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*  Janus kinase 2
... inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes to ... is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of ... Janus kinase 2 has been shown to interact with: DNAJA3, EGFR, EPOR, FYN, Grb2, GHR, IRS1, IL12RB2, IL5RA, PIK3R1, PPP2R4, PTK2 ... Janus Kinase 2 at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal. ...
*  Janus kinase
The four JAK family members are: Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3) Tyrosine kinase 2 (TYK2) ... Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the ... "Janus kinase". The name is taken from the two-faced Roman god of beginnings and endings, Janus, because the JAKs possess two ... JH2 is a "pseudokinase domain", a domain structurally similar to a tyrosine kinase and essential for a normal kinase activity, ...
*  Ion transporter
Examples of the P-type ATPase include Na+/K+-ATPase that is regulated by Janus Kinase-2 as well as Ca2+ ATPase which exhibits ... Hosseinzadeh, Zohreh (2014). "Down-Regulation of the Epithelial Na+ Channel ENaC by Janus kinase 2". The Journal of Membrane ... Using protein kinases to add a phosphate group or phosphatases to dephosphorylate the protein can change the activity of the ... channel functional regulation by phosphorylation of focal adhesion kinase at tyrosine 407 in osmosensitive ion transporting ...
*  PTPN11
Janus kinase 1, Janus kinase 2, LAIR1, LRP1, PDGFRB, PI3K → Akt PLCG2, PTK2B, Ras SLAMF1, SOCS3, SOS1, STAT3, STAT5A, and ... Saito Y, Hojo Y, Tanimoto T, Abe J, Berk BC (Jun 2002). "Protein kinase C-alpha and protein kinase C-epsilon are required for ... "SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates". Biochem. Biophys. Res. Commun. ... Tang H, Zhao ZJ, Huang XY, Landon EJ, Inagami T (Apr 1999). "Fyn kinase-directed activation of SH2 domain-containing protein- ...
*  PPP2R4
... has been shown to interact with PPP2R3A, CCNG1 and Janus kinase 2. GRCh38: Ensembl release 89: ENSG00000119383 - Ensembl ... 1997). "Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha". Science. 276 (5314): 952-5. doi: ... 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975 . PMID 15725353. Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M ... 224 (2): 289-96. doi:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385. Andersen JL, Planelles V (2005). "The role of Vpr in ...
*  YES1
... has been shown to interact with Janus kinase 2, CTNND1, RPL10 and Occludin. GRCh38: Ensembl release 89: ENSG00000176105 - ... "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. ... Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene. This gene is the cellular ... The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity ...
*  Pacritinib
... is a macrocyclic Janus kinase inhibitor that is being developed for the treatment of myelofibrosis. It mainly inhibits Janus ... a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma". ... potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)". Journal of Computer-Aided Molecular Design. ... and Fms-like tyrosine kinase 3 (FLT3). The drug was in Phase III clinical trials as of 2013[update]. The drug was discovered in ...
*  Signal transducing adaptor molecule
... has been shown to interact with HGS, Janus kinase 2. STAMBP, and TIMM8A. GRCh38: Ensembl ... is associated with Janus kinases and involved in signaling for cell growth and c-myc induction". Immunity. 6 (4): 449-57. doi: ... is associated with Janus kinases and involved in signaling for cell growth and c-myc induction". Immunity. 6 (4): 449-57. doi: ... binding to the Janus kinases". FEBS Letters. 477 (1-2): 55-61. doi:10.1016/S0014-5793(00)01760-9. PMID 10899310. Kato M, ...
*  SH2B1
... has been shown to interact with: Grb2, Insulin receptor, Janus kinase 2, and TrkA. Variations close to or in the SH2B1 ... Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE (2005). "Kinase activation through ... O'Brien KB, O'Shea JJ, Carter-Su C (2002). "SH2-B family members differentially regulate JAK family tyrosine kinases". J. Biol ... "Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling". Mol. Cell. Biol. ...
*  Interleukin 12 receptor, beta 2 subunit
... associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases". J. Biol ... 257 (2): 400-4. doi:10.1006/bbrc.1999.0479. ISSN 0006-291X. PMID 10198225. Airoldi I, Guglielmino R, Carra G, et al. (2002). " ... 257 (2): 400-4. doi:10.1006/bbrc.1999.0479. PMID 10198225. Yao BB, Niu P, Surowy CS, Faltynek CR (1999). "Direct interaction of ... 266 (2): 551-5. doi:10.1006/bbrc.1999.1859. PMID 10600539. van Rietschoten JG, Smits HH, Westland R, et al. (2000). "Genomic ...
*  STAT5B
... has been shown to interact with: Glucocorticoid receptor, Janus kinase 1, Janus kinase 2, and PTPN11. STAT5 GRCh38: ... In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and ... Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738- ... 285 (1-2): 1-24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028. This article incorporates text from the United States ...
*  Prolactin
This results in the activation of Janus kinase 2, a tyrosine kinase that initiates the JAK-STAT pathway. Activation also ... results in the activation of mitogen-activated protein kinases and Src kinase. Human prolactin receptors are insensitive to ... 191 (2): 415-25. doi:10.1677/joe.1.06685. PMID 17088411. Shingo T, Gregg C, Enwere E, Fujikawa H, Hassam R, Geary C, Cross JC, ... Table 2 in Beltran L, Fahie-Wilson MN, McKenna TJ, Kavanagh L, Smith TP (Oct 2008). "Serum total prolactin and monomeric ...
*  SH2B2
... and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling". Endocrinology. 148 (4): 1615-21. doi:10.1210/en.2006- ... O'Brien KB, O'Shea JJ, Carter-Su C (2002). "SH2-B family members differentially regulate JAK family tyrosine kinases". J. Biol ... "Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated ... SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene. The protein encoded by this gene is expressed ...
*  Erythropoietin receptor
Huang LJ, Constantinescu SN, Lodish HF (Dec 2001). "The N-terminal domain of Janus kinase 2 is required for Golgi processing ... Erythropoietin receptor has been shown to interact with: CRKL, Erythropoietin, Grb2, Janus kinase 2, LYN, PIK3R1, PTPN6, SOCS2 ... 3-kinase and for EpR-associated PI 3-kinase activity". The Journal of Biological Chemistry. 270 (40): 23402-8. doi:10.1074/jbc. ... In addition to activating Ras/AKT and ERK/MAP kinase, phosphatidylinositol 3-kinase/AKT pathway and STAT transcription factors ...
*  Growth hormone receptor
... has been shown to interact with SGTA, PTPN11, Janus kinase 2, Suppressor of cytokine signaling 1 and ... "Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor". J. Biol. Chem. UNITED STATES. 270 ( ... "Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase". J. Biol. Chem. UNITED ... "Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor". Science. 344 (6185): 1249783. doi:10.1126/ ...
*  Interleukin-23 receptor
This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand- ... 80 (2): 273-90. doi:10.1086/511051. PMC 1785338 . PMID 17236132. Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A ... 5 (8): 977-81, 981.e1-2. doi:10.1016/j.cgh.2007.05.002. PMID 17678845. Raelson JV, Little RD, Ruether A, Fournier H, Paquin B, ... 154 (2): 452-64. doi:10.1016/j.cell.2013.06.022. PMC 3717207 . PMID 23870131. "Infection and Immunity Immunophenotyping (3i) ...
*  TEC (gene)
... has been shown to interact with: ARHGEF12, CD117, DOK1, GNA12, Janus kinase 2, and Suppressor of cytokine signaling ... Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are ... "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273-82. doi:10.1038/ ... "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273-82. doi:10.1038/ ...
*  Surveyor nuclease assay
The method has been used to detect mutations in epidermal-growth-factor-receptor (EGFR), Janus Kinase 2 (JAK2), p53 and others ... doi:10.1007/978-1-60761-753-2_15. ISSN 1940-6029. PMID 20680839. Ran, F. Ann; Hsu, Patrick D.; Lin, Chie-Yu; Gootenberg, ... 30 (2): 264-273. doi:10.1002/humu.20842. ISSN 1098-1004. PMID 18837007. Voskarides, Konstantinos; Deltas, Constantinos (2009-07 ...
*  TG101348
Fedratinib (TG101348;SAR302503) is an orally available inhibitor of Janus kinase 2 (JAK-2) developed for the treatment of ... Fedratinib acts as a competitive inhibitor of protein kinase JAK-2 with IC50=6 nM; related kinases FLT3 and RET are also ... Significantly less activity was observed against other tyrosine kinases including JAK3 (IC50=169 nM). In treated cells the ... a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and ...
*  STAT5A
Janus kinase 1, Janus kinase 2, MAPK1 NMI, and PTPN11. CBX5, STAT5 GRCh38: Ensembl release 89: ENSG00000126561 - Ensembl, May ... Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): ... In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and ... Pircher TJ, Petersen H, Gustafsson JA, Haldosén LA (April 1999). "Extracellular signal-regulated kinase (ERK) interacts with ...
*  Lestaurtinib
It is an inhibitor of the kinases fms-like tyrosine kinase 3 (FLT3), Janus kinase 2 (JAK2), tropomyosin receptor kinase (trk) A ... Janus kinase inhibitor Shabbir M, Stuart R (2010). "Lestaurtinib, a multitargeted tyrosinse kinase inhibitor: from bench to ... Lestaurtinib was identified early on as a trk receptor tyrosine kinase (RTK) inhibitor, with a concentration inhibiting 50% of ... Lestaurtinib (rINN, codenamed CEP-701) is a tyrosine kinase inhibitor structurally related to staurosporine. This semisynthetic ...
*  Baricitinib
... reversibly inhibits Janus kinase 1 with a half maximal inhibitory concentration (IC50) of 5.9 nM and Janus kinase 2 ... Janus kinase 3 is affected much less (IC50 = 53 nM), and tyrosine kinase 2, which belongs to the same enzyme family, even less ... It acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2. The drug is approved in Europe. In February ...
*  Suppressor of cytokine signaling 1
Janus kinase 2, and TEC. SOCS JAK-STAT signaling pathway GRCh38: Ensembl release 89: ENSG00000185338 - Ensembl, May 2017 GRCm38 ... "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop". EMBO J. 18 (5): ... "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop". EMBO J. 18 (5): ... "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. 272 (43): 27178-82. doi:10.1074/jbc. ...
*  Ruxolitinib
... is a janus kinase inhibitor with selectivity for subtypes JAK1 and JAK2 of this enzyme. Ruxolitinib inhibits ... Wysham, NG; Allada G; Sullivan DR (2013). "An opportunistic infection associated with ruxolitinib, a novel janus kinase 1,2 ... 11 (2): 103-4. doi:10.1038/nrd3652. PMID 22293561. Harrison, C; Mesa, R; Ross, D; Mead, A; Keohane, C; Gotlib, J; Verstovsek, S ... 2] Falto-Aizpurua, L; Choudhary, S; Tosti, A (December 2014). "Emerging treatments in alopecia". Expert opinion on emerging ...
*  SOCS3
... inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells. ... inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells. ... The SOCS3 protein can bind to JAK2 kinase, and inhibits the activity of JAK2 kinase. SOCS3 has been shown to interact with: ... Janus kinase 2, PTPN11, and RAS p21 protein activator 1. There is some evidence that the expression of SOCS3 is regulated by ...
*  Interferon
STAT activation initiates the most well-defined cell signaling pathway for all IFNs, the classical Janus kinase-STAT (JAK-STAT ... Type I IFNs further activate p38 mitogen-activated protein kinase (MAP kinase) to induce gene transcription. Antiviral and ... Production of protein kinase R, for example, can be disrupted in cells infected with JEV Some viruses escape the anti-viral ... The phosphatidylinositol 3-kinase (PI3K) signaling pathway is also regulated by both type I and type II IFNs. PI3K activates ...
*  Risankizumab
Signaling through the IL23R induces Janus kinase 2 (JAK2) and tyrosine kinase 2 (tyk2) phosphorylation and leads to increased ... Risankizumab was associated with clinical improvement in individuals treated with the drug, from week 2 and maintained for up ... 2 × 10(-6)). The conclusion of this clinical drug trial was that Risankizumab was very well tolerated and associated with quick ...