Loading...
*  Mesangial cell
... s are specialised cells in the kidney that make up the mesangium of the glomerulus. Together with the mesangial ... "Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli". Development. 125 (17): 3313- ... Human foetal and infant kidneys stained for alpha smooth muscle actin (α-SMA), a marker for mesangial cells, demonstrated that ... The mesangial cell population accounts for approximately 30-40% of the total cells in the glomerulus. Mesangial cells can be ...
*  Chronic kidney disease
It reflects one aspect of kidney function: how efficiently the glomeruli (filtering units) work. But as they make up ... Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of ... Similarly, after a kidney transplant, the levels may not go back to normal as the transplanted kidney may not work 100%. If it ... Historically, kidney disease has been classified according to the part of the kidney anatomy involved. Vascular disease ...
*  Proteinuria
... may be a sign of renal (kidney) damage. Since serum proteins are readily reabsorbed from urine, the presence of ... There are three main mechanisms to cause proteinuria: Due to disease in the glomerulus Because of increased quantity of ... The 2005 UK Chronic Kidney Disease guidelines states protein/creatinine ratio is a better test than 24-hour urinary protein ... "Identification, management and referral of adults with chronic kidney disease: concise guidelines" (PDF). UK Renal Association ...
*  Kidney failure
... proteins are too large to pass through the kidneys, however, they are able to pass through when the glomeruli are damaged. This ... Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys no longer work. It is ... Kidney failure can be divided into two categories: acute kidney injury or chronic kidney disease. The type of renal failure is ... Acute kidney injuries can be present on top of chronic kidney disease, a condition called acute-on-chronic kidney failure ( ...
*  Podocin
... the glomerular basement membrane and the filtration slits function as the filtration barrier of the kidney glomerulus. ... "Podocin Inactivation in Mature Kidneys Causes Focal Segmental Glomerulosclerosis and Nephrotic Syndrome". Journal of the ...
*  Glomerulus (kidney)
The glomerulus and its surrounding Bowman's capsule constitute a renal corpuscle, the basic filtration unit of the kidney. The ... The glomerulus (/ɡləˈmɛr(j)ələs, ɡloʊ-/), plural glomeruli, is a network of capillaries known as a tuft, located at the ... Glomerulus. Scanning electron microscope of a glomerulus in a mouse (1000x magnification) Scanning electron microscope of a ... The glomerulus is a tuft of small blood vessels called capillaries located within Bowman's capsule within the kidney. ...
*  Prostaglandin EP4 receptor
EP4 protein is found in humans as measured by immunochemistry in pulmonary veins; kidney glomeruli and Tunica media of kidney ... kidney, thymus, uterus, dorsal root ganglions, and brain. ...
*  PDGFRB
"Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli". Development. 125 (17): 3313-22 ... Soriano P (1994). "Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice". Genes & ... kidney, skin and eye. In vitro studies using cultured cells indicate that endothelial cells secrete PDGF, which recruits PDGFRβ ...
*  Laminin, beta 2
It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle ...
*  Retinol binding protein 4
... which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding ...
*  Marilyn Farquhar
George Palade was working on the kidney glomerulus at the time and provided Farquhar with formal training in the field of cell ... She has yielded a number of discoveries in basic biomedical research including: mechanisms of kidney disease, organization of ... Farquhar's research focuses on control of intracellular membrane traffic and the molecular pathogenesis of auto immune kidney ... Farquhar's research has yielded a number of discoveries in basic biomedical research, including mechanisms of kidney disease, ...
*  Lupus nephritis
The diagnosis of lupus nephritis depends on blood tests, urinalysis, X-rays, ultrasound scans of the kidneys, and a kidney ... It is a type of glomerulonephritis in which the glomeruli become inflamed. As the result of SLE, the cause of ... Kidney failure is very rare in this form. Class II is based on a finding of mesangial proliferative lupus nephritis. This form ... Kidney failure is common in this form. Class V is membranous nephritis and is characterized by extreme edema and protein loss. ...
*  Diabetic nephropathy
The GFB is responsible for the highly selective filtration of blood entering the kidney's glomeruli and normally only allows ... Diabetic nephropathy (DN), also known as diabetic kidney disease, is the chronic loss of kidney function occurring in those ... Affected individuals with end-stage kidney disease often require hemodialysis and eventually kidney transplantation to replace ... These changes damage the kidney's glomeruli (networks of tiny blood vessels), which leads to the hallmark feature of albumin in ...
*  Plasma cell dyscrasia
... and various myeloma proteins can deposit selectively in the kidneys glomeruli to cause various forms of organized deposit and ... 0.5 gram/day), which suggests the presence of a particularly severe form of kidney injury (myeloma cast nephropathy), supports ... However, they sometimes causes serious tissue damage with the kidney being a particularly vulnerable target. The toxic effects ... Diagnosis depends or identifying these other syndromes and the identification of complement components on kidney biopsy. ...
*  Glomerulus
... may refer to: the filtering unit of the kidney; see Glomerulus (kidney). the structure in the olfactory bulb; see ... Glomerulus (/ɡləˈmɛr(j)ələs, ɡloʊ-/) is a common term used in anatomy to describe globular structures of entwined vessels, ... Glomerulus is the diminutive of the Latin glomus, meaning "ball of yarn". ... Glomerulus (olfaction). the contact between specific cells in the cerebellum; see Glomerulus (cerebellum). Glomerulation, a ...
*  John Savill
... especially inflammatory disorders of the kidney glomerulus (glomerulonephritis) and interstitium (tubulointerstitial nephritis ...
*  List of MeSH codes (A05)
... kidney cortex MeSH A05.810.453.324.359 --- kidney glomerulus MeSH A05.810.453.324.359.224 --- glomerular basement membrane MeSH ... kidney calices MeSH A05.810.453.736 --- nephrons MeSH A05.810.453.736.520 --- kidney glomerulus MeSH A05.810.453.736.520.224 ... kidney tubules, collecting MeSH A05.810.453.736.560.540 --- kidney tubules, distal MeSH A05.810.453.736.560.570 --- kidney ... kidney medulla MeSH A05.810.453.537 --- kidney pelvis MeSH A05.810.453.537.503 --- ...
*  Cystinuria
... reabsorption of cystine in the proximal convoluted tubules after the filtering of the amino acids by the kidney's glomeruli, ... Rule, A. D.; Krambeck, A. E.; Lieske, J. C. (2011). "Chronic Kidney Disease in Kidney Stone Formers". Clinical Journal of the ... Cystinurics have an increased risk for chronic kidney disease and since kidney damage or poor function is often present in ... and is one of many causes of kidney stones. If not treated properly, the disease could cause serious damage to the kidneys and ...
*  Edema
... syndrome are due to biochemical and structural changes in the basement membrane of capillaries in the kidney glomeruli, and ... Palmer BF, Alpern RJ (1997). "Pathogenesis of edema formation in the nephrotic syndrome". Kidney Int. Suppl. 59: S21-7. PMID ... Raised hydrostatic pressure often reflects retention of water and sodium by the kidney. Generation of interstitial fluid is ...
*  Type III hypersensitivity
... kidney glomeruli and joint tissues respectively) bear the brunt of the damage. Hence, vasculitis, glomerulonephritis and ... These immune complexes insert themselves into small blood vessels, joints, and glomeruli, causing symptoms. Unlike the free ...
*  PDGFRA
... the mutant mice exhibit defects in kidney glomeruli because of a lack of mesangial cells but also suffer an ill-defined blood ...
*  Hypertensive kidney disease
... from mild to sclerosis of glomeruli) and scarring around the glomeruli (periglomerular fibrosis). In advanced stages, kidney ... The idea is that hypertension results in sclerosis of the glomeruli which ultimately means reduced kidney function. As a ... Chronic hypertension with progressive kidney disease progresses over a long period of time. Damage to the glomeruli allows ... Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. HN can ...
*  Rapidly progressive glomerulonephritis
Regardless of the underlying cause, RPGN involves severe injury to the kidneys' glomeruli, with many of the glomeruli ... of glomeruli seen on kidney biopsies. If left untreated, it rapidly progresses into acute renal failure and death within months ... Instead, the glomeruli are damaged in an undefined manner, perhaps through the activation of neutrophils in response to ANCA. ... The predictor of kidney survival is serum creatinine value. The substitution of azathioprine for cyclophosphamide after a 90- ...
*  Glomerular hyperfiltration
... is a situation where the filtration elements in the kidneys called glomeruli produce excessive ... It can be part of a number of medical conditions particularly diabetic nephropathy (kidney damage associated with diabetes). ...
*  Nephron
Kidney tissue Glomerulus This image shows the types of cells present in the glomerulus part of a kidney nephron. Podocytes, ... The nephron (from Greek νεφρός - nephros, meaning "kidney") is the microscopic structural and functional unit of the kidney. It ... and polycystic kidney disease. Distribution of blood vessels in cortex of kidney. (Although the figure labels the efferent ... The glomerulus is the network known as a tuft, of filtering capillaries located at the vascular pole of the renal corpuscle in ...
*  LECT2
Kidney biopsy shows the presence of LECT2-based amyloid predominantly in the renal cortex interstitium, glomeruli, and ... For example, autopsy studies find that up to 3.1% of Hispanics have these deposits in their kidneys but no history of signs or ... They may have histological evidence of LECT2 amyloid deposition in the liver, lung, spleen, kidney, and adrenal glands of ... There is no recommended specific treatment for ALECT2 amyloidosis other than support of kidney function and dialysis. It is ...
*  Nephrotic syndrome
The renal glomerulus filters the blood that arrives at the kidney. It is formed of capillaries with small pores that allow ... The underlying mechanism typically involves damage to the glomeruli of the kidney. Diagnosis is typically based on urine ... The treatment of kidney damage may reverse or delay the progression of the disease. Kidney damage is treated by prescribing ... It is characterized by the appearance of tissue scarring in the glomeruli. The term focal is used as some of the glomeruli have ...