Interleukin 2
February 2014). "Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co- ... Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein ... Interleukin-2 (Aldesleukin). Date accessed: 07 Nov 10. Shi VY, Tran K, Patel F, Leventhal J, Konia T, Fung MA, Wilken R, Garcia ... 2018-07-26). "Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional ...
Interleukin 12 receptor, beta 2 subunit
2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 ... Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2. The mRNA of this protein is subject to ... Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 ... 1997). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad ...
Interleukin 15-like
... (IL-15L) is an interleukin, a type of cytokine signaling in the immune system. It is a secreted protein of ... interleukin 15-like, in mammals; interleukins 2 and 15 co-evolved with this third family member, all sharing binding motifs for ... Malek, Thomas R. (2008-04-01). "The Biology of Interleukin-2". Annual Review of Immunology. 26 (1): 453-479. doi:10.1146/ ... Waldmann, Thomas A. (August 2006). "The biology of interleukin-2 and interleukin-15: implications for cancer therapy and ...
Interleukin
... 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ... di Giovine FS, Duff GW (Jan 1990). "Interleukin 1: the first interleukin". Immunology Today. 11 (1): 13-20. doi:10.1016/0167- ...
Interleukin 25
Interleukin-25 (IL-25) - also known as interleukin-17E (IL-17E) - is a protein that in humans is encoded by the IL25 gene on ... "Entrez Gene: IL25 interleukin 25". Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 ... April 2015). "Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation". Immunity. 42 (4): 692-703. doi:10.1016 ... Angkasekwinai P, Park H, Wang YH, Wang YH, Chang SH, Corry DB, Liu YJ, Zhu Z, Dong C (July 2007). "Interleukin 25 promotes the ...
Interleukin-13 receptor
The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by ... Murata T, Obiri NI, Puri RK (March 1998). "Structure of and signal transduction through interleukin-4 and interleukin-13 ... Chomarat P, Banchereau J (1998). "Interleukin-4 and interleukin-13: their similarities and discrepancies". International ... Lin C, Liu H, Zhang H, He H, Li H, Shen Z, Qin J, Qin X, Xu J, Sun Y (August 2016). "Interleukin-13 receptor α2 is associated ...
Interleukin 8 receptor, alpha
Interleukin Interleukin 8 Interleukin 8 receptor, beta Interleukin receptor Interleukin-8 receptor GRCh38: Ensembl release 89: ... Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by ... "Entrez Gene: IL8RA interleukin 8 receptor, alpha". Bergin DA, Reeves EP, Meleady P, Henry M, McElvaney OJ, Carroll TP, Condron ... This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G- ...
Interleukin-7 receptor
... is expressed on various cell types, including naive and memory T cells and many others. Interleukin-7 ... The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - ... "Entrez Gene: IL7R interleukin 7 receptor". Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, ... Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain ...
Interleukin receptor
They include: Interleukin-10 receptor Interleukin-20 receptor Interleukin-22 receptor Interleukin-28 receptor Interleukin-8 ... Interleukin-3 receptor Interleukin-4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin- ... 9 receptor Interleukin-11 receptor Interleukin-12 receptor Interleukin-13 receptor Interleukin-15 receptor Interleukin-18 ... Type 1 interleukin receptors include: Interleukin-1 receptor Interleukin-2 receptor ...
Interleukin 8 receptor, beta
Interleukin 8 receptor, alpha Interleukin 8 Interleukin Interleukin receptor Cluster of differentiation G protein-coupled ... Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on ... "Entrez Gene: IL8RB interleukin 8 receptor, beta". Auer PL, Teumer A, Schick U, O'Shaughnessy A, Lo KS, Chami N, Carlson C, de ... This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G- ...
Interleukin-6 receptor
Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 ... Interleukin-6 receptor has been shown to interact with Interleukin 6 and ciliary neurotrophic factor. Cluster of ... "Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6". Proc. Natl. Acad. Sci. U.S.A. 90 (24): 11924-8 ... "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". J. Biol. Chem. ...
Interleukin 15
Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), granulocyte colony-stimulating factor (G-CSF), and ... February 2014). "Identification of a gene for an ancient cytokine, interleukin 15-like, in mammals; interleukins 2 and 15 co- ... Liew FY, McInnes IB (November 2002). "Role of interleukin 15 and interleukin 18 in inflammatory response". Annals of the ... December 2007). "Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis ...
Interleukin 7
"Entrez Gene: IL7 interleukin 7". Noguchi M, Nakamura Y, Russell SM, et al. (1994). "Interleukin-2 receptor gamma chain: a ... Aspinall R, Henson S, Pido-Lopez J, Ngom PT (2004). "Interleukin-7: an interleukin for rejuvenating the immune system". Ann. N ... "Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal ... Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by ...
Interleukin-15 receptor
... is a type I cytokine receptor, binding interleukin-15. It consists of an interleukin 15 receptor, alpha ... Receptors,+Interleukin-15 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (CS1 maint: date and ... PDB: 2B5IWang X, Rickert M, Garcia KC (November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, ... "Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes". J. ...
Interleukin 5
... (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 ... The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte ... Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a ... Overview of all the structural information available in the PDB for UniProt: P05113 (Interleukin-5) at the PDBe-KB. (CS1: long ...
Interleukin 1 receptor, type II
This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them ... "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636-41. doi:10.1006 ... Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this ... Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. ...
Interleukin-1 family
"IL37 interleukin 37 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2019-08-31. "IL1F10 interleukin 1 ... Liu N, Li X, Liu C, Zhao Y, Cui B, Ning G (April 2010). "The association of interleukin-1alpha and interleukin-1beta ... "Interleukins and interleukin receptors - HUGO Gene Nomenclature Committee". www.genenames.org. Archived from the original on 15 ... Yoshimoto T, Okamura H, Tagawa YI, Iwakura Y, Nakanishi K (April 1997). "Interleukin 18 together with interleukin 12 inhibits ...
Interleukin 40
Catalan-Dibene, Jovani; McIntyre, Laura L.; Zlotnik, Albert (October 2018). "Interleukin 30 to Interleukin 40". Journal of ... Interleukin 40, or IL-40, also known with other name C17orf99 is encoded by gene that do not belong to any cytokine superfamily ... Interleukin-40 is a promising biomarker associated with type 2 diabetes mellitus risk. Immunol Lett. 2023 Feb;254:1-5. doi: ... The expression of IL-40, an interleukin involved in immune regulation, has been found to be elevated in the synovial fluid of ...
Interleukin-17 receptor
Onishi RM, Gaffen SL (March 2010). "Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease". ... "Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E". Immunity. 35 (4): 611-21. ... Zhang B, Liu C, Qian W, Han Y, Li X, Deng J (May 2014). "Structure of the unique SEFIR domain from human interleukin 17 ... Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory ...
Interleukin 26
"The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor ... Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene. IL-26 is the most recently identified member of ... Interleukin 26 (IL-26) is an inflammatory mediator and a driver of chronic inflammation due to its ability to act as a carrier ... "Entrez Gene: interleukin 26". Knappe A, Hör S, Wittmann S, Fickenscher H (April 2000). "Induction of a novel cellular homolog ...
Harvey Berger
"Biotechnology Report, Medicines in Development, 2006 , Interleukin 2 , Monoclonal Antibody". Scribd. Retrieved 2017-09-25. " ... 77 (2): 316-327. doi:10.1161/01.CIR.77.2.316. ISSN 0009-7322. PMID 3257422. Berger, Harvey J.; Eisner, Robert; DePuey, E. ...
Interleukin 20 receptor, alpha subunit
... is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor. The interleukin 20 ... 2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 ... the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin ... 2002). "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2". J. Biol ...
Interleukin 10 receptor, beta subunit
2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 ... Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene. IL10RB has also ... "Entrez Gene: IL10RB interleukin 10 receptor, beta". Lutfalla G, McInnis MG, Antonarakis SE, Uzé G (1995). "Structure of the ... 2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL ...
Interleukin 8
... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". Eur. Cytokine Netw ... Its receptors were similarly renamed: Interleukin 8 receptor, alpha - CXCR1 Interleukin 8 receptor, beta - CXCR2 GRCh38: ... Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types ... In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 ...
Interleukin 12
... (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B- ... Interleukin 12 (IL-12) is produced by activated antigen-presenting cells (dendritic cells, macrophages). It promotes the ... Wang KS, Frank DA, Ritz J (May 2000). "Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up ... IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which ...
HSH2D
... and Interleukin 2 (IL2). A summary of these proteins is shown below with their suspected functions. The HSH2D protein has been ... "IL2 Interleukin 2". Clark, Peter (2012). "Bioinformatics analysis reveals transcriptome and microRNA signatures and drug ... Isoform 2 has a variant 5' UTR and a different start codon, as well as a shorter N-terminus. The mRNA has a short 5' UTR and a ... Isoform 2 has six exons and is 2,936 bp long. Although isoform 2 has longer mRNA, it still produces the smaller isoform in the ...
IL2RA
Interleukin-2 receptor alpha chain (also called TAC antigen, P55 and mainly CD25) is a protein involved in assembly of high- ... The human protein Interleukin-2 receptor subunit alpha is encoded by a gene called IL2RA with a length around 51,6 kb. ... "Entrez Gene: IL2RA interleukin 2 receptor, alpha". Kalia V, Sarkar S (2018-12-20). "Regulation of Effector and Memory CD8 T ... Interleukin-2 can interact with intermediate-affinity dimeric IL-2 receptor, which consists of beta (CD122) and gamma (CD132) ...
Kendall Smith
Kendall A. Smith is an American scientist most well-known for his work on interleukins, the regulatory molecules of the immune ... The creation of the T cell Growth Factor (IL2) bioassay, 1978 The Scientific Rationale For The Interleukin Nomenclature, . J. ... Smith, Kendall A. (1989). "The Interleukin 2 Receptor". Annual Review of Cell Biology. 5 (1): 397-425. doi:10.1146/annurev.cb. ... 2018 The Interleukin 2 Receptor, Academic Press, New York, 1988 The Quantal Theory of Immunity: The molecular Basis of ...
Interleukin 15 receptor, alpha subunit
... is a subunit of the interleukin 15 receptor that in humans is encoded by the IL15RA gene ... "Identification of an interleukin-15alpha receptor-binding site on human interleukin-15". J. Biol. Chem. 279 (23): 24313-22. doi ... Jacob CO, Mykytyn K, Varcony T, Drabkin HA (1993). "Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 ... Khan IA, Moretto M, Wei XQ, Williams M, Schwartzman JD, Liew FY (2002). "Treatment with soluble interleukin-15Ralpha ...
Interleukin-28 receptor
The interleukin 28 receptor consists of an interleukin-28R alpha chain (IL-28RA) and another receptor, the beta subunit of the ... Wolk K, Witte K, Sabat R (August 2010). "Interleukin-28 and interleukin-29: novel regulators of skin biology". Journal of ... It binds type 3 interferons, interleukin-28 A (Interferon lambda 1), Interleukin-28B (Interferon lambda 2), interleukin 29 ( ... The interleukin-28 receptor, once a ligand is bound will activate a signaling pathway that causes an increase in MHC class 1 ...
Melanoma
"Interleukin-2 (IL2) for Metastatic Melanoma". Melanoma Research Alliance. Retrieved 5 October 2022. Buzaid AC (October 2004). " ... June 2011). "gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma". The New England Journal of Medicine. ... IL-2 may offer the possibility of a complete and long-lasting remission in this disease in a small percentage of people with ... Intralesional IL-2 for in-transit metastases has a high complete response rate ranging from 40 to 100%. Similarly, IFN-a has ...