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*  Janus kinase 2
... (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been ... inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes to ... The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (SH2/SH3) ... Janus kinase 2 has been shown to interact with: DNAJA3, EGFR, EPOR, FYN, Grb2, GHR, IRS1, IL12RB2, IL5RA, PIK3R1, PPP2R4, PTK2 ...
*  Janus kinase
The four JAK family members are: Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3) Tyrosine kinase 2 (TYK2) ... Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the ... "Janus kinase". The name is taken from the two-faced Roman god of beginnings and endings, Janus, because the JAKs possess two ... JH2 is a "pseudokinase domain", a domain structurally similar to a tyrosine kinase and essential for a normal kinase activity, ...
*  Janus kinase 3
Other members of the Janus family include JAK1, JAK2 and TYK2. Janus kinases (JAKs) are relatively large kinases of ... Tyrosine-protein kinase JAK3 is an enzyme that in humans is encoded by the JAK3 gene. Janus kinase 3 is a tyrosine kinase that ... Janus Kinase 3 at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal. ... Janus kinase 3 has been shown to interact with CD247, TIAF1 and IL2RG. GRCh38: Ensembl release 89: ENSG00000105639 - Ensembl, ...
*  Janus kinase 3 deficiency
... or JAK3 deficiency is a defect in the body's cytokine receptors and their signaling. JAK3 encodes ... ISBN 1-4160-2999-0. "JAK3 Janus kinase 3 [ Homo sapiens ]". NCBI. Department of Health & Human Services. Retrieved 17 December ... a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the ...
*  Janus kinase 3 inhibitor
The Janus Kinases is a family of four nonreceptor tyrosine-protein kinases, JAK1, JAK2, JAK3 and TYK2. They signal via the JAK/ ... Janus kinase 3 inhibitors work by inhibiting the action of the enzyme Janus Kinase 3 and therefore interferes with the JAK-STAT ... Janus Kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus Kinase 3 ... De Vries, L. C. S.; Wildenberg, M. E.; De Jonge, W. J.; D'Haens, G. R. (2017-07-01). "The Future of Janus Kinase Inhibitors in ...
*  Common gamma chain
IL2RG has been shown to interact with Janus kinase 3. X-linked severe combined immunodeficiency is caused by mutations in the ... 153 (3): 1310-7. PMID 8027558. Johnson K, Choi Y, Wu Z, Ciardelli T, Granzow R, Whalen C, Sana T, Pardee G, Smith K, Creasey A ... 21 (1): 291-3. doi:10.1006/geno.1994.1265. PMID 8088810. Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, ... 262 (5141): 1880-3. doi:10.1126/science.8266078. PMID 8266078. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, ...
*  TIAF1
... has been shown to interact with Janus kinase 3 and TRIB3. GRCh38: Ensembl release 89: ENSG00000221995 - Ensembl, May 2017 ... 3 (5): 321-9, 341-54. doi:10.1093/dnares/3.5.321. PMID 9039502. Ji H, Zhai Q, Zhu J, et al. (2000). "A novel protein MAJN binds ... 253 (3): 743-9. doi:10.1006/bbrc.1998.9846. PMID 9918798. "Entrez Gene: TIAF1 TGFB1-induced anti-apoptotic factor 1". Ji, H; ...
*  CD247
... has been shown to interact with Janus kinase 3 and Protein unc-119 homolog. Cluster of differentiation ZAP70 GRCh38: ... 28 (3): 323-35. doi:10.1007/BF02970151. PMID 12734410. Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr ... 199 (3): 369-79. doi:10.1084/jem.20030589. PMC 2211793 . PMID 14757743. Geyer M, Fackler OT, Peterlin BM (2001). "Structure-- ...
*  INSL3
Verbsky JW, Bach EA, Fang YF, Yang L, Randolph DA, Fields LE (June 1996). "Expression of Janus kinase 3 in human endothelial ... a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes". Proceedings of the National ... binding to the Janus kinases". FEBS Letters. 477 (1-2): 55-61. doi:10.1016/S0014-5793(00)01760-9. PMID 10899310. Schumacher RF ... Lai KS, Jin Y, Graham DK, Witthuhn BA, Ihle JN, Liu ET (October 1995). "A kinase-deficient splice variant of the human JAK3 is ...
*  Decernotinib
... is an inhibitor of Janus kinase 3 (JAK3) discovered through a process of inhouse screening of a chemical compound ... A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases". Journal of Medicinal Chemistry. 58 ( ...
*  Baricitinib
... reversibly inhibits Janus kinase 1 with a half maximal inhibitory concentration (IC50) of 5.9 nM and Janus kinase 2 ... Janus kinase 3 is affected much less (IC50 = 53 nM), and tyrosine kinase 2, which belongs to the same enzyme family, even less ... It acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2. The drug is approved in Europe. In February ... baricitinib trials baricitinib phase 3 trials Carroll, J (13 April 2017). "We don't know when (exactly) Lilly will announce the ...
*  X-linked severe combined immunodeficiency
... the common gamma subunit activates Janus Kinase 3 (JAK3), which leads to the phosphorylation of Signal Transducer and Activator ... Since only 1/3 of all X-SCID patients have a positive family history of SCID, it is hypothesized that de novo mutations account ...
*  Tofacitinib
It is an inhibitor of the enzyme janus kinase 1 (JAK1) and janus kinase 3 (JAK 3), which means that it interferes with the JAK- ... Tofacitinib (INN) is a drug of the janus kinase (JAK) inhibitor class, discovered and developed by the National Institutes of ... 7 July 2015). "Tofacitinib, an oral Janus kinase inhibitor, for the treatment of chronic plaque psoriasis: results from two, ... Levy LL, Urban J, King BA (2015). "Treatment of recalcitrant atopic dermatitis with the oral Janus kinase inhibitor tofacitinib ...
*  List of cutaneous conditions
Isolated IgA deficiency Isolated primary IgM deficiency Janus kinase 3 deficiency Leukocyte adhesion molecule deficiency LIG4 ... 16 (3): 214-23. doi:10.1046/j.1529-8019.2003.01631.x. PMID 14510878. CS1 maint: Multiple names: authors list (link) Eming R, ... 9 (3): 203-13. doi:10.4088/pcc.v09n0306. PMC 1911167 . PMID 17632653. Harth W, Hermes B, Niemeier V, Gieler U; Hermes; Niemeier ... 53 (3): 357-79. PMID 11546834. CS1 maint: Multiple names: authors list (link) Ramdial PK, Naidoo DK; Naidoo (June 2009). "Drug- ...
*  Index of immunology articles
Janus kinase 3 deficiency Junctional diversity Killer activation receptor Kinase tyrosine-based inhibitory motif Kinetic- ... beta Interleukin receptor Interleukin-1 receptor Interleukin-1 receptor family Interleukin-1 receptor-associated kinase ... 3-dioxygenase Induced-self antigen Inflammasome Inflammation Inflammatory reflex Innate immune system Innate lymphoid cell ... receptor Interleukin-22 receptor Interleukin-23 receptor Interleukin-27 receptor Interleukin-28 receptor Interleukin-3 receptor ...
*  JAKMIP3
Janus kinase and microtubule interacting protein 3 is a protein that in humans is encoded by the JAKMIP3 gene. GRCh38: Ensembl ... Janus kinase and microtubule interacting protein 3". Retrieved 2017-05-31. ...
*  PTPN2
2002). "The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3". Curr. Biol. 12 (6): ... 16 (3): 619-29. doi:10.1006/geno.1993.1239. PMID 8325634. Tiganis T, Flint AJ, Adam SA, Tonks NK (1997). "Association of the T- ... 131 (3): 631-43. doi:10.1083/jcb.131.3.631. PMC 2120615 . PMID 7593185. Maruyama K, Sugano S (1994). "Oligo-capping: a simple ... 18 (3): 1622-34. PMC 108877 . PMID 9488479. Tiganis T, Kemp BE, Tonks NK (1999). "The protein-tyrosine phosphatase TCPTP ...
*  Lestaurtinib
Janus kinase inhibitor Shabbir M, Stuart R (2010). "Lestaurtinib, a multitargeted tyrosinse kinase inhibitor: from bench to ... Janus kinase 2 (JAK2), tropomyosin receptor kinase (trk) A (TrkA), TrkB and TrkC. Lestaurtinib has undergone clinical trials ... It is an inhibitor of the kinases fms-like tyrosine kinase 3 (FLT3), ... Lestaurtinib was identified early on as a trk receptor tyrosine kinase (RTK) inhibitor, with a concentration inhibiting 50% of ...
*  Pacritinib
It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3 (FLT3). The drug was in Phase III clinical trials as of ... a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma". ... potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)". Journal of Computer-Aided Molecular Design. ... Pacritinib (INN) is a macrocyclic Janus kinase inhibitor that is being developed for the treatment of myelofibrosis. ...
*  Janus kinase inhibitor
Hence drugs that inhibit the activity of these Janus kinases block cytokine signalling. More specifically, Janus kinases ... Janus kinase inhibitors, also known as JAK inhibitors or jakinibs, are a type of medication that functions by inhibiting the ... Pesu M, Laurence A, Kishore N, Zwillich SH, Chan G, O'Shea JJ (June 2008). "Therapeutic targeting of Janus kinases". ... Shreberk-Hassidim R, Ramot Y, Zlotogorski A (April 2017). "Janus kinase inhibitors in dermatology: A systematic review". ...
*  Janus kinase 1
... has been shown to interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1, IL10RA, PTPN11, STAM2, STAT3, STAT5A, ... Janus Kinase 1 at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal. ... Gual P, Baron V, Lequoy V, Van Obberghen E (March 1998). "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin ... Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E (1996). "Involvement of Janus kinases in the insulin signaling pathway ...
*  SOCS3
... inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells. ... inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells. ... The SOCS3 protein can bind to JAK2 kinase, and inhibits the activity of JAK2 kinase. SOCS3 has been shown to interact with: ... Janus kinase 2, PTPN11, and RAS p21 protein activator 1. There is some evidence that the expression of SOCS3 is regulated by ...
*  GADD45G
"Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 ... GADD45G prevents the kinase ability of the cyclin b1/Cdk1 complex in a fashion that does not break apart the complex. It plays ... GADD45G was found to inhibit Cdk1 kinase activity, which would cause disruption of cell growth. It also interacts with CRIF, ... Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (2002). "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role ...
*  Jak
... nonreceptor tyrosine kinases including Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3) Jak, character in Jak ... Jak may refer to: JAK members bank, a Swedish interest-free bank Janus kinase, a family of intracellular, ...
*  Non-receptor tyrosine kinase
... inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells. ... Unlike the receptor tyrosine kinases (RTKs), the second subgroup of tyrosine kinases, the non-receptor tyrosine kinases are ... Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that can transfer the phosphate group ... Non-receptor tyrosine kinases do not contain only a tyrosine kinase domain, nRTKs also possess domains that mediate protein- ...
*  Interferon
STAT activation initiates the most well-defined cell signaling pathway for all IFNs, the classical Janus kinase-STAT (JAK-STAT ... Type I IFNs further activate p38 mitogen-activated protein kinase (MAP kinase) to induce gene transcription. Antiviral and ... Production of protein kinase R, for example, can be disrupted in cells infected with JEV Some viruses escape the anti-viral ... In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). This enzyme phosphorylates ...