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*  Jurkat cells
... are an immortalized line of human T lymphocyte cells that are used to study acute T cell leukemia, T cell ... Jurkat Cells at the US National Library of Medicine Medical Subject Headings (MeSH) Cellosaurus entry for Jurkat. ... Different derivatives of the Jurkat cell line that have been mutated to lack certain genes can now be obtained from cell ... The I 9.2 and I 2.1 cell lines. The I 2.1 cell line is functionally defective for FADD and the I 9.2 cell line is functionally ...
*  DOK2
Némorin JG, Laporte P, Bérubé G, Duplay P (2001). "p62dok negatively regulates CD2 signaling in Jurkat cells". J. Immunol. 166 ... Cell. Biol. 23 (8): 2658-68. doi:10.1128/MCB.23.8.2658-2668.2003. PMC 152553 . PMID 12665569. Master Z, Tran J, Bishnoi A, et ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell ... This encoded protein binds p120 (RasGAP) from CML cells. DOK2 has been shown to interact with INPP5D and TEK tyrosine kinase. ...
*  UHRF1
"ICBP90 expression is downregulated in apoptosis-induced Jurkat cells". Annals of the New York Academy of Sciences. 1010: 300-3 ... in tumor cell growth". Molecular Biology of the Cell. 16 (12): 5621-9. doi:10.1091/mbc.E05-03-0194. PMC 1289407 . PMID 16195352 ... www.cell.com/cancer-cell/abstract/S1535-6108%2814%2900031-2 Ku DH, Chang CD, Koniecki J, Cannizzaro LA, Boghosian-Sell L, Alder ... Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S ...
*  Complement component 4B
"Elongation factor-1alpha as a homologous complement activator of Jurkat cells". International Journal of Molecular Medicine. 6 ...
*  TMEM143
Possible human expression of TMEM143 protein occurs in Jurkat cells (T lymphocyte). Organelle association puts TMEM143 in the ... This indicates the possibility of TMEM143 participation in lipid metabolic pathways and lipid cell differentiation "TMEM143 ... indicating the location of the protein inside the cell. Orthologs have been identified in more than 85 vertebrate species. ...
*  EPHB6
Luo H, Wan X, Wu Y, Wu J (2001). "Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells". J. ... Eph Nomenclature Committee". Cell. 90 (3): 403-4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. Hock B, Böhme B, Karn T, et ... 2000). "T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed ... hematopoietic cells". Growth Factors. 18 (1): 63-78. doi:10.3109/08977190009003234. PMID 10831073. Tang XX, Zhao H, Robinson ME ...
*  CDC27
"Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells". Proceedings of the ... "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell ... "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell ... Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene. The protein encoded by this ...
*  Cerebral hypoxia
Nov 2001). "Hypoxia induces apoptosis via two independent pathways in Jurkat cells: differential regulation by glucose". ... Brain cells are very sensitive to reduced oxygen levels. Once deprived of oxygen they will begin to die off within five minutes ... During oxygen deprivation, cells die due to an increasing acidity in the brain tissue (acidosis). Additionally, during the ... Cell Physiology. 281 (5): C1596-603. PMID 11600423. Mattiesen W. R.; et al. (May 2009). "Increased neurogenesis after hypoxic- ...
*  Wee1-like protein kinase
"Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells". Proc. Natl. Acad. Sci. ... Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143-9. doi:10.1038/sj.cr.7290279 ... Baldin V, Ducommun B (1995). "Subcellular localisation of human wee1 kinase is regulated during the cell cycle". J. Cell Sci. ... and G2-M cell population". Cell Growth Differ. UNITED STATES. 11 (4): 211-9. ISSN 1044-9523. PMID 10775038. Shen, M; Stukenberg ...
*  CD2
"The lymphocyte-specific tyrosine protein kinase p56lck is endocytosed in Jurkat cells stimulated via CD2". J. Immunol. 148 (12 ... is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell ... CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence ... The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen ...
*  FASTK
This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ... Mol Cell Biol. 24 (24): 10718-32. doi:10.1128/MCB.24.24.10718-10732.2004. PMC 533970 . PMID 15572676. "Entrez Gene: FASTK Fas- ...
*  PI4K2B
"Type II phosphatidylinositol 4-kinase beta associates with TCR-CD3 zeta chain in Jurkat cells". Mol. Immunol. 43 (5): 454-63. ... Cell. 23 (5): 685-95. doi:10.1016/j.molcel.2006.07.014. PMID 16949365. Srivastava R, Sinha RK, Subrahmanyam G (2006). " ...
*  Mir-143
Akao Y, Nakagawa Y, Iio A, Naoe T (2009). "Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells ... 145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease". Cell Death Differ. ... mir-143 was found to be the most enriched miRNA in mouse embryonic stem cells that were differentiating into cardiac progenitor ... It is co-transcribed with miR-145 in cardiac progenitors before becoming vascular smooth muscle cells (VSMCs). VSMCs are ...
*  Eukaryotic translation elongation factor 1 alpha 1
Effect of knocking down eEF1A1 gene on proliferation and apoptosis in Jurkat cells and its mechanisms]". Zhongguo Shi Yan Xue ... Though it has not been observed to localize to the cell membrane, it can be found in the outer cell surface. Its role in ... knocking down the eEF1A1 gene produces inhibited proliferation and induced apoptosis of Jurkat cells. These effects may be ... eEF1A1 is expressed in most cells while eEF1A2 is only expressed in adult neuronal and muscle cells, and only eEF1A1 induces ...
*  Lck
"CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line". The Journal of ... The function of Lck has been studied using several biochemical methods, including gene knockout (knock-out mice), Jurkat cells ... Soula M, Fagard R, Fischer S (Feb 1992). "Interaction of human immunodeficiency virus glycoprotein 160 with CD4 in Jurkat cells ... It associates with the cytoplasmic tails of the CD4 and CD8 co-receptors on T helper cells and cytotoxic T cells, respectively ...
*  AKT3
... and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805-11. doi:10.1002/eji.1830271110. PMID ... AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide ... Cell Genet. 88 (1-2): 38-40. doi:10.1159/000015481. PMID 10773662. Meucci O, Fatatis A, Simen AA, Miller RJ (2000). "Expression ... Sandirasegarane L, Kester M (2001). "Enhanced stimulation of Akt-3/protein kinase B-gamma in human aortic smooth muscle cells ...
*  AKT2
... and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805-11. doi:10.1002/eji.1830271110. PMID ... Cell. Biol. 18 (4): 1978-84. doi:10.1128/mcb.18.4.1978. PMC 121427 . PMID 9528769. Delcommenne M, Tan C, Gray V, Rue L, ... Cell. Biol. 21 (10): 3534-46. doi:10.1128/MCB.21.10.3534-3546.2001. PMC 100275 . PMID 11313479. Clark DE, Poteet-Smith CE, ... Cell. 6 (2): 395-407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986. Jones PF, Jakubowicz T, Hemmings BA (1992). "Molecular ...
*  PIK3C2B
... and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". European Journal of Immunology. 27 (11): 2805-11. doi:10.1002/eji. ... PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell ... Mazerolles F, Barbat C, Fischer A (Sep 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope ... "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this ...
*  SHC1
p66SHC inhibits ERK1/2 activity and antagonize mitogenic and survival abilities of T-lymphoma Jurkat cell lines. A rise in ... When SgK269 is overexpressed in mammary epithelial cells it promotes the cell growth and might contribute to the progression of ... Wrighton KH (Aug 2013). "Cell signalling: EGF signalling--it's all in SHC1's timing". Nature Reviews Molecular Cell Biology. 14 ... p66SHC operates as a redox enzyme linked to apoptotic cell death. p66SHC has been related to the sirtuin-1 system and has been ...
*  SH2D3C
... positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells". The Journal of Biological Chemistry. ... Dail M, Kalo MS, Seddon JA, Côté JF, Vuori K, Pasquale EB (October 2004). "SHEP1 function in cell migration is impaired by a ... "The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell ... "The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell ...
*  PIK3C3
... and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805-11. doi:10.1002/eji.1830271110. PMID ... Cell. Biol. 13 (12): 7408-17. PMC 364812 . PMID 7504174. Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human ... Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope ... 1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation ...
*  PIK3C2G
... and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805-11. doi:10.1002/eji.1830271110. PMID ... PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell ... Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope ... Anand AR, Ganju RK (2006). "HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45". ...
*  P110δ
... and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805-11. doi:10.1002/eji.1830271110. PMID ... They also lack to B cell subsets: B1 cells (found in body cavities such as the peritoneum) and marginal zone B cells, found in ... This inhibitor selectively impairs B cell, mast cell and neutrophil functions and is therefore a potential immune-modulator. ... p110δ inactivation in regulatory T cells unleashes CD8+ cytotoxic T cells. PIK3CD interacts with PIK3R1, and PIK3R2. ...
*  CD99
"CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C- ... "Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and ... resulted in those cells redifferentiating towards B cells. Consequently, the loss of B-cell differentiation in Hodgkin's ... When CD99 expression is knocked down in human cells with Ewing's sarcoma and those cells are grafted onto mice, tumor and bone ...
*  PIK3CB
... and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805-11. doi:10.1002/eji.1830271110. PMID ... Cell. Biol. 14 (4): 2577-83. doi:10.1128/mcb.14.4.2577. PMC 358625 . PMID 8139559. Milani D, Mazzoni M, Borgatti P, et al. ( ... Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope ... Sotsios Y, Whittaker GC, Westwick J, Ward SG (1999). "The CXC chemokine stromal cell-derived factor activates a Gi-coupled ...
*  Caspase-activated DNase
... prove that theory was based on the introduction of mutated form of this protein inside both TF-1 human cells and Jurkat cells, ... Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process ... The cell diversity is originated by cell differentiation, which has been attributed to the activation of specific transcription ... Despite this gene being present in every cell, this protein is only expressed in different tissues and cell variety such as ...