*Interleukin 2

Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that ... Interleukin-2 (Aldesleukin). Date accessed: 07 Nov 10. Shi VY, Tran K, Patel F, Leventhal J, Konia T, Fung MA, Wilken R, Garcia ... Aldesleukin is a form of recombinant interleukin-2. It is manufactured using recombinant DNA technology and is marketed as a ... Welte K, Wang CY, Mertelsmann R, Venuta S, Feldman SP, Moore MA (August 1982). "Purification of human interleukin 2 to apparent ...

*Interleukin 12 receptor, beta 2 subunit

2002). "The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes". Haematologica. 87 ... Interleukin 12 receptor, beta 2 subunit has been shown to interact with Janus kinase 2. The mRNA of this protein is subject to ... Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 ... 1997). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proc. Natl. Acad ...

*HSH2D

... and Interleukin 2 (IL2). A summary of these proteins is shown below with their suspected functions. The HSH2D protein has been ... "IL2 Interleukin 2". Clark, Peter (2012). "Bioinformatics analysis reveals transcriptome and microRNA signatures and drug ... Isoform 2 has a variant 5' UTR and a different start codon, as well as a shorter N-terminus. The mRNA has a short 5' UTR and a ... Isoform 2 has six exons and is 2,936 bp long. Although isoform 2 has longer mRNA, it still produces the smaller isoform in the ...

*IL2RA

Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene. The interleukin ... "Entrez Gene: IL2RA interleukin 2 receptor, alpha". Triplett, Todd A.; et al. (July 2012). "Defining a functionally distinct ... Kuziel WA, Greene WC (June 1990). "Interleukin-2 and the IL-2 receptor: new insights into structure and function". J. Invest. ... Waldmann TA (February 1991). "The interleukin-2 receptor". J. Biol. Chem. 266 (5): 2681-4. PMID 1993646. Retrieved 2008-08-04. ...

*Janus kinase 3

Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995). "Interleukins 2, 4, 7, and ... Rolling C, Treton D, Beckmann P, Galanaud P, Richard Y (May 1995). "JAK3 associates with the human interleukin 4 receptor and ... Kumar N, Mishra J, Narang VS, Waters CM (October 2007). "Janus kinase 3 regulates interleukin 2-induced mucosal wound repair ... Mishra J, Waters CM, Kumar N (March 2012). "Molecular mechanism of interleukin-2-induced mucosal homeostasis". American Journal ...

*GADD45G

Beadling C, Johnson KW, Smith KA (April 1993). "Isolation of interleukin 2-induced immediate-early genes". Proc. Natl. Acad. ... 213 (2): 121-9. doi:10.1016/j.mce.2003.10.050. PMID 15062559. Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K, Wei W ... 16 (1-2): 129-40. doi:10.1615/critrevoncog.v16.i1-2.120. PMC 3268054 . PMID 22150313. Guo W, Dong Z, Guo Y, Chen Z, Kuang G, ... 88 (1-2): 95-6. doi:10.1159/000015496. PMID 10773677. Yi YW, Kim D, Jung N, Hong SS, Lee HS, Bae I (2000). "Gadd45 family ...

*Substance P

Stimulation of interleukin-2 production by substance p". Journal of Neuroimmunology. 37 (1-2): 65-74. doi:10.1016/0165-5728(92) ... 98 (1-2): 55-62. doi:10.1016/S0167-0115(00)00228-7. PMID 11179779. Gobbi G, Cassano T, Radja F, Morgese MG, Cuomo V, Santarelli ... 494 (2-3): 233-9. doi:10.1016/j.ejphar.2004.05.016. PMID 15212980. O'Connor TM, O'Connell J, O'Brien DI, Goode T, Bredin CP, ... 201 (2): 167-80. doi:10.1002/jcp.20061. PMID 15334652. Bossaller C, Reither K, Hehlert-Friedrich C, Auch-Schwelk W, Graf K, ...

*Gadd45

Beadling, C.; Johnson, K.W.; Smith, K.A. (1993). "Isolation of interleukin 2-induced immediate-early genes". Proceedings of the ...

*TOB1

This interaction inhibits interleukin 2 transcription in T cells. TOB1 has been shown to interact with: CNOT7, MAPK1 MARCKS, ... 6 (2): 131-8. doi:10.1046/j.1365-2443.2001.00406.x. PMID 11260258. Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob ... 2 (12): 1174-82. doi:10.1038/ni730. PMID 11694881. Suzuki T, K-Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, Yamamoto T (Jun 2002 ... 10 (2): 151-63. doi:10.1111/j.1365-2443.2005.00826.x. PMID 15676026. TOB1 human gene location in the UCSC Genome Browser. TOB1 ...

*Cathepsin W

Expression of this gene is up-regulated by interleukin-2. GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017 ... 248 (2): 255-61. doi:10.1006/bbrc.1998.8954. PMID 9675123. "Entrez Gene: CTSW cathepsin W". Gerhard DS, Wagner L, Feingold EA, ... 259 (2): 401-7. doi:10.1006/bbrc.1999.0700. PMID 10362521. Brown J, Matutes E, Singleton A, et al. (1998). "Lymphopain, a ...

*Humanized antibody

"A humanized antibody that binds to the interleukin 2 receptor". Proc Natl Acad Sci U S A. 86 (24): 10029-33. doi:10.1073/pnas. ... 61 (Suppl 2): 70-3. doi:10.1136/ard.61.suppl_2.ii70. PMC 1766697 . PMID 12379628. Stacy JE, Kausmally L, Simonsen B, Nordgard ... 58 (Suppl 1): I70-2. doi:10.1136/ard.58.2008.i70. PMC 1766582 . PMID 10577977. Rau R (Nov 2002). "Adalimumab (a fully human ... 283 (1-2): 247-59. doi:10.1016/j.jim.2003.09.015. PMID 14659916. http://www.theraclone-sciences.com/pdf/Theraclone_ISTAR.pdf ...

*Eosinophilic myocarditis

Mice made hypereosinophilic by the forced overexpression of an interleukin-5 transgene (interleukin 5 stimulates eosinophil ... In the latter model, endocarditis is reduced by inhibiting the cytokine interleukin-4 or eosinophils and is exacerbated by ... Other drugs: digoxin, ranitidine, lenalidomide, methyldopa, interleukin 2, dobutamine, acetazolamide. Contaminants: ... are elevated in the cardiac tissue of myosin-immunized mice that are concurrently depleted of interferon gamma and interleukin- ...

*Holger Lode

Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow. Journal of the National Cancer ... Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy. Blood ... Tumor-targeted IL-2 amplifies T cell-mediated immune response induced by gene therapy with single-chain IL-12. Proc Natl Acad ... Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction [In Process Citation ...

*Tumor antigens recognized by T lymphocytes

gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma ". The New England Journal of Medicine. 364(22): ... 14(2): 135-146. Van den Eynde B., Lethé B., Van Pel A., De Plaen E., Boon T. 1991. " The gene coding for a major tumor ... 18(2): 160-175. Khammari A., Knol A.C., Nguyen J.M., Bossard C., Denis M.G., Pandolfino M.C., Quéreux G., Bercegeay S., Dréno B ... A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS ...

*FOXK2

Li C, Lai CF, Sigman DS, Gaynor RB (1991). "Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like ... Nirula A, Moore DJ, Gaynor RB (1997). "Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding ... 2003). "Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a)". Proteins. 49 (4): 543- ... and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and ...

*ILF2

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene. Nuclear factor of activated T- ... "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa". Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI ( ... NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT ... Zhao G, Shi L, Qiu D, Hu H, Kao PN (May 2005). "NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 ...

*Graham Hill (academic)

"Treatment of ocular squamous cell carcinomas in cattle with interleukin-2". The Veterinary Record (abstract). London: British ... 55 (2): 82-85. doi:10.1111/j.1751-0813.1979.tb15171.x. Retrieved 2009-01-04. Hill, F.W.G.; Kelley, D.F. (1974). "Naturally ... Bingham, J.; Schumacher, C.L.; Hill, F.W.G.; Aubert, A. (1999). "Efficacy of SAG-2 oral rabies vaccine in two species of jackal ...

*Progressive multifocal leukoencephalopathy

Two case reports of using interleukin-2 successfully have been published. Some success have been reported with mirtazapine, but ... "Nonmyeloablative allogeneic stem cell transplantation for refractory Hodgkin's lymphoma complicated by interleukin-2 responsive ... 9 Suppl 1 (2): 38-41. doi:10.1080/13550280390195261. PMID 12709870. Mateen, FJ; Muralidharan, R; Carone, M; Van De Beek, D; ... 2 March 2010. "Off-Label Use of Rituxan Linked to Fatal Leukoencephalopathy". MedScape. WebMD LLC. Kumar, Deepak; Bouldin, ...

*Inolimomab

Its target is the alpha chain of the interleukin-2 receptor. Piñana JL, Valcárcel D, Martino R, et al. (November 2006). " ... "Encouraging results with inolimomab (anti-IL-2 receptor) as treatment for refractory acute graft-versus-host disease". Biology ...

*Histamine dihydrochloride

The combination of histamine dihydrochloride and interleukin-2 was approved for use in AML patients within the European Union ... Histamine dihydrochloride is administered in conjunction with low doses of the immune-activating cytokine interleukin-2 (IL-2) ... "Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 in AML". Scand. J. Immunol. 70 (3): 194-205. ... "Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute ...

*Immunotherapy

Cytokines, Interleukin-7 and Interleukin-2 have been tested in clinical trials. Antimicrobial immunotherapy, which includes ... The helminths down regulate the pro-inflammatory Th1 cytokines, Interleukin-12 (IL-12), Interferon-Gamma (IFN-γ) and Tumour ... These T cells, referred to as tumor-infiltrating lymphocytes (TIL), are multiplied using high concentrations of Interleukin-2, ... Co-evolution with helminths has shaped some of the genes associated with Interleukin expression and immunological disorders, ...

*Doreen Cantrell

"The interleukin-2 T-cell system: a new cell growth model". Science. 224 (4655): 1312-1316. doi:10.1126/science.6427923. ISSN ...

*ATG10

Feldman RD, Hunninghake GW, McArdle WL (1987). "Beta-adrenergic-receptor-mediated suppression of interleukin 2 receptors in ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). " ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using ...

*HIV/AIDS research

Tincati, C; d'Arminio Monforte, A; Marchetti, G (January 2009). "Immunological mechanisms of interleukin-2 (IL-2) treatment in ... Interleukin-1 beta). Seeding of HIV in the body begins within a few days, during the acute phase of HIV infection. Research to ... 5 (2): 753-757. doi:10.3390/v5020753. HIV and AIDS News (ScienceDaily) HIV and AIDS News (Medical News Today) [1]. ... Retrieved 2 May 2013. Saundra Young (3 July 2013). "Patients HIV-free for now after transplant". CNN. Retrieved 4 July 2013. ...

*LCP1

"Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells". Biochemistry. 29 (4): 1055-62. doi ... "65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium- ... Plastin-2 is a protein that in humans is encoded by the LCP1 gene. Plastins are a family of actin-binding proteins that are ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Okumura Y, Yano M, Murakami M, Mori S, Towatari T, Kido H ( ...

*Childbirth

"Fetal distress increases interleukin-6 and interleukin-8 and decreases tumour necrosis factor-alpha cord blood levels in ... 2015 Apr;57(2):15 Lukasse M, Schei B, Ryding EL, Bidens Study Group. Prevalence and associated factors of fear of childbirth in ... 108 (2): 169-178. doi:10.1111/j.1471-0528.2001.00039.x. Giacalone, P. L.; Vignal, J.; Daures, J. P.; Boulot, P.; Hedon, B.; ... 35 (2). Archived from the original on 2016-03-04. Stanton, C.; Armbruster, D; Knight, R.; Ariawan, I.; et al. (February 13, ...