The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon ... The receptor for interleukin-4 is known as the IL-4Rα. This receptor exists in 3 different complexes throughout the body. Type ... Interleukin 4 has many biological roles, including the stimulation of activated B cell and T cell proliferation, and the ... Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor ...
The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the ... Interleukin-4 receptor has been shown to interact with SHC1. The N-terminal (extracellular) portion of interleukin-4 receptor ... They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a ... "Entrez Gene: IL4R interleukin 4 receptor". Thornhill, MH; Wellicome, SM; Mahiouz, DL; Lanchbury, JSS; Kyanaung, U; Haskard, DO ...
... 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ... di Giovine FS, Duff GW (Jan 1990). "Interleukin 1: the first interleukin". Immunology Today. 11 (1): 13-20. doi:10.1016/0167- ...
... (IL-15L) is an interleukin, a type of cytokine signaling in the immune system. It is a secreted protein of ... Waldmann, Thomas A. (August 2006). "The biology of interleukin-2 and interleukin-15: implications for cancer therapy and ... interleukin 15-like, in mammals; interleukins 2 and 15 co-evolved with this third family member, all sharing binding motifs for ... Malek, Thomas R. (2008-04-01). "The Biology of Interleukin-2". Annual Review of Immunology. 26 (1): 453-479. doi:10.1146/ ...
This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them ... Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. ... Sébire G, Delfraissy JF, Demotes-Mainard J, Oteifeh A, Emilie D, Tardieu M (Aug 1996). "Interleukin-13 and interleukin-4 act as ... interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". Journal ...
... (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2α and 2β subunits. ... Receptors,+Interleukin-10 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... The α subunit is exclusive to interleukin-10, however the β subunit is shared with other type II cytokine receptors such as IL- ... The Interleukin-10 receptor is implicated in regulation of gastro-intestinal immune response, primarily in the mucosal layer. ...
Zurawski G, de Vries JE (January 1994). "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but ... Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located ... Interleukin-13 has a critical role in goblet cell metaplasia. Goblet cells are filled with mucin (MUC). MUC5AC Mucin 5AC is a ... October 2004). "Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human ...
Together with Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), granulocyte colony- ... February 2014). "Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co- ... Liew FY, McInnes IB (November 2002). "Role of interleukin 15 and interleukin 18 in inflammatory response". Annals of the ... December 2007). "Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis ...
2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 ... Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene. IL10RB has also ... "Entrez Gene: IL10RB interleukin 10 receptor, beta". Lutfalla G, McInnis MG, Antonarakis SE, Uzé G (1995). "Structure of the ... 2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL ...
... is expressed on various cell types, including naive and memory T cells and many others. Interleukin-7 ... The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - ... "Entrez Gene: IL7R interleukin 7 receptor". Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, ... Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain ...
The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by ... Lin C, Liu H, Zhang H, He H, Li H, Shen Z, Qin J, Qin X, Xu J, Sun Y (August 2016). "Interleukin-13 receptor α2 is associated ... Interleukin 13 (IL-13) is an effector cytokine partially sharing the signaling pathways with IL-4 due to the utilization of a ... Receptors,+Interleukin-13 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ...
... and interleukin-1 (IL-1)) and through stabilization of messenger RNA (mRNA) (e.g., Interleukin-4 (IL-4)). The promoter region ... Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ... 58 (3-4): 1850-1867. doi:10.1159/000133735. "Entrez Gene: VCAM1 vascular cell adhesion molecule 1". Barreiro O, Yanez-Mo M, ...
NO inhibits tyrosine phosphorylation of the kinases involved in production of the interleukin-2 (IL-2) receptor, the expression ... Pouliot P, Turmel V, Gélinas E, Laviolette M, Bissonnette EY (June 2005). "Interleukin-4 production by human alveolar ... Paul WE (May 1991). "Interleukin-4: a prototypic immunoregulatory lymphokine". Blood. 77 (9): 1859-70. doi:10.1182/blood.V77.9. ... interleukin-4 and -10(IL-4, IL-10), and transforming growth factor-β (TGF-β). Nitric oxide (NO) is a major source of ...
Interleukin-4 (IL4) lacking model of MMTV-PyMT; IL4−/− mice. Role of the adhesion molecule CD44 in lung metastasis. Conditional ... 1: 4. doi:10.1186/1471-213X-1-4. PMC 31338. PMID 11299042. Liao, M. J.; Zhang, C. C.; Zhou, B; Zimonjic, D. B.; Mani, S. A.; ... 113 (4): 525-32. doi:10.1002/ijc.20631. PMID 15472905. Cuevas, B. D.; Winter-Vann, A. M.; Johnson, N. L.; Johnson, G. L. (2006 ... 9 (4): 302-12. doi:10.1038/nrc2627. PMID 19308069. S2CID 9161392. Weng, D; Penzner, J. H.; Song, B; Koido, S; Calderwood, S. K ...
... (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 ... The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte ... Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a ... Overview of all the structural information available in the PDB for UniProt: P05113 (Interleukin-5) at the PDBe-KB. (CS1: long ...
Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH (Dec 1996). "NF-AT-Driven interleukin-4 transcription ... interacts with NFATc2 to modulate interleukin 4 gene expression". The Journal of Experimental Medicine. 195 (8): 1003-12. doi: ... "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and ... three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology. 24 (11): 2646-2652. doi ...
Interleukin 8 and Interleukin 17); a promoter of innate immune and autoimmune responses (viz., Interleukin 22); and a cytokine ... Interleukin 5), promote adaptive and allergic immune responses (viz., Interleukin 4), promote allergic responses and tissue ... interleukin 5 and annexin A1). DRESS syndrome: Key elements promoting tissue injury in the DRESS syndrome are: Th2 cells and ... 177 (4): 1102-1112. doi:10.1111/bjd.15498. PMC 5617756. PMID 28346659. Su SC, Hung SI, Fan WL, Dao RL, Chung WH (2016). "Severe ...
"IL37 interleukin 37 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-08-31. "IL1F10 interleukin 1 ... Liu N, Li X, Liu C, Zhao Y, Cui B, Ning G (April 2010). "The association of interleukin-1alpha and interleukin-1beta ... "Interleukins and interleukin receptors - HUGO Gene Nomenclature Committee". www.genenames.org. Archived from the original on 15 ... Yoshimoto T, Okamura H, Tagawa YI, Iwakura Y, Nakanishi K (April 1997). "Interleukin 18 together with interleukin 12 inhibits ...
2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". J. Biol. Chem. 280 (26): ... Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene. The ... "Entrez Gene: IL13RA1 interleukin 13 receptor, alpha 1". Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain ... Interleukin-13 receptor GRCh38: Ensembl release 89: ENSG00000131724 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
... (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family ... Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils ... "Entrez Gene: Interleukin 33". Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, et al. (November 2010). "IL- ... Casciaro M, Cardia R, Di Salvo E, Tuccari G, Ieni A, Gangemi S (May 2019). "Interleukin-33 Involvement in Nonsmall Cell Lung ...
... is mainly activated by cytokines interleukin-4 and interleukin-13. In the human genome, STAT6 protein is encoded by the ... STAT6 is activated by cytokines interleukin-4 (IL-4), and interleukin-13 (IL-13) with their receptors that both contain the α ... Kotanides H, Reich NC (October 1996). "Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of ... Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (September 1994). "An interleukin-4-induced transcription factor ...
Hashimoto-Uoshima M, Noguchi K, Suzuki M, Murata A, Yanagishita M, Ishikawa I (February 2002). "Effects of interleukin-4 on ... interleukin(IL) and vascular endothelial growth factor (VEGF) families of molecules. The upstream 2.5 kilobases of the perlecan ... by injury and interleukin-1alpha". J. Neurochem. 73 (2): 812-20. doi:10.1046/j.1471-4159.1999.0730812.x. PMID 10428080. S2CID ... "Alteration of proteoglycan synthesis in human lung fibroblasts induced by interleukin-1beta and tumor necrosis factor-alpha". J ...
McInnes A, Rennick DM (February 1988). "Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells ... 4 (4): 128-134. doi:10.1016/j.ncrna.2019.11.002. PMC 7012776. PMID 32072080. Kong XN, Yan HX, Chen L, Dong LW, Yang W, Liu Q, ... 115 (4): 919-31. doi:10.1083/jcb.115.4.919. PMC 2289954. PMID 1955462. Pombo A, Cuello P, Schul W, Yoon JB, Roeder RG, Cook PR ... 2002). "Chapter 4: DNA and Chromosomes". Molecular Biology of the Cell (4th ed.). New York: Garland Science. pp. 191-234. ISBN ...
Randall TD, Lund FE, Brewer JW, Aldridge C, Wall R, Corley RB (July 1993). "Interleukin-5 (IL-5) and IL-6 define two ... December 1985). "Synergy of B cell growth factor and interleukin 2 in the proliferation of activated human B cells". European ... Kehrl, John H.; Muraguchi, Atsushi; Goldsmith, Paul K.; Fauci, Anthony S. (1985-11-01). "The direct effects of interleukin 1, ... Paul WE (December 1987). "Interleukin 4/B cell stimulatory factor 1: one lymphokine, many functions". FASEB Journal. 1 (6): 456 ...
Th2 also produce Interleukin 4, which facilitates B cell isotype switching. In general, Th2 responses are more effective ... The Th2 response is characterized by the release of Interleukin 5, which induces eosinophils in the clearance of parasites. ... 4 (7): e229. doi:10.1371/journal.pbio.0040229. PMC 1479700. PMID 16774454. Meki IK, Kariithi HM, Parker AG, Vreysen MJ, Ros VI ... In humans, it takes 4-7 days for the adaptive immune system to mount a significant response. T and B lymphocytes are the cells ...
2003). "Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling". J. Biol. Chem. 278 (5): 2787-2791. doi ... 17 (4): 377-385. doi:10.1089/dna.1998.17.377. PMID 9570154. Hooks SB, Ragan SP, Lynch KR (1998). "Identification of a novel ...
Bamborough P, Hedgecock CJ, Richards WG (1995). "The interleukin-2 and interleukin-4 receptors studied by molecular modelling ... "Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor". Science. 262 (5141): 1880-3. Bibcode ... Interleukin+Receptor+Common+gamma+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of ... The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor ...
These pro-inflammatory cytokines such as TNF, Interleukin-1 and Interleukin-8 lead to acute inflammation and leukocyte ... "Interleukin 4 is localized to and released by human mast cells". Journal of Experimental Medicine. 176 (5): 1381-1386. doi: ... 96 (4): 809-814. doi:10.1378/chest.96.4.809. ISSN 0012-3692. PMID 2529105. Krishna, M T; Huissoon, A P (2010-12-22). "Clinical ... 123 (4): 322-328.e2. doi:10.1016/j.amjmed.2009.07.035. PMID 20176343. Chowdhury, Badrul A.; Dal Pan, Gerald (2010). "The FDA ...
Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex, Science (2003) Structure of the Quaternary ... Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Junttila, Ilkka S.; Creusot, Remi J.; ... "Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines". Nature Chemical Biology. 8 (12): ... 146 (4): 621-632. doi:10.1016/j.cell.2011.06.048. PMC 3166218. PMID 21854986. The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals ...
Interleukin-1 family Interleukin 18 Interleukin 18 receptor Interleukin 18 binding protein Inflammation Carcinogenesis GRCh38: ... Interleukin 37 (IL-37), also known as Interleukin-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine important for ... April 2018). "The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis". ... interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382-384. doi:10.1006/geno.1994.1076. PMID ...