Interleukin 5
... is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin ... Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a ... Overview of all the structural information available in the PDB for UniProt: P05113 (Interleukin-5) at the PDBe-KB. (CS1: long ... Dubucquoi S, Desreumaux P, Janin A, Klein O, Goldman M, Tavernier J, Capron A, Capron M (February 1994). "Interleukin 5 ...
Interleukin-5 receptor
The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and ... Receptors,+Interleukin-5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Protein pages needing a ... Takaki S, Kanazawa H, Shiiba M, Takatsu K (November 1994). "A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor ... Takatsu K, Tominaga A (1991). "Interleukin 5 and its receptor". Prog. Growth Factor Res. 3 (2): 87-102. doi:10.1016/S0955-2235( ...
Interleukin 5 receptor alpha subunit
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 ... "Entrez Gene: IL5RA interleukin 5 receptor, alpha". Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, ... Interleukin 5 receptor alpha subunit has been shown to interact with: Interleukin 5, Janus kinase 2, Protein unc-119 homolog, ... Scibek JJ, Evergren E, Zahn S, Canziani GA, Van Ryk D, Chaiken IM (2003). "Biosensor analysis of dynamics of interleukin 5 ...
Interleukin 36 receptor antagonist
... (IL-36RA) is a member of the interleukin-36 family of cytokines. It was previously named ... Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 ... "Entrez Gene: IL36RN interleukin 36 receptor antagonist". Towne, JE; Garka, KE; Renshaw, BR; Virca, GD; Sims, JE (2 April 2004 ... Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor ...
Interleukin 9
... , also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins ... Renauld J (1995). "Interleukin-9: Structural characteristics and biologic properties". Cytokines: Interleukins and Their ... Interleukin 33 (IL-33) induces IL-9 expression and secretion in T cells, which was confirmed by the results obtained in mice by ... Interleukin-9 has also shown to inhibit melanoma growth in mice. Additionally, it gives rise to the multiplication of ...
Interleukin-12 subunit beta
IL-12B is a common subunit of interleukin 12 and interleukin 23. This gene encodes a subunit of interleukin 12, a cytokine that ... Interleukin-12 p40 also serves as a subunit of interleukin 23. GRCh38: Ensembl release 89: ENSG00000113302 - Ensembl, May 2017 ... "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 (4): ... "Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated ...
Interleukin
... 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ... di Giovine FS, Duff GW (Jan 1990). "Interleukin 1: the first interleukin". Immunology Today. 11 (1): 13-20. doi:10.1016/0167- ...
Interleukin 13
Zurawski G, de Vries JE (January 1994). "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but ... Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located ... Interleukin-13 has a critical role in goblet cell metaplasia. Goblet cells are filled with mucin (MUC). MUC5AC Mucin 5AC is a ... October 2004). "Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human ...
Interleukin 4
Interleukin-4 from Gentaur Recombinant Human Interleukin-4 from Cornell University Interleukin-4 from Allergy Glossary at ... Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor ... The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon ... The receptor for interleukin-4 is known as the IL-4Rα. This receptor exists in 3 different complexes throughout the body. Type ...
Interleukin 24
... (IL-24) is a protein in the interleukin family, a type of cytokine signaling molecule in the immune system. In ... This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing ... March 2016). "The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated ... Wang M, Tan Z, Zhang R, Kotenko SV, Liang P (March 2002). "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric ...
Eosinophil
High levels of interleukin-5 has been observed to up regulate the expression of adhesion molecules, which then facilitate the ... Yamaguchi Y, Suda T, Suda J, Eguchi M, Miura Y, Harada N, Tominaga A, Takatsu K (January 1988). "Purified interleukin 5 ... Sanderson, Colin (1992). "Interleukin-5, Eosinophils, and Disease". Blood. 79 (12): 3101-3109. doi:10.1182/blood.V79.12.3101. ... Eosinophilia in mice models are shown to be associated with high interleukin-5 levels. Furthermore, mucosal bronchial biopsies ...
Severe cutaneous adverse reactions
Interleukin 8 and Interleukin 17); a promoter of innate immune and autoimmune responses (viz., Interleukin 22); and a cytokine ... Interleukin 4), promote allergic responses and tissue fibrosis (viz., Interleukin 13), promote innate, adaptive, and auto- ... interleukin 5 and annexin A1). DRESS syndrome: Key elements promoting tissue injury in the DRESS syndrome are: Th2 cells and ... Interleukin 5), promote adaptive and allergic immune responses (viz., ...
Andrew N. J. McKenzie
His identification of the cytokine Interleukin 13 and the subsequent unearthing of its central role in allergic asthma led to ... McKenzie, Andrew N.J.; Ely, Barry; Sanderson, Colin J. (1991). "Mutated interleukin-5 monomers are biologically inactive". ...
Eosinophilia
... interleukin 3, interleukin 5) that: a) cause bone marrow precursor cells, i.e. CFU-Eos, to proliferate and mature into ... interleukin 3, or interleukin 13. The disorder is usually indolent but infrequently progresses to T-cell lymphoma or Sezary ... interleukin 3, interleukin 5, and colony stimulating factor 2. However, no functional sequence genetic polylmophisms are found ... Prakash Babu S, Chen YK, Bonne-Annee S, Yang J, Maric I, Myers TG, Nutman TB, Klion AD (2017). "Dysregulation of interleukin 5 ...
Reslizumab
... is an interleukin IL-5 antagonist monoclonal antibody. IL-5 is the major cytokine responsible for the growth and ... Reslizumab is a humanized monoclonal antibody against human interleukin-5 (IL-5). Reslizumab binds specifically to IL-5, a key ... WO 1993016184, "Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5", published 19 ... Reslizumab has a volume of distribution of approximately 5 L, clearance of approximately 7 mL/hour, and a half-life of about 24 ...
Interleukin 15 receptor, alpha subunit
... is a subunit of the interleukin 15 receptor that in humans is encoded by the IL15RA gene ... "Identification of an interleukin-15alpha receptor-binding site on human interleukin-15". J. Biol. Chem. 279 (23): 24313-22. doi ... Jacob CO, Mykytyn K, Varcony T, Drabkin HA (1993). "Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 ... Khan IA, Moretto M, Wei XQ, Williams M, Schwartzman JD, Liew FY (2002). "Treatment with soluble interleukin-15Ralpha ...
Interleukin 25
Interleukin-25 (IL-25) - also known as interleukin-17E (IL-17E) - is a protein that in humans is encoded by the IL25 gene on ... "Entrez Gene: IL25 interleukin 25". Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 ... April 2015). "Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation". Immunity. 42 (4): 692-703. doi:10.1016 ... Angkasekwinai P, Park H, Wang YH, Wang YH, Chang SH, Corry DB, Liu YJ, Zhu Z, Dong C (July 2007). "Interleukin 25 promotes the ...
Interleukin 19
Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL- ... Interleukin 19 (IL-19) is an immunosuppressive protein that belongs to the IL-10 cytokine subfamily. Human IL-19 is encoded by ... "IL19 interleukin 19 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-03-01. Leigh T, Scalia RG, ... 2011-11-15). "Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway ...
ETS2
Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J (Apr 1999). "Regulation of the human interleukin-5 ... 89 (4): 1291-5. Bibcode:1992PNAS...89.1291D. doi:10.1073/pnas.89.4.1291. PMC 48435. PMID 1741383. Wei G, Schaffner AE, Baker KM ... 5 (10): 1521-7. PMID 2250910. Watson DK, McWilliams MJ, Lapis P, Lautenberger JA, Schweinfest CW, Papas TS (Nov 1988). " ... doi:10.1016/0165-4608(86)90189-5. PMID 3021321. Fujiwara S, Fisher RJ, Seth A, Bhat NK, Showalter SD, Zweig M, Papas TS (Feb ...
Interleukin 33
... (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family ... Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils ... "Entrez Gene: Interleukin 33". Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, et al. (November 2010). "IL- ... Casciaro M, Cardia R, Di Salvo E, Tuccari G, Ieni A, Gangemi S (May 2019). "Interleukin-33 Involvement in Nonsmall Cell Lung ...
Interleukin 35
... (IL-35) is a recently discovered anti-inflammatory cytokine from the IL-12 family. Member of IL-12 family - IL- ... June 2014). "Interleukin-35 induces regulatory B cells that suppress autoimmune disease". Nature Medicine. 20 (6): 633-41. doi: ... Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40- ... Compared to these two related interleukins, IL-35 is also able to signal through only one of the aforementioned chains. This ...
SIGLEC8
Nutku-Bilir E, Hudson SA, Bochner BS (January 2008). "Interleukin-5 priming of human eosinophils alters siglec-8 mediated ... Ligation of Siglec-8 induces cell death in eosinophils, and, surprisingly, the normally pro-survival cytokines interleukin (IL ... "Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils". Laboratory Investigation; A Journal of ... IL-5 stimulation also appears to alter the mode of cell death of eosinophils induced by Siglec-8 ligation in that cell death ...
Interleukin 3
... is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease ... Tabira T, Chui DH, Fan JP, Shirabe T, Konishi Y (1998). "Interleukin-3 and interleukin-3 receptors in the brain". Ann. N. Y. ... Interleukin 3 has been shown to interact with IL3RA. Interleukin GRCh38: Ensembl release 89: ENSG00000164399 - Ensembl, May ... interleukin-3 (IL-3), and interleukin-5 (IL-5) receptor complexes to chromosome 22q13.1". Human Genetics. 93 (2): 198-200. doi: ...
Interleukin 11
As a signaling molecule, interleukin 11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; ... Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. IL-11 is a ... Chen HF, Lin CY, Chao KH, Wu MY, Yang YS, Ho HN (May 2002). "Defective production of interleukin-11 by decidua and chorionic ... Interleukin 11 is manufactured using recombinant DNA technology.[citation needed] It is marketed as a protein therapeutic ...
Interleukin 16
... is a pro-inflammatory pleiotropic cytokine. It's precursor, pro-interleukin-16 is a protein that in humans is ... Interleukin 16 (IL-16) is released by a variety of cells (including lymphocytes and some epithelial cells) that has been ... Interleukin 16 has been shown to interact with: GRIN2A, GRIN2D, KCNJ10, KCNJ15, Kir2.1, PPP1R12A, and PPP1R12B. GRCh38: Ensembl ... "Entrez Gene: IL16 interleukin 16 (lymphocyte chemoattractant factor)". Cruikshank W, Center DM (June 1982). "Modulation of ...
Interleukin 6
... (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In ... Interleukin-6 has been shown to interact with interleukin-6 receptor, glycoprotein 130, and Galectin-3. There is considerable ... Other cytokines that signal through receptors containing gp130 are Interleukin 11 (IL-11), Interleukin 27 (IL-27), ciliary ... "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". The Journal of ...
Interleukin-38
... (IL-38) is a member of the interleukin-1 (IL-1) family and the interleukin-36 (IL-36) subfamily. It is important ... Jung, MY; Kang, SW; Kim, SK; Kim, H-J; Yun, DH; Yim, S-V; Hong, SJ; Chung, J-H (2010-02-09). "The interleukin-1 family gene ... Yuan, X. L.; Li, Y.; Pan, X. H.; Zhou, M.; Gao, Q. Y.; Li, M. C. (May 2016). "Production of recombinant human interleukin-38 ... Also serum levels of IL-17 and interleukin-22 were lower in these mice what approves in vitro observation that IL-38 could ...
Interleukin 29
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 ( ... "Entrez Gene: interleukin 29 (interferon". Wang JM, Huang AF, Xu WD, Su LC (December 2019). "Insights into IL-29: Emerging role ... Pagliaccetti NE, Eduardo R, Kleinstein SH, Mu XJ, Bandi P, Robek MD (October 2008). "Interleukin-29 functions cooperatively ... Articles with short description, Short description matches Wikidata, Genes on human chromosome 19, Interleukins, Cytokines, ...
Interleukin 37
Interleukin-1 family Interleukin 18 Interleukin 18 receptor Interleukin 18 binding protein Inflammation Carcinogenesis GRCh38: ... Interleukin 37 (IL-37), also known as Interleukin-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine important for ... April 2018). "The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis". ... interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382-384. doi:10.1006/geno.1994.1076. PMID ...
Interleukin 15
Together with Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), granulocyte colony- ... February 2014). "Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co- ... Liew FY, McInnes IB (November 2002). "Role of interleukin 15 and interleukin 18 in inflammatory response". Annals of the ... December 2007). "Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis ...