... (HMWK or HK) is a circulating plasma protein which participates in the initiation of blood ... Higashiyama S, Ohkubo I, Ishiguro H, Kunimatsu M, Sawaki K, Sasaki M (April 1986). "Human high molecular weight kininogen as a ... Its current accepted name is to contrast it with low-molecular-weight kininogen (LMWK) which has a similar function to HMWK in ... Fong D, Smith DI, Hsieh WT (June 1991). "The human kininogen gene (KNG) mapped to chromosome 3q26-qter by analysis of somatic ...
Semba U, Shibuya Y, Okabe H, Hayashi I, Yamamoto T (2000). "Whale high-molecular-weight and low-molecular-weight kininogens". ... Low-molecular-weight kininogen is a form of kininogen, which has been identified in mice, guinea pigs, and whales. It is also ... Low-Molecular-Weight+Kininogen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ... and low-molecular-weight kininogens". Int Immunopharmacol. 4 (10-11): 1391-400. doi:10.1016/j.intimp.2004.06.003. PMID 15313436 ...
There are two main types of kininogen (KNG), high-molecular-weight-kininogen and low-molecular-weight-kininogen, with a third ... "Evidence for the presence of a kininogen-like species in a case of total deficiency of low and high molecular weight kininogens ... High-molecular-weight-kininogen (HK) is a non-enzymatic cofactor involved in the kinin-kallikrein system, which plays a role in ... "Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary ...
Kininogen-1 is the precursor protein to high-molecular-weight kininogen (HMWK), low-molecular-weight kininogen (LMWK), and ... KNG1 gene → low-molecular-weight kininogen (LMWK) protein (contains 427 amino acids) or high-molecular-weight kininogen (HMWK) ... high-molecular-weight kininogen low-molecular-weight kininogen bradykinin GRCh38: Ensembl release 89: ENSG00000113889 - Ensembl ... high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK). HMWK in turn is cleaved by the enzyme ...
Herwald H, Jahnen-Dechent W, Alla SA, Hock J, Bouma BN, Müller-Esterl W (1993). "Mapping of the high molecular weight kininogen ... Thompson RE, Mandle R, Kaplan AP (1980). "Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen ... Hermann A, Buchinger P, Somlev B, Rehbock J (1996). "High and low molecular weight kininogen and plasma prekallikrein/plasma ... Kallikrein and prekallikrein have been shown to interact with High-molecular-weight kininogen. GRCh38: Ensembl release 89: ...
One contains a binding site for thrombin, another for high molecular weight kininogen, a third one for factor IX, heparin and ... Warn-Cramer BJ, Bajaj SP (1986). "Stoichiometry of binding of high molecular weight kininogen to factor XI/XIa". Biochemical ... "Immunologic studies of human coagulation factor XI and its complex with high molecular weight kininogen". Blood. 62 (5): 1123- ... High levels of factor XI have been implicated in thrombosis, although it is uncertain what determines these levels and how ...
Turk B, Stoka V, Turk V, Johansson G, Cazzulo JJ, Björk I (August 1996). "High-molecular-weight kininogen binds two molecules ... Shi GP, Munger JS, Meara JP, Rich DH, Chapman HA (April 1992). "Molecular cloning and expression of human alveolar macrophage ...
Vroman, L.; Adams, AL; Fischer, GC; Munoz, PC (1980). "Interaction of high molecular weight kininogen, factor XII, and ... low molecular weight proteins are displaced by high molecular weight protein while the opposite, high molecular weight being ... fibrinogen displaces earlier adsorbed proteins on a biopolymer surface and is later replaced by high molecular weight kininogen ... The highest mobility proteins generally arrive first and are later replaced by less mobile proteins that have a higher affinity ...
... and low-molecular-weight kininogens". International Immunopharmacology. 4 (10-11): 1391-400. doi:10.1016/j.intimp.2004.06.003. ... Triple-X syndrome (XXX). XXX girls tend to be tall and thin and have a higher incidence of dyslexia. Turner syndrome (X instead ... Molecular Cell Biology. 18 (3): 141-158. doi:10.1038/nrm.2016.159. PMC 5319910. PMID 28053344. Wilson, John (2002). Molecular ... In molecular biology application, this allows for its isolation from plasmid DNA by centrifugation of lysed bacteria and ...
"Molecular modeling of the prekallikrein structure provides insights into high-molecular-weight kininogen binding and zymogen ... is an 85,000 Mr serine protease that complexes with high-molecular-weight kininogen. PK is the precursor of plasma kallikrein, ...
Moreover, plasmin induces the generation of bradykinin in mice and humans through high-molecular-weight kininogen cleavage. ... and low-molecular-weight kininogen. Plasmin has been shown to interact with Thrombospondin 1, Alpha 2-antiplasmin and IGFBP3. ... Forsgren M, Råden B, Israelsson M, Larsson K, Hedén LO (March 1987). "Molecular cloning and characterization of a full-length ... The mutant plasminogen protein has been shown to be a highly efficient kininogenase that directly releases bradykinin from high ...
High-molecular weight kininogen (HMWK) and low-molecular weight kininogen (LMWK) are precursors of the polypeptides. They have ... Heinrich Kraut and Eugen Werle discovered high-molecular weight kininogen in urine around 1930. kinin [Gk] kīn(eîn) to move, ... Kinins are small peptides produced from kininogen by kallikrein and are broken down by kininases. They act on phospholipase and ... The system was discovered in 1909 when researchers discovered that injection with urine (high in kinins) led to hypotension ( ...
... salivary protein inhibits activation of the plasma contact system by binding to factor XII and high molecular weight kininogen ...
... namely prekallikrein and high-molecular-weight kininogen, respectively. Factor VI[citation needed] is unassigned, as accelerin ... The contact activation pathway begins with formation of the primary complex on collagen by high-molecular-weight kininogen ( ... FVIIa circulates in a higher amount than any other activated coagulation factor. The process includes the following steps: ... variant of Factor V or high levels of FVIII, also may lead to a thrombotic tendency.[citation needed] Antithrombin is a serine ...
... may refer to: High-molecular-weight keratin High-molecular-weight kininogen This disambiguation page lists articles ...
The kinin-kallikrein system makes bradykinin by proteolytic cleavage of its kininogen precursor, high-molecular-weight ... Low levels of bradykinin in the body correlate to a high body mass index in adolescents; it has been proposed that bradykinin ... kininogen (HMWK or HK), by the enzyme kallikrein. Moreover, there is compelling evidence that plasmin, a fibrinolytic enzyme, ...
... and high molecular weight kininogen. Excess levels of factor XII can predispose individuals towards greater risk of venous ... Factor XII (FXII, Hageman factor) is a plasma glycoprotein of approximately 90 kDa molecular weight is part of the coagulation ... The purpose of increasing this time is so that the patient may reaching a higher level of medical care before succumbing from ... Human Molecular Genetics. 4 (7): 1235-1237. doi:10.1093/hmg/4.7.1235. PMID 8528215. Hofferbert S, Müller J, Köstering H, von ...
... and low-molecular-weight kininogen. Tongue swellings are a very frequent and characterizing symptom in patients with hereditary ... People in whom episodes occur at least once a month or who are at high risk of developing laryngeal edema require long-term ... kininogen 1 [HAE with a kininogen 1 (KNG1) mutation]; and heparan sulfate-glucosamine 3-sulfotransferase 6 [HAE with a heparan ... A second molecular subtype of HAE with normal C1-inhibitor is caused by a mutation of the plasminogen gene, namely a rare ...
... an enzyme that proteolytically cleaves high-molecular-weight kininogen to produce bradykinin, which is a vasodilator; it is ... EGF is a low-molecular-weight polypeptide first purified from the mouse submandibular gland, but since then found in many human ... higher than plasma) 1.4-39 mmol/L phosphate Iodine (mmol/L concentration is usually higher than plasma, but dependent variable ... These laws may not strictly enforced, but in Singapore, the fine for spitting may be as high as SGD$2,000 for multiple offenses ...
... kininogen, high-molecular-weight MeSH D12.776.124.125.635.490 - kininogen, low-molecular-weight MeSH D12.776.124.125.662.537 - ...
... a name for high-molecular-weight kininogen, a blood coagulation protein Lorentz-FitzGerald contraction hypothesis, physics The ...
... high molecular weight kininogen as well as bacteria. GPIb-IX-V offers a critical role in thrombosis, metastasis, and the life ... GPIb-IX-V consists of four different subunits namely: GPIbα (molecular weight (MW) 135 kDa), GPIbβ (MW 26 kDa), GPIX (MW 20 kDa ... on damaged sub-endothelium under conditions of high fluid shear stress. Although the primary ligand for the GPIb-V-IX receptor ...
Hidradenitis suppurativa Hidrotic ectodermal dysplasia type Christianson Fouris High scapula High-molecular-weight kininogen ...
... and high molecular weight kininogen (HK), bind to a surface and cause blood coagulation and inflammation. FXII and PK are ...
"Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: ... Molecular characterization of CD93 revealed that this protein is identical with C1qRp, a human protein identified as a putative ... In the context of late B cell differentiation, CD93 has been shown to be important for the maintenance of high antibody titres ... Indeed, CD93 deficient mice failed to maintain high antibody level upon immunization and present a lower amount of antigen ...
... kininogen, high-molecular-weight MeSH D23.469.050.375.425.400 - kininogen, low-molecular-weight MeSH D23.469.050.375.850 - ... kininogen, high-molecular-weight MeSH D23.119.630.490 - kininogen, low-molecular-weight MeSH D23.125.300.070 - beta- ...
... kininogen, high-molecular-weight MeSH D12.644.276.875.654.400 - kininogen, low-molecular-weight MeSH D12.644.276.875.900 - ...
"Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: ... Huang Y, Wang KK (2001). "The calpain family and human disease". Trends in Molecular Medicine. 7 (8): 355-62. doi:10.1016/S1471 ... Bradford HN, Jameson BA, Adam AA, Wassell RP, Colman RW (1994). "Contiguous binding and inhibitory sites on kininogens required ...
"Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: ... "Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease". ...
4 out of 5 of the possible glycosylation sites are used in vivo giving the protein a molecular weight of 50-60 kDA. uPAR is a ... Smokers have significantly higher suPAR compared to non-smokers. Urokinase receptors have been found to be highly expressed on ... the role of the urokinase receptor system and kininogen in inflammation". Biochemical Society Transactions. 30 (2): 168-73. doi ... All three three-finger domains are necessary for high affinity binding of the primary ligand, urokinase. In addition, uPAR also ...