*Lymphokine-activated killer cell

The mechanism of LAK cells is distinctive from that of natural killer cells because they can lyse cells that NK cells cannot. ... In cell biology, a lymphokine-activated killer cell (also known as a LAK cell) is a white blood cell that has been stimulated ... LAK cells are specific to tumor cells and do not display activity against normal cells. LAK cells, along with the ... Lymphokine-Activated Killer Cells at the US National Library of Medicine Medical Subject Headings (MeSH). ...

*Cytokine-induced killer cell

... of CIK cells by the National Cancer Institute Natural killer cell Natural killer T cell Lymphokine-activated killer cell ... CIK cells is distinctive from that of natural killer cells or LAK cells because they can lyse cells that NK cells and LAK cells ... Cytokine-induced killer cells or CIK cells are a group of immune effector cells featuring a mixed T- and natural killer (NK) ... Several sources also call them natural killer cell-like T cells due to their close relationship to NK cells. Others propose to ...

*Antibody-dependent cell-mediated cytotoxicity

... peripheral blood mononuclear cell), of which a small percentage are NK cells (Natural Killer cell); less often they are purfied ... ADCC requires an effector cell which classically is known to be natural killer (NK) cells that typically interact with IgG ... the Natural Killer cell releases cytotoxic factors that cause the death of the target cell. During replication of a virus some ... NK cells are involved in killing tumor cells and other cells that may lack MHC I on their surface, indicating a non-self cell. ...

*Granzyme B

... natural killer cells (NK cells) and cytotoxic T cells. It is secreted by these cells along with the pore forming protein ... Granzyme B is secreted by regulatory T cells to kill CD4+ T cells that have not been exposed to host cells that are restricted ... It is produced by many types of cell to protect themselves from accidental granzyme B mediated cell death. PI-9 is metastable ... The destruction of insulin producing β cells in pancreatic islets is mediated by T cells and granzyme B contributing to Type 1 ...

*Natural killer cell

Natural Body Guards: How Your Killer Cells Get Motivated. Livescience.com. Retrieved on 2007-10-20. Natural Killer Cells at the ... Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system. The role NK cells ... NK cells are thought to be an important cell type in this process. These cells are known as "uterine NK cells" (uNK cells) and ... "Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells". eLife. 3: ...

*Natural killer T cell

Natural killer T cells should not be confused with natural killer cells. The term "NK T cells" was first used in mice to define ... Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer ... Cytotoxic T cell (killer T cell) Jerud, ES; Bricard G; Porcelli SA (2006). "Natural Killer T cells: Roles in Tumor ... NKT cells include both NK1.1+ and NK1.1−, as well as CD4+, CD4−, CD8+ and CD8− cells. Natural killer T cells can share other ...

*Killer-cell immunoglobulin-like receptor

Because natural killer cells target virally infected host cells and tumor cells, inhibitory KIR receptors are important in ... Natural killer (NK) cells are a type of lymphocyte cell involved in the innate immune system's response to viral infection and ... Natural killer cell cytolysis of target cells and cytokine production is controlled by a balance of inhibitory and activating ... KIR3DS1 NK cell receptors bind directly to the MHC class I molecules on the surface of target cells. Human killer cell ...

*Hybrid resistance

This rejection is caused by natural killer (NK) cells of the recipient. The model which describes this event is called "The ... signaling of murine natural killer cells. Seminars in Immunology. April 1995, roč. 7, čís. 2, s. 121-127. PMID 7579194 Liu, ... The activity of these cells (NK cells) is ihnibited, if there is cell signaling through inhibitory receptros (Ly49 - mouse, KIR ... signaling of murine natural killer cells". Semin Immunol. 7: 121-7. doi:10.1006/smim.1995.0016. PMID 7579194. Ljunggren, HG; ...

*DNK

Decidual Natural Killer Cell. NK cell Digital Network Knowledge, Indonesia ICT Company.. ...

*The Compatibility Gene

... that a cell was diseased, and should be killed by a Natural Killer (NK) cell. 8. Sex and Smelly T-shirts The chapter describes ... and natural killer cells. These last are elements of the immune system which recognise cancer cells as non-self and kill them, ... "Focus on Natural Killer Cells: Classics". Nature Immunology. 9 (5). 2008. With help from experts in the field, we have compiled ... Alan Townsend found that killer T-cells destroyed cells that carried an HLA protein and small fragments of viral protein. Those ...

*Eva Klein

... tumor cells or cells infected with viruses. Klein named them "natural killer cells". Klein has had a longstanding interest in ... killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer ... a Hungarian-Swedish scientist best known for leading the discovery of natural killer cells and developing Burkitt Lymphoma cell ... malignant behavior can be suppressed by genes in normal cells. In the 1960s, Eva Klein developed cell lines from Burkitt ...

*Adaptive NK cells

Adaptive natural killer (NK) cells is a sub-population of natural killer cells, a cell type of the innate immune system. ... Sun, JC; Beilke, JN; Lanier, LL (Jan 29, 2009). "Adaptive immune features of natural killer cells". Nature. 457 (7229): 557-561 ... "The Broad Spectrum of Human Natural Killer Cell Diversity". Immunity. 5 (47): 820-833. doi:10.1016/j.immuni.2017.10.008. PMID ... Adaptive NK cells have been identified in both humans and mice.. The term adaptive NK cells stems from their described ...

*Cortisol

"Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity ... Natural killer cells are affected by cortisol. Cortisol stimulates many copper enzymes (often to 50% of their total potential ... alpha by antigen-presenting cells (APCs) and T helper (Th)1 cells, but upregulates IL-4, IL-10, and IL-13 by Th2 cells. This ... The suppressor immune cells are not affected by GRMF, so the immune cells' effective setpoint may be even higher than the ...

*CD244

It is also known as Natural Killer Cell Receptor 2B4 This gene encodes a cell surface receptor expressed on natural killer ... natural killer cell receptor 2B4". Online Mendelian Inheritance in Man (OMIM) 605554 "CD244 molecule, natural killer cell ... 1999). "2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48". J. Exp. Med. 188 ... Kumaresan PR, Mathew PA (2000). "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel ...

*CD48

... which is also a member of the CD2 subfamily SLAM of IgSF expressed on natural killer cells (NK cells) and other leukocytes. The ... Brown MH, Boles K, van der Merwe PA, Kumar V, Mathew PA, Barclay AN (December 1998). "2B4, the natural killer and T cell ... Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells". Mol. Immunol. ... CD48 is expressed on all peripheral blood lymphocytes (PBL) including T cells, B cells, Null cell and thymocytes. It is also ...

*Chemorepulsion

Other innate leukocytes include natural killer cells, mast cells, eosinophils, basophils, macrophages, and dendritic cells. ... dendritic cells) and Lymphoid lineage cells (T-cells, B-cells, NK-cells). The chemorepulsion of immune cells was first ... Farrell, HE; Degli-Esposti, Davis-Poynter NJ (1999). "Cytomegalovirus evasion of natural killer cell responses". Immunology ... Cancer cells leverage the chemorepulsion of immune cells to evade recognition and destruction by immune cells. Without a ...

*Herpesviridae

These two events allow for immune evasion by suppressing the cell-mediated immune response and natural killer cell response, ... This prevents the natural killer cell response.[citation needed] There are nine distinct viruses in this family known to cause ... clinical signs such as swollen or tender lymph nodes and immunological findings such as reduced levels of natural killer cells ... Infection is initiated when a viral particle contacts a cell with specific types of receptor molecules on the cell surface. ...

*Netherton syndrome

... and immature natural killer cells. These Natural Killer cells have a reduced lytic function; which can be improved with regular ... but are not as vulnerable to opportunistic pathogens as patients with true Natural Killer cell deficiency-type SCID. Netherton ...

*Cytosis

Some cells are specially designed to phagocytize. These cells include Natural Killer cells, macrophages, and neutrophils. All ... Endocytosis is when a cell absorbs molecules, such as proteins, from outside the cell by engulfing it with the cell membrane. ... The vesicles fuse with the cell membrane and their content, usually protein, is released out of the cell. There are two types ... Methods of cytosis not only move substances in, out of, and through cells, but also add and subtract membrane from the cell's ...

*LabCentral

"LabCentral resident Conkwest treats Cancer with Natural Killer Cells". LabCentral. Retrieved 10 October 2013. "LabCentral ...

*HLA-E

... has a very specialized role in cell recognition by natural killer cells (NK cells). HLA-E binds a restricted subset of ... "Human natural killer cells: their origin, receptors and function". European Journal of Immunology. 32 (5): 1205-11. doi:10.1002 ... "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature. 391 (6669): 795-9. doi:10.1038/35869. PMID 9486650. ... This allows HLA-E to assemble correctly and to be expressed on the cell surface. NK cells recognize the HLA-E+peptide complex ...

*CD96

Smyth, Mark J.; Martinet, L. (March 2015). "Balancing natural killer cell activation through paired receptors". Nature Reviews ... The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the ... is a receptor expressed on T cells and NK cells, and shares sequence similarity with CD226 (also known as DNAM-1). The protein ... Fuchs, Anja; Colonna, M. (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor ...

*NKG7

Natural killer cell granule protein 7 is a protein that in humans is encoded by the NKG7 gene. GRCh38: Ensembl release 89: ... Natural killer cell granule protein 7". Retrieved 2016-02-23. ...

*Fc receptor

... natural killer cells) or adaptive immune system (e.g., B cells). They allow these cells to bind to antibodies that are attached ... Trinchieri G, Valiante N (1993). "Receptors for the Fc fragment of IgG on natural killer cells". Natural Immunity. 12 (4-5): ... natural killer cells, T and B cells) and the signalling properties of each receptor. All of the Fcγ receptors (FcγR) belong to ... FcγRIII receptors on the surface of natural killer (NK) cells stimulate the NK cells to release cytotoxic molecules from their ...

*XCR1

Maghazachi AA (1999). "Intracellular signalling pathways induced by chemokines in natural killer cells". Cell. Signal. 11 (6): ... Cell Genet. 87 (3-4): 265-8. doi:10.1159/000015443. PMID 10702689. Kurt RA, Bauck M, Harma S, et al. (2001). "Role of C ... 1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25-35. doi:10.1089/ ... chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo". Cell. Immunol. 209 ( ...

*LILRA3

Norman PJ, Carey BS, Stephens HA, Vaughan RW (June 2003). "DNA sequence variation and molecular genotyping of natural killer ... and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743-51. doi:10.1084/jem. ... an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions ... "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells ...

*Tetrabromobisphenol A

Kibakaya, EC; Stephen K; Whalen MM (2009). "Tetrabromobisphenol A has immunosuppressive effects on human natural killer cells ... and by reducing natural killer cell activity. A 2013 literature review on TBBPA concludes that TBBPA does not produce "adverse ... TBBPA likely also suppresses immune responses by inhibiting expression of CD25 receptors on T cells, preventing their ...