The structure of iproniazid is chemically, in both structure and reactivity, similar to isoniazid. Iproniazid is a substituted ... Iproniazid is metabolized in the body. Iproniazid is converted to isopropyl hydrazine and isonicotinic acid in an initial ... Iproniazid can also be metabolised by O-dealkylation from iproniazid to acetone and isoniazid. Isoniazid can undergo further ... After dehydrogenation iproniazid further reacts with the enzyme. Inhibition of MAOs by iproniazid is competitive and sensitive ...

"Iproniazid". Archived from the original on 27 September 2013. Retrieved 24 September 2013. Centers for Disease Control and ...

Iproniazid • Isocarboxazid • Isoniazid • Linezolid • Mebanazine • Metfendrazine • Nialamide • Octamoxin • Paraxazone • ...

West ED, Dally PJ (June 1959). "Effects of iproniazid in depressive syndromes". British Medical Journal. 1 (5136): 1491-1494. ... Dally were studying the effects of iproniazid, an MAOI, on patients with depression. They found consistencies among the ... responded notably well to the iproniazid. In general, atypical depression tends to cause greater functional impairment than ...

Hydrazide derivatives include isoniazid, iproniazid, and nialamide. Amide and ester derivatives include ethionamide and ...

Ernst Zeller found Iproniazid to be a potent Monoamine oxidase inhibitor. Nevertheless, Iproniazid remained relatively obscure ... Later, Jackson Smith, Gordon Kamman, George E. Crane, and Frank Ayd, described the psychiatric applications of Iproniazid. ... and Iproniazid. Only patients with a poor prognosis were initially treated. Nevertheless, their condition improved dramatically ... Roche put a significant marketing effort behind Iproniazid. Its sales grew until it was recalled in 1961, due to reports of ...

Iproniazid, however, was revealed to have its own benefits; some people felt it made them feel happier. It was withdrawn from ... In 1956, the first antidepressant, iproniazid, was accidentally created during an experiment while synthesizing isoniazid. ...

1952 The first monoamine oxidase inhibitor (MAOI) antidepressant iproniazid was discovered. 1953 Russian-born physiologist ...

"Effects of amino acid feedings in schizophrenic patients treated with iproniazid". Science. 133 (3446): 104-5. Bibcode:1961Sci ...

"Positive reinforcement produced by stimulating hypothalamus with iproniazid and other compounds." Science 127:1175-76. 1965 " ...

Iproniazid was the result of a failed medicinal chemistry attempt to improve on the anti-tubercular activity of isoniazid. It ... Iproniazid is no longer used because it caused an unacceptable incidence in jaundice. Nevertheless, related agents such as ... The so-called golden era also covers the discovery of the first monoamine oxidase inhibitor, iproniazid (Marsilid), which is ...

Isoniazid, iproniazid, hydralazine, and phenelzine are medications whose molecules contain hydrazine-like structures. 2,4- ...

It possesses 50 times the relative activity of iproniazid and 25x nialamide (see patent). 3-Cyclohexene-1-carbaldehyde [100-50- ...

In 1952, iproniazid, an antimycobacterial agent, was discovered to have psychoactive properties while researched as a possible ... Researchers noted that patients given iproniazid became cheerful, more optimistic, and more physically active. Soon after its ... development, iproniazid and related substances were shown to slow enzymatic breakdown of serotonin, dopamine, and ...

The first monoamine oxidase inhibitor (MAOI), iproniazid, was discovered accidentally when developing the new antitubercular ...

... and a related drug, iproniazid, were among the first drugs to be referred to as antidepressants. Isoniazid is an ...

... and Iproniazid in Angina of Effort". Heart. 21 (3): 315-322. doi:10.1136/hrt.21.3.315. ISSN 1355-6037. PMC 1017586. PMID ...

... iproniazid's antidepressant properties were discovered when researchers noted that the depressed patients given iproniazid ... The knowledge of MAOIs began with the serendipitous discovery that iproniazid was a potent MAO inhibitor (MAOI). Originally ... Iproniazid (Marsilid, Iprozid, Ipronid, Rivivol, Propilniazida) Mebanazine (Actomol) Nialamide (Niamid) Octamoxin (Ximaol, ...

Souskova, M; Votava, Z; Roth, Z (1964). "Effect of Iproniazid, Propazepine, Reserpine and Their Combinations on the Orientation ...

There are also cases where other hydrazine derivative drugs, such as the MAOI antidepressant iproniazid, are associated with ... "The lack of hepatotoxicity in the rat with the new and reversible MAO-A inhibitor moclobemide in contrast to iproniazid". ...

... was found to be 93% eluted by urine within 24 hours of being produced in the body as a byproduct of Iproniazid in ...

... and the anti-tuberculosis agents isoniazid and iproniazid respectively. The psychiatric mechanisms of action of these drugs ...

In 1964, Kline earned his second Lasker Award for the study of the introduction and use of iproniazid, a monoamine oxidase ...

Iproniazid, an inhibitor of MAO, was noted to elevate mood in depressed patients in the early 1950s, and soon thereafter was ... This was based on similar evidence to that which produced the NA theory as reserpine, imipramine, and iproniazid affect the 5- ...

Along with the discovery and introduction of the monoamine oxidase inhibitor iproniazid as an antidepressant around the same ...

In 1952, iproniazid, a drug being trialed against tuberculosis, was serendipitously discovered to have anti-depressant effects ... and iproniazid, one of the first antidepressants, was first synthesized in 1957. In 1959 imipramine, the first tricyclic ...

... idiosyncratic Inhalants Iproniazid (withdrawn) - idiosyncratic Methapyrilene Methotrexate 3-methylcholanthrene. All penicillins ...

... iproniazid MeSH D03.066.349.410 - isoniazid MeSH D03.066.349.490 - nialamide MeSH D03.066.349.570 - prothionamide MeSH D03.066. ... iproniazid MeSH D03.383.725.394.582 - isoniazid MeSH D03.383.725.394.628 - nialamide MeSH D03.383.725.394.675 - prothionamide ...

... iproniazid (INN) ipronidazole (INN) iproplatin (INN) iprotiazem (INN) iproxamine (INN) iprozilamine (INN) ipsalazide (INN) ...

SKF-64139 SKF-7698 Nonselective Benmoxin Caroxazone Echinopsidine Furazolidone Hydralazine Indantadol Iproclozide Iproniazid ...