Loading...
*  Interleukin-1 receptor
... (IL-1R) is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. The type I ... Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445- ... Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP ... Receptors, Interleukin-1 at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Interleukin-1 family
Liu N, Li X, Liu C, Zhao Y, Cui B, Ning G (2010). "The association of interleukin-1alpha and interleukin-1beta polymorphisms ... The Interleukin-1 family (IL-1 family) is a group of 11 cytokines, which plays a central role in the regulation of immune and ... The interleukin-1 superfamily has 11 members, which have similar gene structure, although originally it contained only four ... Dinarello CA (2011). "Interleukin-1 in the pathogenesis and treatment of inflammatory diseases". Blood. 117 (14): 3720-32. doi: ...
*  Interleukin 1 beta
... interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". Eur. Cytokine Netw. 13 (2): 161-72. ... There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic ... "Entrez Gene: IL1B interleukin 1, beta". Masters SL, Simon A, Aksentijevich I, Kastner DL (2009). "Horror autoinflammaticus: the ... This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. The molecular weight of the ...
*  Interleukin-1 receptor family
The term interleukin-1 includes IL-1α, IL-1β and Interleukin 1 receptor antagonist (IL-1Ra). IL-1Rs are involved in immune host ... Jul 1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261: 472-5. doi: ... There are four main groups of TIR domain-containing proteins in animals; Toll-like receptors, Interleukin-1 receptor (IL-1R), ... Weber A, Wasiliew P, Kracht M (Jan 2010). "Interleukin-1 (IL-1) pathway". Journal Nature Reviews Immunology. Dinarello CA. (Apr ...
*  Interleukin 1 receptor antagonist
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially ... Interleukin 1 receptor antagonist is used in horses for the treatment of equine lameness secondary to joint and soft-tissue ... An interleukin 1 receptor antagonist is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 ... "Entrez Gene: IL1RN interleukin 1 receptor antagonist". Langdahl BL, Løkke E, Carstens M, Stenkjaer LL, Eriksen EF (March 2000 ...
*  Interleukin-1 receptor associated kinase
Interleukin 1 is a cytokine that acts locally and systemically in the innate immune system. IL-1a and IL-1ß are known for ... The interleukin-1 receptor (IL-1R) associated kinase (IRAK) family plays a crucial role in the protective response to pathogens ... Interleukin-1 Receptor-Associated Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) Suzuki, N., ... Identification of Interleukin 1 Receptor-associated Kinase as a Conserved Component in the p75-Neurotrophin Receptor Activation ...
*  Interleukin 1 receptor, type I
1989). "Cloning the interleukin 1 receptor from human T cells". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946-50. doi:10.1073/ ... Interleukin 1 receptor, type I has been shown to interact with PIK3R1, Myd88 and IL1RAP. Cluster of differentiation Interleukin ... Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. ... The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a ...
*  Interleukin 1 receptor, type II
"Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636-41. doi:10.1006 ... Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this ... "Entrez Gene: IL1R2 interleukin 1 receptor, type II". McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE ... Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. ...
*  Deficiency of the interleukin-1-receptor antagonist
Interleukin 1 receptor antagonist(IL1RN) has a total of five alleles, of those the (IL1RN*1) and (IL1RN*2) are the most common ... "Deficiency of interleukin-1 receptor antagonist, Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". ... Deficiency of the interleukin-1-receptor antagonist (DIRA) is a autosomal recessive, genetic autoinflammatory syndrome ... The mutations result in an abnormal protein that is not secreted, exposing the cells to unopposed interleukin 1 activity. This ...
*  Interleukin 13 receptor, alpha 1
2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". J. Biol. Chem. 280 (26): ... Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene. The ... Interleukin-13 receptor GRCh38: Ensembl release 89: ENSG00000131724 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Orchansky PL, Kwan R, Lee F, Schrader JW (1999). "Characterization of the cytoplasmic domain of interleukin-13 receptor-alpha ...
*  Interleukin 12 receptor, beta 1 subunit
1998). "Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 ... "Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor ... Interleukin 12 receptor, beta 1 is a subunit of the interleukin 12 receptor. IL12RB1, is its human gene. IL12RB1 is also known ... 1995). "Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist". Eur. J. Immunol. 25 (1): 200-6. doi:10.1002/eji ...
*  Silver phosphate
Taichman, R. S.; Hauschka, P. V. (1992). "Effects of interleukin-1? And tumor necrosis factor-? On osteoblastic expression of ... www.nims.go.jp Nanocoated film as a bacteria killer 23/1/2009 , www.nanowerk.com Silver pyrophosphate www.chemicalbook.com ...
*  Gout
... which converts pro-interleukin 1β into active interleukin 1β, one of the key proteins in the inflammatory cascade. An ... "Interleukin-1 inhibitors for acute gout". The Cochrane Database of Systematic Reviews. 9 (9): CD009993. doi:10.1002/14651858. ... Gout affects about 1 to 2% of the Western population at some point in their lives. It has become more common in recent decades ... Roddy, Edward (Oct 1, 2013). "Gout". BMJ. 347: f5648. doi:10.1136/bmj.f5648. Archived from the original on 2013-12-04. Hak AE, ...
*  Periodic fever syndrome
Interleukin-1, inflammasome and autoinflammatory diseases]". La Revue de medecine interne. PMID 27639913. John R. Lukens, ... Thus, IL-1β has become a common therapeutic target, and medications such as anakinra, rilonacept, and canakinumab have ... showed a reduction in Prevotella abundance and were accompanied by significantly reduced expression levels of pro-Interleukin-1 ... Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease*. Annu Rev Immunol 2009;27(1):621-68 ...
*  Toll-Interleukin receptor
The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signaling domain found in MyD88, interleukin-1 ... Interleukin-1 receptor InterPro: IPR004075 IL18R1; IL18RAP; IL1R1; IL1RAP; IL1RAPL1; IL1RAPL2; IL1RL1; IL1RL2; MYD88; SIGIRR; ... These proteins are type-I transmembrane receptors that share an intracellular 200 residue domain with the interleukin-1 ... "T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family". J. Biol. Chem. 271 (10): 5777-5783 ...
*  Tamas Bartfai
Bartfai's group showed interleukin-1, then called the endogenous pyrogen, is released from the adrenal medulla and brain and ... Cytokines, such as interleukin-1 can be synthesized and released by neurons. ... "Interleukin-1 in adrenal chromaffin cells". Neuroscience. 30 (3): 805-10. doi:10.1016/0306-4522(89)90171-1. CS1 maint: Multiple ... and as a consultant to Novartis the sphingosine 1-phosphate agonist gilenya-fingolimod as the first oral multiple sclerosis ...
*  Canakinumab
... (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has ... including interleukin-1 alpha. Canakinumab was approved for the treatment of cryopyrin-associated periodic syndromes (CAPS) by ... "Interleukin-1 inhibitors for acute gout". The Cochrane Database of Systematic Reviews. 9: CD009993. doi:10.1002/14651858. ... 2 (1): 3-13. doi:10.4161/mabs.2.1.10328. PMC 2828573 . PMID 20065636. Lachmann, HJ; Kone-Paut I; Kuemmerle-Deschner JB; et al ...
*  Diacerein
... works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of ... It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial effect on ...
*  PTX3
"Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P ... 7 (1): 1-8. doi:10.1016/j.micinf.2004.09.004. PMID 15716076. Latini R, Maggioni AP, Peri G, Gonzini L, Lucci D, Mocarelli P, ... 107 (1): 151-8. doi:10.1182/blood-2005-03-1112. PMID 16166594. Mantovani A, Garlanda C, Bottazzi B (2004). "Pentraxin 3, a non- ... Lee GW, Lee TH, Vilcek J (1993). "TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the ...
*  TICAM2
Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in ... TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor ... 2004). "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces ... 2007). "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates". J. Immunol. 178 (7): ...
*  Anakinra
"Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 ... It is an interleukin 1 (IL1) receptor antagonist. It is produced by Swedish Orphan Biovitrum. Anakinra is a recombinant version ... "Anti-Interleukin-1 Agents in Adult Onset Still's Disease". Hindawi. 2012-02-07. Retrieved 2012-10-13. "New type of drug helpful ... Sturfelt, G.; Roux-Lombard, P.; Wollheim, F. A.; Dayer, J. M. (1997-12-01). "Low levels of interleukin-1 receptor antagonist ...
*  Deoxyribonuclease I
1988). "A human urine-derived interleukin 1 inhibitor. Homology with deoxyribonuclease I". J. Exp. Med. 168 (5): 1767-79. doi: ... 59 (Pt 1): 1-15. doi:10.1111/j.1469-1809.1995.tb01601.x. PMID 7762978. Yasuda T, Nadano D, Iida R, et al. (1995). "Chromosomal ... 508 (1): 131-5. doi:10.1016/S0014-5793(01)03040-X. PMID 11707283. Tsutsumi S, Kaneko Y, Asao T, et al. (2002). "DNase I is ... 47 (1): 121-6. PMC 1683738 . PMID 2349940. Kabsch W, Mannherz HG, Suck D, et al. (1990). "Atomic structure of the actin:DNase I ...
*  Psychoneuroimmunology
Interleukin-2 (IL-2), interleukin-6 (IL-6), Interleukin-12 (IL-12), Interferon-gamma (IFN-Gamma) and tumor necrosis factor ... Besedovsky, H.; del Rey, A.; Sorkin, E.; Dinarello, C. A. (1986-08-08). "Immunoregulatory feedback between interleukin-1 and ... Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP (1998). "The pathophysiologic roles of interleukin-6 in human disease". ... Molecules called pro-inflammatory cytokines, which include interleukin-1 (IL-1), ...
*  IL36A
Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A ... 2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF- ... "Entrez Gene: IL1F6 interleukin 1 family, member 6 (epsilon)". Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the ... 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718-25. doi:10.1006/geno. ...
*  Decoy receptors
"IL1R2 interleukin 1 receptor, type II [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. National Center for Biotechnology ... 1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of ... VEGFR-1 inhibits the activity of VEGFR-2 by sequestering VEGF, thus preventing VEGFR-2 from binding to VEGF. Axl receptor ... VEGFR-1 is a kinase-defective receptor tyrosine kinase that negatively modulates angiogenesis by acting as a decoy receptor. ...
*  Childbirth
"Fetal distress increases interleukin-6 and interleukin-8 and decreases tumour necrosis factor-alpha cord blood levels in ... 47 (1): 26-30. doi:10.1111/j.1479-828X.2006.00674.x. PMID 17261096. Reiter, R. J.; Tan, D. X.; Korkmaz, A.; Rosales-Corral, S. ... Retrieved 1 February 2017. Handel, M.; Swaab, H.; De Vries, L.S.; Jongmans, M.J. (2007). "Long-term cognitive and behavioral ... 25 (1): 67-72. doi:10.1111/j.1552-6909.1996.tb02515.x. PMID 8627405. Callister, L.C.; Khalaf, I.; Semenic, S.; Kartchner, R.; ...