... profile in course of treatment of non-small cell lung cancer patients with epidermal growth factor receptor tyrosine kinase ... Some of the factors that should be considered are the level of efficacy of various genetic tests in the general population, ... This drug is only used if a patient's cancer is tested for over-expression of the HER2/neu receptor. Two tissue-typing tests ... April 2005). "Complement factor H variant increases the risk of age-related macular degeneration". Science. 308 (5720): 419-21 ...

... kinase and enhance platelet-derived growth factor receptor down-regulation". J. Biol. Chem. 281 (9): 5956-64. doi:10.1074/jbc. ... 2009). "Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder". Mol. Psychiatry. 14 (5): ...

In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or ... "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". The Journal of Biological ... "Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for ... required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor ...

... line of therapeutics used for treating breast cancer is targeting of kinases like human epidermal growth factor receptor 2 ( ... This is a form of enzymatic deactivation.[citation needed] Growth factor expression levels can also promote resistance to ... One example of this is the loss of estrogen receptor (ER) and progesterone receptor (PR) upon anti-estrogen treatment of breast ... while sensitive cells did not express significant levels of the growth factor. IL-6 activates the CCAAT enhancer-binding ...

... and epidermal growth factor receptor (EGFR) kinases. It inhibits them by covalently binding with a cysteine side chain in those ... Like lapatinib and afatinib, it is a dual inhibitor of the human epidermal growth factor receptor 2 (Her2) ... Neratinib (INN), sold under the brand name Nerlynx, is a tyrosine kinase inhibitor anti-cancer medication used for the ... February 2008). "The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP". Proceedings of ...

"Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity". ... "Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C". ... The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine ... Both M2 and M3 muscarinic receptors are expressed in the smooth muscles of the airway, with the majority of the receptors being ...

It blocks the activity of Abelson cytoplasmic tyrosine kinase (ABL), c-Kit and the platelet-derived growth factor receptor ( ... platelet-derived growth factor receptor). In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion ... imatinib is being used as an experimental agent to suppress platelet-derived growth factor (PDGF) by inhibiting its receptor ( ... myelodysplastic/myeloproliferative diseases associated with platelet-derived growth factor receptor gene rearrangements, ...

Molecular Characterization of neurotrophin expression and the corresponding tropomyosin receptor kinases (trks) in epithelial ... tumor cell lines in response to human prostate stromal cell secretory proteins containing a specific nerve growth factor-like ... Studies of prostate cancer (1990-2010) examined the expression of the neurotrophins and their receptors (Trk family and p75NTR ... Djakiew, D., Byers, S.W. & Dym, M. (1984). Receptor-mediated endocytosis of transferrin and alpha2-macroglobulin by rat ...

"Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the ... "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement ... interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a ... Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. ...

... growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in ... Progesterone raises epidermal growth factor-1 (EGF-1) levels, a factor often used to induce proliferation, and used to sustain ... It has been found that RANKLTooltip Receptor activator of nuclear factor kappa-B ligand is a critical downstream mediator of ... Progesterone mediates ductal development mainly via induction of the expression of amphiregulin, the same growth factor that ...

... after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase. FGF2 has been shown in ... Fibroblast growth factor 2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling ... Angiogenesis Anxiety disorders Cytokine Fibroblast growth factor Growth factor Proteases in angiogenesis Receptor (biochemistry ... Ribatti D, Vacca A, Rusnati M, Presta M (2007). "The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and ...

Serum levels of PGF and sFlt-1 (soluble fms-like tyrosine kinase-1, also known as soluble VEGF receptor-1) are altered in women ... Placental growth factor (PlGF) is a protein that in humans is encoded by the PGF gene. Placental growth factor (PGF) is a ... The placental growth factor (PGF) gene is a protein-coding gene and a member of the vascular endothelial growth factor (VEGF) ... residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt ...

... and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. ... Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is ... Hepatocyte+growth+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Hepatocyte growth factor on ... Epidermal growth factor Insulin-like growth factor 1 Epithelial-mesenchymal transition Madin-Darby Canine Kidney Cells GRCh38: ...

Pollen Tube Growth by Binding to Phosphatidylinositol 3-Phosphate and the Extracellular Domain of the Pollen Receptor Kinase ... Huang WJ, Liu HK, McCormick S, Tang WH (June 2014). "Tomato Pistil Factor STIG1 Promotes in Vivo ... In plant reproduction, CRPs are involved in pollen tube growth and guidance and early embryo patterning, in addition to other ... Several CRPs bind known receptors, but most CRP signaling mechanisms and protein interactions are uncharacterized. ...

"SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase ... 2006). "Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and ... 2004). "Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma ... Watanabe R, Shen ZP, Tsuda K, Yamada Y (2008). "Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in ...

Pemigatinib (Pemazyre) is a kinase inhibitor of fibroblast growth factor receptor 2 (FGFR2) that was approved for medical use ... Infigratinib (Truseltiq) is a tyrosine kinase inhibitor of fibroblast growth factor receptor (FGFR) that was approved for ... unresectable locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or ... Although most people present without any known risk factors evident, a number of risk factors for the development of ...

In addition, gefitinib, an inhibitor of epidermal growth factor receptor (EGFR) -tyrosine kinase, has therapeutic efficacy on ... vascular endothelial growth factor, epidermal growth factor, interferon-gamma inducible protein, and matrix metallopeptidase-9 ... September 2004). "EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with ... It cannot be deduced that identified genetic change is an inducing factor of the disease of interest. Hence, a large sample ...

... a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 ... a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 ... Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). ... SCF binds to the c-KIT receptor (CD 117), a receptor tyrosine kinase. c-Kit is expressed in HSCs, mast cells, melanocytes, and ...

Growth factors bind to receptor tyrosine kinases resulting in the polymerization of actin filaments, which, when cross-linked, ... Directed transport of receptor-bound epidermal growth factor (EGF) along filopodia has also been described, supporting the ... growth factors stimulate the formation of filopodia in fibroblasts to direct fibroblast migration and wound closure. In ... In developing neurons, filopodia extend from the growth cone at the leading edge. In neurons deprived of filopodia by partial ...

... epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). ... Tesevatinib binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor ... June 2007). "Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647". Clinical Cancer ... June 2007). "Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647". Clinical Cancer ...

... "low affinity nerve growth factor receptor). TrkC is a receptor tyrosine kinase (meaning it mediates its actions by causing the ... Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the ... NT-3 binds three receptors on the surface of cells which are capable of responding to this growth factor: TrkC (pronounced " ... Also as mentioned, there are other neurotrophic factors structurally related to NT-3: NGF (for "Nerve Growth Factor") BDNF (for ...

... kinase (PI 3-kinase), that are activated by the insulin-like growth factor-I receptor. His group also showed that very low ... Phosphatidylinositol 3' kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression ... Phosphatidylinositol 3' kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression ... growth factor I-induced differentiation and downstream activation signals of the insulin-like I growth factor receptor in ...

Cyclin-dependent kinase 7, DACH1, Death associated protein 6, L-DOPA, EFCAB6, Epidermal growth factor receptor, FOXO1, GAPDH, ... One of the known target genes of androgen receptor activation is the insulin-like growth factor 1 receptor (IGF-1R). Thus, ... "The androgen receptor associates with the epidermal growth factor receptor in androgen-sensitive prostate cancer cells". ... One example is serum response factor, a protein that activates several genes that cause muscle growth. Androgen receptor is ...

They interact with fibroblast growth factor receptor 1, which suggests it may be linked to the modulating of neuronal ... They are also important in the formation of heterophilic interactions with NCAM, TAG-1, F11 and receptor tyrosine kinases ( ... Some studies have proved that L1 has a role in tumor growth, tumor cell invasion, metastasis of melanoma, ovarian and colon ... Because L1CAM is considered to be a key factor in metastasis, it has been suggested that blocking this protein may inhibit ...

Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proc. ... It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF ... "Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase". Mol. Cell ... Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is ...

Mechanism of action: The drug binds to receptor activator nuclear factor κB ligand (RANKL), preventing the interaction with ... For example, bevacizumab/aflibercept is a monoclonal antibody that specifically binds to vascular endothelial growth factor ( ... it inhibits cellular signalling by targeting multiple receptor tyrosine kinases. It reduces the blood supply to the tumour by ... Risk factors include: Dental treatment (e.g. dentoalveolar surgery/procedure that impacts bone) - it is possible for MRONJ to ...

... insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a ... The Insulin Receptor is a type of tyrosine kinase receptor, in which the binding of an agonistic ligand triggers ... "Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease". ... Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". The Journal of Biological ...

"The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway". EMBO J. 20 (11): 2789- ... This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. ... with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor ... "Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells". Cytokine Growth ...

NGF promotes neuron viability and differentiation by binding to TrkA, a tyrosine receptor kinase. This receptor is important in ... The experiment compared the protein activity of control neurons with the activity of neurons treated with nerve growth factor ( ... Other neurotrophic factor proteomes are needed to guide neurons to each other to create synapses. The broad scope of the ... These receptor proteins are unable to initiate the intracellular signaling processes that enable the neuron to live, and ...

"Isolation and characterization of the human DTK receptor tyrosine kinase". Growth Factors. 11 (2): 137-44. doi:10.3109/ ... "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". ... "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway". ... "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. ...

"Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway". Molecular Cancer ... PELP1 is phosphorylated by hormonal and growth factor signals. PELP1 phosphorylation status is also influenced by cell cycle ... is a transcriptional corepressor for nuclear receptors such as glucocorticoid receptors and a coactivator for estrogen ... also known as modulator of non-genomic activity of estrogen receptor (MNAR) and transcription factor HMX3 is a protein that in ...

2004). "A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor ... "Isolation and characterization of a human putative receptor protein kinase cDNA STYK1". Mol Biol Rep. 30 (2): 91-6. doi:10.1023 ... Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: STYK1 serine/threonine/tyrosine kinase 1". Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro ...

An example of RTKs that undergo autophosphorylation is the Epidermal Growth Factor receptor (EGFR). EGFR was the first ... src-kinase deregulation can enhance tumor growth and invasive potential of cancer cells. The activity of src kinases is ... "Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases". Molecules and Cells ... Src kinases are involved in intracellular signaling pathways that influence cell growth and cell adhesion strength. The latter ...

It has also shown activity against the receptors for platelet derived growth factor and vascular endothelial growth factor. ... Non-receptor tyrosine kinase inhibitors, Piperazines, Catechol ethers, Quinolines, Aromatic nitriles, Anilines, Chloroarenes, ... It is an ATP-competitive Bcr-Abl tyrosine-kinase inhibitor with an additional inhibitory effect on Src family kinases ( ... Bosutinib, sold under the brand name Bosulif, is a small molecule BCR-ABL and src tyrosine kinase inhibitor used for the ...

... which can be detected by P2 purinergic receptors, or nerve growth factor, which can be detected by Tropomyosin receptor kinase ... express the tropomyosin receptor kinase A (TrkA), which is a receptor to nerve growth factor (NGF). However, transcription ... and they express a completely different type of growth factor. There currently is a lot of research about the differences ... each of which express a distinct repertoire of ion channels and receptors. Their specializations allow the receptors to ...

Normally, the ACVR1 gene encodes the activin receptor type-1 transmembrane kinase that bind BMP receptors (Type I BMPR and Type ... BMPs belong to a superfamily of proteins known as Transforming growth factor-beta (TGF-β) proteins. The binding of ACVR1 ... The ACVR1 gene encodes a bone morphogenic protein (BMP) receptor; this gene is mutated in FOP. It is responsible for growth and ... ACVR1 encodes activin receptor type-1, a BMP type-1 receptor. The mutation causes substitution of codon 206 from arginine to ...

... (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor ... Holmes K, Roberts OL, Thomas AM, Cross MJ (October 2007). "Vascular endothelial growth factor receptor-2: structure, function, ... Matsumoto T, Mugishima H (June 2006). "Signal transduction via vascular endothelial growth factor (VEGF) receptors and their ... Petrova TV, Makinen T, Alitalo K (November 1999). "Signaling via vascular endothelial growth factor receptors". Experimental ...

... of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor ... "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor". J. Biol. ... "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor". J. Biol. ... "The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase ...

2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in ... Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain ... TENC1 has been shown to interact with AXL receptor tyrosine kinase. GRCh38: Ensembl release 89: ENSG00000111077 - Ensembl, May ... "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem ...

35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase ... "The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo". Molecular and ... Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in ... Annexin A2 has been shown to interact with Prohibitin, CEACAM1, S100A10, PCNA, complement Factor H, and a number of viral ...

... is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain. Thus gefitinib ... "Nationwide Real-world Cohort Study of First-line Tyrosine Kinase Inhibitor Treatment in Epidermal Growth Factor Receptor- ... survival in advanced epidermal growth factor receptor mutated non-small cell lung cancer using different tyrosine kinase ... Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts signaling through the epidermal growth factor receptor (EGFR) ...

2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in ...

For example, growth and differentiation is dependent on CSF-1 and a functional CSF-1 receptor, a member of the tyrosine kinase ... which may carry unwanted growth factors, are removed. Next, IL-3 and IL-1, two growth factors, are often added to increase ... Exogenous media containing growth factors and other serums must also be added to make the cells continually viable. Full growth ... BMDMs can differentiate into mature macrophages in the presence of growth factors and other signaling molecules. ...

... a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor ... 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, ... It efficiently inhibited growth factor-induced EGFR and ErbB2 phosphorylation in tumors for >72 h, a phenomenon correlating ... growth factor-induced EGFR and ErbB2 phosphorylation was also efficiently inhibited with IC50s of 11 and 220 nM, respectively. ...

... the vitamin D3 receptor VDR, Raf kinase, calpain, and the epidermal growth factor receptor. Upon activation, protein kinase C ... membrane-bound receptor for activated protein kinase C proteins). The protein kinase C enzymes are known for their long-term ... In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are ... The consensus sequence of protein kinase C enzymes is similar to that of protein kinase A, since it contains basic amino acids ...

July 2016). "Polo-like kinase 1 inhibition diminishes acquired resistance to epidermal growth factor receptor inhibition in non ... Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), ... Kinase activity is regulated at least in part, by the polo-boxes that are functionally important for both auto-inhibition and ... S. cerevisiae polo kinase CDC5 is required to phosphorylate and remove meiotic cohesion during the first cell division. In CDC5 ...

mTOR is activated in tumor cells by various mechanisms including growth factor surface receptor tyrosine kinases, oncogenes, ... is a kinase enzyme inside the cell that collects and interprets the numerous and varied growth and survival signals received by ... When the kinase activity of mTOR is activated, its downstream effectors, the synthesis of cell cycle proteins such as cyclin D ... and hypoxia-inducible factor-1a (HIF-1a) are increased. HIF-1a then stimulates VEGF. Whether or not mTOR kinase is activated, ...

It is a small molecule inhibitor of fibroblast growth factor receptor (FGFR) used for the treatment of cancer. FGFRs are a ... Saxty, Gordon (3 November 2011). "Pyrazolyl quinazoline kinase inhibitors". Google Patents. Bahleda R, Italiano A, Hierro C, ... Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors". Clin. Cancer Res. ... Protein kinase inhibitors, Johnson & Johnson brands, Pyrazoles, Quinoxalines). ...

"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 ( ... C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor ... The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/ ... "Entrez Gene: FIGF c-fos induced growth factor (vascular endothelial growth factor D)". Stacker SA, Caesar C, Baldwin ME, ...

"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 ( ... "Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor ... Jeltsch was the first to show that VEGF-C and VEGF-D are the principal growth factors for the lymphatic vasculature and his ... "Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis". The EMBO Journal. 20 (4): 672-82. ...

He became famous for his discoveries of several receptor tyrosine kinases (RTKs) and the first growth factor capable of ... "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". ... "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine ... a novel acidic fibroblast growth factor receptor with a distinct expression pattern". The EMBO Journal. 10 (6): 1347-54. doi: ...

The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor ... There are 11 growth factors that activate ErbB receptors. The ability ('+') or inability ('-') of each growth factor to ... "Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor α". ... "Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor ...

... transforming growth factor (TGF-𝝱). TGF-𝝱 works by binding to cell-surface receptors and activating the Smad gene regulatory ... as the kinase activation in these cancers is connected to exposure to both growth factors and estradiol. Third, downstream ... Other well-known mitogenic growth factors include platelet derived growth factor (PDGF) and epidermal growth factor (EGF). ... This is not true for all growth factors, as some growth factors instead appear to cause mitogenic effects like growth ...

Sam68 is also downstream of the epidermal growth factor receptor (EGFR), hepatocyte growth factor (HGF)/Met receptor (c-Met), ... protein by which signals from growth factors or soluble tyrosine kinases, such as Src family kinases, act to regulate cellular ... leptin and tumor necrosis factor (TNF) receptors. While the role of Sam68 in these pathways is slowly emerging much remains to ... "Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor". J Biol Chem. 284 (46): 31903-13. doi ...

... has been shown to interact with Tropomyosin receptor kinase A. Protein targeting Nervous system VGF Nerve ... Growth Factor-inducible, a protein whose expression is induced by NGF Neurotrophin Nerve growth factor receptor Growth factor ... "Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors". The ... This pathway begins with the Trk receptor complex-recruitment of a second adaptor protein called growth factor-receptor bound ...

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene. HGS has ... "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor". J. Biol. Chem. 276 (10): ... Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA ... "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate". Raiborg C, Bache KG, Mehlum A, Stang E, ...

"Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases". The ... basic fibroblast growth factor, platelet-derived growth factor, estrogen, lysophosphatidic acid, phosphoinositides, ETK, AKT, ... "Basic fibroblast growth factor-induced translocation of p21-activated kinase to the membrane is independent of phospholipase C- ... "Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated ...

... neutralization or VEGF receptor tyrosine kinase inhibition. A randomized, double-blind, placebo-controlled phase II study ... but its anti-angiogenic effects do not appear to be linked to vascular endothelial growth factor (VEGF) ...

2000). "Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino) ... It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 ... Khurana V, Minocha M, Pal D, Mitra AK (May 2014). "Inhibition of OATP-1B1 and OATP-1B3 by tyrosine kinase inhibitors". Drug ... "Role of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitors". Drug Metabol Drug Interact. 29 (3): 179 ...

... upregulated for renal tissue repair and regeneration by encoding the receptor tyrosine kinase c-MET of hepatocyte growth factor ... "Risk Factors for Kidney Cancer". www.cancer.org. Retrieved 2020-04-08. Rhoades Smith KE, Bilen MA (November 2019). "A Review of ... Additionally, other risk factors such as smoking, obesity, and high blood pressure can influence the pathogenesis of PRCC. ... April 2012). "Prognostic factors in a large multi-institutional series of papillary renal cell carcinoma". BJU International. ...