoadipate-semialdehyde dehydrogenase is a protein that in humans is encoded by the AASDH gene. This gene encodes a member of ... a putative PQQ-dependent AAS dehydrogenase". Mol. Biol. Rep. 32 (1): 47-53. doi:10.1007/s11033-003-2716-4. PMID 15865210. S2CID ...
L-aminoadipate-semialdehyde dehydrogenase
... aminoadipate semialdehyde dehydrogenase, 2-aminoadipate semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde ... dehydrogenase, alpha-aminoadipate reductase, 2-aminoadipic semialdehyde dehydrogenase, L-alpha-aminoadipate delta-semialdehyde ... a L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) is an enzyme that catalyzes the chemical reaction L-2-aminoadipate 6- ... L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine, and ...
Pyrroloquinoline quinone
L-aminoadipate-semialdehyde dehydrogenase, EC 1.2.1.31 Wen H, He Y, Zhang K, Yang X, Hao D, Jiang Y, He B. Mini-review: ... L-aminoadipate-semialdehyde dehydrogenase (Homo sapiens). July 2015. Retrieved 18 July 2015. {{cite encyclopedia}}: ,work= ... It was reported that aminoadipate semialdehyde dehydrogenase (AASDH) might also use PQQ as a cofactor, suggesting a possibility ... Quinoprotein glucose dehydrogenase is used as a glucose sensor in bacteria. PQQ stimulates growth in bacteria. It was ...
AASDHPPT
Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been ... L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase is an enzyme that in humans is encoded by the ... "Entrez Gene: AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase". Rual JF, Venkatesan K, Hao T, ... which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. ...
Α-Aminoadipate pathway
This is then reduced by aminoadipate reductase via an acyl-enzyme intermediate to a semialdehyde. Reaction with glutamate by ... This is then converted to homoaconitate by homoaconitase and then to homoisocitrate by homoisocitrate dehydrogenase. A nitrogen ... The α-aminoadipate pathway is a biochemical pathway for the synthesis of the amino acid L-lysine. In the eukaryotes, this ... α-Aminoadipic acid is the conjugate acid of α-aminoadipate, the latter of which is the prevalent form at physiological pH. A ...
Biosynthesis
Aspartate-semialdehyde dehydrogenase catalyzes the reduction reaction by dephosphorylation of aspartyl-β-phosphate to yield ... There are two distinct lysine biosynthetic pathways: the diaminopimelic acid pathway and the α-aminoadipate pathway. The most ... Aspartate semialdehyde dehydrogenase catalyzes the NADPH-dependent reduction of aspartyl phosphate to yield aspartate ... "Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino ...
Chromosome 4
AASDH: aminoadipate-semialdehyde dehydrogenase ACVR1: activin-like kinase 2 (ALK-2) ACOX3: encoding enzyme Peroxisomal acyl- ... NAD-dependent methylenetetrahydrofolate dehydrogenase 2-like protein MYL5: Myosin light chain 5 NAP1L5: encoding protein ...
Saccharopine dehydrogenase (NAD+, L-glutamate-forming)
2-aminoadipate 6-semialdehyde + NADH + H+ The 3 substrates of this enzyme are N6-(L-1,3-dicarboxypropyl)-L-lysine, NAD+, and ... L-2-aminoadipic-delta-semialdehyde and, glutamate forming), aminoadipic semialdehyde synthase, saccharopine dehydrogenase (NAD+ ... 2-aminoadipate 6-semialdehyde, NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on ... In enzymology, a saccharopine dehydrogenase (NAD+, L-glutamate-forming) (EC 1.5.1.9) is an enzyme that catalyzes the chemical ...
Saccharopine dehydrogenase
... alpha-ketoglutarate Saccharopine dehydrogenase EC catalyses the condensation to of l-alpha-aminoadipate-delta-semialdehyde ( ... The Saccharopine dehydrogenase enzyme can be classified under EC 1.5.1.7, EC 1.5.1.8, EC 1.5.1.9, and EC 1.5.1.10. It has an ... Saccharopine+Dehydrogenases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Protein pages needing a ... Andi B, Xu H, Cook PF, West AH (November 2007). "Crystal structures of ligand-bound saccharopine dehydrogenase from ...
Saccharopine dehydrogenase (NADP+, L-glutamate-forming)
... dehydrogenase, aminoadipic semialdehyde-glutamic reductase, aminoadipate semialdehyde-glutamate reductase, aminoadipic ... semialdehyde-glutamate reductase, epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase, (L-2-aminoadipate-semialdehyde ... L-2-aminoadipate 6-semialdehyde + NADPH + H+ The 3 substrates of this enzyme are N6-(L-1,3-dicarboxypropyl)-L-lysine, NADP+, ... and H2O, whereas its 4 products are L-glutamate, L-2-aminoadipate 6-semialdehyde, NADPH, and H+. This enzyme belongs to the ...
Alpha-aminoadipic semialdehyde synthase
"AASS - aminoadipate-semialdehyde synthase". RCSB Protein Data Bank. Archived from the original on 2017-11-07. Retrieved 2017-03 ... GCDH is deficient in glutaric aciduria type 1. The intermediate 2-oxoadipate is metabolized by 2-oxoadipate dehydrogenase, ... "Entrez Gene: AASS aminoadipate-semialdehyde synthase". "hyperlysinemia". Genetics Home Reference. Retrieved 2017-03-04. "Alpha- ... Alpha-aminoadipic semialdehyde synthase is an enzyme encoded by the AASS gene in humans and is involved in their major lysine ...
Saccharopine
2-aminoadipate 6-semialdehyde Saccharopinuria (high amounts of saccharopine in the urine) and saccharopinemia (an excess of ... The reactions involved, catalysed by saccharopine dehydrogenases, are: lysine + alpha-ketoglutarate ⇌ saccharopine ⇌ glutamate ... It is a precursor of lysine in the alpha-aminoadipate pathway which occurs in fungi and euglenids. In mammals and higher plants ...
Lysine
In fungi, AAA is reduced to α‑aminoadipate-semialdehyde via AAA reductase (E.C 1.2.1.95) in a unique process involving both ... AAS dehydrogenase (AASD) (E.C 1.2.1.31) then further dehydrates the molecule into AAA. Subsequently, PLP-AT catalyses the ... Whereas the α-aminoadipate (AAA) pathway is part of the glutamate biosynthetic family. The DAP pathway is found in both ... In a variant AAA pathway found in some prokaryotes, AAA is first converted to N‑acetyl-α-aminoadipate, which is phosphorylated ...
List of MeSH codes (D08)
... l-aminoadipate-semialdehyde dehydrogenase MeSH D08.811.682.657.163.812 - malonate-semialdehyde dehydrogenase (acetylating) MeSH ... succinate-semialdehyde dehydrogenase MeSH D08.811.682.657.163.875 - succinate-semialdehyde dehydrogenase (NAD(P)+) MeSH D08.811 ... aminomuconate-semialdehyde dehydrogenase MeSH D08.811.682.657.163.374 - aspartate-semialdehyde dehydrogenase MeSH D08.811. ... betaine-aldehyde dehydrogenase MeSH D08.811.682.657.163.562 - glutamate-5-semialdehyde dehydrogenase MeSH D08.811.682.657. ...
List of EC numbers (EC 1)
L-aminoadipate-semialdehyde dehydrogenase EC 1.2.1.32: aminomuconate-semialdehyde dehydrogenase EC 1.2.1.33: (R)- ... IMP dehydrogenase EC 1.2.1.15: malonate-semialdehyde dehydrogenase EC 1.2.1.16: succinate-semialdehyde dehydrogenase [NAD(P)+] ... glutarate-semialdehyde dehydrogenase EC 1.2.1.21: glycolaldehyde dehydrogenase EC 1.2.1.22: lactaldehyde dehydrogenase EC 1.2. ... succinate-semialdehyde dehydrogenase (acylating) EC 1.2.1.77: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) EC 1.2. ...
Methionine
Aspartokinase Aspartate-semialdehyde dehydrogenase Homoserine dehydrogenase Homoserine O-transsuccinylase Cystathionine-γ- ... but not via α-aminoadipate). The main backbone is derived from aspartic acid, while the sulfur may come from cysteine, ... 7) The enzyme α-ketoacid dehydrogenase converts α-ketobutyrate to propionyl-CoA, which is metabolized to succinyl-CoA in a ... First, aspartic acid is converted via β-aspartyl semialdehyde into homoserine by two reduction steps of the terminal carboxyl ...
List of EC numbers (EC 2)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)) kinase EC 2.7.1.116: Now EC 2.7.11.5, [isocitrate dehydrogenase ( ... L-2-aminoadipate 6-kinase (*) EC 2.7.2.18: fatty acid kinase (*) (*) No Wikipedia article EC 2.7.3.1: guanidinoacetate kinase ... L-aspartate semialdehyde sulfurtransferase (*) (*) No Wikipedia article EC 2.8.2.1: aryl sulfotransferase EC 2.8.2.2: alcohol ... 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)) kinase EC 2.7.11.5: [isocitrate dehydrogenase (NADP+)] kinase EC ...