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*  N-Arachidonoyl dopamine
... ion channel. NADA was first described as a putative endocannabinoid (agonist for the CB1 receptor) in 2000 and was subsequently ... It activates the TRPV1 channel with an EC50 of approximately of 50nM which makes it the putative endogenous TRPV1 agonist. In ...
*  HCN4
Cyclic nucleotide-gated ion channel Funny current GRCh38: Ensembl release 89: ENSG00000138622 - Ensembl, May 2017 GRCm38: ... "Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated ... "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and ... The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation. HCN4 has been shown ...
*  TRPC6
... is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as ... Walz G (September 2005). "Slit or pore? A mutation of the ion channel TRPC6 causes FSGS". Nephrology, Dialysis, Transplantation ... Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of ... Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium. 33 (5-6 ...
*  Chloride channel
Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many ... Chloride channels are also important for maintaining safe ion concentrations within plant cells. The CLC channel structure has ... For the channels, when the slow gate is closed, no ions permeate through the pore. When the slow gate is open, the fast gates ... In the channels, the protein does not shield chloride ions at one binding site from the neighboring negatively charged ...
*  TRPC
"Transient Receptor Potential Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. In terms of structure, ... Many of TRPC channel subunits are able to coassemble. The predominant TRPC channels in the mammalian brain are the TRPC 1,4 and ... TRPC3 and TRPC6 channels are activated by PLC stimulation and diacylglycerol (DAG) production. Both these TRPC channel types ...
*  KCNE1
Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and ... "Polymorphism of the gene encoding a human minimal potassium ion channel (minK)". Gene. 151 (1-2): 339-40. doi:10.1016/0378-1119 ... "Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) ... Potassium voltage-gated channel subfamily E member 1 is a protein that in humans is encoded by the KCNE1 gene. ...
*  TRPV6
Unlike most TRP channels, TRPV6 is selective for Ca2+ ions, a property shared with its close homologue, TRPV5, which is mainly ... TRPV Cation Channels at the US National Library of Medicine Medical Subject Headings (MeSH) TRPV6 protein, human at the US ... TRPV6 is a membrane calcium channel which is particularly involved in the first step in calcium absorption in the intestine. ... Heiner I, Eisfeld J, Lückhoff A (2004). "Role and regulation of TRP channels in neutrophil granulocytes". Cell Calcium. 33 (5-6 ...
*  Voltage-gated calcium channel
04, January 2009, 2009 BIOTREND Chemicals AG "Voltage-Gated Ion Channels". IUPHAR Database of Receptors and Ion Channels. ... Glutamate receptors Inositol triphosphate receptor Ion channels NMDA receptors Ryanodine receptor Voltage-gated ion channels ... These channels are slightly permeable to sodium ions, so they are also called Ca2+-Na+ channels, but their permeability to ... High-voltage-gated calcium channels include the neural N-type channel blocked by ω-conotoxinGVIA, the R-type channel (R stands ...
*  Ligand-gated ion channel
... calcium channel Calcium-activated potassium channel Cyclic nucleotide-gated ion channel Acid-sensing ion channel Ryanodine ... In contrast to ligand-gated ion channels, there are also receptor systems in which the receptor and the ion channel are ... If these receptors are ligand-gated ion channels, a resulting conformational change opens the ion channels, which leads to a ... "Revised Recommendations for Nomenclature of Ligand-Gated Ion Channels". IUPHAR Database of Receptors and Ion Channels. ...
*  TRPV1
This protein is a member of the TRPV group of transient receptor potential family of ion channels. The function of TRPV1 is ... The dorsal root ganglion (DRG) neurons of mammals were known to express a heat-sensitive ion channel that could be activated by ... a heat-activated ion channel in the pain pathway". Nature. 389 (6653): 816-24. doi:10.1038/39807. PMID 9349813. Xue Q, Yu Y, ... and CBDV are also agonists of this ion channel. TRPV1 is also expressed at high levels in the central nervous system and has ...
*  Calcium channel
A calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous as voltage- ... "Voltage-Gated Ion Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... "calcium channel" at Dorland's Medical Dictionary Striggow F, Ehrlich BE (August 1996). "Ligand-gated calcium channels inside ... the receptor-operated calcium channels (in vasoconstriction) P2X receptors L-type calcium channel blockers are used to treat ...
*  Inward-rectifier potassium channel
In this regard Kir channels are PIP2 ligand-gated ion channels. Kir channels are found in multiple cell types, including ... IRK channels possess a pore domain, homologous to that of voltage-gated ion channels, and flanking transmembrane segments (TMSs ... "Inwardly Recifying Potassium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... Bertil Hille (2001). Ion Channels of Excitable Membranes 3rd ed. (Sinauer: Sunderland, MA), p. 151. ISBN 0-87893-321-2. Hille, ...
*  Calcium channel opener
A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels. An example is Bay K8644 ... Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels ... TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type. Calcium channel blocker Schramm M, ... This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly ...
*  Synthetic ion channels
They are man-made analogues of natural ion channels, and are thus also known as artificial ion channels. Compared to biological ... They may be related to lipid ion channels, but to date their mechanism remains elusive. Certain synthetic ion channels have ... Many synthetic ion channels show unique properties in one or more of these aspects. An "ion-channel forming" molecule can often ... and ion channel transporters. While synthetic ion channel research attempts to prepare compounds that show conductance via a ...
*  Ion channel
... transport Potassium ion channels Sodium ion channel Synthetic ion channels Transmembrane receptor MeSH entry for Ion channels ... ion channels are a frequent target. There are over 300 types of ion channels just in the cells of the inner ear. Ion channels ... Ion channels may be classified by gating, i.e. what opens and closes the channels. Voltage-gated ion channels open or close ... Sodium channels Voltage-gated sodium channels (NaVs) Epithelial sodium channels (ENaCs) Calcium channels (CaVs) Proton channels ...
*  TRPA (ion channel)
TRPA is a family of transient receptor potential ion channels. The sole member of the TRPA sub-family, TRPA1, contains 14 N- ... Nilius B, Owsianik G, Voets T, Peters JA (2007). "Transient receptor potential cation channels in disease". Physiol. Rev. 87 (1 ... a non-electrophilic reference agonist of the TrpA1 channel". Bioorganic. Med. Chem. Lett. (21): 4857-4859. doi:10.1016/j.bmcl. ... a manually curated database of protein-protein interactions for mammalian TRP channels. ...
*  Light-gated ion channel
... ligand-gated ion channels, mechanosensitive ion channels, and temperature-gated ion channels. Most light-gated ion channels ... Light-gated ion channels are a family of ion channels regulated by electromagnetic radiation. Other gating mechanisms for ion ... Such ion channels have been modified by binding a photoswitch to confer photosensitivity on the ion channel. This is done ... Light-gated ion channels function in a similar manner to other gated ion channels. Such transmembrane proteins form pores ...
*  Zinc-activated ion channel
... (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion ... "A novel class of ligand-gated ion channel is activated by Zn2+". The Journal of Biological Chemistry. 278 (2): 712-7. doi: ... "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochemical and Biophysical Research ... channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the ...
*  Acid-sensing ion channel
Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive sodium channels activated by extracellular protons permeable ... Under increased acidic conditions, a proton binds to the channel in the extracellular region, activating the ion channel to go ... In addition, PcTX1 does not inhibit other voltage-gated ion channels or ligand-gated channels. The structure of this inhibitor ... ASIC1a channels additionally facilitate the activation of voltage-gated Ca2+ channels and NMDA receptor channels upon initial ...
*  Voltage-gated ion channel
... voltage-gated ion channels directionally propagate electrical signals. Voltage-gated ion-channels are usually ion-specific, and ... DB Voltage-gated ion channel subunits The IUPHAR Compendium of Voltage-gated Ion Channels 2005 Voltage-Dependent Anion Channels ... Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the ... polycystin cation channels, glutamate-gated ion channels, calcium-dependent chloride channels, monovalent cation:proton ...
*  Cyclic nucleotide-gated ion channel
Cyclic nucleotide-gated ion channels or CNG channels are ion channels that function in response to the binding of cyclic ... Ion channel HCN channel Voltage-dependent calcium channel Fesenko EE, Kolesnikov SS, Lyubarsky AL; Kolesnikov; Lyubarsky (1985 ... CNG channels are nonselective and allow many alkali ions to flow into or out of a cell expressing CNG channels on its membrane ... CNG ions channels in plants are similar in amino acid sequence and structure to non-selective cation CNG channels in animals, ...
*  G protein-gated ion channel
G protein-gated ion channels are a family of transmembrane ion channels in neurons and atrial myocytes that are directly gated ... G protein-gated ion channels are associated with a specific type of G protein-coupled receptor. These ion channels are ... The GIRK subunits come together to form GIRK ion channels. These ion channels, once activated, allow for the flow of potassium ... Generally, G protein-gated ion channels are specific ion channels located in the plasma membrane of cells that are directly ...
*  Ion channel hypothesis of Alzheimer's disease
The ion channel hypothesis of Alzheimer's disease (AD), also known as the channel hypothesis or the amyloid beta ion channel ... The ion channel hypothesis is broadly supported as an explanation for the calcium ion influx that disrupts calcium ion ... the ion channel hypothesis in 1993 introduced the possibility of an ion-channel-forming oligomer of soluble, non-fibrillar Aβ ... Though more recent studies have found that Aβ channels can be blocked by small molecules, the broad variety of Aβ ion channel ...
*  Agmatine
Ion channels. Including: ATP-sensitive K+ channels, voltage-gated Ca2+ channels, and acid-sensing ion channels (ASICs). ... ion channels, nitric oxide (NO) synthesis and polyamine metabolism and this provides bases for further research into potential ... Due to its ability to pass through open cationic channels, agmatine has also been used as a surrogate metric of integrated ... When neural tissue is incubated in agmatine and an external stimulus is applied, only cells with open channels will be filled ...
*  CatSper1
"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels ... Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE (October 2001). "A sperm ion channel required for ... 2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603-9. doi:10.1038/35098027. ...
*  Atrioventricular node
Movement of ions across cell membranes causes these events. The cardiac conduction system (and AV node part of it) coordinates ... A wave of excitation spreads out from the sinoatrial node through the atria along specialized conduction channels. This ...
*  CatSper2
"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels ... The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm ... Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581-2. doi:10.1038/35098164. PMID 11595929. ...