... and EP4 receptors, enprostil is a more selective receptor agonist in that it binds to and activates primarily the EP3 receptor ... December 2000). "Enprostil, a prostaglandin-E(2) analogue, inhibits interleukin-8 production of human colonic epithelial cell ... Prostaglandin receptors EP3 and peptic ulcer Roszkowski AP, Garay GL, Baker S, Schuler M, Carter H (November 1986). "Gastric ... It is an analog of prostaglandin E2 but unlike this prostaglandin, which binds to and activates all four cellular receptors viz ...

The P2X7 subunits can form homomeric receptors only with a typical P2X receptor structure. The P2X7 receptor is a ligand-gated ... Clark AK, Staniland AA, Marchand F, Kaan TK, McMahon SB, Malcangio M (January 2010). "P2X7-dependent release of interleukin- ... One study in mice showed that blockade of P2X7 receptors attenuates onset of liver fibrosis. Purinergic receptor P2X receptor ... P2X7 receptors respond to BzATP more readily than ATP. ADP and AMP are weak agonists of P2X7 receptors, but a brief exposure to ...

Poly I:C is known to interact with toll-like receptor 3 (TLR3), which is expressed at the endosomal membrane of B-cells, ... induces fever in rats via an interleukin-1-dependent mechanism". Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (4): R759-66 ... "Activation of Dendritic Cells by the Novel Toll-Like Receptor 3 Agonist RGC100". Clinical and Developmental Immunology. 2013: ... 21 (11): 905-13. doi:10.1111/cns.12469. PMC 4638223. PMID 26494128. Naumann, Kai; Wehner, Rebekka; Schwarze, Anett; Petzold, ...

... like receptors, retinoic acid inducible gene-I (RIG-I)-like receptors and C-type lectin-like receptors (CLRs). They recognize ... Yoshimoto T (2018). "The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and ... Pattern Recognition Receptors (PRRs) are a family of surface receptors on antigen-presenting cells that includes toll-like ... Kuroki K, Furukawa A, Maenaka K (2012). "Molecular recognition of paired receptors in the immune system". Front Microbiol. 3: ...

High levels of interleukin-5 has been observed to up regulate the expression of adhesion molecules, which then facilitate the ... Mepolizumab and benralizumab are other treatment options that target the alpha subunit of the IL-5 receptor, thereby inhibiting ... Yamaguchi Y, Suda T, Suda J, Eguchi M, Miura Y, Harada N, Tominaga A, Takatsu K (January 1988). "Purified interleukin 5 ... Sanderson, Colin (1992). "Interleukin-5, Eosinophils, and Disease". Blood. 79 (12): 3101-3109. doi:10.1182/blood.V79.12.3101. ...

"TRAIL Receptor Antibodies - HGS". Hgsi.com. Archived from the original on 16 May 2008. Retrieved 12 May 2010. Pukac, L; ... that potently and specifically neutralises interleukin 13, a T-lymphocyte-derived cytokine that plays a key role in the ... In addition, the committee voted 18 - 0 in favour of the risk-benefit profile of raxibacumab". Two anti-TRAIL receptor ... GM-CSF Receptor). In 2007, some elements of the local press suggested this product could be the next HUMIRA. CAM-3001 is ...

Pochampally RR, Ylostalo J, Penfornis P, Matz RR, Smith JR, Prockop DJ (September 2007). "Histamine receptor H1 and ... interleukin-4, and matrix collagen". The Journal of Investigative Dermatology. 112 (5): 706-10. doi:10.1046/j.1523-1747.1999. ... Dermatopontin determined to be found in the interaction sites of Fn on III_13 and III_14 and cryptic site of III_1, which all ... 465 (6): 703-13. doi:10.1007/s00428-014-1666-7. hdl:1887/105336. PMID 25304290. S2CID 24625787. Krishnaswamy VR, Manikandan M, ...

"HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and ... Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they ... and B-cell receptor expression". The Journal of Allergy and Clinical Immunology. 105 (5): 975-82. doi:10.1067/mai.2000.105315. ... Journal of Receptor and Signal Transduction Research. 22 (1-4): 79-110. doi:10.1081/RRS-120014589. PMID 12503609. S2CID ...

June 2007). "Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells". Nature ... chemokine receptor. CCR10 is receptor for CCL27 and CCL28 that was originally called orphan receptor GPR2. CCR10 has been ... The CC chemokine receptors all work by activating the G protein Gi. CCR1 was the first CC chemokine receptor identified and ... This receptor is well defined as a major coreceptor implicated in susceptibility to HIV-1 infection and disease. This receptor ...

Cambien B, Wagner DD (2004). "A new role in hemostasis for the adhesion receptor P-selectin". Trends in Molecular Medicine. 10 ... Woltmann G, McNulty CA, Dewson G, Symon FA, Wardlaw AJ (May 2000). "Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion ... and interleukin-4 (IL-4). Although TNF-a and LPS increase levels of both mRNA and protein in murine models, they do not appear ... and P-selectin and vascular cell adhesion molecule-1 function as signaling receptors". J. Cell Biol. 142 (5): 1381-91. doi: ...

Type II-lectin receptor CD69 is presented on cell surface shortly after activation. The presence of CD69 is not specific for ... The survival of CD25+CD4+ Treg cells is dependent upon interleukin 2 (IL-2), while in vitro differentiation of Th3 cells is ... that can be induced in the gut by oral antigen through T cell receptor (TCR) signalling. The function of T helper cells ... Th3 cells produce vast amounts of TGF-β and to a lesser degree also the anti-inflammatory cytokine interleukin 10 (IL-10). In ...

2005). "Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through ... 2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung- ... specific ligand-receptor pair". J. Immunol. 171 (2): 924-30. doi:10.4049/jimmunol.171.2.924. PMID 12847263. Clark HF, Gurney AL ... 21 (13): 2703-12. doi:10.1002/1522-2683(20000701)21:13. 3.0.CO;2-W. PMID 10949149. S2CID 38601731. Niimi T, Munakata M, Keck- ...

... and not other receptors, in the process of receptor-mediated endocytosis. Addition of an enzyme that frees the folate receptor ... with low dose cytokines interleukin-2 (IL-2) and interferon-α (IFN-α) in patients with refractory or metastatic cancer". J Clin ... January 1999). "Folate receptor type beta is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia ... Parker N, Turk MJ, Westrick E, Lewis JD, Low PS, Leamon CP (March 2005). "Folate receptor expression in carcinomas and normal ...

"Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor." Science (American Association for the ... On 13 June 2013, the United States Supreme Court ruled in the case of Association for Molecular Pathology v. Myriad Genetics ... Liptak, Adam (13 June 2013). "Supreme Court Rules Human Genes May Not Be Patented". The New York Times. Archived from the ...

Koh SS, Chen D, Lee YH, Stallcup MR (2001). "Synergistic enhancement of nuclear receptor function by p160 coactivators and two ... interacts with and is regulated by interleukin enhancer-binding factor 3". J. Biol. Chem. 275 (26): 19866-76. doi:10.1074/jbc. ... "Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1". Curr. Biol. ... "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor ...

It has also been shown that IFN receptors and interleukins in blood serum predicts response to IFN therapy, specially IL-17, ... 2008). "Interleukin-10 and interleukin-12 modulation in patients with relapsing-remitting multiple sclerosis on therapy with ... The collaboration between LTB on Th17 cells and LTBR (Lymphotoxin beta receptor) on meningeal radio-resistant cells is very ... adrenergic receptors and a reduced formation of cAMP, resulting in a reduced uptake of K(+) at the nodes of Ranvier and a ...

Anakinra is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein. Anakinra blocks ... now called interleukin-1 alpha and interleukin-1 beta. IL-1β is a member of the interleukin 1 family of cytokines. This ... interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". European Cytokine ... interleukin 1 beta convertase) to form mature IL-1β. The fever-producing property of human leukocytic pyrogen (interleukin 1) ...

G protein coupled receptor 132, also termed G2A, is classified as a member of the proton sensing G protein coupled receptor ( ... interleukin-6, interleukin-8, and GM-CSF. These activities are G2A-dependent. It is suggested that 9-HODE acts in human skin to ... "Entrez Gene: GPR132 G protein-coupled receptor 132". Obinata H, Izumi T (September 2009). "G2A as a receptor for oxidized free ... the roles of G2A as a pH-sensor or LPC receptor are disputed. Rather, current studies suggest that it is a receptor for certain ...

"Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases". The Journal of Allergy and Clinical ... CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFNγ receptor expression on ... to express functional IFNγ receptors. Further experiments showed that IFN-γ was responsible for inhibition of tumor induced ... 13, pp. 459-463 Street, S.E., Cretney, E. and Smyth, M.J., 2001. Perforin and interferon-γ activities independently control ...

Classic examples of PRRs include toll-like receptors (TLRs) and NOD-like receptors (NLRs). Recognition of PAMPs and DAMPs ... Church LD, Cook GP, McDermott MF (January 2008). "Primer: inflammasomes and interleukin 1beta in inflammatory disorders". ... These receptors upregulate expression of inflammatory cytokines such as IFN α/β, tumour necrosis factor (TNF), IL-6 and IL-12 ... The innate immune system, by using germ-line encoded pattern recognition receptors (PRRs), can recognize a wide range of ...

Delta toxin molecules activate a G-protein-coupled receptor expressed in leukocytes called formyl-peptide receptor 2 (FPR2), ... Delta toxin is also a chemoattractant for leukocytes, leading to a surge of cytokines such as interleukin-8 from neutrophils at ... PSMs, like S. aureus delta toxin, can prevent the activation and proliferations of CD4+ T cells, depending on interleukin-10 ... without a receptor, and integrate into the membrane. Delta toxin degrades the membrane on contact and forms short-lived pores, ...

"Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and ... Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and ... This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription ... "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 ...

Tocilizumab is a humanized antibody that targets the interleukin-6 receptor, which is a key cytokine involved in the ... 13 April 2017. Archived from the original on 22 October 2017. Retrieved 21 October 2017. Moutray TN, Williams MA, Best JL ( ... 13 April 2017. Archived from the original on 22 October 2017. Retrieved 21 October 2017. Weyand CM, Goronzy JJ (July 2014). " ...

... and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an ... a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". The Journal of ... Müller B, Cooper L, Terhorst C (January 1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor ... "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature. ...

The human gene has been localized in close proximity to the interleukin 3 gene within a T helper type 2-associated cytokine ... These include, for example, enhancing neutrophil migration and causing an alteration of the receptors expressed on the cells ... Other genes in the cluster include those encoding interleukins 4, 5, and 13. Human granulocyte-macrophage colony-stimulating ... "A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 ...

Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (Feb 1996). "A novel interleukin-12 p40- ... van Leeuwen JE, Kearse KP (Apr 1996). "Calnexin associates exclusively with individual CD3 delta and T cell antigen receptor ( ... 268 (13): 9585-92. doi:10.1016/S0021-9258(18)98391-2. PMID 8486646. Bellovino D, Morimoto T, Tosetti F, Gaetani S (Jan 1996). " ... 13 (12): 960-9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774. Galvin K, Krishna S, Ponchel F, Frohlich M, ...

... estrogen receptor (ER), progesterone receptor (PR), and HER2/neu. Cells with or without these receptors are called ER positive ... November 2010). "Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells". ... Receptor status. Cells have receptors on their surface and in their cytoplasm and nucleus. Chemical messengers such as hormones ... Receptor status was traditionally considered by reviewing each individual receptor (ER, PR, her2) in turn, but newer approaches ...

November 1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is ... April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated ... The gene for CCL27 is located on human chromosome 9. Studies of a similar murine protein indicate that these protein-receptor ... February 2005). "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and ...

Toll interleukin-1 receptor domain, which is normally present in innate immune cells. The immune system must be able to ... These include TGF-β, Interleukin 35, and Interleukin 10. It also appears that regulatory T cells can induce other cell types to ... A related suggestion with regard to interleukin 2 is that activated regulatory T cells take up interleukin 2 so avidly that ... population and express high levels of the interleukin-2 receptor alpha chain (CD25). In addition to the FOXP3-expressing CD4+ ...

Baird GS, Zacharias DA, Tsien RY (September 1999). "Circular permutation and receptor insertion within green fluorescent ... "Backtracking on the folding landscape of the beta-trefoil protein interleukin-1beta?". Proceedings of the National Academy of ... 165 (2): 407-13. doi:10.1016/S0022-2836(83)80265-4. PMID 6188846. Luger K, Hommel U, Herold M, Hofsteenge J, Kirschner K ( ... 22 (10): 607-13. doi:10.1093/protein/gzp034. PMID 19622546. Cheltsov AV, Barber MJ, Ferreira GC (June 2001). "Circular ...