Together with Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), granulocyte colony- ... Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with ... "Entrez Gene: IL15 interleukin 15". Tagaya Y, Kurys G, Thies TA, Losi JM, Azimi N, Hanover JA, et al. (December 1997). " ... March 2006). "Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors". Nature ...
Waldmann, Thomas A. (August 2006). "The biology of interleukin-2 and interleukin-15: implications for cancer therapy and ... Interleukin 15-like (IL-15L) is an interleukin, a type of cytokine signaling in the immune system. It is a secreted protein of ... Malek, Thomas R. (2008-04-01). "The Biology of Interleukin-2". Annual Review of Immunology. 26 (1): 453-479. doi:10.1146/ ... Articles with short description, Short description with empty Wikidata description, Interleukins). ...
Receptors,+Interleukin-15 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (CS1 maint: date and ... Interleukin-15 receptor is a type I cytokine receptor, binding interleukin-15. It consists of an interleukin 15 receptor, alpha ... PDB: 2B5I​Wang X, Rickert M, Garcia KC (November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, ... "Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes". J. ...
"Identification of an interleukin-15alpha receptor-binding site on human interleukin-15". J. Biol. Chem. 279 (23): 24313-22. doi ... Interleukin 15 receptor, alpha subunit is a subunit of the interleukin 15 receptor that in humans is encoded by the IL15RA gene ... Jacob CO, Mykytyn K, Varcony T, Drabkin HA (1993). "Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 ... Khan IA, Moretto M, Wei XQ, Williams M, Schwartzman JD, Liew FY (2002). "Treatment with soluble interleukin-15Ralpha ...
Patients are typically treated for five consecutive days, three times a day, for fifteen minutes. The following approximately ... Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein ... Interleukin-2 (Aldesleukin). Date accessed: 07 Nov 10. Shi VY, Tran K, Patel F, Leventhal J, Konia T, Fung MA, Wilken R, Garcia ... 2018-07-26). "Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional ...
... is expressed on various cell types, including naive and memory T cells and many others. Interleukin-7 ... The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - ... "Entrez Gene: IL7R interleukin 7 receptor". Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, ... Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain ...
... 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ... Recombinant expression enables cells to process precursor Interleukin 1 Beta to the mature form of the enzyme. Interleukin 1 ... di Giovine FS, Duff GW (Jan 1990). "Interleukin 1: the first interleukin". Immunology Today. 11 (1): 13-20. doi:10.1016/0167- ...
Chazen, G D; Pereira, G M; LeGros, G; Gillis, S; Shevach, E M (1989). "Interleukin 7 is a T-cell growth factor". Proceedings of ... A number of them have been discovered, among them many members of the interleukin family. The thymus is one organ which ... Steel, JC; Waldmann, TA; Morris, JC (January 2012). "Interleukin-15 biology and its therapeutic implications in cancer". Trends ... IL-2[full citation needed] IL-7[full citation needed] IL-9 IL-15 Oppenheim, Joost J. (August 1, 2007). "IL-2: More Than a T ...
March 2011). "Interleukin 10 decreases MICA expression on melanoma cell surface". Immunology and Cell Biology. 89 (3): 447-57. ... Horng T, Bezbradica JS, Medzhitov R (December 2007). "NKG2D signaling is coupled to the interleukin 15 receptor signaling ... Interaction with IL-15 receptor (IL-15R) is a crucial factor for development, homeostasis and survival of NK cells and NKG2D ... 191 (3): 1307-15. doi:10.4049/jimmunol.1300670. PMID 23804716. McQueen B, Trace K, Whitman E, Bedsworth T, Barber A (March 2016 ...
Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL- ... Interleukin 19 (IL-19) is an immunosuppressive protein that belongs to the IL-10 cytokine subfamily. Human IL-19 is encoded by ... "IL19 interleukin 19 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-03-01. Leigh T, Scalia RG, ... Focus on "Interleukin-19 decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule ...
... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". Eur. Cytokine Netw ... Its receptors were similarly renamed: Interleukin 8 receptor, alpha - CXCR1 Interleukin 8 receptor, beta - CXCR2 GRCh38: ... Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types ... In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 ...
Interleukin-4 from Gentaur Recombinant Human Interleukin-4 from Cornell University Interleukin-4 from Allergy Glossary at ... Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor ... The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon ... The receptor for interleukin-4 is known as the IL-4Rα. This receptor exists in 3 different complexes throughout the body. Type ...
... (IL-35) is a recently discovered anti-inflammatory cytokine from the IL-12 family. Member of IL-12 family - IL- ... June 2014). "Interleukin-35 induces regulatory B cells that suppress autoimmune disease". Nature Medicine. 20 (6): 633-41. doi: ... Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40- ... Compared to these two related interleukins, IL-35 is also able to signal through only one of the aforementioned chains. This ...
IRP induced the rapid expression of interleukin 15 (IL15) and other factors. Thus IRP activates the immune system. Studies show ... notably interleukin 15 (IL-15). This produces a number of downstream responses that are pro-inflammatory. The other peptide ... Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides". Gut. 56 (6): 889 ... IL-15 appears to induce increases in MICA and NKG2D that may increase brush-border cell killing. In addition, innate immunity ...
Other factors released include interleukin-15 and vascular endothelial growth factor (VEGF). A reasonable understanding of the ...
... a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This ... 2004). "Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of ... Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. The protein encoded by this gene is a cytokine ... 2005). "Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity". Mol. Cell ...
Interleukin-25 (IL-25) - also known as interleukin-17E (IL-17E) - is a protein that in humans is encoded by the IL25 gene on ... "Entrez Gene: IL25 interleukin 25". Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 ... April 2015). "Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation". Immunity. 42 (4): 692-703. doi:10.1016 ... Angkasekwinai P, Park H, Wang YH, Wang YH, Chang SH, Corry DB, Liu YJ, Zhu Z, Dong C (July 2007). "Interleukin 25 promotes the ...
As a signaling molecule, interleukin 11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; ... Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. IL-11 is a ... Chen HF, Lin CY, Chao KH, Wu MY, Yang YS, Ho HN (May 2002). "Defective production of interleukin-11 by decidua and chorionic ... Interleukin 11 is manufactured using recombinant DNA technology.[citation needed] It is marketed as a protein therapeutic ...
Zurawski G, de Vries JE (January 1994). "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but ... Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located ... Interleukin-13 has a critical role in goblet cell metaplasia. Goblet cells are filled with mucin (MUC). MUC5AC Mucin 5AC is a ... October 2004). "Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human ...
... , also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins ... Renauld J (1995). "Interleukin-9: Structural characteristics and biologic properties". Cytokines: Interleukins and Their ... Interleukin 33 (IL-33) induces IL-9 expression and secretion in T cells, which was confirmed by the results obtained in mice by ... Interleukin-9 has also shown to inhibit melanoma growth in mice. Additionally, it gives rise to the multiplication of ...
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 ( ... "Entrez Gene: interleukin 29 (interferon". Wang JM, Huang AF, Xu WD, Su LC (December 2019). "Insights into IL-29: Emerging role ... Pagliaccetti NE, Eduardo R, Kleinstein SH, Mu XJ, Bandi P, Robek MD (October 2008). "Interleukin-29 functions cooperatively ... Articles with short description, Short description matches Wikidata, Genes on human chromosome 19, Interleukins, Cytokines, ...
Interleukin-1 family Interleukin 18 Interleukin 18 receptor Interleukin 18 binding protein Inflammation Carcinogenesis GRCh38: ... Interleukin 37 (IL-37), also known as Interleukin-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine important for ... April 2018). "The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis". ... interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382-384. doi:10.1006/geno.1994.1076. PMID ...
... (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 ... The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte ... Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a ... Overview of all the structural information available in the PDB for UniProt: P05113 (Interleukin-5) at the PDBe-KB. (CS1: long ...
Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor". Annual Review of ... Media related to Interferons or interleukin-10 (IL-10) at Wikimedia Commons Interleukin-10 at the U.S. National Library of ... Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001-01-01). "Interleukin-10 and the interleukin-10 receptor". Annual ... "Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin ...
... is mainly activated by cytokines interleukin-4 and interleukin-13. In the human genome, STAT6 protein is encoded by the ... STAT6 is activated by cytokines interleukin-4 (IL-4), and interleukin-13 (IL-13) with their receptors that both contain the α ... "Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene". The ... Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (September 1994). "An interleukin-4-induced transcription factor ...
"Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells". Cancer Research. 61 (24): 8851-8858 ... 15 (11): 4555-4561. doi:10.7314/apjcp.2014.15.11.4555. ISSN 1513-7368. PMID 24969884. Mickley, L A; Spengler, B A; Knutsen, T A ... 2004-07-15). "Oncogenic H-Ras Up-Regulates Expression of ERCC1 to Protect Cells from Platinum-Based Anticancer Agents". Cancer ... 15: 71. doi:10.1186/s12935-015-0221-1. PMC 4502609. PMID 26180516. Luqmani, Y.A. (2005). "Mechanisms of Drug Resistance in ...
Catalan-Dibene, Jovani; McIntyre, Laura L.; Zlotnik, Albert (October 2018). "Interleukin 30 to Interleukin 40". Journal of ... Interleukin 40, or IL-40, also known with other name C17orf99 is encoded by gene that do not belong to any cytokine superfamily ... Interleukin-40 is a promising biomarker associated with type 2 diabetes mellitus risk. Immunol Lett. 2023 Feb;254:1-5. doi: ... The expression of IL-40, an interleukin involved in immune regulation, has been found to be elevated in the synovial fluid of ...
Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is ... It binds to the interleukin-1 receptor. It is on the pathway that activates tumor necrosis factor-alpha. Interleukin 1 was ... It was not until 1985 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and ... Nicklin MJ, Weith A, Duff GW (Jan 1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin- ...
"Entrez Gene: IL9R interleukin 9 receptor". Sliva, D; Gu M; Zhu Y X; Chen J; Tsai S; Du X; Yang Y C (February 2000). "14-3-3zeta ... Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also ... Interleukin-9 receptor has been shown to interact with YWHAZ. Cluster of differentiation GRCh38: Ensembl release 89: ... 1992). "Expression cloning of the murine and human interleukin 9 receptor cDNAs". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5690-4 ...
Onishi RM, Gaffen SL (March 2010). "Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease". ... "Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E". Immunity. 35 (4): 611-21. ... Zhang B, Liu C, Qian W, Han Y, Li X, Deng J (May 2014). "Structure of the unique SEFIR domain from human interleukin 17 ... Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory ...