Loading...
*  Interleukin 4
It is closely related and has functions similar to Interleukin 13. Interleukin 4 has many biological roles, including the ... The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon ... The receptor for Interleukin-4 is known as the IL-4Rα. This receptor exists in 3 different complexes throughout the body. Type ... Interleukin-4 at the US National Library of Medicine Medical Subject Headings (MeSH) Interleukin-4 from Gentaur at Gentaur ...
*  Interleukin-4 receptor
The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene. This gene encodes the alpha chain of the ... Interleukin-4 receptor has been shown to interact with SHC1. The N-terminal (extracellular) portion of interleukin-4 receptor ... They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a ... Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the ...
*  VCAM-1
... and Interleukin-1 (IL-1)) and through stabilization of Messenger RNA (mRNA) (e.g., Interleukin-4 (IL-4)). The promoter region ... Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ...
*  Alveolar macrophage
Paul, W. E. "Interleukin-4: A Prototypic Immunoregulatory Lymphokine." Blood 77.9 (1991): 1859-70. Araya, J., et al. "Integrin- ... NO inhibits tyrosine phosphorylation of the kinases involved in production of the interleukin-2 (IL-2) receptor, the expression ... "Interleukin-4 Production by Human Alveolar Macrophages." Clinical & Experimental Allergy 35.6 (2005): 804-10. ... "Legionella Pneumophila Evades Gamma Interferon-Mediated Growth Suppression through Interleukin-10 Induction in Bone Marrow- ...
*  Mouse models of breast cancer metastasis
Interleukin-4 (IL4) lacking model of MMTV-PyMT; IL4−/− mice. Role of the adhesion molecule CD44 in lung metastasis. Conditional ... 1: 4. PMC 31338 . PMID 11299042. Liao, M. J.; Zhang, C. C.; Zhou, B; Zimonjic, D. B.; Mani, S. A.; Kaba, M; Gifford, A; ... 9 (4): 302-12. doi:10.1038/nrc2627. PMID 19308069. Weng, D; Penzner, J. H.; Song, B; Koido, S; Calderwood, S. K.; Gong, J (2012 ... 113 (4): 525-32. doi:10.1002/ijc.20631. PMID 15472905. Cuevas, B. D.; Winter-Vann, A. M.; Johnson, N. L.; Johnson, G. L. (2006 ...
*  NFATC2
Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH (Dec 1996). "NF-AT-Driven interleukin-4 transcription ... interacts with NFATc2 to modulate interleukin 4 gene expression". The Journal of Experimental Medicine. 195 (8): 1003-12. doi: ... "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and ... three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology. 24 (11): 2646-2652. doi ...
*  STAT6
Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (Sep 1994). "An interleukin-4-induced transcription factor: IL-4 ... Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (Sep 1994). "An interleukin-4-induced transcription factor: IL-4 ... Kotanides H, Reich NC (Oct 1996). "Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the ... Mikita T, Campbell D, Wu P, Williamson K, Schindler U (Oct 1996). "Requirements for interleukin-4-induced gene expression and ...
*  Perlecan
Hashimoto-Uoshima M, Noguchi K, Suzuki M, Murata A, Yanagishita M, Ishikawa I (February 2002). "Effects of interleukin-4 on ... interleukin(IL) and vascular endothelial growth factor (VEGF) families of molecules. The upstream 2.5 kilobases of the perlecan ... by injury and interleukin-1alpha". J. Neurochem. 73 (2): 812-20. doi:10.1046/j.1471-4159.1999.0730812.x. PMID 10428080. ... "Alteration of proteoglycan synthesis in human lung fibroblasts induced by interleukin-1beta and tumor necrosis factor-alpha". J ...
*  Cell nucleus
McInnes, A; Rennick DM (1988). "Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells". J Exp ... 115 (4): 919-931. doi:10.1083/jcb.115.4.919. PMC 2289954 . PMID 1955462. Pombo A, Cuello P, Schul W, Yoon J, Roeder R, Cook P, ... 119 (4): 725-735. doi:10.1083/jcb.119.4.725. PMC 2289687 . PMID 1429833. Goldman R, Gruenbaum Y, Moir R, Shumaker D, Spann T ( ... 12 (4): 513-523. doi:10.1162/artl.2006.12.4.513. PMID 16953783. Goldman, Robert D.; Gruenbaum, Y; Moir, RD; Shumaker, DK; Spann ...
*  Adaptive immune system
Th2 also produce Interleukin 4, which facilitates B cell isotype switching. In general, Th2 responses are more effective ... The Th2 response is characterized by the release of Interleukin 5, which induces eosinophils in the clearance of parasites. ... 71 (4): 876-882. PMID 3355895. Arese P, Turrini F, Schwarzer E (2005). "Band 3/complement-mediated recognition and removal of ... 16 (4-6): 133-146. doi:10.1159/000089839. PMID 16301814. Archived from the original (PDF) on 2012-09-29. Williams TN, Mwangi TW ...
*  PPAP2A
2003). "Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling". J. Biol. Chem. 278 (5): 2787-2791. doi ... 17 (4): 377-385. doi:10.1089/dna.1998.17.377. PMID 9570154. Hooks SB, Ragan SP, Lynch KR (1998). "Identification of a novel ...
*  Common gamma chain
Bamborough P, Hedgecock CJ, Richards WG (1995). "The interleukin-2 and interleukin-4 receptors studied by molecular modelling ... "Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor". Science. 262 (5141): 1880-3. doi: ... Interleukin Receptor Common gamma Subunit at the US National Library of Medicine Medical Subject Headings (MeSH). ... The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor ...
*  Organization and expression of immunoglobulin genes
For example, interleukin-4 induces the rearrangements of heavy chain immunoglobulin genes. That is IL- 4 induces the switching ...
*  BCL6
Gupta S, Jiang M, Anthony A, Pernis AB (December 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon ... and has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with ... 169 (4): 1922-9. doi:10.4049/jimmunol.169.4.1922. PMID 12165517. David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May ... 92 (26): 12520-4. doi:10.1073/pnas.92.26.12520. PMC 40389 . PMID 8618933. Shen Y, Ge B, Ramachandrareddy H, McKeithan T, Chan ...
*  Cytokine redundancy
For instance, a pair of redundant cytokines are interleukin 4 and interleukin 13. Cytokine redundancy is associated with the ... "Molecular and structural basis of cytokine receptor pleiotropy in theh interleukin-4/13 system", Cell, 132(2):259-72. Ozaki, K ...
*  Interleukin
... 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Interleukin 7 and 9 seem to be evolutionary related. Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ...
*  Dock10
July 2008). "Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes". Mol. Immunol. 45 (12): ... cells in response to the cytokine IL-4. This suggests that Dock10 may have a role in B-cell activation and proliferation. ...
*  Dock11
... a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes". Molecular Immunology. 45 (12): 3411-8. doi: ... 30 (4): 292-302; discussion 303. doi:10.1111/j.1365-2605.2007.00758.x. PMID 17488342. Côté JF, Vuori K (August 2007). "GEF what ...
*  Lupeol
As an anti-inflammatory agent, lupeol functions primarily on the interleukin system. Lupeol to decreases IL-4 (interleukin 4) ... 4 (2): 72-74. doi:10.1016/j.phytol.2010.08.004. PMC 3099468 . PMID 21617767. Stork, Gilbert; Uyeo, Shoichiro; Wakamatsu, T.; ... One study has also found some activity as a Dipeptidyl peptidase-4 inhibitor and prolyl oligopeptidase inhibitor at high ...
*  IRS2
1996). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. ... Izuhara K, Harada N (1997). "Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells ... as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. Mice lacking IRS2 have a diabetic ... 270 (8): 3471-4. doi:10.1074/jbc.270.8.3471. PMID 7876077. Platanias LC, Uddin S, Yetter A, et al. (1996). "The type I ...
*  Trichuris suis
Parasitic worms generate production of interleukin 4 and interleukin 13, which are Th2 cytokines. This Th2 response restrains ... interleukin 10, and prostaglandin E2 that assist in sustaining host mucosal homeostasis. The FDA has granted pig whipworm ( ... The prepatent period is 6 to 8 weeks and life span is 4 to 5 months. Pigs are the natural host for T. suis, but it can also ... Adult females measure 6 to 8 cm and adult males 3 to 4 cm. T. suis eggs are oval (60 × 25 μm) and yellow-brown with bipolar ...
*  Granulocyte-macrophage colony-stimulating factor
The human gene has been localized in close proximity to the interleukin 3 gene within a T helper type 2-associated cytokine ... Other genes in the cluster include those encoding interleukins 4, 5, and 13. Human granulocyte-macrophage colony-stimulating ... "A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 ... 39 (4): 697-710. doi:10.1016/j.immuni.2013.09.006. PMC 3841917 . PMID 24138881. Hansen PJ, Dobbs KB, Denicol AC (Sep 2014). " ...
*  Janus kinase 3
Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995). "Interleukins 2, 4, 7, and ... Rolling C, Treton D, Beckmann P, Galanaud P, Richard Y (May 1995). "JAK3 associates with the human interleukin 4 receptor and ... Kumar N, Mishra J, Narang VS, Waters CM (October 2007). "Janus kinase 3 regulates interleukin 2-induced mucosal wound repair ... Mishra J, Waters CM, Kumar N (March 2012). "Molecular mechanism of interleukin-2-induced mucosal homeostasis". American Journal ...
*  Interleukin 13
Zurawski G, de Vries JE (January 1994). "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but ... Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located ... Interleukin-13 has a critical role in the Goblet cell metaplasia. Goblet cells are filled with mucin (MUC). MUC5AC Mucin 5AC is ... Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium. 15- ...
*  NFKB1
... direct association and synergistic activation of interleukin-4-induced transcription". Mol. Cell. Biol. 18 (6): 3395-404. doi: ... 18 (4): 995-1005. doi:10.1038/sj.onc.1202374. PMID 10023675. Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG (July ... 21 (4): 1024-35. doi:10.1128/MCB.21.4.1024-1035.2001. PMC 99557 . PMID 11158290. Besta F, Massberg S, Brand K, Müller E, Page S ... 22 (4): 405-22. doi:10.1023/A:1023733231406. PMID 12884915. Kucharczak J, Simmons MJ, Fan Y, Gélinas C (2004). "To be, or not ...
*  Childbirth
"Fetal distress increases interleukin-6 and interleukin-8 and decreases tumour necrosis factor-alpha cord blood levels in ... 68 (4): 448-51. PMID 3748488. Rouse, D.J.; Weiner, S.J.; Bloom, S.L.; Varner, M.W.; et al. (2009). "Second-stage labour ... 187 (4): 824-8. doi:10.1067/mob.2002.127142. PMID 12388957. Archived from the original on 2016-01-18. Peisner, D.B.; Rosen, M.G ... ISBN 978-92-4-159621-3. Archived (PDF) from the original on 2013-07-31. "Maternal mortality ratio falling too slowly to meet ...