In humans, plasma kallikrein (encoded by KLKB1 gene) has no known paralogue, while tissue kallikrein-related peptidases (KLKs) ... As some kallikreins are able to catalyse the activation of other kallikreins, several cascades involving these proteases have ... Distinct from plasma kallikrein, tissue kallikreins (KLKs) are expressed throughout the human body and perform various ... Prekallikrein Kinin-kallikrein system Kinin Aprotinin List of cutaneous conditions Raspi G (September 1996). "Kallikrein and ...
2001). "Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer". Br. J. Cancer. 84 (5): ... Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In ... "Entrez Gene: KLK5 kallikrein-related peptidase 5". Brattsand M, Stefansson K, Lundh C, et al. (2005). "A proteolytic cascade of ... 2003). "The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease ...
Term ''kallikrein 7 may refer to: Stratum corneum chymotryptic enzyme, an enzyme class KLK7, a serine protease that in humans ... is encoded by the KLK7 gene This disambiguation page lists articles associated with the title Kallikrein 7. If an internal link ...
... (EC 3.4.21.119, KLK13, kallikrein mK13, mGK-13, mK13, mKLK13, prorenin converting enzyme 1, PRECE-1, prorenin- ... Kallikrein+13 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (Articles with short ... Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K (March 2006). "Tissue kallikrein mK13 is a candidate ... "Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)". ...
... (EC 3.4.21.118, KLK8, PRSS19, human kallikrein 8, hK8, mK8, ovasin, tumor-associated differentially expressed gene ... Kallikrein+8 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.21). ... Rajapakse S, Ogiwara K, Takano N, Moriyama A, Takahashi T (December 2005). "Biochemical characterization of human kallikrein 8 ... "Activation and enzymatic characterization of recombinant human kallikrein 8" (PDF). Biological Chemistry. 387 (6): 723-31. doi: ...
... (EC 3.4.21.34, serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, ... Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain ... Plasma+kallikrein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (CS1: long volume ... "Entrez Gene: KLKB1 kallikrein B, plasma (Fletcher factor) 1". Thompson RE, Mandle R, Kaplan AP (October 1979). "Studies of ...
... may refer to: Plasma kallikrein, an enzyme Renal tissue kallikrein, an enzyme This set index page lists ...
... pancreatic kallikrein, submandibular kallikrein, submaxillary kallikrein, kidney kallikrein, urinary kallikrein, kallikrein, ... Kallikrein Fiedler F, Fink E, Tschesche H, Fritz H (1981). Porcine glandular kallikreins. Methods in Enzymology. Vol. 80 Pt C. ... Tissue+kallikrein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (CS1: long volume ... Wines DR, Brady JM, Pritchett DB, Roberts JL, MacDonald RJ (May 1989). "Organization and expression of the rat kallikrein gene ...
Kallikreins (tissue and plasma kallikrein) are serine proteases that liberate kinins (BK and KD) from the kininogens, which are ... The kinin-kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research. It ... Kallikrein-Kinin+System at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (CS1 French-language sources ( ... The Kallikrein-Kinin System". E. K. Frey - E. Werle Foundation of the Henning L. Voigt Family. Goodman & Gilman's Pharmacology ...
Kallikreins are serine proteases. They are packaged within lamellar bodies and released into the intercellular space between ... To prevent premature desquamation, granular layer keratincoytes also produce kallikrein-inhibitory proteins. At acral surfaces ... Keratinocytes residing in the stratum granulosum produce corneodesmosome-degrading kallikrein family members, especially KLK1, ...
Kallikreins activate kinins when stimulated. It is a component of the kinin-kallikrein system. Their precursors are kininogens ... The kinin-forming system at nic.sav.sk v t e (Kinin-kallikrein system, All stub articles, Biochemistry stubs). ... Aspirin inhibits the activation of kallenogen by interfering with the formation of kallikrein enzyme which is essential in the ... Kinins are peptides that are cleaved from kininogens by the process of kallikreins. ...
... and kallikrein at 300,000 IU/ml. Its action on kallikrein leads to the inhibition of the formation of factor XIIa. As a result ... Experiments on the Isolation of the Kallikrein Inactivator. V. The Isolation of a Kallikrein Inactivator From the Bovine Lung ... Initially named "kallikrein inactivator", aprotinin was first isolated from cow parotid glands in 1930. and independently as a ... Kraut H, Frey EK, Bauer E (1930). "Über die Inaktivierung des kallikreins". Hoppe-Seyler's Z Physiol Chem (in German). 192: 1- ...
A later molecular modelling study from 1998 used the homology between glandular kallikrein from the mouse and batroxobin, which ... Earps L, Shoolingin-Jordan PM (August 1998). "Molecular modelling of batroxobin on kallikreins". Biochemical Society ... and most notably pancreatic kallikrein. It was therefore concluded that it is indeed a member of the serine protease family. ...
Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene. Kallikreins are a subgroup of serine proteases having ... "Entrez Gene: KLK14 kallikrein-related peptidase 14". Prassas I, Eissa A, Poda G, Diamandis EP (March 2015). "Unleashing the ... Stefansson K, Brattsand M, Ny A, Glas B, Egelrud T (June 2006). "Kallikrein-related peptidase 14 may be a major contributor to ... This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Apart from its common ...
It is an inhibitor of the protein kallikrein and a 60-amino acid polypeptide which was developed from a Kunitz domain through ... Lehmann A (August 2008). "Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the ... Defective or missing C1-inhibitor permits activation of kallikrein, a protease that is responsible for liberating bradykinin ... Ecallantide suppresses this pathogenetic mechanism by selectively and reversibly inhibiting the activity of plasma kallikrein. ...
Kalinska M, Meyer-Hoffert U, Kantyka T, Potempa J (March 2016). "Kallikreins - The melting pot of activity and function". ... Affinity chromatography studies have also reported a physical association between LCHN and kallikreins KLK5 and KLK11, serine ...
She published extensively on the kinin-kallikrein system while at the National Heart, Lung, and Blood Institute. Webster was an ... Webster, Marion E.; Pierce, Jack V. (December 2006). "The Nature of the Kallidins Released from Human Plasma by Kallikreins and ... Webster, Marion E. (June 1966). "The Kallikrein-Kininogen-Kinin System". Arthritis & Rheumatism. 9 (3): 473-482. doi:10.1002/ ... Webster published extensively on the kinin-kallikrein system. An advocate for women in science, Webster believed in helping ...
Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially ... "Entrez Gene: KLK7 kallikrein-related peptidase 7". Lundström A, Egelrud T (1991). "Stratum corneum chymotryptic enzyme: a ... March 2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and ... Brattsand M, Stefansson K, Lundh C, Haasum Y, Egelrud T (January 2005). "A proteolytic cascade of kallikreins in the stratum ...
Kallikrein and kallikrein inhibitor in rats. Acta Physiol Lat Am. 1974;24(5):460-3. Rocha e Silva M, Beraldo WT, Rosenfeld G. ... Beraldo had also an important role in demonstrating that urinary kallikrein is of renal origin and not pancreatic, as it was ... Beraldo, W.T. and Andrade, S.P.: Discovery of bradykinin and the kallikrein-kinin system. In: The Kinin System. Academic Press ...
Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene. Kallikreins are a subgroup of serine proteases having ... "Entrez Gene: KLK12 kallikrein-related peptidase 12". Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein ... Yousef GM, Magklara A, Diamandis EP (2001). "KLK12 is a novel serine protease and a new member of the human kallikrein gene ... This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this ...
Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene. Kallikreins are a subgroup of serine proteases having ... "Entrez Gene: KLK10 kallikrein-related peptidase 10". Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein ... 2006). "Human kallikrein 10, a predictive marker for breast cancer". Biol. Chem. 387 (6): 715-21. doi:10.1515/BC.2006.090. PMID ... 2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk". Int. J. Cancer. 108 (4): 588-91 ...
Homology with the trypsin/kallikrein gene family". The Journal of Biological Chemistry. 263 (16): 7628-31. doi:10.1016/S0021- ... "Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen". Proceedings of the National Academy of ... an enzyme with thrombin-like and kallikrein-like specificities, on tripeptide nitroanilide derivatives". Thrombosis Research. ...
Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene. Kallikreins are a subgroup of serine ... 2005). "Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial- ... "Entrez Gene: KLK4 kallikrein-related peptidase 4". Clements J, Hooper J, Dong Y, Harvey T (2001). "The expanded human ... 2004). "Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer". Cancer Res. 64 (7): 2365-70. ...
Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene. Kallikreins are a subgroup of serine proteases having ... Kallikrein-13 serves as a priming protease during infection by the human coronavirus HKU1. Many kallikreins are implicated in ... As of 2022, the precise physiological functions of Kallikrein 13 remain unknown. It may play a role in the defense of the upper ... This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is ...
Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene. Kallikreins are a subgroup of serine proteases having ... "Entrez Gene: KLK8 kallikrein-related peptidase 8". Underwood LJ, Tanimoto H, Wang Y, et al. (1999). "Cloning of tumor- ... 2007). "Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor ... 2004). "Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ...
Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene. Kallikreins are a subgroup of serine proteases having ... "Entrez Gene: KLK11 kallikrein-related peptidase 11". Mitsui S, Yamada T, Okui A, et al. (2000). "A novel isoform of a ... 2002). "Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma". Cancer Res. 62 (1): 295-300. PMID 11782391. ... 2005). "Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients". Clin. Biochem. 37 (9): 823-9. doi ...
Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene. Kallikreins are a subgroup of serine proteases having ... "Entrez Gene: KLK15 kallikrein-related peptidase 15". Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein ... This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this ... Yousef GM, Scorilas A, Jung K, Ashworth LK, Diamandis EP (Feb 2001). "Molecular cloning of the human kallikrein 15 gene (KLK15 ...
Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue. ... "Entrez Gene: KLK2 Kallikrein-related peptidase 2". Riegman PH, Vlietstra RJ, van der Korput HA, et al. (1992). "Identification ... 2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) ... Schedlich LJ, Bennetts BH, Morris BJ (1988). "Primary structure of a human glandular kallikrein gene". DNA. 6 (5): 429-437. doi ...
Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. Kallikreins ... "Entrez Gene: KLK1 kallikrein 1". Clements J, Hooper J, Dong Y, Harvey T (2001). "The expanded human kallikrein (KLK) gene ... Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and ... Lu HS, Lin FK, Chao L, Chao J (1989). "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation". Int ...
Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene. Kallikrein-6 is also referred to as neurosin, protease M ... Kallikrein inhibitor was introduced to the mice samples, and it successfully inhibited kallikrein function. In vitro studies ... "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in ... "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in ...