... causing viral induction of apoptosis. HeLa cells have been used to study the expression of the papillomavirus E2 and apoptosis ... Tan X, Luo S, Wang D, Su Y, Cheng T, Shi C (2011). "A NIR heptamethine Dye with intrinsic cancer targeting, imaging and ... HeLa cells have been used in research involving fullerenes to induce apoptosis as a part of photodynamic therapy, as well as in ... HeLa cells have also been used to study canine distemper virus' ability to induce apoptosis in cancer cell lines, which could ...
Also apoptosis is increased in the mutant germ cells. The Fanconi anemia DNA repair pathway appears to play a key role in ... protein has intrinsic affinity for nucleic acids with preference for single-stranded forms". J. Biol. Chem. 287 (7): 4800-7. ... Loss of FANCA provokes neural progenitor apoptosis during forebrain development, likely related to defective DNA repair. This ... increased apoptosis and accelerated telomere shortening. FANCA mutations are by far the most common cause of Fanconi anaemia, ...
A key factor in apoptosis initiation is the protein NOXA, which is suppressed in a particularly aggressive form of pancreatic ... which is an intrinsic function of ETO. Oncogenic potential of AML-ETO is exerted because it blocks differentiation and promote ... The most common cause of resistance to therapeutic treatments is the suppression of the programmed cell death (apoptosis) of ... Pharmacological or genetic inhibition of RUNX1 de-represses the NOXA gene and induces apoptosis in pancreatic cancer cells. ...
Overall, the intrinsic structure of E1A is highly disordered, meaning that it lacks a single, three-dimensional structure. ... Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, White E (August 1992). "The adenovirus E1A proteins induce apoptosis, ... Pelka P, Ablack JN, Fonseca GJ, Yousef AF, Mymryk JS (August 2008). "Intrinsic structural disorder in adenovirus E1A: a viral ... and induce apoptosis. When in coordination with E1B or other oncogenic genes such as activated ras, E1A is able to transform ...
In some cases, the effector itself may possess intrinsic GAP activity, which then can help deactivate the pathway. This is true ... and is potentially involved in apoptosis. Epinephrine - released by the adrenal medulla during the fasting state, when body is ...
Therefore, these susceptible organisms have intrinsic mechanisms to protect from oxidative damage; glutathione plays a key role ... or for activation of apoptosis. Glutathione reductase is another enzyme that helps maintain cellular redox homeostasis by ...
... and initiation of apoptosis. Unlike other microtubule-stabilizing agents, most taccalonolides do not bind to the taxane-binding ... intrinsic and acquired drug resistance limit their anticancer properties. Unlike taxanes, taccalonolides appear to work through ...
p53 inhibits the glycolytic pathway by upregulating the expression of TP53-induced glycolysis and apoptosis regulator. Wild- ... Similar resistance have been found with intrinsic gemcitabine and radiation resistance in pancreatic cancer. Glutaminolysis is ... July 1998). "Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis". Nature. 394 (6692 ...
If DNA damage is too severe, ATM will mediate the process of programmed cell death (apoptosis) to eliminate the cell and ... Sharma NK, Lebedeva M, Thomas T, Kovalenko OA, Stumpf JD, Shadel GS, Santos JH (January 2014). "Intrinsic mitochondrial DNA ... Lee Y, Chong MJ, McKinnon PJ (September 2001). "Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the ... "Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes". Molecular Cell. 34 ( ...
The p50 and p52 proteins have no intrinsic ability to activate transcription and thus have been proposed to act as ... Defects in NF-κB results in increased susceptibility to apoptosis leading to increased cell death. This is because NF-κB ... Therefore, NF-κB promotes Fas-mediated apoptosis in cancer cells, and thus inhibition of NF-κB may suppress Fas-mediated ... NF-κB suppression of tumor necrosis factor cytotoxicity (apoptosis) is due to induction of antioxidant enzymes and sustained ...
... possesses little intrinsic deacetylase activity and therefore requires association with the class I HDAC, HDAC3 in order ... Marks PA, Richon VM, Rifkind RA (August 2000). "Histone deacetylase inhibitors: inducers of differentiation or apoptosis of ... Although HDAC7 has shown to have little intrinsic deacetylase activity, studies have shown that HDAC7 may have various ... regulates Nur77 transcription and TCR-mediated apoptosis". Immunity. 18 (5): 687-98. doi:10.1016/S1074-7613(03)00109-2. hdl: ...
A 2015 study suggested Panobinostat was effective in preventing diffuse intrinsic pontine glioma cell growth in vitro and in ... Panobinostat inhibits multiple histone deacetylase enzymes, a mechanism leading to apoptosis of malignant cells via multiple ... June 2015). "Functionally defined therapeutic targets in diffuse intrinsic pontine glioma". Nature Medicine. 21 (6): 555-9. doi ...
... and KP1339 both induce apoptosis in colorectal tumor cell lines SW480 and HT29. This is induced predominantly by a loss ... "Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis( ... Studies have shown oxidative stress to contribute towards KP1019-induced apoptosis. Furthermore, KP1019 has been shown to ...
Cytoplasmic domain is made of short proline-rich motif and has no intrinsic enzymatic activity. Similar to such motif is also ... Membrane distal section is then required for differentiation and survival by prevention of apoptosis and activation of MAPK and ... "Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor". Journal ...
UVB-induced apoptosis V(D)J recombination Vaccine-naive Vermixocin Vernix caseosa Viral phylodynamics Virus quantification ... Interleukin-8 receptor Interleukin-9 receptor Intracellular antibody-mediated degradation Intravascular immunity Intrinsic ... Antigen Antigen presentation Antigen processing Antigenic variation Antigenicity Antimicrobial peptides Antitoxin Apoptosis ...
However, the p21 cells can trigger apoptosis. Apoptosis or programmed cell death is associated with gradual degradation of the ... There are two types of mortality: intrinsic and extrinsic mortality. Intrinsic mortality is defined as mortality due to ageing ... "Mitochondrial DNA (mtDNA) regulates cellular metabolism, apoptosis and oxidative stress control". Damage to mtDNA is therefore ...
DCC can promote apoptosis. The binding of netrin-1 to its receptors inhibits the tumor suppressor p53 dependent apoptosis. Such ... The netrin is expressed by neurons in the corticospinal and rubrospinal projections, and by intrinsic neurons of the spinal ... Netrin-1 and its receptors DCC and UNC-5 show a new mechanism for induction or suppression regulation of apoptosis. Evidence ... receptors share the property of inducing apoptosis in the absence of ligand, hence creating a cellular state of dependence on ...
As a result, double strand breaks in meiotic cells, unlike mitotic cells, do not typically lead to apoptosis, or cell death. ... depending on intrinsic (germ and Sertoli cells) and extrinsic (FSH and LH) factors. The spermatogenesis process in mammals as a ...
DCC can promote apoptosis. The binding of netrin-1 to its receptors inhibits the tumor suppressor p53 dependent apoptosis. Such ... The netrin is expressed by neurons in the corticospinal and rubrospinal projections, and by intrinsic neurons of the spinal ... Netrin-1 and its receptors DCC and UNC-5 show a new mechanism for induction or suppression regulation of apoptosis. Evidence ... receptors share the property of inducing apoptosis in the absence of ligand, hence creating a cellular state of dependence on ...
E2F transcription factors influence cellular proliferation and help control apoptosis. When cardiomyocytes were transfected ... cardiac tissue contains little intrinsic ability to proliferate, as adult human cells arrest in the cell cycle. However, a ...
Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI (July 2009). "Cell-intrinsic transforming growth factor-beta signaling mediates ... "Alpha-lactose reverses liver injury via blockade of Tim-3-mediated CD8 apoptosis in sepsis". Clinical Immunology. 192: 78-84. ...
"Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors". Oncogene. Springer Science and ... "Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis". Journal of Cell ...
Xenopus laevis also serves as an ideal model system for the study of the mechanisms of apoptosis. In fact, iodine and thyroxine ... Although lacking a vocal sac, the males make a mating call of alternating long and short trills, by contracting the intrinsic ... Tamura K, Takayama S, Ishii T, Mawaribuchi S, Takamatsu N, Ito M (2015). "Apoptosis and differentiation of Xenopus tail-derived ... This T3 increase also induces germ cell apoptosis, mediated through genes left over from tadpole metamorphosis.) The effects of ...
The causes of death include cell lysis, alterations to the cell's surface membrane and apoptosis. Often cell death is caused by ... Pressing J, Reanney DC (1984). "Divided genomes and intrinsic noise". Journal of Molecular Evolution. 20 (2): 135-46. Bibcode: ... 115-46 Collier p. 115 Roulston A, Marcellus RC, Branton PE (1999). "Viruses and apoptosis". Annual Review of Microbiology. 53: ... escape from apoptosis, and antigenic shift. Other viruses, called 'neurotropic viruses', are disseminated by neural spread ...
It is also important in the regulation of some physiological and cellular processes including apoptosis, as well as preventing ... Proteins with larger degrees of intrinsic disorder also tend to have short cellular half-life, with disordered segments having ... Caspases are an important group of proteases involved in apoptosis or programmed cell death. The precursors of caspase, ...
The Germline hypothesis suggests that the ability to bind to MHC is intrinsic and encoded within the germline DNA that are ... When primary lymphocytes are developing and differentiating in the thymus or bone marrow, T cells die by apoptosis if they ... The selection hypothesis argues that instead of being an intrinsic property, MHC restriction is imposed on the T cells during ...
The questions which are relevant to understanding of the structure and function of the membrane are: 1) Do intrinsic membrane ... neuronal stress and apoptosis. Annular lipid shell Collodion bag Lipid YashRoy, Rakesh c. (1991). "Protein heat denaturation ... Spin-labeled and brominated lipid derivatives are able to quench the intrinsic tryptophan fluorescence from membrane proteins. ...
Increasing anandamide seems to increase the intrinsic value of food, not necessarily by stimulation of appetite or hunger. ... with inflammation and apoptosis in the case of the pancreas. CB1R inhibition with peripherally restricted antagonists and ... high doses injected directly into the cerebral fluid of the brain of mice shows evident cell apoptosis (programmed cell death) ...
These intrinsic properties could lead to applications such as NEMS as pressure sensors and resonators. Due to its large surface ... apoptosis, autophagy, and necrosis. A 2020 study showed that the toxicity of graphene is dependent on several factors such as ... These ripples may be intrinsic to the material as a result of the instability of two-dimensional crystals, or may originate ... Morozov, S.V.; Novoselov, K.; Katsnelson, M.; Schedin, F.; Elias, D.; Jaszczak, J.; Geim, A. (2008). "Giant Intrinsic Carrier ...
Section 4. Intrinsic X-Ray Fluorescence". In Bani, Lucia (ed.). Metallomics and the Cell. Metal Ions in Life Sciences. Vol. 12 ... either by apoptosis or necrosis, to eliminate the threat it can cause to the organism's survival. The ancestry of each present ... Autophagy is the primary intrinsic degradative system for peptides, fats, carbohydrates, and other cellular structures. In both ... and apoptosis. Numerous biochemical structures, as well as processes that detect damage in DNA, are ATM and ATR, which induce ...