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*  K562 cells
... were the first human immortalised myelogenous leukemia line to be established. K562 cells are of the erythroleukemia ... Many factors and components play a role in the cell cycle of K562 cells in terms of growth, cell differentiation, and apoptosis ... abl over-expression may actually increase cell adherence to cell culture plastic. K562 cells can spontaneously develop ... The problem with K562 cells, and many other cancer cell types, is an overabundance of Aurora kinases. These kinases play a role ...
*  Mir-451 microRNA
Bruchova-Votavova H, Yoon D, Prchal JT (2010). "miR-451 enhances erythroid differentiation in K562 cells". Leuk Lymphoma. 51 (4 ... "MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells". Mol Cell. 37 (5): 620-32 ... Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S (2010). "microRNA-451: A conditional switch controlling glioma cell ... Cell Biology. 42 (8): 1282-90. doi:10.1016/j.biocel.2010.01.014. PMID 20083225. Courts, C; Madea, B (Aug 9, 2011). "Specific ...
*  Duffy antigen system
Chaudhuri A, Zbrzezna V, Polyakova J, Pogo AO, Hesselgesser J, Horuk R (1994). "Expression of the Duffy antigen in K562 cells. ... While the Duffy antigen is expressed on erythrocytes it is also found on some epithelial cells, Purkinje cells of the ... Interactions between the metastasis suppressor KAI1 on tumor cells and the cytokine receptor DARC on adjacent vascular cells ... They display dosage (react more strongly to homozygous cells versus heterozygous cells). Typically mild but may be serious, ...
*  Mir-153 microRNA precursor family
Liu, L.; Chen, R.; Huang, S.; Wu, Y.; Li, G.; Zhang, B.; Liu, Q.; Yin, D.; Liang, Y. (2011). "MiR-153 sensitized the K562 cells ... Xu, J.; Liao, X.; Wong, C. (2009). "Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 ... precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients". Journal ... thereby increasing the abundance of histone H4 biotinylation marks in HEK-293 human kidney cells". The Journal of Nutritional ...
*  Cladonia furcata
Polysaccharides isolated from C. furcata were shown to induce cell death (apoptosis) in human leukemia K562 cells. Furthermore ... "Cladonia furcata polysaccharide induced apoptosis in human leukemia K562 cells". Acta Pharmacologica Sinica. 22 (8): 716-20. ... Extracts of this species have been shown to kill leukemia cells in vitro, and may have possible value in the treatment of ... C. furcata polysaccharides decreased the activity of telomerase, an enzyme that helps some cancer cells avoid death; this ...
*  Harmine
"Harmine showed cytotoxicity against HL60 and K562 cell lines. This could explain the cytotoxic effect of P. harmala on these ... cells." "Harmine was shown to promote differentiation of osteoblasts (bone-forming cells), and chondrocytes (cells in the ... "The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells". Bone. 49: 264-274. doi:10.1016/ ... cartilage)." It was also shown to inhibit osteoclastogenesis (the formation of bone resorbing cells) Harmine, and plants ...
*  Mir-223
"MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells". J Cell Mol Med. 13 (11-12): 4551 ... Cell. 129 (3): 617-31. doi:10.1016/j.cell.2007.02.048. PMID 17482553. Sun G, Li H, Rossi JJ (2010). "Sequence context outside ... Cell. 123 (5): 819-31. doi:10.1016/j.cell.2005.09.023. PMID 16325577. Sugatani T, Hruska KA (2007). "MicroRNA-223 is a key ... Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G (2010). "Cell-cycle ...
*  TSPAN3
Wu YJ, Noguchi CT (1991). "Activation of globin gene expression by cDNAs from induced K562 cells. Evidence for involvement of ... Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The ... Cell Sci. 114 (Pt 23): 4143-51. PMID 11739647. Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap ... proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and ...
*  MIR34A
... "miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53". Blood. 114 (10): 2181-92. doi: ... Cell Cycle. 10 (24): 4256-71. doi:10.4161/cc.10.24.18552. PMID 22134354. Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Deng G ... "miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells". Clinical Cancer Research. 17 (9): 2712- ... induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells". Journal of Virology. 86 (12): 6889-98. ...
*  Cardiotoxin III
Yang SH, Chien CM, Lu MC, Lu YJ, Wu ZZ, Lin SR (July 2005). "Cardiotoxin III induces apoptosis in K562 cells through a ... Recent evidence has shown that CTX III may induce apoptosis in K562 cells via the release of cytochrome c. This protein belongs ...
*  GFI1B
Huang DY, Kuo YY, Chang ZF (2005). "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells". Nucleic Acids Res. ... 1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation". Mol. Cell. Biol. 18 (5): ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... doi:10.1016/j.cell.2006.03.032. PMID 16713569. Xu W, Kee BL (2007). "Growth factor independent 1B (Gfi1b) is an E2A target gene ...
*  BATF2
Huang, Q; Li, X. Q.; Yang, Y; Huang, S. A. (2011). "Influence of BCR-ABL inhibitor STI571 on SARI expression in K562 cells". ... by BCR-ABL in human leukemia cells". Tumour biology : the journal of the International Society for Oncodevelopmental Biology ...
*  Coproporphyrinogen III oxidase
"Expression of coproporphyrinogen oxidase and synthesis of hemoglobin in human erythroleukemia K562 cells". European Journal of ...
*  HEMGN
"Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells". J. Biomed. Sci. 11 (1): 104 ... 2005). "EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the ... 2006). "The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells". ... of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells". ...
*  Zinc finger protein 266
Li XB, Chen J, Deng MJ, Wang F, Du ZW, Zhang JW (2011). "Zinc finger protein HZF1 promotes K562 cell proliferation by ... gene and its function in erythroid and megakaryocytic differentiation of K562 cells". Leukemia. 20 (6): 1109-16. doi:10.1038/sj ... DNA and Cell Biology. 14 (2): 125-36. doi:10.1089/dna.1995.14.125. PMID 7865130. Peng H, Du ZW, Zhang JW (Jun 2006). " ... "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937 ...
*  KIAA1704
... promoter showed significant histone 3 lysine 4 trimethylation peaks in K562 cells (erythroid cell line). It also ... An expression study found that KIAA1704 is significantly up-regulated in U937 cells (macrophage-like human cell line) when ... KIAA1704 has at least a 5 fold expression loss associated with mantle cell lymphoma. In a second study, researchers used a ... "Microarray analysis of nicotine-induced changes in gene expression in a macrophage-like human cell line". J. Periodont. Res. 42 ...
*  12-O-Tetradecanoylphorbol-13-acetate
Huang (2014). "Megakaryocytic Differentiation of K562 Cells Induced by PMA Reduced the Activity of Respiratory Chain Complex IV ... To view the chromosomes, a cytogenetic test requires dividing cells. TPA is used to stimulate division of B-cells during ... TPA is also commonly used together with ionomycin to stimulate T-cell activation, proliferation, and cytokine production, and ... TPA induces KSHV reactivation in PEL cell cultures via stimulation of the mitogen-activated protein kinase (MAPK)/extracellular ...
*  VDAC2
"VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation". Molecular ... Danial NN, Korsmeyer SJ (Jan 2004). "Cell death: critical control points". Cell. 116 (2): 205-19. doi:10.1016/S0092-8674(04) ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. Yoo BC, Fountoulakis M, Cairns N, Lubec G (Jan 2001). " ... an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and ...
*  P-glycoprotein
"Rab4 interacts with the human P-glycoprotein and modulates its surface expression in multidrug resistant K562 cells". ... P-gp is also used to differentiate transitional B-cells from naive B-cells. Dyes such as rhodamine 123 and MitoTracker dyes ... in liver cells where it pumps them into bile ducts, in the cells of the proximal tubule of the kidney where it pumps them into ... is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP- ...
*  Paraptosis
In the NB4 cell line, paraptosis was the primary method of cell death. In K562 cells, apoptosis was the primary mechanism, with ... Cell death induced by IGFIR-IC in 293T cells demonstrated cell death without associated caspase activity. This is in comparison ... to stimulate cell death in 293T cells and mouse embryonic fibroblasts, observing distinct differences from other forms of cell ... This then caused cells to undergo programmed cell death with considerable vacuolization and an absence of DNA fragmentation and ...
*  DCas9 activation system
The antibodies successfully bound to SunTag polypeptides and activated target CXCR4 gene in K562 cell lines. Comparing with the ... Cells can also be reprogrammed or differentiated from on cell type into another by increasing the expression of certain genes ... they were able to increase the CXCR4 gene expression 5-25 times greater in K562 cell lines. Not only was there a greater CXCR4 ... Cell. 159 (3): 635-646. PMID 25307933. PMCID: PMC4252608. DOI: 10.1016/j.cell.2014.09.039. Dominguez, A.A., Lim, W.A., and Qi, ...
*  PTPN7
... phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells". ... Cell Biol. 1 (5): 305-11. doi:10.1038/13024. PMID 10559944. Pettiford SM, Herbst R (2000). "The MAP-kinase ERK2 is a specific ... Cell Biol. 1 (5): 305-11. doi:10.1038/13024. PMID 10559944. Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (April ... This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function ...
*  Diosgenin
Liu MJ, Wang Z, Ju Y, Wong RN, Wu QY (2005). "Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells ...
*  Yam (vegetable)
Liu MJ, Wang Z, Ju Y, Wong RN, Wu QY (2005). "Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells ... contained in the cells of the tuber, which converts it into water, carbon dioxide, and heat energy. During this transformation ...
*  ARL6IP5
2005). "Regulation of a novel cell differentiation-associated gene, JWA during oxidative damage in K562 and MCF-7 cells". J. ... 2004). "[Effect of differentiation inducer and heat stress on the expression of JWA protein and Hsp70 of K562 cells]". Zhonghua ... A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the ... 2006). "JWA, a novel signaling molecule, involved in all-trans retinoic acid induced differentiation of HL-60 cells". J. Biomed ...
*  Mitochondrial ferritin
... an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells ... Cell Biol. 40 (10): 2110-9. doi:10.1016/j.biocel.2008.02.010. PMID 18372207. Snyder AM, Wang X, Patton SM, et al. (2009). " ... Cell. Biol. 26 (7): 2845-56. doi:10.1128/MCB.26.7.2845-2856.2006. PMC 1430308 . PMID 16537925. Hasan MR, Tosha T, Theil EC ( ... J. Physiol., Cell Physiol. 293 (2): C641-9. doi:10.1152/ajpcell.00599.2006. PMID 17459943. Campanella A, Rovelli E, ...